Multivalent Integrin-Specific Ligands Enhance Tissue Healing and Biomaterial Integration

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Science Translational Medicine

• Publication date

  2010-08-18

• Fields of study

  Medicine, Materials Science, Chemistry, Engineering

• Identifiers
  DOI 10.1126/scitranslmed.3001002PMID 20720217PMCID PMC3128787
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Cell fate regulation by coupling mechanical cycles to biochemical signaling pathways.

  2009cited by this paper
• Environmental sensing through focal adhesions

  2009cited by this paper
• Simple application of fibronectin–mimetic coating enhances osseointegration of titanium implants

  2009cited by this paper
• Impact of order and disorder in RGD nanopatterns on cell adhesion.

  2009cited by this paper
• The effect of integrin-specific bioactive coatings on tissue healing and implant osseointegration.

  2008influential reference
• Foreign body reaction to biomaterials.

  2008cited by this paper
• The effect of RGD peptides on osseointegration of hydroxyapatite biomaterials.

  2008cited by this paper
• Tumor targeting with RGD peptide ligands-design of new molecular conjugates for imaging and therapy of cancers.

  2007cited by this paper
• Biomolecular surface coating to enhance orthopaedic tissue healing and integration.

  2007cited by this paper
• Peri-implant bone formation and implant integration strength of peptide-modified p(AAM-co-EG/AAC) interpenetrating polymer network-coated titanium implants.

  2007cited by this paper
• Controlling Cell Adhesion to Titanium: Functionalization of Poly[oligo(ethylene glycol)methacrylate] Brushes with Cell‐Adhesive Peptides

  2007influential reference
• Integrin specificity and enhanced cellular activities associated with surfaces presenting a recombinant fibronectin fragment compared to RGD supports.

  2006cited by this paper
• Synthetic RGD‐containing α‐helical coiled coil peptides promote integrin‐dependent cell adhesion

  2006cited by this paper
• Synthetic RGD-containing alpha-helical coiled coil peptides promote integrin-dependent cell adhesion.

  2006cited by this paper
• Integrin Dimerization and Ligand Organization: Key Components in Integrin Clustering for Cell Adhesion

  2005cited by this paper
• Get a grip: integrins in cell-biomaterial interactions.

  2005cited by this paper
• Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering

  2005cited by this paper
• Integrin binding specificity regulates biomaterial surface chemistry effects on cell differentiation

  2005cited by this paper
• Bio-adhesive Surfaces to Promote Osteoblast Differentiation and Bone Formation

  2005cited by this paper
• Quantitative methods for analysis of integrin binding and focal adhesion formation on biomaterial surfaces.

  2005cited by this paper
• Designing materials for biology and medicine

  2004cited by this paper
• Skeletal Phenotype of Growing Transgenic Mice that Express a Function-Perturbing Form of β1 Integrin in Osteoblasts

  2004cited by this paper
• Two-piconewton slip bond between fibronectin and the cytoskeleton depends on talin

  2003cited by this paper
• An RGD Spacing of 440 nm Is Sufficient for Integrin a,,ß3-mediated Fibroblast Spreading and 140 nm for Focal Contact and Stress Fiber Formation

  2002cited by this paper
• Co-regulation of cell adhesion by nanoscale RGD organization and mechanical stimulus.

  2002cited by this paper
• Simulations of cell-surface integrin binding to nanoscale-clustered adhesion ligands.

  2002cited by this paper
• Integrins: bidirectional, allosteric signaling machines.

  2002cited by this paper
• Effect of RGD peptide coating of titanium implants on periimplant bone formation in the alveolar crest. An experimental pilot study in dogs.

  2002cited by this paper
• Trimers of the fibronectin cell adhesion domain localize to actin filament bundles and undergo rearward translocation.

  2002cited by this paper
• Bone mineralization and osteoblast differentiation are negatively modulated by integrin alpha(v)beta3.

  2001cited by this paper
• Transmembrane crosstalk between the extracellular matrix--cytoskeleton crosstalk.

  2001cited by this paper
• Transmembrane crosstalk between the extracellular matrix and the cytoskeleton

  2001cited by this paper
• Focal Adhesion Kinase Activity Is Required for Bone Morphogenetic Protein—Smad1 Signaling and Osteoblastic Differentiation in Murine MC3T3‐E1 Cells

  2001cited by this paper
• Bone Mineralization and Osteoblast Differentiation Are Negatively Modulated by Integrin αvβ3

  2001cited by this paper
• Cell adhesion and motility depend on nanoscale RGD clustering.

  2000cited by this paper
• Multilineage potential of adult human mesenchymal stem cells.

  1999cited by this paper
• Fibronectin is a survival factor for differentiated osteoblasts.

  1998cited by this paper
• Interactions between integrin receptors and fibronectin are required for calvarial osteoblast differentiation in vitro.

  1997cited by this paper
• Integrin function: molecular hierarchies of cytoskeletal and signaling molecules

  1995cited by this paper
• Synergistic roles for receptor occupancy and aggregation in integrin transmembrane function

  1995cited by this paper
• An RGD spacing of 440 nm is sufficient for integrin alpha V beta 3- mediated fibroblast spreading and 140 nm for focal contact and stress fiber formation

  1991cited by this paper
• New perspectives in cell adhesion: RGD and integrins.

  1987cited by this paper

• Modulating Integrin and Growth Factor Signaling With Peptides: Strategies to Synergistically Enhance Bone Tissue Regeneration.

  2026cites this paper
• An Engineered Multivalent TMV Nanodisk Platform for Modulating Integrin Clustering and Cell Signaling.

  2025cites this paper
• Nanoscale distribution of bioactive ligands on biomaterials regulates cell mechanosensing through translocation of actin into the nucleus

  2025cites this paper
• Implantable Medical Devices, Biomaterials, and the Foreign Body Response: A Surgical Perspective.

  2025cites this paper
• Protein Adsorption and Cell Adhesion on Metallic Biomaterial Surfaces

  2025cites this paper
• Framework Nucleic Acid‐Based Selective Cell Catcher for Endogenous Stem Cell Recruitment

  2024cites this paper
• Programmable DNA Scaffolds Enable Orthogonal Engineering of Cell Membrane-Based Nanovesicles for Therapeutic Development.

  2024cites this paper
• Biomaterials‐Based Technologies in Skeletal Muscle Tissue Engineering

  2024cites this paper
• Liquid Crystalline Hydroxyapatite Nanorods Orchestrate Hierarchical Bone‐Like Mineralization

  2024cites this paper
• Enhancement of electronic effects at a biomolecule-inorganic interface by multivalent interactions.

  2023cites this paper
• A guide to functionalisation and bioconjugation strategies to surface-initiated polymer brushes

  2023cites this paper
• Molecular Modeling Insights into the Structure and Behavior of Integrins: A Review

  2023cites this paper
• Biomimetic Coatings in Implant Dentistry: A Quick Update

  2023cites this paper
• Dynamic surface adapts to multiple service stages by orchestrating responsive polymers and functional peptides.

  2023cites this paper
• Cellular Flocculation Driven by Concentrated Polymer Brush-Modified Cellulose Nanofibers with Different Surface Charges.

  2022cites this paper
• Biomaterial-related cell microenvironment in tissue engineering and regenerative medicine

  2022cites this paper
• Fluid nanoporous microinterface enables multiscale-enhanced affinity interaction for tumor-derived extracellular vesicle detection

  2022cites this paper
• Thermal based surface modification techniques for enhancing the corrosion and wear resistance of metallic implants: A review

  2022cites this paper
• A chondrogenesis induction system based on a functionalized hyaluronic acid hydrogel sequentially promoting hMSC proliferation, condensation, differentiation, and matrix deposition.

  2021cites this paper
• Cationic polymer brush-coated bioglass nanoparticles for the design of bioresorbable RNA delivery vectors

  2021cites this paper
• Effect of Polymeric Matrix Stiffness on Osteogenic Differentiation of Mesenchymal Stem/Progenitor Cells: Concise Review

  2021cites this paper
• A Topologically Engineered Gold Island for Programmed In Vivo Stem Cell Manipulation.

  2021cites this paper
• Cellular responses of histatin-derived peptides immobilized titanium surface using a tresyl chloride-activated method.

  2021cites this paper
• Combination of dip coating of BMP-2 and spray coating of PLGA on dental implants for osseointegration

  2021cites this paper
• High‐Throughput Screening and Hierarchical Topography‐Mediated Neural Differentiation of Mesenchymal Stem Cells

  2020cites this paper
• Biomimetic Multiscale Hierarchical Topography Enhances Osteogenic Differentiation of Human Mesenchymal Stem Cells

  2020cites this paper
• Fully synthetic matrices for in vitro culture of primary human intestinal enteroids and endometrial organoids.

  2020cites this paper
• Acellular PCL Scaffolds Laden with Fibroblast/Endothelial Cell-Derived Extracellular Matrix for Bone Regeneration.

  2020cites this paper
• Surface-Immobilized Biomolecules

  2020cites this paper
• Lineage Commitment, Signaling Pathways, and the Cytoskeleton Systems in Mesenchymal Stem Cells

  2020cites this paper
• Surface modification of polymeric electrospun scaffolds via a potent and high-affinity integrin α4β1 ligand improved the adhesion, spreading and survival of human chorionic villus-derived mesenchymal stem cells: a new insight for fetal tissue engineering.

  2020cites this paper
• Combining Biologically Active β-Lactams Integrin Agonists with Poly(l-lactic acid) Nanofibers: Enhancement of Human Mesenchymal Stem Cell Adhesion

  2020cites this paper
• Fluidic Multivalent Membrane Nanointerface Enables Synergetic Enrichment of Circulating Tumor Cells with High Efficiency and Viability.

  2020cites this paper
• Three-Dimensional (3D) and Drug-Eluting Nanofiber Coating for Prosthetic Implants

  2020cites this paper
• Nano ZnO imprinted dextran hybrid poly (N-isopropylacrylamide)/poly ethylene glycol composite hydrogels for in vitro release of ciprofloxacin

  2020cites this paper
• Advancing Cell-Instructive Biomaterials Through Increased Understanding of Cell Receptor Spacing and Material Surface Functionalization

  2020cites this paper
• Integrin and Heparan Sulfate Dual-targeting Peptide Assembly Suppresses Cancer Metastasis.

  2020cites this paper
• Rapid construction of polyetheretherketone (PEEK) biological implants incorporated with brushite (CaHPO4·2H2O) and antibiotics for anti-infection and enhanced osseointegration.

  2020cites this paper
• Surface decoration of development-inspired synthetic N-cadherin motif via Ac-BP promotes osseointegration of metal implants

  2020cites this paper
• PTH(1-34) activates the migration and adhesion of BMSCs through the rictor/mTORC2 pathway

  2020influential citation
• Cell migration regulated by RGD nanospacing and enhanced under moderate cell adhesion on biomaterials.

  2020cites this paper
• Novel fibrin-fibronectin matrix accelerates mice skin wound healing

  2020cites this paper
• Three-Dimensional (3D) Fibronectin Nano-Array Presented on Fibrin Matrix Accelerates Mice Skin Wound Healing

  2020cites this paper
• Bioinspired surface modification of orthopedic implants for bone tissue engineering.

  2019cites this paper
• Heparin‐Conjugated Decellularized Bone Particles Promote Enhanced Osteogenic Signaling of PDGF‐BB to Adipose‐Derived Stem Cells in Tissue Engineered Bone Grafts

  2019cites this paper
• Large-Area Biomolecule Nanopatterns on Diblock Copolymer Surfaces for Cell Adhesion Studies

  2019cites this paper
• The physico-chemistry of adhesions of protein resistant and weak polyelectrolyte brushes to cells and tissues.

  2019cites this paper
• Niche-inspired synthetic matrices for epithelial organoid culture

  2019cites this paper
• Mechanisms of noncanonical binding dynamics in multivalent protein–protein interactions

  2019cites this paper
• DNA framework-programmed cell capture via topology-engineered receptor-ligand interactions.

  2019cites this paper
• A Vitronectin-Derived Bioactive Peptide Improves Bone Healing Capacity of SLA Titanium Surfaces

  2019cites this paper
• Tailoring Cell-Material Interactions via Poly(acrylic) Acid Brushes to Enhance Nonviral Substrate-Mediated Gene Delivery

  2019cites this paper
• Bioactive Materials: A Comprehensive Review on Interactions with Biological Microenvironment Based on the Immune Response

  2019cites this paper
• RGD Mutation of the Heparin Binding II Fragment of Fibronectin for Guiding Mesenchymal Stem Cell Behavior on Titanium Surfaces.

  2019cites this paper
• Nanotopographical cues mediate osteogenesis of stem cells on virus substrates through BMP-2 intermediate.

  2019cites this paper
• Nanoscale Coatings for Ultralow Dose BMP‐2‐Driven Regeneration of Critical‐Sized Bone Defects

  2018cites this paper
• Immobilization of vitronectin-binding heparan sulfates onto surfaces to support human pluripotent stem cells.

  2018cites this paper
• Three-Dimensional Nanostructured Architectures Enable Efficient Neural Differentiation of Mesenchymal Stem Cells via Mechanotransduction.

  2018cites this paper
• Facile Strategy to Generate Aligned Polymer Nanofibers: Effects on Cell Adhesion.

  2018cites this paper
• Modification of Titanium Implant and Titanium Dioxide for Bone Tissue Engineering.

  2018cites this paper
• Nano-scale design of cardiovascular biomaterials

  2018cites this paper
• Multivalent Presentation of Peptide Targeting Groups Alters Polymer Biodistribution to Target Tissues.

  2018cites this paper
• Integrin Clustering Matters: A Review of Biomaterials Functionalized with Multivalent Integrin‐Binding Ligands to Improve Cell Adhesion, Migration, Differentiation, Angiogenesis, and Biomedical Device Integration

  2018cites this paper
• Recombinant fibronectin fragment III8-10/polylactic acid hybrid nanofibers enhance the bioactivity of titanium surface.

  2018cites this paper
• Design of Polymer Brushes for Cell Culture and Cellular Delivery

  2017cites this paper
• Stimuli-responsive nanomaterials for controlled delivery by light, magnetic and electrical triggers

  2017cites this paper
• Engineered Potato virus X nanoparticles support hydroxyapatite nucleation for improved bone tissue replacement.

  2017cites this paper
• Peptide-functionalized poly[oligo(ethylene glycol) methacrylate] brushes on dopamine-coated stainless steel for controlled cell adhesion.

  2017cites this paper
• Bio-Instructive Cues in Scaffolds for Musculoskeletal Tissue Engineering and Regenerative Medicine

  2017cites this paper
• Material-driven fibronectin fibrillogenesis to engineer cell function.

  2017cites this paper
• Nano-scale clustering of integrin-binding ligands regulates endothelial cell adhesion, migration, and endothelialization rate: novel materials for small diameter vascular graft applications.

  2017cites this paper
• Force regulated conformational change of integrin αVβ3.

  2017cites this paper
• Study of cell response over nanopatterned ligands on diblock copolymer surfaces

  2017cites this paper
• The effect of HPMC and MC as pore formers on the rheology of the implant microenvironment and the drug release in vitro.

  2017cites this paper
• Electrospun PHEA-PLA/PCL Scaffold for Vascular Regeneration: A Preliminary in Vivo Evaluation.

  2017cites this paper
• 4.13 Peptide- and Protein-Modified Surfaces☆

  2017cites this paper
• Understanding Peptide Oligomeric State in Langmuir Monolayers of Amphiphilic 3-Helix Bundle-Forming Peptide-PEG Conjugates.

  2016cites this paper
• Design and mechanisms of antifouling materials for surface plasmon resonance sensors.

  2016cites this paper
• Living biointerfaces based on non-pathogenic bacteria support stem cell differentiation

  2016cites this paper
• Polymer brush: a promising grafting approach to scaffolds for tissue engineering

  2016cites this paper
• Assessment of a polyelectrolyte multilayer film coating loaded with BMP-2 on titanium and PEEK implants in the rabbit femoral condyle.

  2016cites this paper
• Cell-secreted matrices perpetuate the bone-forming phenotype of differentiated mesenchymal stem cells.

  2016cites this paper
• Subcellular cell geometry on micropillars regulates stem cell differentiation.

  2016cites this paper
• Extracellular matrix biomimicry for the creation of investigational and therapeutic devices.

  2016cites this paper
• Impact of the Molecular Environment on Thiol-Ene Coupling For Biofunctionalization and Conjugation.

  2016cites this paper
• Tailoring biomaterial surface properties to modulate host-implant interactions: implication in cardiovascular and bone therapy.

  2016cites this paper
• Spatially patterned matrix elasticity directs stem cell fate

  2016cites this paper
• The Needs of Current Implant Technology in Orthopaedic Prosthesis Biomaterials Application to Reduce Prosthesis Failure Rate

  2016cites this paper
• Noninvasive imaging of embryonic stem cell cultures by multiphoton microscopy reveals the significance of collagen hydrogel preparation parameters

  2016cites this paper
• Biosynthesis of Bioadaptive Materials: A Review on Developing Materials Available for Tissue Adaptation

  2016cites this paper
• Characterization of Biopolymeric Micro- Nano Structured 3D Porous Matrices in Combination with Bone Marrow Derived Mesenchymal Stem Cells for Bone Regeneration

  2016cites this paper
• Diversification and enrichment of clinical biomaterials inspired by Darwinian evolution.

  2016cites this paper
• Gene Expression of Human Mesenchymal Stem Cells Cultured on Titanium Dental Implant Surfaces

  2016cites this paper
• Copper-Mediated Living Radical Polymerization (Atom Transfer Radical Polymerization and Copper(0) Mediated Polymerization): From Fundamentals to Bioapplications.

  2016cites this paper
• Material-based strategies to engineer fibronectin matrices for regenerative medicine

  2015cites this paper
• Fabrication of RGD micro/nanopattern and corresponding study of stem cell differentiation.

  2015cites this paper
• Fluorescent hydrogels for embryoid body formation and osteogenic differentiation of embryonic stem cells.

  2015cites this paper
• In vivo comparison of biomineralized scaffold-directed osteogenic differentiation of human embryonic and mesenchymal stem cells

  2015cites this paper
• A gene expression-based comparison of cell adhesion to extracellular matrix and RGD-terminated monolayers.

  2015cites this paper
• Effects of Nanoscale Spatial Arrangement of Arginine-Glycine-Aspartate Peptides on Dedifferentiation of Chondrocytes.

  2015cites this paper