Type 3 adenylyl cyclase: a key enzyme mediating the cAMP signaling in neuronal cilia.

No abstract is available for this paper.

• Publication year

  2016

• Venue

  International Journal of Physiology, Pathophysiology and Pharmacology

• Publication date

  2016-09-30

• Fields of study

  Biology, Medicine

• Identifiers
  PMID 27785336PMCID PMC5078481
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• High-Density Genetic Mapping Identifies New Susceptibility Variants in Sarcoidosis Phenotypes and Shows Genomic-driven Phenotypic Differences.

  2016cited by this paper
• Genome-wide association analysis identifies three new susceptibility loci for childhood body mass index.

  2016cited by this paper
• Adenylate cyclase 3: a new target for anti‐obesity drug development

  2016cited by this paper
• ‘Smelling’ the cerebrospinal fluid: olfactory signaling molecules are expressed in and mediate chemosensory signaling from the choroid plexus

  2016cited by this paper
• Hepatic adenylate cyclase 3 is upregulated by Liraglutide and subsequently plays a protective role in insulin resistance and obesity

  2016cited by this paper
• Disruption of polycystin-L causes hippocampal and thalamocortical hyperexcitability.

  2016cited by this paper
• Ablation of Type III Adenylyl Cyclase in Mice Causes Reduced Neuronal Activity, Altered Sleep Pattern, and Depression-like Phenotypes.

  2016cited by this paper
• The primary cilium as a cellular receiver: organizing ciliary GPCR signaling.

  2016cited by this paper
• Primary Cilia Are Not Calcium-Responsive Mechanosensors

  2016cited by this paper
• Type 3 Adenylyl Cyclase and Somatostatin Receptor 3 Expression Persists in Aged Rat Neocortical and Hippocampal Neuronal Cilia

  2016cited by this paper
• Influences of Primary Cilia on Cortical Morphogenesis and Neuronal Subtype Maturation

  2015cited by this paper
• Controlling fertilization and cAMP signaling in sperm by optogenetics

  2015cited by this paper
• The Type 3 Adenylyl Cyclase Is Required for the Survival and Maturation of Newly Generated Granule Cells in the Olfactory Bulb

  2015cited by this paper
• Modelling kidney disease with CRISPR-mutant kidney organoids derived from human pluripotent epiblast spheroids

  2015cited by this paper
• Ciliary adenylyl cyclases control the Hedgehog pathway

  2015influential reference
• Overexpression of the Type 1 Adenylyl Cyclase in the Forebrain Leads to Deficits of Behavioral Inhibition

  2015cited by this paper
• A genome-wide association study of body mass index across early life and childhood

  2015cited by this paper
• G protein-coupled odorant receptors underlie mechanosensitivity in mammalian olfactory sensory neurons

  2014cited by this paper
• A Gain-of-Function Mutation in Adenylate Cyclase 3 Protects Mice from Diet-Induced Obesity

  2014cited by this paper
• Adenylyl cyclase 6 mediates loading‐induced bone adaptation in vivo

  2014cited by this paper
• Primary cilia are required in a unique subpopulation of neural progenitors

  2014cited by this paper
• Flagellar synchronization through direct hydrodynamic interactions

  2014cited by this paper
• Central role of soluble adenylyl cyclase and cAMP in sperm physiology.

  2014cited by this paper
• Primary cilia in neurodevelopmental disorders

  2014cited by this paper
• Olfaction as a marker for depression in humans.

  2014cited by this paper
• Upregulation of adenylate cyclase 3 (ADCY3) increases the tumorigenic potential of cells by activating the CREB pathway

  2013cited by this paper
• Testing the Sorption Hypothesis in Olfaction: A Limited Role for Sniff Strength in Shaping Primary Odor Representations During Behavior

  2013cited by this paper
• The ciliary G-protein-coupled receptor Gpr161 negatively regulates the Sonic hedgehog pathway via cAMP signaling.

  2013cited by this paper
• Arborization of Dendrites by Developing Neocortical Neurons Is Dependent on Primary Cilia and Type 3 Adenylyl Cyclase

  2013influential reference
• Neuropeptide Y family receptors traffic via the Bardet-Biedl syndrome pathway to signal in neuronal primary cilia.

  2013influential reference
• Characterization of ciliary targeting sequence of rat melanin-concentrating hormone receptor 1.

  2013cited by this paper
• Leptin resistance is a secondary consequence of the obesity in ciliopathy mutant mice

  2013cited by this paper
• Cilia, tubby mice, and obesity

  2013cited by this paper
• dTULP, the Drosophila melanogaster Homolog of Tubby, Regulates Transient Receptor Potential Channel Localization in Cilia

  2013cited by this paper
• Chemically inducible diffusion trap at cilia reveals molecular sieve–like barrier

  2013cited by this paper
• Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity.

  2013cited by this paper
• Transducing emotionality: the role of adenylyl cyclases.

  2012cited by this paper
• Meta-analysis identifies common variants associated with body mass index in East Asians

  2012cited by this paper
• Primary cilia and graded Sonic Hedgehog signaling

  2012cited by this paper
• The primary cilium as a dual sensor of mechanochemical signals in chondrocytes

  2012cited by this paper
• Synaptic Dysfunction in Depression: Potential Therapeutic Targets

  2012cited by this paper
• Central nervous system control of metabolism

  2012cited by this paper
• Genetic architectures of psychiatric disorders: the emerging picture and its implications

  2012cited by this paper
• Targeting neuronal adenylyl cyclase for the treatment of chronic pain.

  2012influential reference
• Stimulation of Electro-Olfactogram Responses in the Main Olfactory Epithelia by Airflow Depends on the Type 3 Adenylyl Cyclase

  2012cited by this paper
• Structure and function of vertebrate cilia, towards a new taxonomy.

  2012cited by this paper
• Polycystin-2 and phosphodiesterase 4C are components of a ciliary A-kinase anchoring protein complex that is disrupted in cystic kidney diseases

  2011cited by this paper
• All in a sniff: olfaction as a model for active sensing.

  2011cited by this paper
• In touch - the molecular basis of mechanosensory transduction.

  2011cited by this paper
• Ciliogenesis: building the cell's antenna

  2011cited by this paper
• Cilia in the CNS: the quiet organelle claims center stage.

  2011cited by this paper
• The role of primary cilia in neuronal function.

  2010cited by this paper
• Olfactory signalling in vertebrates and insects: differences and commonalities

  2010cited by this paper
• Ciliary dysfunction and obesity

  2010cited by this paper
• Primary cilium‐dependent mechanosensing is mediated by adenylyl cyclase 6 and cyclic AMP in bone cells

  2010cited by this paper
• C. elegans TRP family protein TRP-4 is a pore-forming subunit of a native mechanotransduction channel.

  2010cited by this paper
• Maternal Behavior is Impaired in Female Mice Lacking Type 3 Adenylyl Cyclase

  2010cited by this paper
• A Septin Diffusion Barrier at the Base of the Primary Cilium Maintains Ciliary Membrane Protein Distribution

  2010cited by this paper
• The major α-tubulin K40 acetyltransferase αTAT1 promotes rapid ciliogenesis and efficient mechanosensation

  2010cited by this paper
• Force generation and dynamics of individual cilia under external loading.

  2010cited by this paper
• Mechanics of microtubules.

  2010cited by this paper
• Reduced olfactory bulb volume and olfactory sensitivity in patients with acute major depression.

  2010cited by this paper
• Faculty Opinions recommendation of The major alpha-tubulin K40 acetyltransferase alphaTAT1 promotes rapid ciliogenesis and efficient mechanosensation.

  2010cited by this paper
• Functional expression of the olfactory signaling system in the kidney

  2009cited by this paper
• Capturing adenylyl cyclases as potential drug targets

  2009influential reference
• Adult Type 3 Adenylyl Cyclase–Deficient Mice Are Obese

  2009influential reference
• The vertebrate primary cilium in development, homeostasis, and disease.

  2009cited by this paper
• Why sniff fast? The relationship between sniff frequency, odor discrimination, and receptor neuron activation in the rat.

  2009cited by this paper
• Primary cilia regulate hippocampal neurogenesis by mediating sonic hedgehog signaling

  2008cited by this paper
• Calcium-sensitive adenylyl cyclases in depression and anxiety: behavioral and biochemical consequences of isoform targeting.

  2008cited by this paper
• When cilia go bad: cilia defects and ciliopathies

  2008cited by this paper
• Difference in physiogenomics between male and female infertility

  2008cited by this paper
• Genetic variation of the adenylyl cyclase 3 (AC3) locus and its influence on type 2 diabetes and obesity susceptibility in Swedish men

  2008cited by this paper
• Cholangiocyte primary cilia are chemosensory organelles that detect biliary nucleotides via P2Y12 purinergic receptors.

  2008cited by this paper
• Disruption of intraflagellar transport in adult mice leads to obesity and slow-onset cystic kidney disease.

  2007cited by this paper
• The sensory cilia of Caenorhabditis elegans.

  2007cited by this paper
• Dual functions of mammalian olfactory sensory neurons as odor detectors and mechanical sensors

  2007cited by this paper
• Sniffing controls an adaptive filter of sensory input to the olfactory bulb

  2007cited by this paper
• Type III adenylyl cyclase localizes to primary cilia throughout the adult mouse brain

  2007influential reference
• The Retinal Ciliopathies

  2007cited by this paper
• Comprehensive analysis of the expression patterns of the adenylate cyclase gene family in the developing and adult mouse brain

  2006cited by this paper
• The sniff as a unit of olfactory processing.

  2006cited by this paper
• The Primary Cilium as the Cell's Antenna: Signaling at a Sensory Organelle

  2006influential reference
• Xenopus TRPN1 (NOMPC) localizes to microtubule-based cilia in epithelial cells, including inner-ear hair cells.

  2005cited by this paper
• Proteomic analysis of a eukaryotic cilium

  2005cited by this paper
• Cilia and centrosomes: a unifying pathogenic concept for cystic kidney disease?

  2005cited by this paper
• Platelet adenylyl cyclase activity: a biological marker for major depression and recent drug use.

  2005cited by this paper
• Intraflagellar transport and cilia-dependent renal disease: the ciliary hypothesis of polycystic kidney disease.

  2004cited by this paper
• Overexpression of type-1 adenylyl cyclase in mouse forebrain enhances recognition memory and LTP

  2004cited by this paper
• The vertebrate primary cilium is a sensory organelle.

  2003cited by this paper
• Calmodulin-regulated adenylyl cyclases: cross-talk and plasticity in the central nervous system.

  2003cited by this paper
• Molecular and biochemical evidence for the presence of Type III adenylyl cyclase in human platelets

  2003cited by this paper
• Hedgehog signalling in the mouse requires intraflagellar transport proteins

  2003cited by this paper
• Intraflagellar transport

  2002cited by this paper
• Polycystin-2 localizes to kidney cilia and the ciliary level is elevated in orpk mice with polycystic kidney disease.

  2002cited by this paper
• Isoforms of mammalian adenylyl cyclase: multiplicities of signaling.

  2002cited by this paper
• Increased Expression of Adenylyl Cyclase Isoforms in the Adrenal Gland of Diabetic Goto-Kakizaki Rat

  2002cited by this paper
• Intraflagellar transport and cilia-dependent diseases.

  2002cited by this paper
• Adenylyl Cyclase 3 Mediates Prostaglandin E2-induced Growth Inhibition in Arterial Smooth Muscle Cells*

  2001cited by this paper
• How the olfactory system makes sense of scents

  2001cited by this paper

• A Mutation in the Transmembrane Domain of Adenylate Cyclase 3 Impairs Enzymatic Function to Cause Sex‐Specific Depression‐ and Anxiety‐Like Behaviors and Food Seeking in a Rat Model

  2025cites this paper
• The role of primary cilia in physiological and pathological states of the central nervous system.

  2025cites this paper
• Cilia in the brain display region-dependent oscillations of length and orientation

  2025cites this paper
• Adenylyl Cyclases as Therapeutic Targets in Neuroregeneration

  2025cites this paper
• GDF15 controls primary cilia morphology and function thereby affecting progenitor proliferation

  2024cites this paper
• The Primary Cilium and its Hedgehog Signaling in Nociceptors Contribute to Inflammatory and Neuropathic Pain

  2024cites this paper
• Postnatal Dynamic Ciliary ARL13B and ADCY3 Localization in the Mouse Brain

  2024cites this paper
• Joubert syndrome causing mutation in C2 domain of CC2D2A affects structural integrity of cilia and cellular signaling molecules

  2024cites this paper
• The Nociceptor Primary Cilium Contributes to Mechanical Nociceptive Threshold and Inflammatory and Neuropathic Pain

  2024cites this paper
• Olfactory toxicity of tetrabromobisphenol A to the goldfish Carassius auratus.

  2024cites this paper
• Role of Ectopic Olfactory Receptors in the Regulation of the Cardiovascular–Kidney–Metabolic Axis

  2024cites this paper
• Growth/differentiation factor 15 controls primary cilia morphology in the murine ventricular-subventricular zone thereby affecting progenitor proliferation

  2023cites this paper
• Characterization of Primary Cilia Formation in Human ESC-Derived Retinal Organoids

  2023cites this paper
• Technologies, strategies, and cautions when deconvoluting genome‐wide association signals: FTO in focus

  2023cites this paper
• The Primary Cilium and its Hedgehog Signaling in Nociceptors Contribute to Inflammatory and Neuropathic Pain

  2023cites this paper
• The Role of cAMP in Topographic Organization of the Olfactory System

  2023cites this paper
• [Low-frequency pulsed electromagnetic fields promote osteoblast mineralization and maturation of rats through the PC2/sAC/PKA/CREB signaling pathway].

  2022cites this paper
• Primary Cilia Dysfunction in Neurodevelopmental Disorders beyond Ciliopathies

  2022cites this paper
• Axonal Regeneration: Underlying Molecular Mechanisms and Potential Therapeutic Targets

  2022cites this paper
• Loss-of-function variants in the schizophrenia risk gene SETD1A alter neuronal network activity in human neurons through the cAMP/PKA pathway

  2022cites this paper
• Mechanisms of Weight Control by Primary Cilia

  2022cites this paper
• Primary cilia in the postnatal brain: Subcellular compartments for organizing neuromodulatory signaling.

  2022cites this paper
• Distribution of prototypical primary cilia markers in subtypes of retinal ganglion cells

  2022cites this paper
• Role of Neurotransmitters in the Functioning of Olfactory Sensory Neurons

  2022cites this paper
• Neuronal primary cilia regulate pyramidal cell positioning to the deep and superficial sublayers in the hippocampal CA 1

  2021cites this paper
• The type 3 adenylyl cyclase is crucial for intestinal mucosal neural network in the gut lamina propria

  2021cites this paper
• Polyphenol rich mung bean (Vigna radiata) yogurt for obesity prevention

  2021cites this paper
• Loss-of-function variants in the schizophrenia risk gene SETD1A alter neuronal network activity in human neurons through cAMP/PKA pathway

  2021cites this paper
• Hypothalamic primary cilium: A hub for metabolic homeostasis

  2021cites this paper
• Adenylyl cyclase 3 regulates osteocyte mechanotransduction and primary cilium.

  2021cites this paper
• Primary Cilia in Glial Cells: An Oasis in the Journey to Overcoming Neurodegenerative Diseases

  2021cites this paper
• Neuropathological Examinations in the Mouse Brain-Investigation of a New Pharmaceutical Target in the Cuprizone Model and Comparative Histological Analyses of Primary Cilia in the Physiological Central Nervous System

  2021cites this paper
• Loss-of-function variants in the schizophrenia risk gene SETD1A alter neuronal network activity in human neurons through cAMP/PKA pathway

  2021cites this paper
• Cilia Directionality Reveals a Slow Reverse Movement of Principal Neurons for Positioning and Lamina Refinement in the Cerebral Cortex

  2021cites this paper
• Type 3 adenylyl cyclase in the MOE is involved in learning and memory in mice.

  2020cites this paper
• Discovery of ciliary G protein-coupled receptors regulating pancreatic islet insulin and glucagon secretion

  2020cites this paper
• Impaired hypocretin/orexin system alters responses to salient stimuli in obese male mice.

  2020cites this paper
• Acid-Sensing Ion Channels Contribute to Type III Adenylyl Cyclase–Independent Acid Sensing of Mouse Olfactory Sensory Neurons

  2020cites this paper
• Diverged morphology changes of astrocytic and neuronal primary cilia under reactive insults

  2020cites this paper
• Acid-Sensing Ion Channels Mediate Type III Adenylyl Cyclase-Independent Acid-Sensing of Mouse Olfactory Sensory Neurons

  2019cites this paper
• Olig2 regulates terminal differentiation and maturation of peripheral olfactory sensory neurons

  2019cites this paper
• Comparative Phosphoproteomic Profiling of Type III Adenylyl Cyclase Knockout and Control, Male, and Female Mice

  2019influential citation
• Quantitative Comparison of Primary Cilia Marker Expression and Length in the Mouse Brain

  2018cites this paper
• α-Cedrene protects rodents from high-fat diet-induced adiposity via adenylyl cyclase 3

  2018cites this paper
• Neuronal and astrocytic primary cilia in the mature brain

  2018influential citation
• Interaction between an ADCY3 Genetic Variant and Two Weight-Lowering Diets Affecting Body Fatness and Body Composition Outcomes Depending on Macronutrient Distribution: A Randomized Trial

  2018cites this paper
• Drosophila Model for the Analysis of Genesis of LIM-kinase 1-Dependent Williams-Beuren Syndrome Cognitive Phenotypes: INDELs, Transposable Elements of the Tc1/Mariner Superfamily and MicroRNAs

  2017cites this paper