Embelin, an Inhibitor of X Chromosome-Linked Inhibitor-of-Apoptosis Protein, Blocks Nuclear Factor-κB (NF-κB) Signaling Pathway Leading to Suppression of NF-κB-Regulated Antiapoptotic and Metastatic Gene Products

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Molecular Pharmacology

• Publication date

  2007-01-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1124/mol.106.028787
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Plumbagin (5-Hydroxy-2-methyl-1,4-naphthoquinone) Suppresses NF-κB Activation and NF-κB-regulated Gene Products Through Modulation of p65 and IκBα Kinase Activation, Leading to Potentiation of Apoptosis Induced by Cytokine and Chemotherapeutic Agents*

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• Chemopreventive effects of embelin and curcumin against N-nitrosodiethylamine/phenobarbital-induced hepatocarcinogenesis in Wistar rats.

  2005influential reference
• TAK1 Is Recruited to the Tumor Necrosis Factor-α (TNF-α) Receptor 1 Complex in a Receptor-interacting Protein (RIP)-dependent Manner and Cooperates with MEKK3 Leading to NF-κB Activation*

  2005cited by this paper
• Essential function for the kinase TAK1 in innate and adaptive immune responses

  2005cited by this paper
• TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo.

  2005cited by this paper
• Role of NF-κB signaling in hepatocyte growth factor/scatter factor-mediated cell protection

  2005cited by this paper
• Nuclear factor-kappaB: the enemy within.

  2004influential reference
• TNF Activates Syk Protein Tyrosine Kinase Leading to TNF-Induced MAPK Activation, NF-κB Activation, and Apoptosis1

  2004cited by this paper
• Active Repression of Antiapoptotic Gene Expression by RelA(p65) NF-κB

  2004cited by this paper
• Discovery of embelin as a cell-permeable, small-molecular weight inhibitor of XIAP through structure-based computational screening of a traditional herbal medicine three-dimensional structure database.

  2004cited by this paper
• Genetic Deletion of Glycogen Synthase Kinase-3β Abrogates Activation of IκBα Kinase, JNK, Akt, and p44/p42 MAPK but Potentiates Apoptosis Induced by Tumor Necrosis Factor*

  2004cited by this paper
• Signalling pathways of the TNF superfamily: a double-edged sword

  2003cited by this paper
• Tumor Necrosis Factor-induced Nuclear Factor κB Activation Is Impaired in Focal Adhesion Kinase-deficient Fibroblasts*

  2003cited by this paper
• Faculty Opinions recommendation of Tumor necrosis factor-induced nuclear factor kappaB activation is impaired in focal adhesion kinase-deficient fibroblasts.

  2003cited by this paper
• Cigarette smoke condensate activates nuclear transcription factor-κB through phosphorylation and degradation of IκBα: correlation with induction of cyclooxygenase-2

  2002cited by this paper
• Cigarette smoke condensate activates nuclear transcription factor-kappaB through phosphorylation and degradation of IkappaB(alpha): correlation with induction of cyclooxygenase-2.

  2002cited by this paper
• Protein Kinase C-ζ Regulates Transcription of the Matrix Metalloproteinase-9 Gene Induced by IL-1 and TNF-α in Glioma Cells via NF-κB*

  2002cited by this paper
• Duration of nuclear NF-kappaB action regulated by reversible acetylation.

  2001cited by this paper
• Duration of Nuclear NF-κB Action Regulated by Reversible Acetylation

  2001cited by this paper
• Assay for redox-sensitive transcription factor.

  2000cited by this paper
• The interaction of p62 with RIP links the atypical PKCs to NF‐κB activation

  1999cited by this paper
• Mechanisms by which IkappaB proteins control NF-kappaB activity.

  1999cited by this paper
• The kinase TAK1 can activate the NIK-IκB as well as the MAP kinase cascade in the IL-1 signalling pathway

  1999cited by this paper
• NF-κB activation by tumour necrosis factor requires the Akt serine–threonine kinase

  1999cited by this paper
• NF-κB Controls Cell Growth and Differentiation through Transcriptional Regulation of Cyclin D1

  1999cited by this paper
• Coordinate Regulation of IκB Kinases by Mitogen-Activated Protein Kinase Kinase Kinase 1 and NF-κB-Inducing Kinase

  1998influential reference
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  1998influential reference
• Coordinate regulation of IkappaB kinases by mitogen-activated protein kinase kinase kinase 1 and NF-kappaB-inducing kinase.

  1998influential reference
• Constitutive activation of NF-kappaB causes resistance to apoptosis in human cutaneous T cell lymphoma HuT-78 cells. Autocrine role of tumor necrosis factor and reactive oxygen intermediates.

  1998cited by this paper
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  1995cited by this paper
• Inducible phosphorylation of I kappa B alpha is not sufficient for its dissociation from NF-kappa B and is inhibited by protease inhibitors.

  1994cited by this paper
• Antitumor, anti-inflammatory and analgesic property of embelin, a plant product.

  1994cited by this paper
• Changes in the concentrations of testosterone, luteinising hormone and progesterone associated with administration of embelin.

  1991cited by this paper
• Some pharmacological investigations of embelin and its semisynthetic derivatives.

  1977cited by this paper
• Some pharmacological investigations of embelin and its semisynthetic derivatives.

  1977cited by this paper
• Derivate des Methylendioxybenzols, 35. Eine neue Synthese der Verbindungen 3.6‐Dihydroxy‐‐2äthyl‐benzochinon‐(1.4), Embelin, Vilangin, Rapanon, Dihydromaesachinon, Bhogatin, Spinulosin und Oosporein

  1972cited by this paper
• [Derivatives of methylenedioxybenzene. 35. A novel synthesis of 3,6 dihydroxy-2-ethyl-1,4-benzoquinone, embelin, vilangin, rapanone, dihydromaesaquinone, bhogatin, spinulosin and oosporein].

  1972cited by this paper
• [STUDY OF VERMIFUGES. I. ISOLATION OF EMBELIN FROM THE FRUIT OF MUGUA-WHA (EMBELIA OBLONGIFOLIA HEMSL.)].

  1963cited by this paper
• [STUDY OF VERMIFUGES. I. ISOLATION OF EMBELIN FROM THE FRUIT OF MUGUA-WHA (EMBELIA OBLONGIFOLIA HEMSL.)].

  1963cited by this paper

• Artificial intelligence driven multi-omics framework identifies COL6A3 as a diagnostic biomarker and a putative gene target modulated by Embelin in Colorectal cancer

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• Synthesis of Quinoline and Dihydroquinoline Embelin Derivatives as Cardioprotective Agents

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