Transcription factor LKLF is sufficient to program T cell quiescence via a c-Myc–dependent pathway

No abstract is available for this paper.

• Publication year

  2001

• Venue

  Nature Immunology

• Publication date

  2001-08-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/90633PMID 11477405
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Generation and maintenance of memory T cells.

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  1997cited by this paper
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  1997cited by this paper
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  1996cited by this paper
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  1996cited by this paper
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  1995cited by this paper
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