Transgenic mice possessing increased numbers of nociceptors do not exhibit increased behavioral sensitivity in models of inflammatory and neuropathic pain

No abstract is available for this paper.

• Publication year

  2003

• Venue

  Pain

• Publication date

  2003-12-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.pain.2003.09.016PMID 14659533
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Activation of presynaptic NMDA receptors coupled to NaV1.8-resistant sodium channel C-fibers causes retrograde mechanical nociceptor sensitization

  2003cited by this paper
• Primary afferent terminals that express presynaptic NR1 in rats are mainly from myelinated, mechanosensitive fibers

  2003cited by this paper
• Quantitative single-cell differences in mu-opioid receptor mRNA distinguish myelinated and unmyelinated nociceptors.

  2003cited by this paper
• Glial cell line-derived neurotrophic factor contributes to delayed inflammatory hyperalgesia in adjuvant rat pain model

  2003cited by this paper
• Neuropathic sensitization of behavioral reflexes and spinal NMDA receptor/CaM kinase II interactions are disrupted in PSD-95 mutant mice.

  2003cited by this paper
• Quantitative Single-Cell Differences in μ-Opioid Receptor mRNA Distinguish Myelinated and Unmyelinated Nociceptors

  2003cited by this paper
• Up-regulation of substance P and NMDA receptor mRNA in dorsal horn and preganglionic sympathetic neurons during adjuvant-induced noxious stimulation in rats.

  2002cited by this paper
• Behavioral evidence supporting a differential role for spinal group I and II metabotropic glutamate receptors in inflammatory hyperalgesia in sheep.

  2002cited by this paper
• GDNF and NGF reverse changes in repriming of TTX-sensitive Na(+) currents following axotomy of dorsal root ganglion neurons.

  2002cited by this paper
• Two N‐methyl‐D‐aspartate receptors in rat dorsal root ganglia with different subunit composition and localization

  2002cited by this paper
• ERK MAP Kinase Activation in Superficial Spinal Cord Neurons Induces Prodynorphin and NK-1 Upregulation and Contributes to Persistent Inflammatory Pain Hypersensitivity

  2002cited by this paper
• Glial Cell Line-Derived Neurotrophic Factor is a Survival Factor for Isolectin B4-Positive, but not Vanilloid Receptor 1-Positive, Neurons in the Mouse

  2002cited by this paper
• Peripheral group I metabotropic glutamate receptors modulate nociception in mice

  2001influential reference
• Pro- and anti-inflammatory cytokine gene expression in rat sciatic nerve chronic constriction injury model of neuropathic pain.

  2001cited by this paper
• Differential effects of NMDA and group I mGluR antagonists on both nociception and spinal cord protein kinase C translocation in the formalin test and a model of neuropathic pain in rats

  2001cited by this paper
• Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method.

  2001cited by this paper
• Neuronal plasticity and signal transduction in nociceptive neurons: implications for the initiation and maintenance of pathological pain.

  2001cited by this paper
• Metabotropic glutamate 1α receptors on peripheral primary afferent fibers: Their role in nociception

  2001cited by this paper
• GDNF and NGF family members and receptors in human fetal and adult spinal cord and dorsal root ganglia

  2001cited by this paper
• Equal proportions of small and large DRG neurons express opioid receptor mRNAs

  2001cited by this paper
• Agmatine reverses pain induced by inflammation, neuropathy, and spinal cord injury.

  2000cited by this paper
• Positive and negative interactions of GDNF, NTN and ART in developing sensory neuron subpopulations, and their collaboration with neurotrophins.

  2000cited by this paper
• Vanilloid receptor-1 is essential for inflammatory thermal hyperalgesia

  2000cited by this paper
• Murine models of inflammatory, neuropathic and cancer pain each generates a unique set of neurochemical changes in the spinal cord and sensory neurons.

  2000cited by this paper
• Possible role of inflammatory mediators in tactile hypersensitivity in rat models of mononeuropathy

  2000cited by this paper
• Potent analgesic effects of GDNF in neuropathic pain states.

  2000cited by this paper
• Impaired nociception and pain sensation in mice lacking the capsaicin receptor.

  2000cited by this paper
• Moxonidine, a selective imidazoline-alpha2 -adrenergic receptor agonist, produces spinal synergistic antihyperalgesia with morphine in nerve-injured mice.

  2000cited by this paper
• Expression of glial cell line‐derived neurotrophic factor family of growth factors in peripheral nerve injury in rats

  2000cited by this paper
• GDNF, RET and GFRalpha-1-3 mRNA expression in the developing human spinal cord and ganglia.

  1999cited by this paper
• Decreased expression of N-methyl-D-aspartate (NMDA) receptors in rat dorsal root ganglion following complete Freund's adjuvant-induced inflammation: an immunocytochemical study for NMDA NR1 subunit.

  1999cited by this paper
• A role for inflammation in chronic pain

  1999cited by this paper
• Overexpression of Nerve Growth Factor in Skin Selectively Affects the Survival and Functional Properties of Nociceptors

  1999cited by this paper
• Growth responses of different subpopulations of adult sensory neurons to neurotrophic factors in vitro

  1999cited by this paper
• Sodium channel expression in NGF‐overexpressing transgenic mice

  1999cited by this paper
• In vivo NGF deprivation reduces SNS expression and TTX-R sodium currents in IB4-negative DRG neurons.

  1999influential reference
• A capsaicin-receptor homologue with a high threshold for noxious heat

  1999cited by this paper
• Heritability of nociception I: responses of 11 inbred mouse strains on 12 measures of nociception.

  1999cited by this paper
• Pre- and/or post-synaptic localisation of metabotropic glutamate receptor 1alpha (mGluR1alpha) and 2/3 (mGluR2/3) in the rat spinal cord.

  1999cited by this paper
• A Distinct Subgroup of Small DRG Cells Express GDNF Receptor Components and GDNF Is Protective for These Neurons after Nerve Injury

  1998cited by this paper
• Neurogenic inflammation in an animal model of neuropathic pain.

  1998cited by this paper
• Expression of neurturin, GDNF, and their receptors in the adult mouse CNS

  1998cited by this paper
• Rescue of alpha-SNS sodium channel expression in small dorsal root ganglion neurons after axotomy by nerve growth factor in vivo.

  1998influential reference
• Tackling Pain at the Source: Minireview New Ideas about Nociceptors

  1998cited by this paper
• Tackling pain at the source: new ideas about nociceptors.

  1998cited by this paper
• The expression of P2X3 purinoreceptors in sensory neurons: effects of axotomy and glial-derived neurotrophic factor.

  1998influential reference
• P2X3 is expressed by DRG neurons that terminate in inner lamina II

  1998influential reference
• Preserved acute pain and reduced neuropathic pain in mice lacking PKCgamma.

  1997cited by this paper
• IB4-binding DRG neurons switch from NGF to GDNF dependence in early postnatal life.

  1997cited by this paper
• Regulation of expression of the sensory neuron-specific sodium channel SNS in inflammatory and neuropathic pain.

  1997influential reference
• NMDA-receptor regulation of substance P release from primary afferent nociceptors

  1997cited by this paper
• Overexpression of nerve growth factor in skin causes preferential increases among innervation to specific sensory targets

  1997cited by this paper
• NGF has opposing effects on Na+ channel III and SNS gene expression in spinal sensory neurons

  1997influential reference
• Overexpression of Nerve Growth Factor in Skin Increases Sensory Neuron Size and Modulates Trk Receptor Expression

  1997influential reference
• Temporal changes in spinal cord expression of mRNA for substance P, dynorphin and enkephalin in a model of chronic pain.

  1997cited by this paper
• Opioid receptors on peripheral sensory axons.

  1997cited by this paper
• Phenotypic modification of primary sensory neurons: the role of nerve growth factor in the production of persistent pain.

  1996cited by this paper
• Pain due to nerve damage: Are inflammatory mediators involved

  1995cited by this paper
• Role of peri-axonal inflammation in the development of thermal hyperalgesia and guarding behavior in a rat model of neuropathic pain.

  1995cited by this paper
• The biological effects of endogenous nerve growth factor on adult sensory neurons revealed by a trkA-IgG fusion molecule

  1995cited by this paper
• Double in situ hybridization study on coexistence of μ-, δ- and κ-opioid receptor mRNAs with preprotachykinin A mRNA in the rat dorsal root ganglia

  1995cited by this paper
• Double in situ hybridization study on coexistence of mu-, delta- and kappa-opioid receptor mRNAs with preprotachykinin A mRNA in the rat dorsal root ganglia.

  1995cited by this paper
• Expression of mu-, delta-, and kappa-opioid receptor-like immunoreactivities in rat dorsal root ganglia after carrageenan-induced inflammation

  1995cited by this paper
• Evidence for presynaptic N-methyl-D-aspartate autoreceptors in the spinal cord dorsal horn.

  1994cited by this paper
• Nerve growth factor contributes to the generation of inflammatory sensory hypersensitivity.

  1994cited by this paper
• Protons: small stimulants of capsaicin-sensitive sensory nerves.

  1994cited by this paper
• Overexpression of nerve growth factor in epidermis of transgenic mice causes hypertrophy of the peripheral nervous system

  1994cited by this paper
• In situ hybridization study of μ- and κ-opioid receptor mRNAs in the rat spinal cord and dorsal root ganglia

  1994cited by this paper
• In situ hybridization study of mu- and kappa-opioid receptor mRNAs in the rat spinal cord and dorsal root ganglia.

  1994cited by this paper
• Mu, delta, and kappa opioid receptor mRNA expression in the rat CNS: An in situ hybridization study

  1994cited by this paper
• NK-1 and NK-3 type tachykinin receptor mRNA expression in the rat spinal cord dorsal horn is increased during adjuvant or formalin- induced nociception

  1994cited by this paper
• AMPA, KA and NMDA receptors are expressed in the rat DRG neurones.

  1993cited by this paper
• An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat

  1992cited by this paper
• Excitation and sensitization of fine articular afferents from cat's knee joint by prostaglandin E2.

  1988cited by this paper
• Regulation of calcium homeostasis in sensory neurons by bradykinin

  1988cited by this paper
• An Enzyme‐Linked Immunoassay for Nerve Growth Factor (NGF): A Tool for Studying Regulatory Mechanisms Involved in NGF Production in Brain and in Peripheral Tissues

  1987cited by this paper
• Changes of nerve growth factor synthesis in nonneuronal cells in response to sciatic nerve transection

  1987influential reference
• Bradykinin and serotonin effects on various types of cutaneous nerve fibres

  1974cited by this paper

• Glial cell line-derived neurotrophic factors (GFLs) and small molecules targeting RET receptor for the treatment of pain and Parkinson’s disease

  2020cites this paper
• Immune System, Pain and Analgesia

  2020cites this paper
• Neural progenitors for sensory and motor repair

  2017cites this paper
• Effect of naltrexone on neuropathic pain in mice locally transfected with the mutant μ‐opioid receptor gene in spinal cord

  2015cites this paper
• Ligation of mouse L4 and L5 spinal nerves produces robust allodynia without major motor function deficit.

  2015cites this paper
• New insights into mechanisms of opioid inhibitory effects on capsaicin-induced TRPV1 activity during painful diabetic neuropathy.

  2014cites this paper
• Repeated variate stress in male rats induces increased voiding frequency, somatic sensitivity, and urinary bladder nerve growth factor expression.

  2013cites this paper
• VGLUTs in Peripheral Neurons and the Spinal Cord: Time for a Review

  2013cites this paper
• Reduced number, G protein coupling, and antinociceptive efficacy of spinal mu-opioid receptors in diabetic rats are reversed by nerve growth factor.

  2013cites this paper
• Nerve growth factor induces sensitization of nociceptors without evidence for increased intraepidermal nerve fiber density

  2013cites this paper
• Glial cell line-derived neurotrophic factor modulates the excitability of nociceptive trigeminal ganglion neurons via a paracrine mechanism following inflammation

  2013cites this paper
• Repeated variate stress (RVS) in male rats induces increased voiding frequency, somatic sensitivity and urinary bladder NGF expression

  2013cites this paper
• Molecular mechanisms of phenotypic change in intact nociceptors

  2012cites this paper
• Intervertebral Disc Degeneration-induced Expression of Pain-related Molecules: Glial Cell-derived Neurotropic Factor as a Key Factor

  2011cites this paper
• p38 Mitogen–activated Protein Kinase Activation by Nerve Growth Factor in Primary Sensory Neurons Upregulates &mgr;-Opioid Receptors to Enhance Opioid Responsiveness Toward Better Pain Control

  2011cites this paper
• Cutaneous C-polymodal fibers lacking TRPV1 are sensitized to heat following inflammation, but fail to drive heat hyperalgesia in the absence of TPV1 containing C-heat fibers

  2010cites this paper
• Species and strain differences in rodent sciatic nerve anatomy: Implications for studies of neuropathic pain

  2008cites this paper
• Postnatal roles of glial cell line-derived neurotrophic factor family members in nociceptors plasticity.

  2008cites this paper
• Pharmacological characterization and gene expression profiling of an L5/L6 spinal nerve ligation model for neuropathic pain in mice.

  2008cites this paper
• Thermal nociception and TRPV1 function are attenuated in mice lacking the nucleotide receptor P2Y2

  2008cites this paper
• The Skin as a Neurotrophic Organ

  2007cites this paper
• MOLECULAR MECHANISMS OF AGING IN THE PERIPHERAL NOCICEPTIVE SYSTEM

  2007cites this paper
• Nerve growth factor governs the enhanced ability of opioids to suppress inflammatory pain.

  2007cites this paper
• Artemin Overexpression in Skin Enhances Expression of TRPV1 and TRPA1 in Cutaneous Sensory Neurons and Leads to Behavioral Sensitivity to Heat and Cold

  2006cites this paper
• ArteminOverexpressioninSkinEnhancesExpressionof TRPV1andTRPA1inCutaneousSensoryNeuronsandLeads toBehavioralSensitivitytoHeatandCold

  2006cites this paper
• 344 NERVE GROWTH FACTOR GOVERNS THE ENHANCED ABILITY OF OPIOIDS TO SUPPRESS INFLAMMATORY PAIN

  2006cites this paper
• Nerve growth factor mediates peripheral mechanical hypersensitivity that accompanies experimental cystitis in mice.

  2006cites this paper
• GlialCellLine-DerivedNeurotrophicFactorFamilyMembers SensitizeNociceptorsInVitroandProduceThermal HyperalgesiaInVivo

  2006cites this paper
• Artemin Regulates Nociceptor Responses to Thermal and Chemical Stimuli

  2006cites this paper
• Glial Cell Line-Derived Neurotrophic Factor Family Members Sensitize Nociceptors In Vitro and Produce Thermal Hyperalgesia In Vivo

  2006cites this paper
• Impaired inflammatory pain and thermal hyperalgesia in mice expressing neuron-specific dominant negative mitogen activated protein kinase kinase (MEK)

  2006cites this paper
• Enhanced thermal avoidance in mice lacking the ATP receptor P2X3

  2005cites this paper
• Overexpression of NGF or GDNF alters transcriptional plasticity evoked by inflammation

  2005cites this paper
• Endogenous opioid analgesia in peripheral tissues and the clinical implications for pain control

  2005cites this paper
• Differential Sensitivity of N- and P/Q-Type Ca2+ Channel Currents to a μ Opioid in Isolectin B -Positive and -Negative Dorsal Root Ganglion Neurons

  2004influential citation
• Differential Sensitivity of N- and P/Q-Type Ca 2 (cid:1) Channel Currents to a (cid:1) Opioid in Isolectin B 4 -Positive and -Negative Dorsal Root Ganglion Neurons

  2004influential citation