The regenerative capacity of zebrafish reverses cardiac failure caused by genetic cardiomyocyte depletion

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Development

• Publication date

  2011-08-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1242/dev.068601PMID 21752928PMCID PMC3143562
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• tcf21+ epicardial cells adopt non-myocardial fates during zebrafish heart development and regeneration

  2011cited by this paper
• The zebrafish heart regenerates after cryoinjury-induced myocardial infarction

  2011cited by this paper
• Transient Regenerative Potential of the Neonatal Mouse Heart

  2011cited by this paper
• Retinoic acid production by endocardium and epicardium is an injury response essential for zebrafish heart regeneration.

  2011cited by this paper
• Extensive scar formation and regression during heart regeneration after cryoinjury in zebrafish

  2011cited by this paper
• Regeneration of Cryoinjury Induced Necrotic Heart Lesions in Zebrafish Is Associated with Epicardial Activation and Cardiomyocyte Proliferation

  2011cited by this paper
• Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors.

  2010cited by this paper
• PDGF signaling is required for epicardial function and blood vessel formation in regenerating zebrafish hearts

  2010cited by this paper
• Primary contribution to zebrafish heart regeneration by gata4+ cardiomyocytes

  2010cited by this paper
• Clinical practice. Systolic heart failure.

  2010cited by this paper
• Zebrafish heart regeneration occurs by cardiomyocyte dedifferentiation and proliferation

  2010cited by this paper
• Wnt11 patterns a myocardial electrical gradient via regulation of the L-type Ca2+ channel

  2010cited by this paper
• Voltage-Gated Sodium Channels Are Required for Heart Development in Zebrafish

  2010cited by this paper
• Drug-Sensitized Zebrafish Screen Identifies Multiple Genes, Including GINS3, as Regulators of Myocardial Repolarization

  2009cited by this paper
• Neuregulin1/ErbB4 signaling induces cardiomyocyte proliferation and repair of heart injury.

  2009cited by this paper
• Skeletal muscle stem cells in developmental versus regenerative myogenesis

  2009cited by this paper
• Compensatory growth of healthy cardiac cells in the presence of diseased cells restores tissue homeostasis during heart development.

  2008cited by this paper
• Targeted ablation of beta cells in the embryonic zebrafish pancreas using E. coli nitroreductase.

  2007cited by this paper
• Conditional targeted cell ablation in zebrafish: A new tool for regeneration studies

  2007cited by this paper
• Regulated addition of new myocardial and epicardial cells fosters homeostatic cardiac growth and maintenance in adult zebrafish

  2007cited by this paper
• Preservation of Left Ventricular Function and Attenuation of Remodeling After Transplantation of Human Epicardium-Derived Cells Into the Infarcted Mouse Heart

  2007cited by this paper
• Organ size is limited by the number of embryonic progenitor cells in the pancreas but not the liver

  2007cited by this paper
• A dynamic epicardial injury response supports progenitor cell activity during zebrafish heart regeneration.

  2006cited by this paper
• Re-programming of newt cardiomyocytes is induced by tissue regeneration

  2006cited by this paper
• Postnatal isl1+ cardioblasts enter fully differentiated cardiomyocyte lineages

  2005cited by this paper
• Fgf signaling instructs position-dependent growth rate during zebrafish fin regeneration

  2005cited by this paper
• Cell Depletion Due to Diphtheria Toxin Fragment A after Cre-Mediated Recombination

  2004cited by this paper
• Diphtheria Toxin-induced Autophagic Cardiomyocyte Death Plays a Pathogenic Role in Mouse Model of Heart Failure*

  2004cited by this paper
• Cardiac progenitor cells from adult myocardium: Homing, differentiation, and fusion after infarction

  2003cited by this paper
• Adult cardiac stem cells are multipotent and support myocardial regeneration.

  2003cited by this paper
• Transplantation and in vivo imaging of multilineage engraftment in zebrafish bloodless mutants

  2003cited by this paper
• Heart Regeneration in Zebrafish

  2002influential reference
• In vivo imaging of embryonic vascular development using transgenic zebrafish.

  2002cited by this paper
• Cell cycle reentry of ventricular and atrial cardiomyocytes and cells within the epicardium following amputation of the ventricular apex in the axolotl, Amblystoma mexicanum: confocal microscopic immunofluorescent image analysis of bromodeoxyuridine-labeled nuclei

  2002cited by this paper
• Diphtheria toxin receptor–mediated conditional and targeted cell ablation in transgenic mice

  2001cited by this paper
• Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus

  2001cited by this paper
• Conditional lineage ablation to model human diseases.

  1998cited by this paper
• Structural basis of end-stage failure in ischemic cardiomyopathy in humans.

  1994cited by this paper
• Genetic ablation: targeted expression of a toxin gene causes microphthalmia in transgenic mice.

  1987cited by this paper
• Myocardial Infarct Size and Ventricular Function in Rats

  1979cited by this paper
• Response of the adult newt ventricle to injury.

  1974cited by this paper
• Post-injury DNA synthesis, mitosis and ultrastructural reorganization of adult frog cardiac myocytes

  1973cited by this paper
• An Electron Microscopic Autoradiographic Study

  1973cited by this paper
• tcf 21 + epicardial cells adopt non-myocardial fates during zebrafish heart development and regeneration

  year unknowninfluential reference

• Attenuation of epicardial activation and myofibroblast abundance via the Fbln2-Nupr1b axis stimulates cardiac regeneration in zebrafish.

  2026cites this paper
• Cardiac Regeneration and Repair in Zebrafish and Mammalian Models

  2025cites this paper
• Cited4a limits cardiomyocyte dedifferentiation and proliferation during zebrafish heart regeneration.

  2025cites this paper
• Ddx61-enriched condensates refine heart regeneration programs

  2025cites this paper
• Border-zone cardiomyocytes and macrophages regulate extracellular matrix remodeling to promote cardiomyocyte protrusion during cardiac regeneration

  2025cites this paper
• Nr4a1 modulates inflammation and heart regeneration in zebrafish

  2025cites this paper
• Regenerative therapies for myocardial infarction: exploring the critical role of energy metabolism in achieving cardiac repair

  2025cites this paper
• Cardiac Regeneration in Adult Zebrafish: A Review of Signaling and Metabolic Coordination

  2025cites this paper
• Cell cycle arrest of cardiomyocytes in the context of cardiac regeneration

  2025cites this paper
• Signal control during tissue regeneration in adult animals.

  2025cites this paper
• Induced Mitophagy Promotes Cell Cycle Re-Entry in Adult Cardiomyocytes

  2025cites this paper
• Lessons for cardiac regeneration from non-mammalian model organisms.

  2025cites this paper
• Squamate ventricular cardiomyocytes: Ploidy, proliferation, and heart muscle cell size in the leopard gecko ( Eublepharis macularius )

  2025cites this paper
• Primordial cardiomyocytes orchestrate myocardial morphogenesis and vascularization but are dispensable for regeneration

  2025cites this paper
• Mechanochemical coupling of cell shape and organ function optimizes heart size and contractile efficiency in zebrafish.

  2025cites this paper
• Cardiac regeneration: Unraveling the complex network of intercellular crosstalk.

  2025cites this paper
• The Role of the Extracellular Matrix in Inducing Cardiac Cell Regeneration and Differentiation

  2025cites this paper
• Epicardial Tcf21 facilitates cardiomyocyte dedifferentiation and heart regeneration in zebrafish

  2025influential citation
• Mathematical model of the zebrafish ventricular cardiomyocyte action potential and calcium transient.

  2025cites this paper
• Zebrafish Models of Induced Lymphangiogenesis: Current Advancements and Therapeutic Discovery

  2025cites this paper
• Nkx2.7 is a conserved regulator of craniofacial development

  2025cites this paper
• Distinct mechanisms regulate ventricular and atrial chamber wall formation

  2024cites this paper
• The innate immune regulator MyD88 dampens fibrosis during zebrafish heart regeneration

  2024cites this paper
• Harnessing the regenerative potential of interleukin11 to enhance heart repair

  2024cites this paper
• High-Resolution Tissue Doppler and Strain Imaging for Adult Zebrafish Myocardial Tissue Through Ultrafast High-Frequency Ultrasound Vector Doppler Estimation

  2024cites this paper
• Single-cell chromatin profiling reveals genetic programs activating proregenerative states in nonmyocyte cells

  2024cites this paper
• Systemic inhibition of mitochondrial fatty acid β-oxidation impedes zebrafish ventricle regeneration.

  2024cites this paper
• Cross-species single-cell RNA-seq analysis reveals disparate and conserved cardiac and extracardiac inflammatory responses upon heart injury

  2024cites this paper
• Differential vegfc expression dictates lymphatic response during zebrafish heart development and regeneration.

  2024cites this paper
• ptx3a+ fibroblast/epicardial cells provide a transient macrophage niche to promote heart regeneration

  2024cites this paper
• A Chemically Inducible Muscle Ablation System for the Zebrafish

  2024cites this paper
• Antigen presentation plays positive roles in the regenerative response to cardiac injury in zebrafish

  2024cites this paper
• Cardiac regeneration: 20 years of development and update in zebrafish and mouse

  2024cites this paper
• Loss of developmentally derived Irf8+ macrophages promotes hyperinnervation and arrhythmia in the adult zebrafish heart

  2024cites this paper
• Thyroxine (T3)‐mediated regulation of early cardiac repair in a chemical‐induced hypoxia/reoxygenation model of adult zebrafish (Danio rerio)

  2024cites this paper
• Harnessing the regenerative potential of interleukin11 to enhance heart repair

  2024cites this paper
• Neutrophils facilitate the epicardial regenerative response after zebrafish heart injury.

  2024cites this paper
• Adducin Regulates Sarcomere Disassembly During Cardiomyocyte Mitosis

  2024cites this paper
• A cardiac transcriptional enhancer is repurposed during regeneration to activate an anti-proliferative program

  2024influential citation
• ZebraReg—a novel platform for discovering regulators of cardiac regeneration using zebrafish

  2024influential citation
• The transmembrane glycoprotein Gpnmb is required for the immune and fibrotic responses during zebrafish heart regeneration

  2024cites this paper
• Gata6 functions in zebrafish endoderm to regulate late differentiating arterial pole cardiogenesis.

  2024cites this paper
• Genome Editing and Cardiac Regeneration.

  2023cites this paper
• The translation initiation factor homolog eif4e1c regulates cardiomyocyte metabolism and proliferation during heart regeneration

  2023cites this paper
• Networks that Govern Cardiomyocyte Proliferation to Facilitate Repair of the Injured Mammalian Heart

  2023cites this paper
• An injury-responsive mmp14b enhancer is required for heart regeneration

  2023cites this paper
• The Chordate Origins of Heart Regeneration

  2023cites this paper
• Foxm1 regulates cardiomyocyte proliferation in adult zebrafish after cardiac injury.

  2023cites this paper
• Kardiale Entwicklungs- und Regenerationsmechanismen

  2023cites this paper
• GABA Regulates Electrical Activity and Tumor Initiation in Melanoma

  2023cites this paper
• Comparative Analysis of Heart Regeneration: Searching for the Key to Heal the Heart—Part I: Experimental Injury Models to Study Cardiac Regeneration

  2023cites this paper
• Small fish, big discoveries: zebrafish shed light on microbial biomarkers for neuro-immune-cardiovascular health

  2023cites this paper
• Animal models to study cardiac regeneration

  2023cites this paper
• Exposure to the aryl hydrocarbon receptor agonist dioxin disrupts formation of the muscle, nerves, and vasculature in the developing jaw

  2023cites this paper
• Transcriptomic data meta-analysis reveals common and injury model specific gene expression changes in the regenerating zebrafish heart

  2023cites this paper
• Regeneration of the heart: from molecular mechanisms to clinical therapeutics

  2023cites this paper
• The multifaceted nature of endogenous cardiac regeneration

  2023cites this paper
• Two decades of heart regeneration research: Cardiomyocyte proliferation and beyond.

  2023cites this paper
• Cross-species single-cell comparison of systemic and cardiac inflammatory responses after cardiac injury

  2023cites this paper
• Cardiomyocyte maturation and its reversal during cardiac regeneration

  2022cites this paper
• An enhancer-based gene-therapy strategy for spatiotemporal control of cargoes during tissue repair.

  2022cites this paper
• Activation of a transient progenitor state in the epicardium is required for zebrafish heart regeneration

  2022cites this paper
• How can the adult zebrafish and neonatal mice teach us about stimulating cardiac regeneration in the human heart?

  2022cites this paper
• Comparative Study in Zebrafish and Medaka Unravels the Mechanisms of Tissue Regeneration

  2022cites this paper
• Single-cell analysis reveals an Angpt4-initiated EPDC-EC-CM cellular coordination cascade during heart regeneration

  2022cites this paper
• Mending a broken heart—targeting cardiomyocyte regeneration: a literature review

  2022cites this paper
• Aging Activates the Immune System and Alters the Regenerative Capacity in the Zebrafish Heart

  2022cites this paper
• Porcine Organotypic Epicardial Slice Protocol: A Tool for the Study of Epicardium in Cardiovascular Research

  2022cites this paper
• Activation of an injury-associated transient progenitor state in the epicardium is required for zebrafish heart regeneration

  2022cites this paper
• Hippo-Yap/Taz signalling in zebrafish regeneration

  2022cites this paper
• Remuscularization of Ventricular Infarcts Using the Existing Cardiac Cells

  2022cites this paper
• Detecting Cardiovascular Protein-Protein Interactions by Proximity Proteomics

  2022cites this paper
• Zebrafish Models of Cardiac Disease: From Fortuitous Mutants to Precision Medicine

  2022cites this paper
• Tissue mechanics coevolves with fibrillar matrisomes in healthy and fibrotic tissues.

  2022cites this paper
• Enhancer selection dictates gene expression responses in remote organs during tissue regeneration

  2022cites this paper
• A chemically inducible muscle ablation system for zebrafish

  2022cites this paper
• Zebrafish heart regeneration after coronary dysfunction-induced cardiac damage.

  2022cites this paper
• Activation of Nkx2.5 transcriptional program is required for adult myocardial repair

  2022cites this paper
• Leukocyte-Mediated Cardiac Repair after Myocardial Infarction in Non-Regenerative vs. Regenerative Systems

  2022cites this paper
• Foxm1 drives cardiomyocyte proliferation in adult zebrafish after cardiac injury

  2022cites this paper
• Modulation of VEGFA Signaling During Heart Regeneration in Zebrafish.

  2022cites this paper
• hapln1 Defines an Epicardial Cell Subpopulation Required for Cardiomyocyte Expansion During Heart Morphogenesis and Regeneration

  2022cites this paper
• Krüppel-like factor 1 is a core cardiomyogenic trigger in zebrafish

  2021cites this paper
• Cardiomyocyte heterogeneity during zebrafish development and regeneration.

  2021cites this paper
• Metformin accelerates zebrafish heart regeneration by inducing autophagy

  2021cites this paper
• Biodiversity-based development and evolution: the emerging research systems in model and non-model organisms

  2021cites this paper
• Molecular regulation of myocardial proliferation and regeneration

  2021cites this paper
• Ex Vivo Techniques to Study Heart Regeneration in Zebrafish.

  2021cites this paper
• Ventricular Cryoinjury as a Model to Study Heart Regeneration in Zebrafish.

  2021cites this paper
• Myocardial Infarction Techniques in Adult Mice.

  2021cites this paper
• Zebrafish Heart Failure Models

  2021cites this paper
• The interaction of Notch and Wnt signaling pathways in vertebrate regeneration

  2021cites this paper
• A Genetic Cardiomyocyte Ablation Model for the Study of Heart Regeneration in Zebrafish.

  2021cites this paper
• Endogenous Mechanisms for Cardiomyocyte Regeneration

  2021cites this paper
• Oxytocin promotes epicardial cell activation and heart regeneration after cardiac injury

  2021cites this paper
• Metformin accelerates zebrafish heart regeneration by inducing autophagy

  2021cites this paper
• A Swimming-based Assay to Determine the Exercise Capacity of Adult Zebrafish Cardiomyopathy Models.

  2021cites this paper
• Targeting cardiomyocyte proliferation as a key approach of promoting heart repair after injury

  2021cites this paper
• Inflammation induces zebrafish regeneration

  2021cites this paper
• Zebrafish heart regenerates after chemoptogenetic cardiomyocyte depletion

  2021cites this paper