Ubiquitination of p53 at Multiple Sites in the DNA-Binding Domain

No abstract is available for this paper.

• Publication year

  2006

• Venue

  Molecular Cancer Research

• Publication date

  2006-01-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1158/1541-7786.MCR-05-0097PMID 16446403
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The C-terminal lysines fine-tune P53 stress responses in a mouse model but are not required for stability control or transactivation.

  2005cited by this paper
• The N-terminal Regulatory Domain of Cyclin A Contains Redundant Ubiquitination Targeting Sequences and Acceptor Sites

  2005cited by this paper
• Yin Yang 1 is a negative regulator of p53.

  2004cited by this paper
• The ubiquitin ligase COP1 is a critical negative regulator of p53

  2004cited by this paper
• How Many Mutant p53 Molecules Are Needed To Inactivate a Tetramer?

  2004cited by this paper
• Neddylating the Guardian: Mdm2 Catalyzed Conjugation of Nedd8 to p53

  2004cited by this paper
• Mdm2-mediated NEDD8 conjugation of p53 inhibits its transcriptional activity.

  2004cited by this paper
• Differences in the ubiquitination of p53 by Mdm2 and the HPV protein E6

  2003cited by this paper
• Proteasome-mediated degradation of p21 via N-terminal ubiquitinylation.

  2003cited by this paper
• Pirh2, a p53-induced ubiquitin-protein ligase, promotes p53 degradation.

  2003cited by this paper
• Polyubiquitination of p53 by a Ubiquitin Ligase Activity of p300

  2003cited by this paper
• Mdm2: A regulator of cell growth and death.

  2003cited by this paper
• Germline TP53 mutations and Li‐Fraumeni syndrome

  2003cited by this paper
• Mono- Versus Polyubiquitination: Differential Control of p53 Fate by Mdm2

  2003cited by this paper
• Context of multiubiquitin chain attachment influences the rate of Sic1 degradation.

  2003cited by this paper
• The candidate tumor suppressor ING1b can stabilize p53 by disrupting the regulation of p53 by MDM2.

  2002cited by this paper
• Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization

  2002cited by this paper
• Deubiquitination of p 53 by HAUSP is an important pathway for p 53 stabilization

  2002cited by this paper
• Convergence of the fanconi anemia and ataxia telangiectasia signaling pathways.

  2002cited by this paper
• MdmX Is a RING Finger Ubiquitin Ligase Capable of Synergistically Enhancing Mdm2 Ubiquitination*

  2002cited by this paper
• Cyclin F Is Degraded during G2-M by Mechanisms Fundamentally Different from Other Cyclins*

  2002cited by this paper
• Acetylation of p53 Inhibits Its Ubiquitination by Mdm2*

  2002cited by this paper
• Identification of p53 Sequence Elements That Are Required for MDM2-Mediated Nuclear Export

  2001cited by this paper
• C-Terminal Ubiquitination of p53 Contributes to Nuclear Export

  2001cited by this paper
• Multiple C-Terminal Lysine Residues Target p53 for Ubiquitin-Proteasome-Mediated Degradation

  2000cited by this paper
• Multiple Lysine Mutations in the C-Terminal Domain of p53 Interfere with MDM2-Dependent Protein Degradation and Ubiquitination

  2000cited by this paper
• Degradation of Cyclin A Does Not Require Its Phosphorylation by CDC2 and Cyclin-dependent Kinase 2*

  2000cited by this paper
• SUMO‐1 modification activates the transcriptional response of p53

  1999cited by this paper
• p53 Sites Acetylated In Vitro by PCAF and p300 Are Acetylated In Vivo in Response to DNA Damage

  1999cited by this paper
• Activation of p53 by conjugation to the ubiquitin‐like protein SUMO‐1

  1999cited by this paper
• Nucleolar Arf sequesters Mdm2 and activates p53

  1999cited by this paper
• MDM2 and MDMX bind and stabilize the p53-related protein p73.

  1999cited by this paper
• The ubiquitin system.

  1998cited by this paper
• DNA damage activates p53 through a phosphorylation-acetylation cascade.

  1998cited by this paper
• Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain.

  1997cited by this paper
• Sensitivity of p53 lysine mutants to ubiquitin-directed degradation targeted by human papillomavirus E6.

  1996cited by this paper
• Somatic point mutations in the p53 gene of human tumors and cell lines: updated compilation

  1996cited by this paper
• Mutagenic analysis of the destruction signal of mitotic cyclins and structural characterization of ubiquitinated intermediates.

  1996cited by this paper
• Redistribution of the CDK inhibitor p27 between different cyclin.CDK complexes in the mouse fibroblast cell cycle and in cells arrested with lovastatin or ultraviolet irradiation.

  1995cited by this paper
• The domain of p53 required for binding HPV 16 E6 is separable from the degradation domain.

  1995cited by this paper
• p53: at the crossroads of molecular carcinogenesis and risk assessment.

  1993cited by this paper
• Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

  1992cited by this paper
• Expression of mutant p53 proteins in lung cancer correlates with the class of p53 gene mutation.

  1992cited by this paper
• A cellular protein mediates association of p53 with the E6 oncoprotein of human papillomavirus types 16 or 18.

  1991cited by this paper

• The functions of herpesvirus shuttling proteins in the virus lifecycle

  2025cites this paper
• Nucleosomes specify co-factor access to p53.

  2025cites this paper
• Detection of protein structural hotspots using AI distillation and explainability: application to the DAX-1 protein

  2025cites this paper
• CHI3L1 mediates radiation resistance in colorectal cancer by inhibiting ferroptosis via the p53/SLC7A11 pathway

  2025cites this paper
• Structure and function of MDM2 and MDM4 in health and disease

  2025cites this paper
• Ubiquitination is involved in PKC-mediated degradation of cell surface Kv1.5 channels

  2024cites this paper
• Targeting UBE2T potentiates gemcitabine efficacy in pancreatic cancer by regulating pyrimidine metabolism and replication stress.

  2023cites this paper
• Generation and Characterization of Site‐Specifically Mono‐Ubiquitylated p53

  2022cites this paper
• TRIM47 promotes malignant progression of renal cell carcinoma by degrading P53 through ubiquitination

  2020cites this paper
• Ubiquitination and Proteasomal Regulation of Pannexin 1 and Pannexin 3

  2020cites this paper
• Long noncoding RNA MEG3 blocks telomerase activity in human liver cancer stem cells epigenetically

  2020cites this paper
• Role of post-translational modifications in regulation of tumor suppressor p53 function

  2020cites this paper
• Reciprocal negative regulation between the tumor suppressor protein p53 and B cell CLL/lymphoma 6 (BCL6) via control of caspase-1 expression

  2018cites this paper
• USP15-dependent lysosomal pathway controls p53-R175H turnover in ovarian cancer cells

  2018cites this paper
• Prediction aided in vitro analysis of octa-decanoic acid from Cyanobacterium Lyngbya sp. as a proapoptotic factor in eliciting anti-inflammatory properties

  2017cites this paper
• Regulation of transcriptional activators by DNA-binding domain ubiquitination

  2017cites this paper
• Regulation of E2F1 in Keratinocytes During UV-Damage and Differentiation

  2016cites this paper
• Wnt Signaling Promotes Breast Cancer by Blocking ITCH-Mediated Degradation of YAP/TAZ Transcriptional Coactivator WBP2.

  2016cites this paper
• ZEB1-induced tumourigenesis requires senescence inhibition via activation of DKK1/mutant p53/Mdm2/CtBP and repression of macroH2A1

  2016cites this paper
• The Tail That Wags the Dog: How the Disordered C-Terminal Domain Controls the Transcriptional Activities of the p53 Tumor-Suppressor Protein.

  2016cites this paper
• IRGM governs the core autophagy machinery to conduct antimicrobial defense.

  2015cites this paper
• The regulation of radiosensitivity by p53 and its acetylation.

  2015cites this paper
• Mono-ubiquitylated ORF45 Mediates Association of KSHV Particles with Internal Lipid Rafts for Viral Assembly and Egress

  2015cites this paper
• Mechanisms of p53 degradation.

  2015cites this paper
• Limiting the power of p 53 through the ubiquitin proteasome pathway

  2014cites this paper
• Limiting the power of p53 through the ubiquitin proteasome pathway

  2014cites this paper
• Dissecting the non-canonical functions of p53 through novel target identification and p53 acetylation

  2014cites this paper
• Mdm2 protein expression is strongly associated with survival in malignant pleural mesothelioma.

  2014cites this paper
• The p53-Mdm2 loop: a critical juncture of stress response.

  2014cites this paper
• Ubiquitination of the transcription factor c‐maf is mediated by multiple lysine residues (LB188)

  2014cites this paper
• GRK2 as new onco-modulator of breast tumoural transformation through the regulation of the p53/Mdm2 axis

  2014cites this paper
• Cell Fate Decisions Regulated by K63 Ubiquitination of Tumor Necrosis Factor Receptor 1

  2014cites this paper
• Organizing the Ubiquitin-dependent Response to DNA Double-Strand Breaks

  2014cites this paper
• The Increased Level of Serum p53 in Hepatitis B-Associated Liver Cirrhosis

  2014cites this paper
• Residues 240–250 in the C-Terminus of the Pirh2 Protein Complement the Function of the RING Domain in Self-Ubiquitination of the Pirh2 Protein

  2013cites this paper
• Controlled access of p53 to the nucleus regulates its proteasomal degradation by MDM2.

  2013cites this paper
• Extensive Post-translational Modification of Active and Inactivated Forms of Endogenous p53*

  2013cites this paper
• Cytoplasmic Translocation of p53 by Human Cytomegalovirus Infection

  2013cites this paper
• Back to your heart: ubiquitin proteasome system-regulated signal transduction.

  2012cites this paper
• p53 N-terminal phosphorylation: a defining layer of complex regulation.

  2012cites this paper
• Ubiquitin-Specific Protease 4 Inhibits Mono-Ubiquitination of the Master Growth Factor Signaling Kinase PDK1

  2012cites this paper
• Ubiquitylation - Dependent Signaling in Heart Disease

  2012cites this paper
• Chromatin remodelling protein SMAR1 inhibits p53 dependent transactivation by regulating acetyl transferase p300.

  2012cites this paper
• p53 regulation by ubiquitin

  2011cites this paper
• E3 Ligases Determine Ubiquitination Site and Conjugate Type by Enforcing Specificity on E2 Enzymes*

  2011cites this paper
• Pharmacological targeting of mutant p53 family members

  2011cites this paper
• Regulation of MDM2 and the p53 Family by the NEDD8 Pathway

  2011cites this paper
• Modelling the interaction between the p53 DNA‐binding domain and the p28 peptide fragment of Azurin

  2011cites this paper
• Allosteric regulation of MDM2 protein

  2010cites this paper
• Cooperation between MDM2 and MDMX in the Regulation of p53

  2010cites this paper
• Protein Posttranslational Modification: A Potential Target in Pharmaceutical Development

  2010cites this paper
• Ubiquitin Family Members in the Regulation of the Tumor Suppressor p53.

  2010cites this paper
• New insights into p53 activation

  2010cites this paper
• The multiple levels of regulation by p53 ubiquitination

  2010cites this paper
• Identification of residues on Hsp70 and Hsp90 ubiquitinated by the cochaperone CHIP.

  2010cites this paper
• Targeting the MDM2–p53 interaction as a therapeutic strategy for the treatment of cancer

  2010cites this paper
• TRIM24 enters the RING

  2009cites this paper
• p53 ubiquitination by Mdm2: a never ending tail?

  2009cites this paper
• Modes of p53 regulation.

  2009cites this paper
• p53: balancing tumour suppression and implications for the clinic.

  2009cites this paper
• Interaction of p53 with Mdm2 and azurin as studied by atomic force spectroscopy

  2009cites this paper
• Acetylation of the DNA Binding Domain Regulates Transcription-independent Apoptosis by p53*

  2009cites this paper
• Protein methylation : a new regulator of the p 53 tumor suppressor

  2009cites this paper
• Regulation of cellular functions of p53 by ubiquitination

  2009cites this paper
• Regulation of p53 - insights into a complex process

  2009cites this paper
• Regulation of p53: TRIM24 enters the RING

  2009cites this paper
• Leading Edge Review Modes of p 53 Regulation

  2009cites this paper
• Probing the interaction between p53 and the bacterial protein azurin by single molecule force spectroscopy

  2008cites this paper
• Protein methylation: a new mechanism of p53 tumor suppressor regulation.

  2008cites this paper
• Characterization of the Ubiquitin/Nedd8 E3 ligase activity of the Mdm2/MdmX complex

  2007cites this paper
• Regulation of p53 Nuclear Export through Sequential Changes in Conformation and Ubiquitination*

  2007cites this paper
• Regulation of the p53 Tumor‐Suppressor Protein by Ubiquitin and Ubiquitin‐Like Molecules

  2007cites this paper
• The p53 Isoform Deltap53 lacks intrinsic transcriptional activity and reveals the critical role of nuclear import in dominant-negative activity.

  2007cites this paper
• Ubiquitin and Ubiquitin-Like Modifications of the p 53 Family 1

  2006cites this paper
• Ubiquitin and ubiquitin-like modifications of the p53 family.

  2006cites this paper