Parietal Lobes in Schizophrenia: Do They Matter?

Objective. Despite observations that abnormal parietal lobe (PL) function is associated with psychotic-like experiences, our knowledge about the nature of PL involvement in schizophrenia is modest. The objective of this paper is to investigate the role of the PL in schizophrenia. Method. Medline databases were searched for English language publications using the following key words: parietal lobe, combined with schizophrenia, lesions, epilepsy, cognition, rare genetic disorders, MRI, fMRI, PET, and SPECT, respectively, followed by cross-checking of references. Results. Imaging studies in childhood onset schizophrenia suggest that grey matter abnormalities start in parietal and occipital lobes and proceed to frontal regions. Although, the findings are inconsistent, several studies with patients at risk to develop schizophrenia indicate early changes in the PL. Conclusions. We want to propose that in a proportion of individuals with emerging schizophrenia structural and functional alterations may start in the PL and progress to frontal regions.

• Publication year

  2011

• Venue

  Schizophrenia Research and Treatment

• Publication date

  2011-10-16

• Fields of study

  Medicine, Psychology

• Identifiers
  DOI 10.1155/2011/581686PMID 22937268PMCID 3420742
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Age at Onset and Causes of Disease

  2015cited by this paper
• Parietal Lobe Epilepsy

  2012cited by this paper
• Volumetric abnormalities predating the onset of schizophrenia and affective psychoses: an MRI study in subjects at ultrahigh risk of psychosis.

  2012cited by this paper
• Cortical thickness reduction in individuals at ultra-high-risk for psychosis.

  2011cited by this paper
• Duration of untreated psychosis is associated with orbital-frontal grey matter volume reductions in first episode psychosis.

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• Disturbed functional connectivity within brain networks subserving domain-specific subcomponents of working memory in schizophrenia: relation to performance and clinical symptoms.

  2010cited by this paper
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  2010cited by this paper
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  2010cited by this paper
• Regional gray matter volume in monozygotic twins concordant and discordant for schizophrenia.

  2010cited by this paper
• Voxel-based morphometric multisite collaborative study on schizophrenia.

  2009cited by this paper
• [Not Available].

  2009cited by this paper
• Duration of illness, regional brain morphology and neurocognitive correlates in schizophrenia.

  2009cited by this paper
• Aberrant Frontoparietal Function during Recognition Memory in Schizophrenia: A Multimodal Neuroimaging Investigation

  2009cited by this paper
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