The candidate tumor suppressor ING1b can stabilize p53 by disrupting the regulation of p53 by MDM2.

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Cancer Research

• Publication date

  2002-09-01

• Fields of study

  Biology, Medicine

• Identifiers
  PMID 12208736
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  1998influential reference
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  1998cited by this paper
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