Low fidelity bypass of O(2)-(3-pyridyl)-4-oxobutylthymine, the most persistent bulky adduct produced by the tobacco specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone by model DNA polymerases.

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Chemical Research in Toxicology

• Publication date

  2012-05-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1021/tx200483gPMID 22533615
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Kinetic analysis of the bypass of a bulky DNA lesion catalyzed by human Y-family DNA polymerases.

  2012cited by this paper
• Facile syntheses of O(2)-[4-(3-pyridyl-4-oxobut-1-yl]thymidine, the major adduct formed by tobacco specific nitrosamine 4-methylnitrosamino-1-(3-pyridyl)-1-butanone (NNK) in vivo, and its site-specifically adducted oligodeoxynucleotides.

  2011cited by this paper
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  2011cited by this paper
• DynaFit--a software package for enzymology.

  2009cited by this paper
• Versatility of Y-family Sulfolobus solfataricus DNA Polymerase Dpo4 in Translesion Synthesis Past Bulky N2-Alkylguanine Adducts*

  2009cited by this paper
• Alpha,beta-methylene-2'-deoxynucleoside 5'-triphosphates as noncleavable substrates for DNA polymerases: isolation, characterization, and stability studies of novel 2'-deoxycyclonucleosides, 3,5'-cyclo-dG, and 2,5'-cyclo-dT.

  2008cited by this paper
• Progress and challenges in selected areas of tobacco carcinogenesis.

  2008cited by this paper
• Mgmt deficiency alters the in vivo mutational spectrum of tissues exposed to the tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK).

  2008cited by this paper
• Formation of purine-purine mispairs by Sulfolobus solfataricus DNA polymerase IV.

  2008cited by this paper
• Formation of formaldehyde adducts in the reactions of DNA and deoxyribonucleosides with alpha-acetates of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL), and N-nitrosodimethylamine (NDMA).

  2008cited by this paper
• Sulfolobus solfataricus DNA Polymerase Dpo4 Is Partially Inhibited by “Wobble” Pairing between O6-Methylguanine and Cytosine, but Accurate Bypass Is Preferred*

  2007cited by this paper
• Formation and accumulation of pyridyloxobutyl DNA adducts in F344 rats chronically treated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and enantiomers of its metabolite, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol.

  2007cited by this paper
• Quantitation of pyridyloxobutyl DNA adducts of tobacco-specific nitrosamines in rat tissue DNA by high-performance liquid chromatography-electrospray ionization-tandem mass spectrometry.

  2006cited by this paper
• Translesion synthesis past the C8- and N2-deoxyguanosine adducts of the dietary mutagen 2-Amino-3-methylimidazo[4,5-f]quinoline in the NarI recognition sequence by prokaryotic DNA polymerases.

  2006cited by this paper
• Structure of purine-purine mispairs during misincorporation and extension by Escherichia coli DNA polymerase I.

  2006cited by this paper
• Fidelity of mispair formation and mispair extension is dependent on the interaction between the minor groove of the primer terminus and Arg668 of DNA polymerase I of Escherichia coli.

  2005cited by this paper
• Escherichia coli DNA Polymerase I (Klenow Fragment) Uses a Hydrogen-bonding Fork from Arg668 to the Primer Terminus and Incoming Deoxynucleotide Triphosphate to Catalyze DNA Replication*[boxs]

  2004cited by this paper
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  2004cited by this paper
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  2004cited by this paper
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  2003cited by this paper
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  2002cited by this paper
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  2001cited by this paper
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  2000cited by this paper
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  1999cited by this paper
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  1998cited by this paper
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  1998cited by this paper
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  1997cited by this paper
• Pyridyloxobutyl adduct O6-[4-oxo-4-(3-pyridyl)butyl]guanine is present in 4-(acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanone-treated DNA and is a substrate for O6-alkylguanine-DNA alkyltransferase.

  1997cited by this paper
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  1997cited by this paper
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  1996cited by this paper
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  1993cited by this paper
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  1992cited by this paper
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  1992cited by this paper
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  1991cited by this paper
• Sequence-specific recognition of double helical nucleic acids by proteins.

  1976cited by this paper

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  2025cites this paper
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  2022cites this paper
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  2019cites this paper
• DFT and MD Studies of Formaldehyde-Derived DNA Adducts: Molecular Level Insights Into the Differential Mispairing Potentials of the Adenine, Cytosine and Guanine Lesions.

  2019cites this paper
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  2018cites this paper
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  2017cites this paper
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