Multiple Muscarinic Acetylcholine Receptor Subtypes Modulate Striatal Dopamine Release, as Studied with M1–M5 Muscarinic Receptor Knock-Out Mice

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Journal of Neuroscience

• Publication date

  2002-08-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1523/JNEUROSCI.22-15-06347.2002PMID 12151512PMCID PMC6758135
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Muscarinic induction of hippocampal gamma oscillations requires coupling of the M1 receptor to two mixed cation currents.

  2002cited by this paper
• Characterization of Central Inhibitory Muscarinic Autoreceptors by the Use of Muscarinic Acetylcholine Receptor Knock-Out Mice

  2002cited by this paper
• Cholinergic dilation of cerebral blood vessels is abolished in M5 muscarinic acetylcholine receptor knockout mice

  2001influential reference
• Hyperactivity and Intact Hippocampus-Dependent Learning in Mice Lacking the M1 Muscarinic Acetylcholine Receptor

  2001cited by this paper
• Coordinated expression of muscarinic receptor messenger RNAs in striatal medium spiny neurons.

  2001influential reference
• Mice lacking the M3 muscarinic acetylcholine receptor are hypophagic and lean

  2001cited by this paper
• Hyperactivity, elevated dopaminergic transmission, and response to amphetamine in M1 muscarinic acetylcholine receptor-deficient mice

  2001cited by this paper
• Biotinylated m4-toxin demonstrates more M4 muscarinic receptor protein on direct than indirect striatal projection neurons.

  2001cited by this paper
• Multiple functional defects in peripheral autonomic organs in mice lacking muscarinic acetylcholine receptor gene for the M3 subtype.

  2000cited by this paper
• Acetylcholine-mediated modulation of striatal function.

  2000cited by this paper
• Synaptic integration mediated by striatal cholinergic interneurons in basal ganglia function.

  2000cited by this paper
• Enhancement of D1 dopamine receptor-mediated locomotor stimulation in M(4) muscarinic acetylcholine receptor knockout mice.

  1999cited by this paper
• Regulation of the Subcellular Distribution of m4 Muscarinic Acetylcholine Receptors in Striatal Neurons In Vivo by the Cholinergic Environment: Evidence for Regulation of Cell Surface Receptors by Endogenous and Exogenous Stimulation

  1999cited by this paper
• Pronounced pharmacologic deficits in M2 muscarinic acetylcholine receptor knockout mice.

  1999cited by this paper
• Disruption of the m1 receptor gene ablates muscarinic receptor-dependent M current regulation and seizure activity in mice.

  1997cited by this paper
• Muscarinic Modulation of Striatal Dopamine, Glutamate, and GABA Release, as Measured with In Vivo Microdialysis

  1997cited by this paper
• Molecular biology of muscarinic acetylcholine receptors.

  1996cited by this paper
• Muscarinic receptors modulate N-, P-, and L-type Ca2+ currents in rat striatal neurons through parallel pathways

  1995cited by this paper
• Modulation of ion-channel fundion by G-protein-coupled receptors

  1994cited by this paper
• Distribution of m1-m4 muscarinic receptor proteins in the rat striatum: light and electron microscopic immunocytochemistry using subtype- specific antibodies

  1994influential reference
• Modulatory functions of neurotransmitters in the striatum: ACh/dopamine/NMDA interactions.

  1994cited by this paper
• Effect of M1- and M2-muscarinic drugs on striatal dopamine release and metabolism: an in vivo microdialysis study comparing normal and 6-hydroxydopamine-lesioned rats.

  1993cited by this paper
• Muscarinic receptors--characterization, coupling and function.

  1993cited by this paper
• Interacting Presynaptic k‐Opioid and GABAA Receptors Modulate Dopamine Release from Rat Striatal Synaptosomes

  1993cited by this paper
• Development of antisera selective for m4 and m5 muscarinic cholinergic receptors: distribution of m4 and m5 receptors in rat brain.

  1993cited by this paper
• Phenotypical characterization of the rat striatal neurons expressing muscarinic receptor genes

  1992influential reference
• Distinct muscarinic receptors inhibit release of gamma-aminobutyric acid and excitatory amino acids in mammalian brain.

  1991cited by this paper
• Identification and localization of muscarinic acetylcholine receptor proteins in brain with subtype-specific antibodies

  1991cited by this paper
• Neurotransmitters and neuromodulators in the basal ganglia.

  1990influential reference
• Muscarinic receptors mediate direct inhibition of GABA release from rat striatal nerve terminals.

  1990cited by this paper
• Antimuscarinic drugs in the treatment of movement disorders.

  1990cited by this paper
• The GABA and substance P input to dopaminergic neurones in the substantia nigra of the rat.

  1990cited by this paper
• Localization of m5 muscarinic receptor mRNA in rat brain examined by in situ hybridization histochemistry.

  1990cited by this paper
• Expression of muscarinic acetylcholine and dopamine receptor mRNAs in rat basal ganglia.

  1990influential reference
• Distinct presynaptic control of dopamine release in striosomal and matrix areas of the cat caudate nucleus.

  1989cited by this paper
• Differential effects of M1- and M2-muscarinic drugs on striatal dopamine release and metabolism in freely moving rats.

  1989cited by this paper
• Modulation of neurotransmitter release by presynaptic autoreceptors.

  1989cited by this paper
• Muscarine receptor-mediated modulation of [3H]dopamine and [14C]acetylcholine release from rat neostriatal slices: selective antagonism by gallamine but not pirenzepine.

  1986cited by this paper
• Heterogeneity of presynaptic muscarinic receptors regulating neurotransmitter release in the rat brain.

  1984cited by this paper
• Muscarinic receptors on dopamine terminals in the cat caudate nucleus: neuromodulation of [3H]dopamine release in vitro by endogenous acetylcholine.

  1982cited by this paper
• Brain neurotransmitter changes in Parkinson's disease

  1981cited by this paper
• Biochemical evidence for the presence of presynaptic receptors on dopaminergic nerve terminals.

  1978cited by this paper

• Exploring Adjunctive Novel Therapeutic Approach of KarXT (Xanomeline‐Trospium Chloride) for Managing Psychotic Symptoms in Patients With Schizophrenia and Alzheimer's Disease

  2026cites this paper
• The Novel Functions of M4 Muscarinic Receptors

  2025cites this paper
• Cholinergic system in schizophrenia: A systematic review and meta-analysis

  2025cites this paper
• Quantitative Systems Pharmacology Development and Application in Neuroscience.

  2025cites this paper
• Novel opportunities for treating complex neuropsychiatric and neurocognitive conditions based on recent developments with xanomeline

  2025cites this paper
• Acetylcholine receptors (muscarinic) in GtoPdb v.2025.3

  2025cites this paper
• Does Dysregulation Of The Indirect Pathway Contribute To The Pathophysiology Of Catatonia Through Neurotransmitter Imbalance?

  2025cites this paper
• Current Findings and Potential Mechanisms of KarXT (Xanomeline–Trospium) in Schizophrenia Treatment

  2024cites this paper
• Dysregulated acetylcholine-mediated dopamine neurotransmission in the eIF4E Tg mouse model of autism spectrum disorders

  2024cites this paper
• Effects of oxotremorine on convulsions in mice induced by scopolamine and food intake after fasting.

  2024cites this paper
• Effects of Age and MPTP-Induced Parkinson’s Disease on the Expression of Genes Associated with the Regulation of the Sleep–Wake Cycle in Mice

  2024cites this paper
• IUPHAR Review on muscarinic M1 and M4 receptors as drug treatment targets relevant to the molecular pathology of schizophrenia.

  2024cites this paper
• Acute Hypobaric Hypoxia Causes Alterations in Acetylcholine-Mediated Signaling Through Varying Expression of Muscarinic Receptors in the Prefrontal Cortex and Cerebellum of Rats’ Brain

  2024cites this paper
• Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of a Muscarinic M3 Receptor‐Positive Allosteric Modulator ASP8302 Following Single and Multiple Ascending Oral Doses in Healthy Volunteers

  2024cites this paper
• Potential of olfactory neuroepithelial cells as a model to study schizophrenia: A focus on GPCRs (Review)

  2023cites this paper
• G protein-coupled receptor modulation of striatal dopamine transmission: Implications for substance use disorders

  2023cites this paper
• Selective M5 muscarinic acetylcholine receptor negative allosteric modulator VU6008667 blocks acquisition of opioid self-administration.

  2023cites this paper
• G protein‐coupled receptor modulation of striatal dopamine transmission: Implications for psychoactive drug effects

  2023cites this paper
• Dynamics of burst synchronization induced by excitatory inputs on midbrain dopamine neurons

  2023cites this paper
• Acetylcholine receptors (muscarinic) in GtoPdb v.2023.1

  2023cites this paper
• Targeting muscarinic receptors for the treatment of alcohol use disorders: Opportunities and hurdles for clinical development

  2023cites this paper
• Drug Design Targeting the Muscarinic Receptors and the Implications in Central Nervous System Disorders

  2022cites this paper
• Blockade of M4 muscarinic receptors on striatal cholinergic interneurons normalizes striatal dopamine release in a mouse model of TOR1A dystonia.

  2022cites this paper
• Chemogenetic activation of VGLUT3-expressing neurons decreases movement.

  2022cites this paper
• Cannabis induced psychosis: a systematic review on the role of genetic polymorphisms.

  2022cites this paper
• Modulation of Muscarinic Signalling in the Central Nervous System by Steroid Hormones and Neurosteroids

  2022cites this paper
• Striatal synaptic dysfunction in dystonia and levodopa-induced dyskinesia.

  2022cites this paper
• Acetylcholine receptors (muscarinic) in GtoPdb v.2021.2

  2021cites this paper
• Acetylcholine receptors (muscarinic) in GtoPdb v.2021.3

  2021cites this paper
• Two Players in the Field: Hierarchical Model of Interaction between the Dopamine and Acetylcholine Signaling Systems in the Striatum

  2021cites this paper
• Fine Tuning Muscarinic Acetylcholine Receptor Signaling Through Allostery and Bias

  2021cites this paper
• CalDAG-GEFI mediates striatal cholinergic modulation of dendritic excitability, synaptic plasticity and psychomotor behaviors

  2021cites this paper
• Increased Endogenous GDNF in Mice Protects Against Age-Related Decline in Neuronal Cholinergic Markers

  2021cites this paper
• Huperzine A inhibits heroin-seeking behaviors induced by cue or heroin priming in rats

  2020cites this paper
• Sex differences in dopamine release regulation in the striatum

  2020cites this paper
• Therapeutic Potential of Multifunctional Derivatives of Cholinesterase Inhibitors

  2020cites this paper
• BLOCKADE OF M4 MUSCARINIC RECEPTORS ON STRIATAL CHOLINERGIC INTERNEURONS NORMALIZES STRIATAL DOPAMINE RELEASE IN A MOUSE MODEL OF DYT1-TOR1A DYSTONIA

  2020cites this paper
• Heterogeneity in striatal dopamine circuits: Form and function in dynamic reward seeking

  2020cites this paper
• Striatal Dopamine D2-Muscarinic Acetylcholine M1 Receptor–Receptor Interaction in a Model of Movement Disorders

  2020cites this paper
• Allosteric modulation of muscarinic receptors in alcohol and substance use disorders.

  2020cites this paper
• Conventional and novel pharmacological approaches to treat dopamine-related disorders. Focus on Parkinson's disease and schizophrenia.

  2020cites this paper
• An acetylcholine‐dopamine interaction in the nucleus accumbens and its involvement in ethanol's dopamine‐releasing effect

  2020cites this paper
• Roles of the M4 acetylcholine receptor in the basal ganglia and the treatment of movement disorders

  2019cites this paper
• The neurobiological basis for novel experimental therapeutics in dystonia.

  2019cites this paper
• Constitutional 763.3 Kb chromosome 1q43 duplication encompassing only CHRM3 gene identified by next generation sequencing (NGS) in a child with intellectual disability

  2019cites this paper
• Beta-amyloid short- and long-term synaptic entanglement.

  2019cites this paper
• Striatal Cholinergic Interneurons Are a Novel Target of Corticotropin Releasing Factor

  2019influential citation
• Trihexyphenidyl rescues the deficit in dopamine neurotransmission in a mouse model of DYT1 dystonia.

  2019cites this paper
• Acetylcholine receptors (muscarinic) (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

  2019cites this paper
• The Pharmacology of Visual Hallucinations in Synucleinopathies

  2019cites this paper
• Widespread Changes in Positive Allosteric Modulation of the Muscarinic M1 Receptor in Some Participants With Schizophrenia

  2019cites this paper
• Rivastigmine does not alter cocaine-induced subjective effects or self-administration.

  2019cites this paper
• Is there a role for antibodies targeting muscarinic acetylcholine receptors in the pathogenesis of schizophrenia?

  2019cites this paper
• A regulatory variant of CHRM3 is associated with cannabis-induced hallucinations in European Americans

  2019cites this paper
• Selective allosteric modulation of muscarinic acetylcholine receptors for the treatment of schizophrenia and substance use disorders.

  2019cites this paper
• Eckol as a Potential Therapeutic against Neurodegenerative Diseases Targeting Dopamine D3/D4 Receptors

  2019cites this paper
• Muscarinic agonist, (±)-quinuclidin-3-yl-(4-fluorophenethyl)(phenyl)carbamate: High affinity, but low subtype selectivity for human M1 - M5 muscarinic acetylcholine receptors.

  2019cites this paper
• The striatal cholinergic system in l-dopa-induced dyskinesias

  2018cites this paper
• Rôle du système cholinergique striatal dans la physiopathologie des dystonies : un modèle expérimental chez le primate non-humain

  2018cites this paper
• Cholinergic modulation of striatal microcircuits

  2018cites this paper
• Acetylcholine Neurotransmitter Receptor Densities in the Striatum of Hemiparkinsonian Rats Following Botulinum Neurotoxin-A Injection

  2018cites this paper
• Potential Therapeutic Application for Nicotinic Receptor Drugs in Movement Disorders.

  2018cites this paper
• A new outlook on cholinergic interneurons in Parkinson's disease and L-DOPA-induced dyskinesia.

  2018cites this paper
• Evolution in Neuromodulation—The Differential Roles of Acetylcholine in Higher Order Association vs. Primary Visual Cortices

  2018cites this paper
• Cholinergic interneurons as a novel target of CRF in the striatum that is spared by repeated stress

  2018influential citation
• M1 muscarinic activation induces long‐lasting increase in intrinsic excitability of striatal projection neurons

  2017cites this paper
• Muscarinic receptor binding changes in postmortem Parkinson’s disease

  2017cites this paper
• The Cholinergic Interneuron of the Striatum

  2017cites this paper
• Vesicular acetylcholine transporter (VAChT) over‐expression induces major modifications of striatal cholinergic interneuron morphology and function

  2017cites this paper
• Dynamic changes in murine forebrain miR-211 expression associate with cholinergic imbalances and epileptiform activity

  2017cites this paper
• Anticholinergic activity in the nervous system: Consequences for visuomotor function.

  2017cites this paper
• Cholinergic System and Post-translational Modifications: An Insight on the Role in Alzheimer’s Disease

  2017cites this paper
• Identification and in vivo Characterization of a Potential TAAR1 Antagonist

  2017cites this paper
• Cholinergic Projections to the Substantia Nigra Pars Reticulata Inhibit Dopamine Modulation of Basal Ganglia through the M4 Muscarinic Receptor.

  2017cites this paper
• Physiological roles of CNS muscarinic receptors gained from knockout mice

  2017influential citation
• Muscarinic receptor subtype distribution in the central nervous system and relevance to aging and Alzheimer's disease.

  2017cites this paper
• Ligand regulation of muscarinic acetylcholine receptor organisation

  2016cites this paper
• A threshold model for opposing actions of acetylcholine on reward behavior: Molecular mechanisms and implications for treatment of substance abuse disorders.

  2016cites this paper
• Pharmacological profile of N-(2,6-dichlorophenyl)-2-(4-methyl-1-piperidinyl)acetamide, a novel analogue of lidocaine.

  2016cites this paper
• Allosteric modulation of cholinergic system: Potential approach to treating cognitive deficits of schizophrenia

  2016cites this paper
• Striatal dopamine neurotransmission: regulation of release and uptake.

  2016cites this paper
• Cholinergic modulation of the mesostriatal pathway

  2016cites this paper
• The Cholinergic System: An Emerging Drug Target for Schizophrenia.

  2016cites this paper
• Activation and modulation of GABA(B) receptor systems in physiogenic and pathophysiological conditions

  2015cites this paper
• The Central Role of RMTg GABA Neurons in Morphine-induced Locomotion

  2015cites this paper
• Changes in cholinergic and glutamatergic markers in the striatum from a sub-set of subjects with schizophrenia.

  2015cites this paper
• Omega-3 fatty acids prevent the ketamine-induced increase in acetylcholinesterase activity in an animal model of schizophrenia.

  2015cites this paper
• Cholinergic interneurons in the dorsal and ventral striatum: anatomical and functional considerations in normal and diseased conditions

  2015cites this paper
• Striatal cholinergic dysfunction as a unifying theme in the pathophysiology of dystonia.

  2015cites this paper
• Understanding responder neurobiology in schizophrenia using a quantitative systems pharmacology model: Application to iloperidone

  2015cites this paper
• Cholinergic Modulation of Stimulus-Specific Adaptation in the Inferior Colliculus

  2015cites this paper
• Neurons of Mouse Ileum Regulating Acetylcholine Release From Myenteric Muscarinic Receptors in

  2015cites this paper
• PRE-OSTEOBLASTIC CELLS PROLIFERATIVE PROPERTY OF BIOACTIVE COMPOUNDS IN GERMINATED BROWN RICE : A PROMISING IN VITRO POTENTIALS IN OSTEOPOROSIS

  2015cites this paper
• Striatal cholinergic interneuron regulation and circuit effects

  2014cites this paper
• Loss of Feedback Inhibition via D2 Autoreceptors Enhances Acquisition of Cocaine Taking and Reactivity to Drug-Paired Cues

  2014cites this paper
• Pharmacological evaluation of a putative M5 antagonist at M1, M3 and M5 receptors

  2014cites this paper
• Role of Muscarinic Acetylcholine Receptors in Adult Neurogenesis and Cholinergic Seizures

  2014influential citation
• THE CONTRIBUTION OF CHOLINERGIC NEUROCIRCUITS OVER THE MODULATION OF DOPAMINE ACTIVITY IN THE STRIATUM Review Article

  2014cites this paper
• Citicoline in addictive disorders: a review of the literature

  2014cites this paper
• M4 mAChR-mediated modulation of glutamatergic transmission at corticostriatal synapses.

  2014cites this paper