Gating of Sensory Input at Spinal and Cortical Levels during Preparation and Execution of Voluntary Movement

All bodily movements stimulate peripheral receptors that activate neurons in the brain and spinal cord through afferent feedback. How these reafferent signals are processed within the CNS during movement is a key question in motor control. We investigated cutaneous sensory-evoked potentials in the spinal cord, primary somatosensory and motor cortex, and premotor cortex in monkeys performing an instructed delay task. Afferent inputs from cutaneous receptors were suppressed at several levels in a task-dependent manner. We found two types of suppression. First, suppression during active limb movement was observed in the spinal cord and all three cortical areas. This suppression was induced by both bottom-up and top-down gating mechanisms. Second, during preparation for upcoming movement, evoked responses were suppressed exclusively in the motor cortical areas and the magnitude of suppression was correlated with the reaction time of the subsequent movement. This suppression could be induced by a top-down gating mechanism to facilitate the preparation and execution of upcoming movement.

• Publication year

  2012

• Venue

  Journal of Neuroscience

• Publication date

  2012-01-18

• Fields of study

  Biology, Medicine, Psychology

• Identifiers
  DOI 10.1523/JNEUROSCI.4958-11.2012PMID 22262887PMCID PMC3293372
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Gating of Sensory Input at Spinal and Cortical Levels during Preparation and Execution of Voluntary Movement

  2012cited by this paper
• Clarke's Column Neurons as the Focus of a Corticospinal Corollary Circuit

  2010cited by this paper
• Task-dependent modulation of primary afferent depolarization in cervical spinal cord of monkeys performing an instructed delay task.

  2009cited by this paper
• Motor cortex gates vibrissal responses in a thalamocortical projection pathway.

  2007cited by this paper
• Attenuation of Self-Generated Tactile Sensations Is Predictive, not Postdictive

  2006cited by this paper
• Evidence for sensory prediction deficits in schizophrenia.

  2005cited by this paper
• Changes in the centrifugal gating effect on somatosensory evoked potentials depending on the level of contractile force

  2005cited by this paper
• Modulation of lemniscal input during conditioned arm movements in the monkey

  2004influential reference
• The site of saccadic suppression

  2004cited by this paper
• Reduction in perceived intensity of cutaneous stimuli during movement: a quantitative study

  2004cited by this paper
• Contribution of eye positioning to control of the upside-down standing posture

  2004cited by this paper
• Movement-related modulation of vibrotactile detection thresholds in the human orofacial system

  2003cited by this paper
• Sensory input to primate spinal cord is presynaptically inhibited during voluntary movement

  2003cited by this paper
• Abnormal premovement gating of somatosensory input in writer's cramp.

  2000cited by this paper
• Central cancellation of self-produced tickle sensation

  1998cited by this paper
• Activity of spinal interneurons and their effects on forearm muscles during voluntary wrist movements in the monkey.

  1998cited by this paper
• A flexible method for fabrication of nerve cuff electrodes

  1996cited by this paper
• On the mechanism of the post-activation depression of the H-reflex in human subjects

  1996cited by this paper
• Primate premotor cortex: modulation of preparatory neuronal activity by gaze angle.

  1995cited by this paper
• Corticocortical and thalamocortical responses of neurons in the monkey primary motor cortex and their relation to a trained motor task.

  1994cited by this paper
• Preparation for movement: neural representations of intended direction in three motor areas of the monkey.

  1990cited by this paper
• A comparison of preparation-related neuronal activity changes in the prefrontal, premotor, primary motor and posterior parietal areas of the monkey cortex: preliminary results.

  1990cited by this paper
• Modulation of cutaneous cortical evoked potentials during isometric and isotonic contractions in the monkey.

  1990cited by this paper
• Corticocortical synaptic influences on morphologically identified pyramidal neurones in the motor cortex of the monkey.

  1988cited by this paper
• Localization, timing and specificity of gating of somatosensory evoked potentials during active movement in man.

  1987cited by this paper
• The primate premotor cortex: past, present, and preparatory.

  1985cited by this paper
• 'Gating' of somatosensory evoked potentials begins before the onset of voluntary movement in man.

  1985cited by this paper
• Velocity-dependent suppression of cutaneous sensitivity during movement.

  1982influential reference
• Gating of somatosensory evoked potentials during different kinds of movement in man.

  1981cited by this paper
• Thalamic relay to motor cortex: afferent pathways from brain stem, cerebellum, and spinal cord in monkeys.

  1980cited by this paper
• Short-latency peripheral inputs to thalamic neurones projecting to the motor cortex in the monkey

  1979cited by this paper
• Pyramidal tract control over cutaneous and kinesthetic sensory transmission in the cat thalamus

  1975cited by this paper
• Sensory transmission through lemniscal pathway during voluntary movement in the cat.

  1974cited by this paper
• Inhibition of afferent transmission in cuneate nucleus during voluntary movement in the cat.

  1972cited by this paper
• Depolarization of central terminals of afferent fibers in the cervical spinal cord of the cat.

  1963cited by this paper
• DEPOLARIZATION OF THE CENTRAL TERMINALS OF CUTANEOUS AFFERENT FIBERS

  1963cited by this paper
• Synaptic action during and after repetitive stimulation

  1960cited by this paper
• Modality and topographic properties of single neurons of cat's somatic sensory cortex.

  1957cited by this paper

• Tactile suppression during movement as optimal integration of somatosensory feedback across time

  2026cites this paper
• Temporal dynamics of early somatosensory processing in goal-directed actions

  2026cites this paper
• Automatic learning mechanisms for flexible human locomotion

  2026cites this paper
• Somatotopy-independent reduction of audio-tactile intersensory facilitation for looming sounds within the peripersonal space during arm movements execution

  2026cites this paper
• Prior knowledge changes initial sensory processing in the human spinal cord

  2025cites this paper
• Cortical somatosensory responses evoked by orofacial skin stretch experimentally applied during speech movement planning in stuttering and nonstuttering adults

  2025cites this paper
• Tactile–Thermal Interactions: Cooperation and Competition

  2025cites this paper
• Frequency dependence of cortical somatosensory evoked response to peripheral nerve stimulation with controlled afferent excitation

  2025cites this paper
• Electrical Spinal Imaging: A noninvasive, high-resolution approach that enables electrophysiological mapping of the human spinal cord

  2025cites this paper
• Speed-dependent modulation of tactile edge orientation discrimination

  2025cites this paper
• Sensitivity to Instruction Strategies in Motor Learning Is Predicted by Anterior–Posterior TMS Motor Thresholds

  2025cites this paper
• Beyond the neural underpinnings of action emulation in expert athletes: an EEG study.

  2025cites this paper
• Pathophysiology of voluntary motor commands at the level of the spinal motoneuron in patients with multiple sclerosis

  2025cites this paper
• Modulatory Effects of the Motor Imagery and Jendrassik Maneuver upon the Forearm H-Reflex and Electroencephalographic Activity

  2025cites this paper
• Dynamic and context-dependent modulation of proprioceptive input in primate primary motor cortex

  2025influential citation
• The neural basis of sensorimotor expertise: investigating the role of theta oscillations and the superior parietal lobule using repetitive transcranial magnetic stimulation (rTMS).

  2025cites this paper
• Suppressing Sensation during Action across Species and Sensory Modalities: Predictive and Nonpredictive Mechanisms of Sensory Modulation

  2025cites this paper
• Goal‐directed action preparation in humans entails a mixture of corticospinal neural computations

  2025cites this paper
• Integrating multiple sensory modalities during dyadic interactions drives self-other differentiation at the behavioral and electrocortical level

  2025cites this paper
• Temporal modulation of tactile perception during balance control

  2024cites this paper
• Intracortical microstimulation of human somatosensory cortex induces natural perceptual biases.

  2024cites this paper
• The Many Roles of Precision in Action

  2024cites this paper
• Multimodal sensory control of motor performance by glycinergic interneurons of the mouse spinal cord deep dorsal horn.

  2024cites this paper
• Modulation of somatosensory signal transmission in the primate cuneate nucleus during voluntary hand movement.

  2024cites this paper
• Corticocortical and Corticomuscular Connectivity Dynamics in Standing Posture: Electroencephalography Study

  2024cites this paper
• Preserved force control by the digits via minimal sparing of cortico‐spinal connectivity after stroke

  2024cites this paper
• Volitional control of movement interacts with proprioceptive feedback in motor cortex during brain-computer interface control in humans

  2024cites this paper
• Distinct role of central predictive mechanisms in tactile suppression

  2024cites this paper
• Goal-directed action preparation in humans entails a mixture of corticospinal neural computations

  2024cites this paper
• The Lycra arm sleeve for treatment of glenohumeral subluxation in people with sub-acute stroke: a randomized controlled (RC) feasibility study

  2024cites this paper
• Adaptation in the spinal cord after stroke: Implications for restoring cortical control over the final common pathway

  2024cites this paper
• Descending motor command to prime mover of dependent finger induces tactile gating in target and distant non-target finger

  2024cites this paper
• Tactile suppression is linked to movement onset for startle-triggered responses.

  2024cites this paper
• Intracortical microstimulation of human somatosensory cortex is sufficient to induce perceptual biases

  2024cites this paper
• Aberrant Functional Connectivity of the Salience Network in Adult Patients with Tic Disorders: A Resting-State fMRI Study

  2024cites this paper
• Neural oscillations guiding action during effects imagery.

  2024cites this paper
• Haptic Perception and Its Relation to Action.

  2024cites this paper
• Force monitoring reveals single trial dynamics of motor control in a stop signal task

  2024cites this paper
• The effects of verbal and spatial working memory on short- and long-latency sensorimotor circuits in the motor cortex

  2024cites this paper
• Seeing our hand or a tool during visually-guided actions: Different effects on the somatosensory and visual cortices.

  2023cites this paper
• Youth with Cerebral Palsy Display Abnormal Somatosensory Cortical Activity during a Haptic Exploration Task.

  2023cites this paper
• Sensory Gating during Voluntary Finger Movement in Amyotrophic Lateral Sclerosis with Sensory Cortex Hyperexcitability

  2023cites this paper
• Decoding hand kinetics and kinematics using somatosensory cortex activity in active and passive movement

  2023influential citation
• Impact of Arm Dominance and Location on Detecting Electrotactile Stimuli during Voluntary Motor Activation in Older Adults

  2023cites this paper
• Distinct effects of different neurofeedback protocols on the neural mechanisms of response inhibition in ADHD.

  2023cites this paper
• Cortico-cortical connectivity changes during motor execution associated with sensory gating to frontal cortex: An rTMS study

  2023cites this paper
• Presynaptic gating of monkey proprioceptive signals for proper motor action

  2023cites this paper
• Multimodal sensory control of motor performance by glycinergic interneurons of the spinal cord deep dorsal horn

  2023cites this paper
• Effects of prolonged local vibration superimposed to muscle contraction on motoneuronal and cortical excitability

  2023cites this paper
• A dissociable functional relevance of theta- and beta-band activities during complex sensorimotor integration.

  2023cites this paper
• Neural ensemble dynamics in trunk and hindlimb sensorimotor cortex encode for the control of postural stability.

  2023cites this paper
• Modulation of somatosensory signal transmission in the primate cuneate nucleus during voluntary hand movement

  2023cites this paper
• Phantom touch illusion, an unexpected phenomenological effect of tactile gating in the absence of tactile stimulation

  2023cites this paper
• Transient gamma events delineate somatosensory modality in S1

  2023cites this paper
• Chronic Adaptations in the Dorsal Horn Following a Cervical Spinal Cord Injury in Primates

  2023cites this paper
• The neurophysiology of continuous action monitoring

  2023cites this paper
• Automatic learning mechanisms for flexible human locomotion

  2023cites this paper
• A haptic device-based reproduction system of active finger movement and its evaluation using sensory evoked potentials

  2023cites this paper
• Tactile facilitation during actual and mere expectation of object reception

  2022cites this paper
• Tactile suppression stems from specific sensorimotor predictions

  2022cites this paper
• The role of grasping demands on tactile suppression.

  2022cites this paper
• Sensorimotor Integration and Pain Perception: Mechanisms Integrating Nociceptive Processing. A Systematic Review and ALE-Meta Analysis

  2022cites this paper
• Alteration of ankle proprioceptive threshold during gait in the presence of acute experimental pain

  2022cites this paper
• Acceptability of Lycra arm sleeve in people with sub-acute stroke: patients’, carers’ and clinicians’ perspectives

  2022cites this paper
• Corticospinal excitability and somatosensory information processing of the lower limb muscle during upper limb voluntary or electrically induced muscle contractions

  2022cites this paper
• Differential Changes in Somatosensory Evoked Potentials and Motor Performance: Pursuit Movement Task versus Force Matching Tracking Task.

  2022cites this paper
• Cancelling cancellation? Sensorimotor control, agency, and prediction.

  2022cites this paper
• Gating at cortical level contributes to auditory-motor synchronization during repetitive finger tapping.

  2022cites this paper
• Modulation of sensorimotor oscillation by sensory gating in the frontal cortex

  2022cites this paper
• Seeing our hand or a tool during visually-guided actions: different effects on the somatosensory and visual cortices

  2022cites this paper
• Aberrant movement‐related somatosensory cortical activity mediates the extent of the mobility impairments in persons with cerebral palsy

  2022cites this paper
• Precise and stable edge orientation signaling by human first-order tactile neurons

  2022cites this paper
• Processing of embedded response plans is modulated by an interplay of fronto-parietal theta and beta activity.

  2022cites this paper
• Deep Residual Convolutional Neural Networks for Brain–Computer Interface to Visualize Neural Processing of Hand Movements in the Human Brain

  2022cites this paper
• Tactile perception of right middle fingertip suppresses excitability of motor cortex supplying right first dorsal interosseous muscle.

  2022cites this paper
• The Effects of Different Theta and Beta Neurofeedback Training Protocols on Cognitive Control in ADHD

  2022cites this paper
• Dexterous manual movement facilitates information processing in the primary somatosensory cortex: A magnetoencephalographic study

  2021cites this paper
• Human Somatosensory Cortex Is Modulated during Motor Planning

  2021cites this paper
• The corticospinal tract primarily modulates sensory inputs in the mouse lumbar cord

  2021cites this paper
• Dynamic modulation of cortico-muscular coupling during real and imagined sensorimotor synchronisation

  2021cites this paper
• Abnormal center of mass feedback responses during balance: A potential biomarker of falls in Parkinson’s disease

  2021cites this paper
• Assessing the effective connectivity of premotor areas during real vs imagined grasping: a DCM-PEB approach

  2021cites this paper
• Sensorimotor feedback loops are selectively sensitive to reward

  2021cites this paper
• Peripheral Somatosensory Entrainment Modulates the Cross-Frequency Coupling of Movement-Related Theta-Gamma Oscillations

  2021cites this paper
• Brain Plasticity Mechanisms Underlying Motor Control Reorganization: Pilot Longitudinal Study on Post-Stroke Subjects

  2021cites this paper
• Somatosensory perturbations influence cortical activity associated with single-limb balance performance

  2021cites this paper
• Effects of low-intensity exercise on local skin and whole-body thermal sensation in hypothermic young males.

  2021cites this paper
• The neural mechanisms of manual dexterity

  2021cites this paper
• Impact of Abducting at the Shoulder on Perceiving Torques about the Elbow

  2021cites this paper
• Cardiac activity impacts cortical motor excitability

  2021cites this paper
• Modulation of cutaneous responses in the cuneate nucleus of macaques during active movement

  2021cites this paper
• Somatosensory inputs modulate the excitability of cerebellar-cortical interaction.

  2021cites this paper
• Abnormal changes in motor cortical maps in humans with spinal cord injury

  2021cites this paper
• Tactile suppression stems from sensation-specific sensorimotor predictions

  2021cites this paper
• Proprioceptive Augmentation With Illusory Kinaesthetic Sensation in Stroke Patients Improves Movement Quality in an Active Upper Limb Reach-and-Point Task

  2021cites this paper
• Motor impairment evoked by direct electrical stimulation of human parietal cortex during object manipulation

  2021cites this paper
• Rehabilitation of Post Stroke Sensory Dysfunction—A Scoping Review

  2021cites this paper
• Behavioral and Physiological Evidence of a favored Hand Posture in the Body Representation for Action

  2021cites this paper
• Event-related synchronization/desynchronization and functional neuroanatomical regions associated with fatigue effects on cognitive flexibility.

  2021cites this paper
• Cortical stimulation for somatosensory feedback: translation from nonhuman primates to clinical applications

  2021cites this paper