The Unfolded Protein Response in the Immune Cell Development: Putting the Caretaker in the Driving Seat.

No abstract is available for this paper.

• Publication year

  2018

• Venue

  Current Topics in Microbiology and Immunology

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1007/82_2017_1PMID 28702709
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The unfolded protein response in immunity and inflammation

  2016cited by this paper
• Epithelial ER Stress in Crohn's Disease and Ulcerative Colitis

  2016cited by this paper
• Protein misfolding in the endoplasmic reticulum as a conduit to human disease

  2016cited by this paper
• Schlafen2 mutation unravels a role for chronic ER stress in the loss of T cell quiescence

  2016cited by this paper
• Bile Acids Protect Expanding Hematopoietic Stem Cells from Unfolded Protein Stress in Fetal Liver

  2015cited by this paper
• From the Reticuloendothelial to Mononuclear Phagocyte System – The Unaccounted Years

  2015cited by this paper
• The small molecule ISRIB reverses the effects of eIF2α phosphorylation on translation and stress granule assembly

  2015cited by this paper
• Proteostasis control by the unfolded protein response

  2015cited by this paper
• PERK Limits Drosophila Lifespan by Promoting Intestinal Stem Cell Proliferation in Response to ER Stress

  2015cited by this paper
• N-linked sugar-regulated protein folding and quality control in the ER.

  2015cited by this paper
• ER Stress Sensor XBP1 Controls Anti-tumor Immunity by Disrupting Dendritic Cell Homeostasis.

  2015cited by this paper
• Crystal structures reveal transient PERK luminal domain tetramerization in endoplasmic reticulum stress signaling

  2015cited by this paper
• Blimp-1 controls plasma cell function through regulation of immunoglobulin secretion and the unfolded protein response

  2015cited by this paper
• The transcription factor XBP1 is selectively required for eosinophil differentiation

  2015cited by this paper
• Role of endoplasmic reticulum stress and autophagy as interlinking pathways in the pathogenesis of inflammatory bowel disease

  2015cited by this paper
• Cellular differences in protein synthesis regulate tissue homeostasis.

  2014cited by this paper
• Monocytes and macrophages: developmental pathways and tissue homeostasis

  2014cited by this paper
• The unfolded protein response governs integrity of the haematopoietic stem-cell pool during stress

  2014cited by this paper
• Haematopoietic stem cells require a highly regulated protein synthesis rate

  2014cited by this paper
• Ire1 Has Distinct Catalytic Mechanisms for XBP1/HAC1 Splicing and RIDD

  2014cited by this paper
• A synthetic biology approach identifies the mammalian UPR RNA ligase RtcB.

  2014cited by this paper
• The unfolded-protein-response sensor IRE-1α regulates the function of CD8α+ dendritic cells

  2014cited by this paper
• Dppa5 improves hematopoietic stem cell activity by reducing endoplasmic reticulum stress.

  2014cited by this paper
• Getting RIDD of RNA: IRE1 in cell fate regulation.

  2014cited by this paper
• Regulated IRE1‐dependent decay participates in curtailing immunoglobulin secretion from plasma cells

  2014cited by this paper
• Metabolic requirements for the maintenance of self-renewing stem cells

  2014cited by this paper
• ER stress induces epithelial differentiation in the mouse oesophagus

  2014cited by this paper
• Phosphorylation of eIF2&agr; Is Dispensable for Differentiation but Required at a Posttranscriptional Level for Paneth Cell Function and Intestinal Homeostasis in Mice

  2014cited by this paper
• Allosteric Inhibition of the IRE1a RNase Preserves Cell Viability and Function during Endoplasmic Reticulum Stress

  2014cited by this paper
• Spliced X-box binding protein 1 couples the unfolded protein response to hexosamine biosynthetic pathway.

  2014cited by this paper
• Dendritic cells, monocytes and macrophages: a unified nomenclature based on ontogeny

  2014cited by this paper
• The RtcB RNA ligase is an essential component of the metazoan unfolded protein response

  2014cited by this paper
• Mechanistic rationale for targeting the unfolded protein response in pre-B acute lymphoblastic leukemia

  2014cited by this paper
• XBP1 Promotes Triple Negative Breast Cancer By Controlling the HIF1 α Pathway

  2014cited by this paper
• Physiological roles of regulated Ire1 dependent decay

  2014cited by this paper
• Emerging functions of the unfolded protein response in immunity

  2014cited by this paper
• Inhibition of ER stress-associated IRE-1/XBP-1 pathway reduces leukemic cell survival.

  2014cited by this paper
• Conventional and monocyte-derived CD11b(+) dendritic cells initiate and maintain T helper 2 cell-mediated immunity to house dust mite allergen.

  2013cited by this paper
• ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death

  2013cited by this paper
• Xbp1s-negative tumor B cells and pre-plasmablasts mediate therapeutic proteasome inhibitor resistance in multiple myeloma.

  2013cited by this paper
• Negative feedback by IRE1β optimizes mucin production in goblet cells

  2013cited by this paper
• Intestinal tumorigenesis initiated by dedifferentiation and acquisition of stem-cell-like properties.

  2013cited by this paper
• Plasma cells require autophagy for sustainable immunoglobulin production

  2013cited by this paper
• HIF-2α protects human hematopoietic stem/progenitors and acute myeloid leukemic cells from apoptosis induced by endoplasmic reticulum stress.

  2013cited by this paper
• The unfolded protein response and chemical chaperones reduce protein misfolding and colitis in mice.

  2013cited by this paper
• Diverse and heritable lineage imprinting of early haematopoietic progenitors

  2013cited by this paper
• Paneth cells as a site of origin for intestinal inflammation

  2013cited by this paper
• ER stress transcription factor Xbp1 suppresses intestinal tumorigenesis and directs intestinal stem cells

  2013cited by this paper
• Origins and functional specialization of macrophages and of conventional and monocyte-derived dendritic cells in mouse skin.

  2013cited by this paper
• Endoplasmic reticulum stress sensing in the unfolded protein response.

  2013cited by this paper
• Membrane lipid saturation activates IRE1α without inducing clustering

  2013cited by this paper
• Mapping the crossroads of immune activation and cellular stress response pathways

  2013cited by this paper
• Glucocorticoids alleviate intestinal ER stress by enhancing protein folding and degradation of misfolded proteins

  2013cited by this paper
• Membrane lipid saturation activates endoplasmic reticulum unfolded protein response transducers through their transmembrane domains

  2013cited by this paper
• The UPR and lung disease

  2013cited by this paper
• The UPR in atherosclerosis

  2013cited by this paper
• IL-10 promotes production of intestinal mucus by suppressing protein misfolding and endoplasmic reticulum stress in goblet cells.

  2013cited by this paper
• The dendritic cell lineage: ontogeny and function of dendritic cells and their subsets in the steady state and the inflamed setting.

  2013cited by this paper
• Maintenance of Hematopoietic Stem Cells through Regulation of Wnt and mTOR Pathways

  2012cited by this paper
• Endoplasmic Reticulum Stress Controls M2 Macrophage Differentiation and Foam Cell Formation*

  2012cited by this paper
• The ER stress transducer IRE1β is required for airway epithelial mucin production

  2012cited by this paper
• Acute Inducible Ablation of GRP78 Reveals Its Role in Hematopoietic Stem Cell Survival, Lymphogenesis and Regulation of Stress Signaling

  2012cited by this paper
• Vitamin D Suppression of Endoplasmic Reticulum Stress Promotes an Antiatherogenic Monocyte/Macrophage Phenotype in Type 2 Diabetic Patients*

  2012cited by this paper
• The Endoplasmic Reticulum Stress Transducer OASIS Is involved in the Terminal Differentiation of Goblet Cells in the Large Intestine*

  2012cited by this paper
• The interplay between endoplasmic reticulum stress and inflammation

  2012cited by this paper
• PKR protects colonic epithelium against colitis through the unfolded protein response and prosurvival signaling

  2012cited by this paper
• Structural basis of the unfolded protein response.

  2012cited by this paper
• Induction of GADD34 Is Necessary for dsRNA-Dependent Interferon-β Production and Participates in the Control of Chikungunya Virus Infection

  2012cited by this paper
• High Rate of Antibody Secretion Is not Integral to Plasma Cell Differentiation as Revealed by XBP-1 Deficiency

  2012cited by this paper
• The unfolded protein response in fission yeast modulates stability of select mRNAs to maintain protein homeostasis

  2012cited by this paper
• Principles of translational control: an overview.

  2012cited by this paper
• IRE1 activation protects mice against acetaminophen-induced hepatotoxicity

  2012cited by this paper
• AGR2 is induced in asthma and promotes allergen-induced mucin overproduction.

  2012cited by this paper
• The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent ‘+4’ cell markers

  2012cited by this paper
• Regulation of HSF1 function in the heat stress response: implications in aging and disease.

  2011cited by this paper
• Identification of an Ire1alpha endonuclease specific inhibitor with cytotoxic activity against human multiple myeloma.

  2011cited by this paper
• Road to Ruin: Targeting Proteins for Degradation in the Endoplasmic Reticulum

  2011cited by this paper
• Induction of the unfolded protein response after monocyte to macrophage differentiation augments cell survival in early atherosclerotic lesions

  2011cited by this paper
• Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress

  2011cited by this paper
• The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation

  2011cited by this paper
• Unfolded Proteins Are Ire1-Activating Ligands That Directly Induce the Unfolded Protein Response

  2011cited by this paper
• Protein synthesis in plasma cells is regulated by crosstalk between endoplasmic reticulum stress and mTOR signaling

  2011cited by this paper
• Blockade of XBP1 splicing by inhibition of IRE1α is a promising therapeutic option in multiple myeloma.

  2011cited by this paper
• Anti-apoptotic function of Xbp1 as an IL-3 signaling molecule in hematopoietic cells

  2011cited by this paper
• Plasma cell differentiation initiates a limited ER stress response by specifically suppressing the PERK-dependent branch of the unfolded protein response

  2010cited by this paper
• BiP Binding to the ER-Stress Sensor Ire1 Tunes the Homeostatic Behavior of the Unfolded Protein Response

  2010cited by this paper
• Flavonol activation defines an unanticipated ligand-binding site in the kinase-RNase domain of IRE1.

  2010cited by this paper
• TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages

  2010cited by this paper
• Double-stranded RNA-dependent protein kinase links pathogen sensing with stress and metabolic homeostasis.

  2010cited by this paper
• Disruption of Paneth and goblet cell homeostasis and increased endoplasmic reticulum stress in Agr2-/- mice.

  2010cited by this paper
• An intestinal epithelial defect conferring ER stress results in inflammation involving both innate and adaptive immunity

  2010cited by this paper
• Regulation of basal cellular physiology by the homeostatic unfolded protein response

  2010cited by this paper
• Hematopoietic Stem Cell Differentiation Regulated by a Single Ubiquitin Ligase: Substrate Complex

  2009cited by this paper
• Messenger RNA targeting to endoplasmic reticulum stress signalling sites.

  2009cited by this paper
• Reduced apoptosis and plaque necrosis in advanced atherosclerotic lesions of Apoe-/- and Ldlr-/- mice lacking CHOP.

  2009cited by this paper
• Regulated Ire1-dependent decay of messenger RNAs in mammalian cells

  2009cited by this paper
• The protein disulfide isomerase AGR2 is essential for production of intestinal mucus

  2009cited by this paper
• XBP1 governs late events in plasma cell differentiation and is not required for antigen-specific memory B cell development

  2009cited by this paper
• The unfolded protein response signals through high-order assembly of Ire1

  2009cited by this paper
• XBP-1 regulates signal transduction, transcription factors and bone marrow colonization in B cells

  2009cited by this paper

• Control of immune cell function by the unfolded protein response

  2023cites this paper
• Canonical IRE1 function needed to sustain vigorous natural killer cell proliferation during viral infection

  2023cites this paper
• At the crossway of ER‐stress and proinflammatory responses

  2019cites this paper
• Antigen presentation unfolded: identifying convergence points between the UPR and antigen presentation pathways.

  2018cites this paper
• Interplay Between the Unfolded Protein Response and Immune Function in the Development of Neurodegenerative Diseases

  2018cites this paper