TACI and BAFF-R mediate isotype switching in B cells

The tumor necrosis factor family members BAFF and APRIL induce Ig isotype switching in human B cells. We analyzed the ability of BAFF and APRIL to induce isotype switching in murine B cells to IgG1, IgA, and IgE. APRIL and BAFF each engage two receptors, transmembrane activator and calcium-modulator and cytophilin ligand interactor (TACI) and B cell maturation antigen (BCMA), on B cells. In addition, BAFF engages a third receptor on B cells, BAFF-R. To determine the role of these receptors in isotype switching, we examined B cells from mice deficient in TACI, BCMA, and BAFF-R. The results obtained indicate that both TACI and BAFF-R are able to transduce signals that result in isotype switching.

• Publication year

  2005

• Venue

  Journal of Experimental Medicine

• Publication date

  2005-01-03

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1084/jem.20032000PMID 15630136PMCID 2212754
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Requirement for TRAF3 in Signaling by LMP1 But Not CD40 in B Lymphocytes

  2004cited by this paper
• Impaired IgA class switching in APRIL-deficient mice.

  2004cited by this paper
• The regulation of immunoglobulin E class-switch recombination

  2003cited by this paper
• BAFF AND APRIL: a tutorial on B cell survival.

  2003influential reference
• Hyper IgM syndromes

  2003cited by this paper
• Loss of TACI causes fatal lymphoproliferation and autoimmunity, establishing TACI as an inhibitory BLyS receptor.

  2003cited by this paper
• DCs induce CD40-independent immunoglobulin class switching through BLyS and APRIL

  2002influential reference
• The binding site for TRAF2 and TRAF3 but not for TRAF6 is essential for CD40-mediated immunoglobulin class switching.

  2002cited by this paper
• The CD40-TRAF6 axis controls affinity maturation and the generation of long-lived plasma cells

  2002cited by this paper
• Insulin-induced cortical actin remodeling promotes GLUT4 insertion at muscle cell membrane ruffles.

  2001cited by this paper
• Glucocorticoids upregulate CD40 ligand expression and induce CD40L-dependent immunoglobulin isotype switching.

  2001cited by this paper
• Regulation of the T-independent humoral response by TACI.

  2001cited by this paper
• Activation and accumulation of B cells in TACI-deficient mice

  2001cited by this paper
• B-Cell Maturation Protein, Which Binds the Tumor Necrosis Factor Family Members BAFF and APRIL, Is Dispensable for Humoral Immune Responses

  2001cited by this paper
• BAFF-R, a Newly Identified TNF Receptor That Specifically Interacts with BAFF

  2001cited by this paper
• Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme.

  2000cited by this paper
• B cells genetically deficient in the c-Rel transactivation domain have selective defects in germline CH transcription and Ig class switching.

  1997cited by this paper
• B cell differentiation and isotype switching is related to division cycle number

  1996cited by this paper
• Induction of alloantigen-specific tolerance by B cells from CD40-deficient mice.

  1996cited by this paper
• CD40-deficient mice generated by recombination-activating gene-2-deficient blastocyst complementation.

  1994cited by this paper
• The inhibitory effect of polymyxin B on endotoxin-induced endogenous pyrogen production.

  1982cited by this paper
• Pathogenesis: Regulation of Ige Production Cd40 Ligand/cd40 Deficiency

  year unknowncited by this paper

• The efficacy of rituximab plus telitacicept in neuropsychiatric systemic lupus erythematosus: A retrospective study.

  2026cites this paper
• The Complexity of Immunoglobulin A Immune Responses in Respiratory Syncytial Virus Infection.

  2026cites this paper
• Advances in Novel Biologics Targeting BAFF/APRIL in the Treatment of IgA Nephropathy

  2026cites this paper
• Telitacicept as an alternative to non-steroidal immunosuppressive therapies in the treatment of myasthenia gravis: a study on clinical efficacy and steroid-sparing effect

  2025cites this paper
• AAV-mediated delivery of a proliferation inducing ligand (APRIL) to cortical neurons limits inflammation and demyelination in the corpus callosum of the cuprizone mouse model

  2025cites this paper
• Cytokine Profile and Early Immune Response to SARS-CoV-2 in Occupationally Lead-Exposed Individuals: A Cross-Sectional Study.

  2025cites this paper
• Piezo1 selectively enhances TGF-β1-induced IgA class switching by B cells

  2025cites this paper
• Biological targeted therapy for lupus nephritis–the role of BLYS and APRIL

  2025cites this paper
• BCMA biology and therapeutic targeting in multiple myeloma: From ligand signaling to antigen escape.

  2025cites this paper
• Multiparametric Optimization of Human Primary B‐Cell Cultures Using Design of Experiments

  2025cites this paper
• BAFF in autoimmune kidney diseases: pathogenic pathways, biomarker potential, and therapeutic horizons

  2025cites this paper
• Immunoglobulin class‐switch recombination: Mechanism, regulation, and related diseases

  2024cites this paper
• Past and present discovery of the BAFF/APRIL system - A bibliometric study from 1999 to 2023.

  2024cites this paper
• A multicenter, randomized, open‐label, phase 2 clinical study of telitacicept in adult patients with generalized myasthenia gravis

  2024cites this paper
• Small Intestinal Goblet Cells Control Humoral Immune Responses and Mobilization During Enteric Infection

  2024cites this paper
• New Insights and Future Perspectives of APRIL in IgA Nephropathy

  2024cites this paper
• Systemic dysregulation and molecular insights into poor influenza vaccine response in the aging population

  2024cites this paper
• Chemical chaperone TUDCA selectively inhibits production of allergen-specific IgE in a low-dose model of allergy.

  2024cites this paper
• Leveraging pleiotropy identifies common-variant associations with selective IgA deficiency

  2024cites this paper
• Characterization of class-switched B cells in chickens

  2024cites this paper
• The role of BAFF and APRIL in IgA nephropathy: pathogenic mechanisms and targeted therapies

  2024cites this paper
• Role of cellular effectors in the induction and maintenance of IgA responses leading to protective immunity against enteric bacterial pathogens

  2024cites this paper
• Targeting TNF/TNFR superfamilies in immune-mediated inflammatory diseases

  2024cites this paper
• An overview of early genetic predictors of IgA deficiency

  2024cites this paper
• IgA-producing B cells in lung homeostasis and disease

  2023cites this paper
• Spatial heterogeneity for APRIL production by eosinophils in the small intestine.

  2023cites this paper
• BAFF induces CXCR5 expression during B cell differentiation in bone marrow

  2023cites this paper
• Case report: Invasive fungal infection in a patient with a rare CVID-causing gene (TNFRSF13B) mutation undergoing AML treatment

  2023cites this paper
• Metabolic fitness of IgA+ plasma cells in the gut requires DOCK8

  2023cites this paper
• Systems immunology reveals the molecular mechanisms of heterogeneous influenza vaccine response in the elderly

  2023cites this paper
• A PRoliferation-Inducing Ligand (APRIL) in the Pathogenesis of Immunoglobulin A Nephropathy: A Review of the Evidence

  2023cites this paper
• The yin and yang of B cells in a constant state of battle: intestinal inflammation and inflammatory bowel disease

  2023cites this paper
• Therapeutic targeting of gut‐originating regulatory B cells in neuroinflammatory diseases

  2023cites this paper
• The BAFF-APRIL System in Cancer

  2023cites this paper
• Teclistamab Monotherapy for the Treatment of Adult Patients with Relapsed and Refractory Multiple Myeloma

  2023cites this paper
• NF-kB’s contribution to B cell fate decisions

  2023cites this paper
• Cutting Edge: Neutrophil Complement Receptor Signaling Is Required for BAFF-Dependent Humoral Responses in Mice.

  2022cites this paper
• IgA vasculitis update: Epidemiology, pathogenesis, and biomarkers

  2022cites this paper
• T cell help in the autoreactive germinal center

  2022cites this paper
• The role of retinoic acid in the production of immunoglobulin A

  2022cites this paper
• Considerations for Novel COVID-19 Mucosal Vaccine Development

  2022cites this paper
• Elucidating the Role of Innate and Adaptive Immune Responses in the Pathogenesis of Canine Chronic Inflammatory Enteropathy—A Search for Potential Biomarkers

  2022cites this paper
• Developing high-affinity decoy receptors to treat multiple myeloma and diffuse large B cell lymphoma

  2022cites this paper
• BAFF antagonism via the BAFF receptor 3 binding site attenuates BAFF 60-mer-induced classical NF-κB signaling and metabolic reprogramming of B cells.

  2022cites this paper
• B cell class switching in intestinal immunity in health and disease

  2022cites this paper
• Aberrant B Cell Signaling in Autoimmune Diseases

  2022cites this paper
• Isolation of CD35+ follicular dendritic cells and its role in the differentiation from B cells to IgA+GL7+ cells.

  2022cites this paper
• Immunoglobin A Deficiency and Squamous Cell Carcinoma With a Rare Presentation as Anal Cancer

  2022cites this paper
• Interleukin-33 Exacerbates IgA Glomerulonephritis in Transgenic Mice Overexpressing B Cell Activating Factor

  2022cites this paper
• Reductions in circulating B cell subsets and immunoglobulin G levels with long-term belimumab treatment in patients with SLE

  2022cites this paper
• Analysis of TNFSF13B polymorphisms and BAFF expression in rheumatoid arthritis and primary Sjögren's syndrome patients

  2022cites this paper
• Selective IgA Deficiency and Allergy: A Fresh Look to an Old Story

  2022cites this paper
• The effects of B‐cell–activating factor on the population size, maturation and function of murine natural killer cells

  2022cites this paper
• Mature naive B cells regulate the outcome of murine acute graft-versus-host disease in an IL-10 independent manner.

  2022cites this paper
• BAFF Promotes Heightened BCR Responsiveness and Manifestations of Chronic GVHD after Allogeneic Stem Cell Transplantation.

  2021cites this paper
• Fruit and Vegetable Supplemented Diet Modulates the Pig Transcriptome and Microbiome after a Two-Week Feeding Intervention

  2021cites this paper
• Identification of 38 novel loci for systemic lupus erythematosus and genetic heterogeneity between ancestral groups

  2021cites this paper
• Genetic mapping reveals Nfkbid as a central regulator of humoral immunity to Toxoplasma gondii

  2021cites this paper
• Different regulatory effects of CD40 ligand and B-cell activating factor on the function of B cells.

  2021cites this paper
• Protein kinase Cδ is essential for the IgG response against T-cell-independent type 2 antigens and commensal bacteria

  2021cites this paper
• Immune Monitoring upon Treatment with Biologics in Sjögren’s Syndrome: The What, Where, When, and How

  2021cites this paper
• JAK Inhibitors and Modulation of B Cell Immune Responses in Rheumatoid Arthritis

  2021cites this paper
• Immunoglobulin A, an Active Liaison for Host-Microbiota Homeostasis

  2021cites this paper
• [Common variable immunodeficiency disorders: Updated diagnostic criteria and genetics].

  2021cites this paper
• Compartmentalized multicellular crosstalk in lymph nodes coordinates the generation of potent cellular and humoral immune responses

  2021cites this paper
• Plasma levels of BAFF and APRIL are elevated in patients with asthma in Saudi Arabia

  2021cites this paper
• Pollutants enhance IgE sensitization in the gut via local alteration of vitamin D-metabolizing enzymes

  2021cites this paper
• Review article: targeting the B cell activation system in autoimmune hepatitis

  2021cites this paper
• Telitacicept as a BLyS/APRIL dual inhibitor for autoimmune disease

  2021cites this paper
• B cell activating factor antagonism attenuates the growth of experimental abdominal aortic aneurysm.

  2021cites this paper
• Homeostatic apoptosis prevents competition-induced atrophy in follicular B cells.

  2021influential citation
• Protein kinase Cδ is essential for the IgG response against T cell-independent type 2 antigens and commensal bacteria

  2021cites this paper
• Regnase-1 is essential for B cell homeostasis to prevent immunopathology

  2021cites this paper
• Production and Function of Immunoglobulin A.

  2021cites this paper
• The Wanderings of Gut-Derived IgA Plasma Cells: Impact on Systemic Immune Responses

  2021cites this paper
• The Immunomodulatory Effect of the Gut Microbiota in Kidney Disease

  2021cites this paper
• Know your enemy or find your friend?—Induction of IgA at mucosal surfaces

  2021cites this paper
• TNFRSF13B genotypes control immune-mediated pathology by regulating the functions of innate B cells

  2021cites this paper
• Polyethylene Glycol Immunogenicity: Theoretical, Clinical, and Practical Aspects of Anti-Polyethylene Glycol Antibodies.

  2021cites this paper
• TNFRSF13B Diversification Fueled by B Cell Responses to Environmental Challenges—A Hypothesis

  2021influential citation
• Targeting co-stimulatory molecules in autoimmune disease

  2020cites this paper
• LT-K63 Enhances B Cell Activation and Survival Factors in Neonatal Mice That Translates Into Long-Lived Humoral Immunity

  2020cites this paper
• The BAFF / APRIL system as therapeutic target in multiple sclerosis

  2020cites this paper
• Gut T cell–independent IgA responses to commensal bacteria require engagement of the TACI receptor on B cells

  2020cites this paper
• Neurological disorders-associated anti-glycosphingolipid IgG-antibodies display differentially restricted IgG subclass distribution

  2020cites this paper
• Targeting co-stimulatory molecules in autoimmune disease

  2020cites this paper
• Single-cell repertoire tracing identifies rituximab-resistant B cells during myasthenia gravis relapses.

  2020cites this paper
• Significant immunomodulatory properties of curcumin in patients with osteoarthritis; a successful clinical trial in Iran.

  2020cites this paper
• TRAF3 Acts as a Checkpoint of B Cell Receptor Signaling to Control Antibody Class Switch Recombination and Anergy

  2020cites this paper
• The roles of B cell activation factor (BAFF) and a proliferation-inducing ligand (APRIL) in allergic asthma.

  2020cites this paper
• Increased Ileal Immunoglobulin A Production and Immunoglobulin A-Coated Bacteria in Diarrhea-Predominant Irritable Bowel Syndrome

  2020cites this paper
• Trimeric HIV-1 gp140 fused with APRIL, BAFF, and CD40L on the mucosal gp140-specific antibody responses in mice.

  2020cites this paper
• Human IgA Monoclonal Antibodies That Neutralize Poliovirus, Produced by Hybridomas and Recombinant Expression

  2020cites this paper
• Nfkbid is required for immunity and antibody responses to Toxoplasma gondii

  2020cites this paper
• Transmembrane Activator and CAML Interactor (TACI): Another Potential Target for Immunotherapy of Multiple Myeloma?

  2020cites this paper
• Identification of 38 novel loci for systemic lupus erythematosus and genetic heterogeneity that may underly population disparities in this disease

  2020cites this paper
• High APRIL Levels Are Associated With Slow Disease Progression and Low Immune Activation in Chronic HIV-1-Infected Patients

  2020cites this paper
• Integrated safety profile of atacicept: an analysis of pooled data from the atacicept clinical trial programme

  2019cites this paper
• TLR9 activation induces aberrant IgA glycosylation via APRIL- and IL-6-mediated pathways in IgA nephropathy.

  2019cites this paper
• Phosphatidylethanolamine binding protein-4 (PEBP4) is increased in IgA nephropathy and is associated with IgA-positive B-cells in affected kidneys.

  2019influential citation