After a decade of study-ING, a PHD for a versatile family of proteins.

No abstract is available for this paper.

• Publication year

  2007

• Venue

  TIBS -Trends in Biochemical Sciences. Regular ed

• Publication date

  2007-11-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/J.TIBS.2007.08.006PMID 17949986
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Expression profiles of mRNA transcript variants encoding the human inhibitor of growth tumor suppressor gene family in normal and neoplastic tissues.

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• A chromatin landmark and transcription initiation at most promoters in human cells.

  2007cited by this paper
• Stabilized phosphatidylinositol-5-phosphate analogues as ligands for the nuclear protein ING2: chemistry, biology, and molecular modeling.

  2007cited by this paper
• Combined Action of PHD and Chromo Domains Directs the Rpd3S HDAC to Transcribed Chromatin

  2007cited by this paper
• Inhibitor of growth 4 suppresses cell spreading and cell migration by interacting with a novel binding partner, liprin alpha1.

  2007cited by this paper
• Methylation of lysine 4 on histone H3: intricacy of writing and reading a single epigenetic mark.

  2007cited by this paper
• Deletion of p37Ing1 in mice reveals a p53-independent role for Ing1 in the suppression of cell proliferation, apoptosis, and tumorigenesis.

  2007cited by this paper
• Detection of novel mRNA splice variants of human ING4 tumor suppressor gene

  2007cited by this paper
• The Plant Homeodomain Fingers of Fission Yeast Msc1 Exhibit E3 Ubiquitin Ligase Activity*

  2007cited by this paper
• Proteome-wide Analysis in Saccharomyces cerevisiae Identifies Several PHD Fingers as Novel Direct and Selective Binding Modules of Histone H3 Methylated at Either Lysine 4 or Lysine 36*

  2007cited by this paper
• The ING1b tumor suppressor facilitates nucleotide excision repair by promoting chromatin accessibility to XPA.

  2007cited by this paper
• Histone H3 recognition and presentation by the WDR5 module of the MLL1 complex

  2006cited by this paper
• ING2 PHD domain links histone H3 lysine 4 methylation to active gene repression

  2006cited by this paper
• ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation.

  2006cited by this paper
• HSP70 Induction by ING Proteins Sensitizes Cells to Tumor Necrosis Factor Alpha Receptor-Mediated Apoptosis

  2006cited by this paper
• A functional link between the tumour suppressors ARF and p33ING1

  2006cited by this paper
• The Yng1p Plant Homeodomain Finger Is a Methyl-Histone Binding Module That Recognizes Lysine 4-Methylated Histone H3

  2006cited by this paper
• The novel tumor suppressor p33ING2 enhances nucleotide excision repair via inducement of histone H4 acetylation and chromatin relaxation.

  2006cited by this paper
• Stress-ING Out: Phosphoinositides Mediate the Cellular Stress Response

  2006cited by this paper
• MAGE-A tumor antigens target p53 transactivation function through histone deacetylase recruitment and confer resistance to chemotherapeutic agents.

  2006cited by this paper
• The Polybasic Region That Follows the Plant Homeodomain Zinc Finger 1 of Pf1 Is Necessary and Sufficient for Specific Phosphoinositide Binding*

  2006cited by this paper
• Subcellular Targeting of p33ING1b by Phosphorylation-Dependent 14-3-3 Binding Regulates p21WAF1 Expression

  2006cited by this paper
• Nuclear PtdIns5P as a transducer of stress signaling: an in vivo role for PIP4Kbeta.

  2006cited by this paper
• Yng1 PHD finger binding to H3 trimethylated at K4 promotes NuA3 HAT activity at K14 of H3 and transcription at a subset of targeted ORFs.

  2006cited by this paper
• Novel Splice Variants of ING4 and Their Possible Roles in the Regulation of Cell Growth and Motility*

  2006cited by this paper
• The p33ING1b tumor suppressor cooperates with p53 to induce apoptosis in response to etoposide in human osteosarcoma cells.

  2006cited by this paper
• Targeted disruption of the mouse ing1 locus results in reduced body size, hypersensitivity to radiation and elevated incidence of lymphomas

  2006cited by this paper
• Histone H3 Lys 4 methylation: caught in a bind?

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• Molecular basis for site-specific read-out of histone H3K4me3 by the BPTF PHD finger of NURF

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• Recognition of Histone H3 Lysine-4 Methylation by the Double Tudor Domain of JMJD2A

  2006cited by this paper
• Solution structure and NMR characterization of the binding to methylated histone tails of the plant homeodomain finger of the tumour suppressor ING4

  2006cited by this paper
• Grow-ING, Age-ING and Die-ING: ING proteins link cancer, senescence and apoptosis.

  2006cited by this paper
• A PHD finger of NURF couples histone H3 lysine 4 trimethylation with chromatin remodelling

  2006cited by this paper
• Molecular mechanism of histone H3K4me3 recognition by plant homeodomain of ING2

  2006cited by this paper
• Leucine zipper‐like domain is required for tumor suppressor ING2‐mediated nucleotide excision repair and apoptosis

  2006cited by this paper
• The PHD finger, a nuclear protein-interaction domain.

  2006cited by this paper
• Double chromodomains cooperate to recognize the methylated histone H3 tail

  2005cited by this paper
• Human but Not Yeast CHD1 Binds Directly and Selectively to Histone H3 Methylated at Lysine 4 via Its Tandem Chromodomains*

  2005cited by this paper
• Chd1 chromodomain links histone H3 methylation with SAGA- and SLIK-dependent acetylation

  2005cited by this paper
• Function of the ING family of PHD proteins in cancer.

  2005cited by this paper
• ING2 Regulates the Onset of Replicative Senescence by Induction of p300-Dependent p53 Acetylation

  2005cited by this paper
• WDR5 associates with histone H3 methylated at K4 and is essential for H3 K4 methylation and vertebrate development.

  2005cited by this paper
• A polybasic motif allows N-WASP to act as a sensor of PIP(2) density.

  2005cited by this paper
• Multiple variants of the ING1 and ING2 tumor suppressors are differentially expressed and thyroid hormone-responsive in Xenopus laevis.

  2005cited by this paper
• Phylogenetic analysis of the ING family of PHD finger proteins.

  2005cited by this paper
• Histone H3 lysine 9 methylation and HP1gamma are associated with transcription elongation through mammalian chromatin.

  2005cited by this paper
• Nuclear localization signal of ING4 plays a key role in its binding to p53.

  2005cited by this paper
• The diverse functions of histone lysine methylation

  2005cited by this paper
• The PCNA-associated factor KIAA0101/p15(PAF) binds the potential tumor suppressor product p33ING1b.

  2005cited by this paper
• The candidate tumor suppressor ING4 represses activation of the hypoxia inducible factor (HIF).

  2005cited by this paper
• The fellowships of the INGs

  2005cited by this paper
• Biological functions of the ING family tumor suppressors

  2004cited by this paper
• The candidate tumour suppressor protein ING4 regulates brain tumour growth and angiogenesis

  2004cited by this paper
• Nucleosome binding by the bromodomain and PHD finger of the transcriptional cofactor p300.

  2004cited by this paper
• ACF1 improves the effectiveness of nucleosome mobilization by ISWI through PHD–histone contacts

  2004cited by this paper
• Components of a Pathway Maintaining Histone Modification and Heterochromatin Protein 1 Binding at the Pericentric Heterochromatin in Mammalian Cells*

  2004cited by this paper
• p33(ING1b) stimulates the transcriptional activity of the estrogen receptor alpha via its activation function (AF) 2 domain.

  2003cited by this paper
• The PHD Finger of the Chromatin-Associated Protein ING2 Functions as a Nuclear Phosphoinositide Receptor

  2003cited by this paper
• ING1 represses transcription by direct DNA binding and through effects on p53.

  2003cited by this paper
• p29ING4 and p28ING5 bind to p53 and p300, and enhance p53 activity.

  2003cited by this paper
• Opposite Role of Yeast ING Family Members in p53-dependent Transcriptional Activation*

  2003cited by this paper
• No evidence for PHD fingers as ubiquitin ligases.

  2003cited by this paper
• The PHD finger of the chromatin-associated protein ING2 functions as a nuclear phosphoinositide receptor.

  2003cited by this paper
• Scores of RINGS but No PHDs in Ubiquitin Signaling

  2003cited by this paper
• Nuclear lipid signalling

  2003cited by this paper
• ING1b decreases cell proliferation through p53‐dependent and ‐independent mechanisms

  2003cited by this paper
• ING1 isoforms differentially affect apoptosis in a cell age-dependent manner.

  2002cited by this paper
• Human ING1 Proteins Differentially Regulate Histone Acetylation*

  2002cited by this paper
• Different HATS of the ING1 gene family.

  2002cited by this paper
• Role of the Sin3-Histone Deacetylase Complex in Growth Regulation by the Candidate Tumor Suppressor p33ING1

  2002cited by this paper
• The candidate tumor suppressor ING1b can stabilize p53 by disrupting the regulation of p53 by MDM2.

  2002cited by this paper
• Role of Histone H3 Lysine 27 Methylation in Polycomb-Group Silencing

  2002cited by this paper
• Drosophila enhancer of Zeste/ESC complexes have a histone H3 methyltransferase activity that marks chromosomal Polycomb sites.

  2002cited by this paper
• Exploration of novel motifs derived from mouse cDNA sequences.

  2002cited by this paper
• UV-induced binding of ING1 to PCNA regulates the induction of apoptosis.

  2001cited by this paper
• hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase.

  2001cited by this paper
• Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins

  2001cited by this paper
• UV induces nucleolar translocation of ING1 through two distinct nucleolar targeting sequences.

  2001cited by this paper
• Differential Association of Products of Alternative Transcripts of the Candidate Tumor Suppressor ING1 with the mSin3/HDAC1 Transcriptional Corepressor Complex*

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• DNA damage-inducible gene p33ING2 negatively regulates cell proliferation through acetylation of p53

  2001cited by this paper
• Translating the Histone Code

  2001cited by this paper
• The tumor suppressor candidate p33(ING1) mediates repair of UV-damaged DNA.

  2001cited by this paper
• Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain

  2001cited by this paper
• Acetylation of p53 activates transcription through recruitment of coactivators/histone acetyltransferases.

  2001cited by this paper
• The puzzle of PCNA's many partners

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• Three Yeast Proteins Related to the Human Candidate Tumor Suppressor p33ING1 Are Associated with Histone Acetyltransferase Activities

  2000cited by this paper
• Adenovirus-mediated transfer of p33ING1 with p53 drastically augments apoptosis in gliomas.

  1999cited by this paper
• The candidate tumour suppressor p33ING1cooperates with p53 in cell growth control

  1998cited by this paper
• A novel candidate tumor suppressor, ING1, is involved in the regulation of apoptosis.

  1997cited by this paper
• Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a.

  1997cited by this paper
• Extension of the replicative life span of human diploid fibroblasts by inhibition of the p33ING1 candidate tumor suppressor

  1997cited by this paper
• Suppression of the novel growth inhibitor p33ING1 promotes neoplastic transformation

  1996cited by this paper

• Protein expression signatures of the ING family in benign odontogenic epithelial lesions.

  2025cites this paper
• Arabidopsis INHIBITOR OF GROWTH 2 promotes flowering by regulating NuA4-dependent H4 acetylation levels at FT and SOC1

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• Exploring KAT6 as a therapeutic target in breast cancer: epigenetic approaches for precision medicine

  2025cites this paper
• Expression and prognostic value of ING3 in advanced laryngeal squamous cell carcinoma

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• A comprehensive pan-cancer analysis unveiling the oncogenic effect of plant homeodomain finger protein 14 (PHF14) in human tumors

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• DNA methylation of RUNX3 promotes the progression of gallbladder cancer through repressing SLC7A11-mediated ferroptosis.

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• Inhibitor of Growth Factors Regulate Cellular Senescence

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• Histone H3 proline 16 hydroxylation regulates mammalian gene expression

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• An in silico study of how histone tail conformation affects the binding affinity of ING family proteins

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• Transcriptional Regulation of ING5 and its Suppressive Effects on Gastric Cancer

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• Molecular mechanisms of inhibitor of growth (ING) family members in health and malignancy

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• Roles of the tumor suppressor inhibitor of growth family member 4 (ING4) in cancer.

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• Cell-Penetrating Peptides Predicted From CASC3, AKIP1, and AHRR Proteins

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• MiR-193 promotes cell proliferation and invasion by ING5/PI3K/AKT pathway of triple-negative breast cancer.

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• Nuclear ING3 Expression Is Correlated With a Good Prognosis of Breast Cancer

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• p33ING1b regulates acetylation of p53 in oral squamous cell carcinoma via SIR2

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• Investigating NF-κB ubiquitination: an in vitro study

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• Biological Functions of the ING Proteins

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• Inhibitor of Growth 4 (ING4) is a positive regulator of rRNA synthesis

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• Are There Common Mechanisms Between the Hutchinson–Gilford Progeria Syndrome and Natural Aging?

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• Regulat-INGs in tumors and diseases: Focus on ncRNAs.

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• Long noncoding RNA UCA1 promotes the proliferation of hypoxic human pulmonary artery smooth muscle cells

  2018cites this paper
• Overexpression of ING5 inhibits HGF-induced proliferation, invasion and EMT in thyroid cancer cells via regulation of the c-Met/PI3K/Akt signaling pathway.

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• ING5 is a Potential Target for Osteosarcoma Therapy

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• Src Regulates the Activity of the ING1 Tumor Suppressor

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• Ing 1 functions in DNA demethylation by directing Gadd 45 a to H 3 K 4 me 3

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• Impact of EBV essential nuclear protein EBNA-3C on B-cell proliferation and apoptosis.

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• Effect of the tumor suppressor gene ING4 on the proliferation of MCF-7 human breast cancer cells.

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