The Functional Role of MnSOD as a Biomarker of Human Diseases and Therapeutic Potential of a New Isoform of a Human Recombinant MnSOD

Reactive oxygen species (ROS) are generated as a consequence of metabolic reactions in the mitochondria of eukaryotic cells. This work describes the role of the manganese superoxide dismutase (MnSOD) as a biomarker of different human diseases and proposes a new therapeutic application for the prevention of cancer and its treatment. The paper also describes how a new form of human MnSOD was discovered, its initial application, and its clinical potentials. The MnSOD isolated from a human liposarcoma cell line (LSA) was able to kill cancer cells expressing estrogen receptors, but it did not have cytotoxic effects on normal cells. Together with its oncotoxic activity, the recombinant MnSOD (rMnSOD) exerts a radioprotective effect on normal cells irradiated with X-rays. The rMnSOD is characterized by the presence of a leader peptide, which allows the protein to enter cells: this unique property can be used in the radiodiagnosis of cancer or chemotherapy, conjugating radioactive substances or chemotherapic drugs to the leader peptide of the MnSOD. Compared to traditional chemotherapic agents, the drugs conjugated with the leader peptide of MnSOD can selectively reach and enter cancer cells, thus reducing the side effects of traditional treatments.

• Publication year

  2014

• Venue

  BioMed Research International

• Publication date

  2014-01-06

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1155/2014/476789PMID 24511533PMCID 3913005
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• A new recombinant MnSOD prevents the cyclosporine A-induced renal impairment.

  2013cited by this paper
• Effect of a recombinant manganese superoxide dismutase on prevention of contrast-induced acute kidney injury

  2013cited by this paper
• Oxidative stress and cancer: an overview.

  2013cited by this paper
• Recombinant human manganese superoxide dismutase reduces liver fibrosis and portal pressure in CCl4-cirrhotic rats.

  2013cited by this paper
• Manganese superoxide dismutase regulation and cancer.

  2012influential reference
• Superoxide‐lowering therapy with TEMPOL reverses arterial dysfunction with aging in mice

  2012cited by this paper
• A Molecular Carrier to Transport and Deliver Cisplatin into Endometrial Cancer Cells

  2012cited by this paper
• Prohibitin 1 Modulates Mitochondrial Stress-Related Autophagy in Human Colonic Epithelial Cells

  2012cited by this paper
• Chemotherapy treatment decision making by professionals and older patients with cancer: a narrative review of the literature.

  2012cited by this paper
• Postformulation peptide drug loading of nanostructures.

  2012cited by this paper
• Nanoparticle delivery systems for cancer therapy: advances in clinical and preclinical research

  2012cited by this paper
• Construction of a graphene oxide based noncovalent multiple nanosupramolecular assembly as a scaffold for drug delivery.

  2012cited by this paper
• Antioxidant activity of β-selenoamines and their capacity to mimic different enzymes

  2012cited by this paper
• Modulation of inflammatory signaling and cytokine release from microglia by celastrol incorporated into dendrimer nanocarriers.

  2012cited by this paper
• A Phase I Study of Concurrent Chemotherapy (Paclitaxel and Carboplatin) and Thoracic Radiotherapy with Swallowed Manganese Superoxide Dismutase Plasmid Liposome Protection in Patients with Locally Advanced Stage III Non-Small-Cell Lung Cancer

  2011cited by this paper
• Antioxidant therapy: current status and future prospects.

  2011cited by this paper
• Nanoparticles for intracellular-targeted drug delivery

  2011cited by this paper
• Manganese Superoxide Dismutase: Guardian of the Powerhouse

  2011cited by this paper
• SOD Mimetics: A Novel Class of Androgen Receptor Inhibitors That Suppresses Castration-Resistant Growth of Prostate Cancer

  2011cited by this paper
• Anticancer therapy with checkpoint inhibitors: what, where and when?

  2011cited by this paper
• Targeted Drug Delivery Using Immunoconjugates: Principles and Applications

  2011cited by this paper
• Selective killing of cancer cells with a small molecule targeting stress response to ROS

  2011cited by this paper
• Anticancer antioxidant regulatory functions of phytochemicals.

  2011cited by this paper
• The leader peptide of a human rec. MnSOD as molecular carrier which delivers high amounts of Cisplatin into tumor cells inducing a fast apoptosis in vitro

  2011cited by this paper
• Polylactide-co-glycolide nanoparticles for controlled delivery of anticancer agents

  2011cited by this paper
• Nanomedicine for cancer: lipid-based nanostructures for drug delivery and monitoring.

  2011cited by this paper
• Superoxide Dismutases: Role in Redox Signaling, Vascular Function, and Diseases

  2011cited by this paper
• The Role of Manganese Superoxide Dismutase in Skin Cancer

  2011cited by this paper
• Micelles from amphiphilic block copolyphosphates for drug delivery.

  2011cited by this paper
• Modulation of MnSOD in Cancer:Epidemiological and Experimental Evidence

  2010cited by this paper
• Roles of dioxins and heavy metals in cancer and neurological diseases using ROS-mediated mechanisms.

  2010cited by this paper
• Generation of antioxidant adenovirus gene transfer vectors encoding CuZnSOD, MnSOD, and catalase.

  2010cited by this paper
• Model mice for tissue‐specific deletion of the manganese superoxide dismutase gene

  2010cited by this paper
• Anti-Cancer , anti-Necrotic and Imaging Tumor Marker role of a novel form of Manganese Superoxide Dismutase and its leader peptide

  2010cited by this paper
• Retargeting Adenoviral Vectors to Improve Gene Transfer into Tumors

  2010cited by this paper
• Mechanism of the peroxidase activity of Cu, Zn superoxide dismutase.

  2010cited by this paper
• Mitochondrial reactive oxygen species regulate cellular signaling and dictate biological outcomes.

  2010cited by this paper
• Complexes of 2-hydroxyacetophenone semicarbazones: A novel series of superoxide dismutase mimetics.

  2010cited by this paper
• Manganese superoxide dismutase: beyond life and death

  2010cited by this paper
• Update on non-viral delivery methods for cancer therapy: possibilities of a drug delivery system with anticancer activities beyond delivery as a new therapeutic tool

  2010cited by this paper
• Natural antioxidants: therapeutic prospects for cancer and neurological diseases.

  2009cited by this paper
• A recombinant MnSOD is radioprotective for normal cells and radiosensitizing for tumor cells.

  2009cited by this paper
• Overexpression of Mn superoxide dismutase does not increase life span in mice.

  2009cited by this paper
• Biophysical and biochemical characterization of a liposarcoma‐derived recombinant MnSOD protein acting as an anticancer agent

  2008cited by this paper
• Protein and lipid nitration: role in redox signaling and injury.

  2008cited by this paper
• Inflammation and immunity in diabetic vascular complications

  2008cited by this paper
• The mitochondrial impairment, oxidative stress and neurodegeneration connection: reality or just an attractive hypothesis?

  2008cited by this paper
• Oxidative and nitrative stress markers in glaucoma.

  2008cited by this paper
• Intracellular redox status and oxidative stress: implications for cell proliferation, apoptosis, and carcinogenesis

  2008cited by this paper
• Mechanisms of disease: The oxidative stress theory of diabetic neuropathy

  2008cited by this paper
• Protein tyrosine nitration--functional alteration or just a biomarker?

  2008cited by this paper
• Telomere Biology and Cardiovascular Disease Vascular Cell Senescence: Contribution to Atherosclerosis Stem Cells and the Regeneration of the Aging Cardiovascular System Mechanisms of Cardiovascular Disease in Accelerated Aging Syndromes Mechanisms Underlying Caloric Restriction and Lifespan Regulati

  2008cited by this paper
• Redox-Regulated Mechanisms in Asthma

  2008cited by this paper
• Brain mitochondrial dysfunction in aging

  2008cited by this paper
• Extracellular redox state regulates features associated with prostate cancer cell invasion.

  2008cited by this paper
• Reconciling the chemistry and biology of reactive oxygen species.

  2008cited by this paper
• Molecular mechanisms of oxidative stress‐induced carcinogenesis: From epidemiology to oxygenomics

  2008cited by this paper
• Oxidative stress in diseases of the human cornea.

  2008cited by this paper
• Manganese superoxide dismutase gene dosage affects chromosomal instability and tumor onset in a mouse model of T cell lymphoma.

  2008cited by this paper
• Oxidative and Inflammatory Pathways in Parkinson’s Disease

  2008cited by this paper
• Redox-Based Therapeutics for Lung Diseases

  2008cited by this paper
• Crosstalk Between Calcium and Redox Signaling: From Molecular Mechanisms to Health Implications

  2008cited by this paper
• Thiol chemistry and specificity in redox signaling.

  2008cited by this paper
• Oxidative Stress in Fanconi Anemia Hematopoiesis and Disease Progression

  2008cited by this paper
• Inflammation and endothelial dysfunction during aging: role of NF-kappaB.

  2008cited by this paper
• A manganese-superoxide dismutase/catalase mimetic extends survival in a mouse model of human prion disease.

  2008cited by this paper
• Regulation of HIF-1α Stability through S-nitrosylation

  2007cited by this paper
• Nitric oxide, a double edged sword in cancer biology: Searching for therapeutic opportunities

  2007cited by this paper
• Regulation of HIF-1alpha stability through S-nitrosylation.

  2007cited by this paper
• Defects of Mitochondrial Electron Transport Chain in Bipolar Disorder: Implications for Mood-Stabilizing Treatment

  2007cited by this paper
• Reactive oxygen species activate the HIF-1alpha promoter via a functional NFkappaB site.

  2007cited by this paper
• Human manganese superoxide dismutase suppresses HER2/neu‐mediated breast cancer malignancy

  2007cited by this paper
• Microcirculation and oxidative stress

  2007cited by this paper
• Tumor suppressive activity of a variant isoform of manganese superoxide dismutase released by a human liposarcoma cell line

  2006cited by this paper
• ALS: a disease of motor neurons and their nonneuronal neighbors.

  2006cited by this paper
• Superoxide, peroxynitrite and oxidative/nitrative stress in inflammation.

  2006cited by this paper
• Enzymatic Activity Is Necessary for the Tumor-Suppressive Effects of MnSOD

  2006cited by this paper
• Protein tyrosine nitration in hydrophilic and hydrophobic environments

  2006cited by this paper
• Review ALS: A Disease of Motor Neurons and Their Nonneuronal Neighbors

  2006cited by this paper
• SOD, oxidative stress and human pathologies: a brief history and a future vision.

  2005cited by this paper
• Mitochondrial Manganese-Superoxide Dismutase Expression in Ovarian Cancer

  2005cited by this paper
• Manganese superoxide dismutase overexpression inhibits the growth of androgen-independent prostate cancer cells

  2005cited by this paper
• Extracellular superoxide dismutase.

  2005cited by this paper
• Manganese Superoxide Dismutase Induces p53-Dependent Senescence in Colorectal Cancer Cells

  2005cited by this paper
• Mechanism of the tumor suppressive effect of MnSOD overexpression.

  2005cited by this paper
• ORGOTEIN: a new antiinflammatory metalloprotein drug evaluation of clinical efficacy and safety in inflammatory conditions of the urinary tract

  2005cited by this paper
• Potent Anti-tumor Effects of an Active Site Mutant of Human Manganese-Superoxide Dismutase

  2004cited by this paper
• Role of superoxide as a signaling molecule.

  2004cited by this paper
• GTPases and reactive oxygen species: switches for killing and signaling

  2004cited by this paper
• Inhibition of Cell Growth by Overexpression of Manganese Superoxide Dismutase (MnSOD) in Human Pancreatic Carcinoma

  2004cited by this paper
• Intraoral manganese superoxide dismutase-plasmid/liposome (MnSOD-PL) radioprotective gene therapy decreases ionizing irradiation-induced murine mucosal cell cycling and apoptosis.

  2004cited by this paper
• Tumor Suppressive Effects of MnSOD Overexpression May Involve Imbalance in Peroxide Generation Versus Peroxide Removal

  2004cited by this paper
• Suppression of the malignant phenotype in human pancreatic cancer cells by the overexpression of manganese superoxide dismutase.

  2003cited by this paper
• Diabetes, oxidative stress, and antioxidants: A review

  2003cited by this paper
• Synthesis and anti-inflammatory activity of a chimeric recombinant superoxide dismutase: SOD2/3.

  2003cited by this paper
• Expression of Antioxidant Enzymes in Diseases of the Human Pancreas: Another Link Between Chronic Pancreatitis and Pancreatic Cancer

  2003cited by this paper
• The role of manganese superoxide dismutase in the growth of pancreatic adenocarcinoma.

  2003cited by this paper
• New Aspects on Angiotensin-Converting Enzyme: from Gene to Disease

  2002cited by this paper
• Manganese superoxide dismutase deficiency enhances cell turnover via tumor promoter-induced alterations in AP-1 and p53-mediated pathways in a skin cancer model

  2002cited by this paper
• Reactive oxygen generated by Nox1 triggers the angiogenic switch

  2002cited by this paper

• The In Vitro Antioxidant and Immunomodulatory Effects of the Irish Monofloral Ivy and Heather Honey Varieties

  2025influential citation
• Beneficial Role of Resveratrol on Oxidative Stress in Women with Polycystic Ovary Syndrome: A Randomized Controlled Trial

  2025cites this paper
• Doxorubicin-induced neurotoxicity differently affects the hippocampal formation subregions in adult mice

  2024cites this paper
• Surface-Enhanced Raman Scatting microfluidic chip based on the identification competition strategy were used for rapid and simultaneous detection of liver cancer related proteins.

  2024cites this paper
• Post-sepsis chronic muscle weakness can be prevented by pharmacological protection of mitochondria

  2024cites this paper
• Interactions of reactive sulfur species with metalloproteins

  2023influential citation
• Insights into Manganese Superoxide Dismutase and Human Diseases

  2022cites this paper
• The structure–function relationships and physiological roles of MnSOD mutants

  2022cites this paper
• New insight into the aptamer conformation and aptamer/protein interaction by surface-enhanced Raman scattering and multivariate statistical analysis.

  2021cites this paper
• Combined oncolytic adenovirus carrying MnSOD and mK5 genes both regulated by survivin promoter has synergistic inhibitory effect on gastric cancer

  2021cites this paper
• Val16A SOD2 Polymorphism Promotes Epithelial–Mesenchymal Transition Antagonized by Muscadine Grape Skin Extract in Prostate Cancer Cells

  2021cites this paper
• Lutein Exerts Antioxidant and Anti-Inflammatory Effects and Influences Iron Utilization of BV-2 Microglia

  2021cites this paper
• Aptamer–Gold(III) Complex Nanoparticles: A New Way to Detect Cu, Zn SOD Glycoprotein

  2020cites this paper
• Development and characterization of pellets for targeted delivery of 5-fluorouracil and phytic acid for treatment of colon cancer in Wistar rat

  2020cites this paper
• Characterisation of recombinant thermostable manganese-superoxide dismutase (NeMnSOD) from Nerium oleander

  2020cites this paper
• Effects of inorganic nitrate in a rat model of monocrotaline‐induced pulmonary arterial hypertension

  2020cites this paper
• Dihydromethysticin, a natural molecule from Kava, suppresses the growth of colorectal cancer via the NLRC3/PI3K pathway

  2020cites this paper
• Neutral Sphingomyelinase Modulation in the Protective/Preventive Role of rMnSOD from Radiation-Induced Damage in the Brain

  2019cites this paper
• Mitochondrion: I am more than a fuel server.

  2019influential citation
• 1 B lymphocytes protect islet beta cells in diabetes prone NOD mice treated with imatinib

  2019cites this paper
• B lymphocytes protect islet β cells in diabetes prone NOD mice treated with imatinib.

  2019cites this paper
• Role of gut microbiota and oxidative stress in the progression of non-alcoholic fatty liver disease to hepatocarcinoma: Current and innovative therapeutic approaches

  2018cites this paper
• Identification of antibody reactive proteins in pancreatic cancer using 2D immunoblotting and mass spectrometry.

  2018cites this paper
• Influence of the Aptamer Grafting on its Conformation and its Interaction with Targeted Protein

  2018cites this paper
• A Review of the Catalytic Mechanism of Human Manganese Superoxide Dismutase

  2018cites this paper
• Cell Penetrating Peptides as Molecular Carriers for Anti-Cancer Agents

  2018cites this paper
• Molecular dynamics of a far positioned SOD1 mutant V14M reveals pathogenic misfolding behavior

  2018cites this paper
• Redox manipulation of the manganese metal in human manganese superoxide dismutase for neutron diffraction

  2018cites this paper
• Polymorphisms of lipid metabolism enzyme-coding genes in patients with diabetic dyslipidemia

  2017cites this paper
• The effect of synthetic estrogen on prooxidant-antioxidant system indexes on different age rats’ organs in vitro

  2016cites this paper
• pH and redox-operated nanovalve for size-selective cargo delivery on hollow mesoporous silica spheres.

  2016cites this paper
• Study on the role of AP-2α in the expression of MnSOD in the lung cancer A549 cells

  2016cites this paper
• Study on the Protective Effect of a New Manganese Superoxide Dismutase on the Microvilli of Rabbit Eyes Exposed to UV Radiation

  2015cites this paper
• Manganese superoxide dismutase and oxidative stress modulation.

  2015cites this paper
• High Sensitivity, High Selectivity SERS Detection of MnSOD Using Optical Nanoantennas Functionalized with Aptamers

  2015cites this paper
• A novel form of the human manganese superoxide dismutase protects rat and human livers undergoing ischaemia and reperfusion injury.

  2014cites this paper
• Combinative effects of thanh hao miet giap thang (sweet wormwood and tortoise shell decoction) ingredients on antioxidative activity in vitro.

  2014cites this paper
• Optimisation de nanostructures plasmoniques pour la détection et la caractérisation structurelle des protéines par Diffusion Raman Exaltée de Surface

  2014cites this paper
• Oxidation and pH responsive nanoparticles based on ferrocene-modified chitosan oligosaccharide for 5-fluorouracil delivery.

  2014cites this paper