Memory CD4+ T cells induce innate responses independently of pathogen

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Nature Medicine

• Publication date

  2010-05-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/nm.2142PMID 20436484PMCID PMC2927232
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Augmented Lung Inflammation Protects against Influenza A Pneumonia

  2009cited by this paper
• Interleukin 12 is a primary cytokine responding to influenza virus infection in the respiratory tract of mice.

  2009cited by this paper
• Inflammatory signals in dendritic cell activation and the induction of adaptive immunity

  2009cited by this paper
• IL-10 Deficiency Unleashes an Influenza-Specific Th17 Response and Enhances Survival against High-Dose Challenge1

  2009cited by this paper
• The induction of antibody production by IL-6 is indirectly mediated by IL-21 produced by CD4+ T cells

  2009cited by this paper
• T cells dampen innate immune responses through inhibition of NLRP1 and NLRP3 inflammasomes

  2009cited by this paper
• CTL mobilization to virus-infected tissue requires CD4+ T cell help

  2009cited by this paper
• Innate immune control and regulation of influenza virus infections

  2009cited by this paper
• Sustained desensitization to bacterial Toll-like receptor ligands after resolutionof respiratory influenza infection

  2008cited by this paper
• The multifunctional NS1 protein of influenza A viruses.

  2008cited by this paper
• Division of labor between dendritic cell subsets of the lung

  2008cited by this paper
• Identification of Oxidative Stress and Toll-like Receptor 4 Signaling as a Key Pathway of Acute Lung Injury

  2008cited by this paper
• Memory-like CD8+ and CD4+ T cells cooperate to break peripheral tolerance under lymphopenic conditions

  2008cited by this paper
• Dendritic Cell-Induced Memory T Cell Activation in Nonlymphoid Tissues

  2008cited by this paper
• Distinct functions of autoreactive memory and effector CD4+ T cells in experimental autoimmune encephalomyelitis.

  2008cited by this paper
• Adaptive immune cells temper initial innate responses

  2007cited by this paper
• Priming with Cold-Adapted Influenza A Does Not Prevent Infection but Elicits Long-Lived Protection against Supralethal Challenge with Heterosubtypic Virus1

  2007cited by this paper
• Sensitive cilia set up the kidney

  2007cited by this paper
• Rapid default transition of CD4 T cell effectors to functional memory cells

  2007cited by this paper
• Inhibition of the cytokine response does not protect against lethal H5N1 influenza infection

  2007cited by this paper
• CD4+ T‐cell memory: generation and multi‐faceted roles for CD4+ T cells in protective immunity to influenza

  2006cited by this paper
• CD4 T Cell-Mediated Protection from Lethal Influenza: Perforin and Antibody-Mediated Mechanisms Give a One-Two Punch1

  2006cited by this paper
• RIG-I-Mediated Antiviral Responses to Single-Stranded RNA Bearing 5'-Phosphates

  2006cited by this paper
• Role of Host Cytokine Responses in the Pathogenesis of Avian H5N1 Influenza Viruses in Mice

  2006cited by this paper
• Activation of thymic T cells by MHC alloantigen requires syngeneic, activated CD4+ T cells and B cells as APC.

  2006cited by this paper
• An unexpected antibody response to an engineered influenza virus modifies CD8+ T cell responses.

  2006cited by this paper
• Consensual immunity: success-driven development of T-helper-1 and T-helper-2 responses

  2005cited by this paper
• Viral-Induced T Helper Type 1 Responses Enhance Allergic Disease by Effects on Lung Dendritic Cells

  2005cited by this paper
• Interleukin-1 Is Responsible for Acute Lung Immunopathology but Increases Survival of Respiratory Influenza Virus Infection

  2005cited by this paper
• Primary type II alveolar epithelial cells present microbial antigens to antigen-specific CD4+ T cells.

  2005cited by this paper
• The Functional Heterogeneity of Type 1 Effector T Cells in Response to Infection Is Related to the Potential for IFN-γ Production1

  2005cited by this paper
• Ex Vivo Characterization of the Autoimmune T Cell Response in the HLA-DR1 Mouse Model of Collagen-Induced Arthritis Reveals Long-Term Activation of Type II Collagen-Specific Cells and Their Presence in Arthritic Joints1

  2005cited by this paper
• Modulating vaccine responses with dendritic cells and Toll‐like receptors

  2004cited by this paper
• CD8+ and CD11b+ Dendritic Cell-Restricted MHC Class II Controls Th1 CD4+ T Cell Immunity

  2004cited by this paper
• Viral-induced T helper type 1 responses enhance allergic disease by effects on lung dendritic cells

  2004cited by this paper
• Toll-like receptor control of the adaptive immune responses

  2004cited by this paper
• Innate Antiviral Responses by Means of TLR7-Mediated Recognition of Single-Stranded RNA

  2004cited by this paper
• CD8alpha+ and CD11b+ dendritic cell-restricted MHC class II controls Th1 CD4+ T cell immunity.

  2003cited by this paper
• CD8α+ and CD11b+ Dendritic Cell-Restricted MHC Class II Controls Th1 CD4+ T Cell Immunity 1

  2003cited by this paper
• Innate immune recognition.

  2002cited by this paper
• Sensing Pathogens and Tuning Immune Responses

  2001cited by this paper
• Noncytolytic control of viral infections by the innate and adaptive immune response.

  2001cited by this paper
• Alveolar epithelial cell chemokine expression triggered by antigen-specific cytolytic CD8(+) T cell recognition.

  2000cited by this paper
• Qualitative Changes Accompany Memory T Cell Generation: Faster, More Effective Responses at Lower Doses of Antigen1

  2000cited by this paper
• Functional Responses and Costimulator Dependence of Memory CD4+ T Cells1

  2000cited by this paper
• IL-6 induces long-term protective immunity against a lethal challenge of influenza virus.

  1999cited by this paper
• Role of Interleukin-12 in Primary Influenza Virus Infection

  1998cited by this paper
• Cellular responses to interferon-gamma.

  1997cited by this paper
• Mig and IP‐10: CXC chemokines that target lymphocytes

  1997cited by this paper
• Genes for chemokines MuMig and Crg-2 are induced in protozoan and viral infections in response to IFN-gamma with patterns of tissue expression that suggest nonredundant roles in vivo.

  1996cited by this paper
• Abnormal development of peripheral lymphoid organs in mice deficient in lymphotoxin.

  1994cited by this paper
• Effect of anti-CD4 on CD4 subsets. I. Anti-CD4 preferentially deletes resting, naive CD4 cells and spares activated CD4 cells.

  1994cited by this paper
• A role for non-MHC genetic polymorphism in susceptibility to spontaneous autoimmunity.

  1994cited by this paper
• Memory effectors: a potent, IL-4-secreting helper T cell population that develops in vivo after restimulation with antigen.

  1993cited by this paper

• Lung tissue-resident memory T cells optimize protection by IL-10 regulation of innate immunity.

  2025cites this paper
• Th1 polarization in Bordetella pertussis vaccine responses is maintained through a positive feedback loop

  2025cites this paper
• T Cell Responses to Influenza Infections in Cattle

  2025cites this paper
• Lung structural cells are altered by influenza virus leading to rapid immune protection following re-challenge

  2025cites this paper
• Bidirectional Communication Between the Innate and Adaptive Immune Systems

  2025cites this paper
• Preexisting vaccine-primed heterosubtypic T cell immunity protects the maternal-fetal unit from adverse influenza outcomes in mice

  2025cites this paper
• The Integrated Pulmonary Immune Response to Pneumonia.

  2025cites this paper
• Identification of broad-spectrum B-cell and T-cell epitopes of H9 subtype avian influenza virus HA protein using polypeptide scanning1

  2024cites this paper
• Ex Pluribus Unum: The CD4 T Cell Response against Influenza A Virus

  2024cites this paper
• Airway-resident memory CD4 T cell activation accelerates antigen presentation and T cell priming in draining lymph nodes

  2024influential citation
• Advancements in research on the carbon dots nanomaterials in immune modulate and immunotherapy

  2024cites this paper
• Prognostic Significance of T Lymphocytes in Immunotherapy for Non-Small Cell Lung Cancer

  2024cites this paper
• Increased Natural Killer (NK)-cell cytotoxicity and Trypanosoma cruzi-specific memory B cells in subjects with discordant serology for Chagas disease.

  2024cites this paper
• Alternative activation of mast cells by CD4+ T helper cells.

  2024cites this paper
• Th1 polarization in Bordetella pertussis vaccine responses is maintained through a positive feedback loop

  2024cites this paper
• New insights into ILC2 memory

  2024cites this paper
• Influenza Vaccination Mediates SARS-CoV-2 Spike Protein Peptide-Induced Inflammatory Response via Modification of Histone Acetylation

  2024cites this paper
• A targeted single mutation in influenza A virus universal epitope transforms immunogenicity and protective immunity via CD4+ T cell activation.

  2024cites this paper
• T helper 1 effector memory CD4+ T cells protect the skin from poxvirus infection.

  2023cites this paper
• Immune responses in mildly versus critically ill COVID-19 patients

  2023cites this paper
• Effector memory T cells induce innate inflammation by triggering DNA damage and a non-canonical STING pathway in dendritic cells

  2023cites this paper
• Triphasic production of IFNγ by innate and adaptive lymphocytes following influenza A virus infection

  2023cites this paper
• STAT1 Controls the Functionality of Influenza-Primed CD4 T Cells but Therapeutic STAT4 Engagement Maximizes Their Antiviral Impact.

  2023cites this paper
• High-dimensional analysis reveals an immune atlas and novel neutrophil clusters in the lungs of model animals with Actinobacillus pleuropneumoniae-induced pneumonia

  2023cites this paper
• Targeting Th17 cells: a promising strategy to treat oral mucosal inflammatory diseases

  2023cites this paper
• Intermediate Levels of Pre-Existing Protective Antibody Allow Priming of Protective T Cell Immunity against Influenza.

  2023cites this paper
• Defending against SARS-CoV-2: The T cell perspective

  2023cites this paper
• SARS-CoV-2-specific T cells in the changing landscape of the COVID-19 pandemic

  2022cites this paper
• Role of the Hematopoietic Stem Cells in Immunological Memory

  2022cites this paper
• Correlates of protection against SARS‐CoV‐2 infection and COVID‐19 disease

  2022cites this paper
• Subsequent AS01-adjuvanted vaccinations induce similar transcriptional responses in populations with different disease statuses

  2022cites this paper
• Effector memory CD4+ T cells induce damaging innate inflammation and autoimmune pathology by engaging CD40 and TNFR on myeloid cells

  2022influential citation
• Bona Fide Th17 Cells without Th1 Functional Plasticity Protect against Influenza

  2022cites this paper
• Journal Pre-proof SARS-CoV-2-specific T cells in the changing landscape of the COVID-19 pandemic.

  2022cites this paper
• Influenza Virus Infection during Pregnancy as a Trigger of Acute and Chronic Complications

  2022cites this paper
• Act Early and at the Right Location: SARS-CoV-2 T Cell Kinetics and Tissue Localization

  2022cites this paper
• Modification of innate immune responses to Bordetella pertussis in babies from pertussis vaccinated pregnancies

  2021cites this paper
• Synergistic effect of non-neutralizing antibodies and interferon-γ for cross-protection against influenza

  2021cites this paper
• Local memory CD4 T cell niches in respiratory viral infection

  2021cites this paper
• Engineered Nanoparticulate Vaccines to Combat Recurring and Pandemic Influenza Threats.

  2021cites this paper
• Monocyte-Derived Dendritic Cells (moDCs) Differentiate into Bcl6+ Mature moDCs to Promote Cyclic di-GMP Vaccine Adjuvant–Induced Memory TH Cells in the Lung

  2021cites this paper
• Potentiating Lung Mucosal Immunity Through Intranasal Vaccination

  2021cites this paper
• Optimize Prime/Boost Vaccine Strategies: Trained Immunity as a New Player in the Game

  2021cites this paper
• Intranasal Nanoparticle Vaccination Elicits a Persistent, Polyfunctional CD4 T Cell Response in the Murine Lung Specific for a Highly Conserved Influenza Virus Antigen That Is Sufficient To Mediate Protection from Influenza Virus Challenge

  2021cites this paper
• Mucosal vaccine adjuvant cyclic di-GMP differentiates lung moDCs into Bcl6+ and Bcl6− mature moDCs to induce lung memory CD4+ TH cells and lung TFH cells respectively

  2020cites this paper
• Emerging Role of Mucosal Vaccine in Preventing Infection with Avian Influenza A Viruses

  2020cites this paper
• Differences in influenza-specific CD4 T cell mediated immunity following acute infection versus inactivated vaccination in children.

  2020cites this paper
• Mechanisms of Dysregulated Humoral and Cellular Immunity by SARS-CoV-2

  2020cites this paper
• CD4 T Helper Cell Subsets and Related Human Immunological Disorders

  2020cites this paper
• Comparative pathogenesis of influenza in ferrets

  2020cites this paper
• T cell immunity to SARS-CoV-2 following natural infection and vaccination

  2020cites this paper
• T-bet optimizes CD4 T-cell responses against influenza through CXCR3-dependent lung trafficking but not functional programming

  2019cites this paper
• Mouse Models Reveal Role of T-Cytotoxic and T-Reg Cells in Immune Response to Influenza: Implications for Vaccine Design

  2019cites this paper
• Alteration of humoral, cellular and cytokine immune response to inactivated influenza vaccine in patients with Sickle Cell Disease

  2019cites this paper
• How to assess the effectiveness of nasal influenza vaccines? Role and measurement of sIgA in mucosal secretions

  2019cites this paper
• Ergoferon Increases IL-2 Production by Activated Lymphocytes

  2019cites this paper
• Memory CD4 T cell-derived IL-2 synergizes with viral infection to exacerbate lung inflammation

  2019cites this paper
• Immunity to Influenza Infection in Humans.

  2019cites this paper
• Integrative Physiology of Pneumonia.

  2018cites this paper
• CD4 T cells in protection from influenza virus: Viral antigen specificity and functional potential

  2018cites this paper
• Distinct and complementary roles of CD4 T cells in protective immunity to influenza virus.

  2018cites this paper
• The Regulation of Inflammation by Innate and Adaptive Lymphocytes

  2018influential citation
• Toxic adjuvants alter the function and phenotype of dendritic cells to initiate adaptive immune responses induced by oral Helicobacter pylori vaccines

  2018cites this paper
• Early programming and late‐acting checkpoints governing the development of CD4 T‐cell memory

  2018cites this paper
• Inflammation and Pneumonia: Why Are Some More Susceptible than Others?

  2018cites this paper
• Legacy of the influenza pandemic 1918: The host T cell response

  2018cites this paper
• Induction of Autonomous Memory Alveolar Macrophages Requires T Cell Help and Is Critical to Trained Immunity.

  2018cites this paper
• Calmette-Guerin induces NOD 2-dependent nonspecific protection from reinfection via epigenetic reprogramming of monocytes

  2018cites this paper
• Tranexamic acid decreases rodent hemorrhagic shock-induced inflammation with mixed end-organ effects

  2018cites this paper
• The roles of resident, central and effector memory CD4 T‐cells in protective immunity following infection or vaccination

  2018cites this paper
• IL-15 supports the generation of protective lung-resident memory CD4 T cells

  2017cites this paper
• Title : 1 A systems approach to the characterization and classification of T-cell 2 responses 3 4 Authors : 5

  2017cites this paper
• Development of an anti-ferret CD4 monoclonal antibody for the characterisation of ferret T lymphocytes

  2017cites this paper
• Enhancing Dendritic Cell Migration to Drive Antitumor Responses

  2017cites this paper
• IL-8 and IP-10 expression from human bronchial epithelial cells BEAS-2B are promoted by Streptococcus pneumoniae endopeptidase O (PepO)

  2017cites this paper
• Selective pre-priming of HA-specific CD4 T cells restores immunological reactivity to HA on heterosubtypic influenza infection

  2017cites this paper
• Pandemic 2009 H1N1 Influenza Venus reporter virus reveals broad diversity of MHC class II-positive antigen-bearing cells following infection in vivo

  2017cites this paper
• A systems approach to the characterization and classification of T-cell responses

  2017cites this paper
• Divergent roles for Ly6C+CCR2+CX3CR1+ inflammatory monocytes during primary or secondary infection of the skin with the intra-phagosomal pathogen Leishmania major

  2017cites this paper
• Roles of transcription factor T-bet in memory CD4+ T cell generation, function, homeostasis and tissue targeting

  2017cites this paper
• A novel role for β2-microglobulin: a precursor of antibacterial chemokine in respiratory epithelial cells

  2016cites this paper
• Direct IL-6 Signals Maximize Protective Secondary CD4 T Cell Responses against Influenza

  2016cites this paper
• CD4 T Cell Immunity to Viral Infection

  2016cites this paper
• Cell-mediated immunity to flavivirus infections

  2016cites this paper
• Immune System Disorders and Epigenetics

  2016cites this paper
• Exploiting Mucosal Immunity for Antiviral Vaccines.

  2016cites this paper
• Gr upSM Regulation of Innate and Adaptive Immune Response to Mycobacterium tuberculosis by Interferons Type I , II and III

  2016cites this paper
• Preconditioning Vaccine Sites for mRNA-Transfected Dendritic Cell Therapy and Antitumor Efficacy.

  2016cites this paper
• Influenza Virus-specific CD8+ T Cells : -longevity, cross-reactivity and viral evasion-

  2016cites this paper
• The Role of CD4 T Cell Memory in Generating Protective Immunity to Novel and Potentially Pandemic Strains of Influenza

  2016cites this paper
• The Role of Late Antigen in CD4 Memory T Cell Formation during Influena [i.e. Influenza] Infection: A Dissertation

  2016cites this paper
• Type I, II, and III Interferons: Regulating Immunity to Mycobacterium tuberculosis Infection

  2016cites this paper
• Beyond receptors and signaling: epigenetic factors in the regulation of innate immunity

  2015cites this paper
• Virus-specific T cells as correlate of (cross-)protective immunity against influenza.

  2015cites this paper
• Memory CD4 T cells in influenza.

  2015cites this paper
• Development and Function of Protective and Pathologic Memory CD4 T Cells

  2015cites this paper
• INFLUENZA SPECIFIC T- AND B-CELL RESPONSES IN IMMUNOSUPPRESSED PATIENTS

  2015cites this paper
• Recombinant influenza viruses as a vaccine vector for HIV

  2015cites this paper
• SOCS4 is dispensable for an efficient recall response to influenza despite being required for primary immunity

  2015cites this paper
• Characterising innate immune responses and the role of PD-1 in patients with COPD

  2015cites this paper