A caudorostral wave of RALDH2 conveys anteroposterior information to the cardiac field

No abstract is available for this paper.

• Publication year

  2003

• Venue

  Development

• Publication date

  2003-11-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1242/dev.00750PMID 13129847
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Erythropoietin and retinoic acid, secreted from the epicardium, are required for cardiac myocyte proliferation.

  2003influential reference
• Cytosolic retinoid dehydrogenases govern ubiquitous metabolism of retinol to retinaldehyde followed by tissue-specific metabolism to retinoic acid.

  2003cited by this paper
• A novel role for retinoids in patterning the avian forebrain during presomite stages

  2003cited by this paper
• Novel retinoic acid generating activities in the neural tube and heart identified by conditional rescue of Raldh2 null mutant mice.

  2002cited by this paper
• Experimental studies on the spatiotemporal expression of WT1 and RALDH2 in the embryonic avian heart: a model for the regulation of myocardial and valvuloseptal development by epicardially derived cells (EPDCs).

  2002cited by this paper
• Stimulation of retinoic acid production and growth by ubiquitously expressed alcohol dehydrogenase Adh3

  2002cited by this paper
• Transcriptional Regulation of Vertebrate Cardiac Morphogenesis

  2002cited by this paper
• Induction of cardiogenesis by Hensen's node and fibroblast growth factors

  2002influential reference
• Extensive cell movements accompany formation of the otic placode.

  2002cited by this paper
• Retinaldehyde dehydrogenase 2 (RALDH2)- independent patterns of retinoic acid synthesis in the mouse embryo

  2002cited by this paper
• Retinoid signaling and cardiac anteroposterior segmentation

  2001cited by this paper
• Embryonic retinoic acid synthesis is essential for heart morphogenesis in the mouse.

  2001influential reference
• Fate map of early avian cardiac progenitor cells.

  2001influential reference
• Hindbrain patterning involves graded responses to retinoic acid signalling.

  2001cited by this paper
• Improved method for chick whole‐embryo culture using a filter paper carrier

  2001cited by this paper
• Sequential programs of retinoic acid synthesis in the myocardial and epicardial layers of the developing avian heart.

  2000cited by this paper
• From the bottom of the heart: anteroposterior decisions in cardiac muscle differentiation.

  2000cited by this paper
• Identification of endogenous retinoids, enzymes, binding proteins, and receptors during early postimplantation development in mouse: important role of retinal dehydrogenase type 2 in synthesis of all-trans-retinoic acid.

  2000cited by this paper
• The rostro‐caudal position of cardiac myocytes affect their fate

  2000cited by this paper
• Chamber-specific cardiac expression of Tbx5 and heart defects in Holt-Oram syndrome.

  1999influential reference
• Complementary domains of retinoic acid production and degradation in the early chick embryo.

  1999cited by this paper
• A retinoic acid-inducible transgenic marker of sino-atrial development in the mouse heart.

  1999cited by this paper
• Retinoid signaling required for normal heart development regulates GATA-4 in a pathway distinct from cardiomyocyte differentiation.

  1999cited by this paper
• Embryonic retinoic acid synthesis is essential for early mouse post-implantation development

  1999cited by this paper
• Retinoic acid is required in the mouse embryo for left-right asymmetry determination and heart morphogenesis.

  1999cited by this paper
• Common role for each of the cGATA-4/5/6 genes in the regulation of cardiac morphogenesis.

  1998cited by this paper
• Increased in situ hybridization sensitivity using non-radioactive probes after staining for β-galactosidase activity

  1998cited by this paper
• In situ hybridization: a practical approach

  1998cited by this paper
• Detection of multiple gene products simultaneously by in situ hybridization and immunohistochemistry in whole mounts of avian embryos.

  1998cited by this paper
• Dynamic patterns of retinoic acid synthesis and response in the developing mammalian heart.

  1998cited by this paper
• Vitamin A deficiency and mutations of RXRalpha, RXRbeta and RARalpha lead to early differentiation of embryonic ventricular cardiomyocytes.

  1997influential reference
• Retinoic acid alters the expression of pattern‐related genes in the developing rat lung

  1996cited by this paper
• Molecular identification of a major retinoic-acid-synthesizing enzyme, a retinaldehyde-specific dehydrogenase.

  1996cited by this paper
• Diversification of cardiomyogenic cell lineages in vitro.

  1995influential reference
• Staging of commitment and differentiation of avian cardiac myocytes.

  1994cited by this paper
• Expression of the atrial-specific myosin heavy chain AMHC1 and the establishment of anteroposterior polarity in the developing chicken heart.

  1994influential reference
• Detection of messenger RNA by in situ hybridization.

  1993influential reference
• Primitive-streak origin of the cardiovascular system in avian embryos.

  1993cited by this paper
• Staging of gastrulating mouse embryos by morphological landmarks in the dissecting microscope.

  1993cited by this paper
• Regulative ability of the prospective cardiogenic and vasculogenic areas of the primitive streak during avian gastrulation

  1993cited by this paper
• Wholemount in situ hybridization of vertebrate embryos

  1992cited by this paper
• Persisting zones of slow impulse conduction in developing chicken hearts.

  1992cited by this paper
• Expression of a retinoic acid response element-hsplacZ transgene defines specific domains of transcriptional activity during mouse embryogenesis.

  1991cited by this paper
• Development of cardiac beat rate in early chick embryos is regulated by regional cues.

  1988cited by this paper
• Characterization of concentration gradients of a morphogenetically active retinoid in the chick limb bud

  1987influential reference
• Effects of retinoid deficiency on the development of the heart and vascular system of the quail embryo

  1986cited by this paper
• Determination of heart polarity (arterio venous axis) in the chicken embryo

  1967influential reference
• A series of normal stages in the development of the chick embryo

  1951cited by this paper

• In vitro modeling of cell types in cardiogenesis and congenital heart disease.

  2025cites this paper
• Molecular Regulation of Cardiomyocyte Maturation

  2025cites this paper
• A retinoic acid:YAP1 signaling axis controls atrial lineage commitment

  2025cites this paper
• Extracellular matrix in cardiac morphogenesis, fibrosis, and regeneration.

  2025cites this paper
• The molecular mechanisms of cardiac development and related diseases

  2024cites this paper
• miR-1 as a Key Epigenetic Regulator in Early Differentiation of Cardiac Sinoatrial Region

  2024influential citation
• A Retinoic Acid:YAP1 signaling axis controls atrial lineage commitment

  2024cites this paper
• Epigenetic determinants and non-myocardial signaling pathways contributing to heart growth and regeneration.

  2024cites this paper
• Retinoic acid signalling regulates branchiomeric neck muscle development at the head trunk interface.

  2024cites this paper
• CD151 expression marks atrial- and ventricular- differentiation from human induced pluripotent stem cells

  2024cites this paper
• Human pluripotent stem cell-based models of heart development and disease.

  2023cites this paper
• The role of Wnt signaling in the development of the epiblast and axial progenitors.

  2023cites this paper
• Human-Induced Pluripotent Stem Cell-Based Differentiation of Cardiomyocyte Subtypes for Drug Discovery and Cell Therapy.

  2023cites this paper
• A patterned human primitive heart organoid model generated by pluripotent stem cell self-organization

  2023cites this paper
• Efficient generation of TBX3+ atrioventricular conduction-like cardiomyocytes from human pluripotent stem cells.

  2023cites this paper
• Generation of left ventricle-like cardiomyocytes with improved structural, functional, and metabolic maturity from human pluripotent stem cells

  2023cites this paper
• Hey2 enhancer activity defines unipotent progenitors for left ventricular cardiomyocytes in juxta-cardiac field of early mouse embryo

  2023cites this paper
• STRA6 is essential for induction of vascular smooth muscle lineages in human embryonic cardiac outflow tract development

  2023cites this paper
• Human multilineage pro-epicardium/foregut organoids support the development of an epicardium/myocardium organoid

  2022cites this paper
• Improved Atrial Differentiation of Human Pluripotent Stem Cells by Activation of Retinoic Acid Receptor Alpha (RARα)

  2022cites this paper
• Dissecting mechanisms of chamber-specific cardiac differentiation and its perturbation following retinoic acid exposure.

  2022cites this paper
• Role of cellular retinol‐binding protein, type 1 and retinoid homeostasis in the adult mouse heart: A multi‐omic approach

  2022cites this paper
• Signaling pathways regulate cardiovascular lineage commitment of hPSCs

  2022cites this paper
• Dynamic MicroRNA Expression Profiles During Embryonic Development Provide Novel Insights Into Cardiac Sinus Venosus/Inflow Tract Differentiation

  2022influential citation
• Modeling Human Heart Development and Congenital Defects Using Organoids: How Close Are We?

  2022cites this paper
• Atypically Shaped Cardiomyocytes (ACMs): The Identification, Characterization and New Insights into a Subpopulation of Cardiomyocytes

  2022cites this paper
• Inhibition of RhoA and Cdc42 by miR-133a Modulates Retinoic Acid Signalling during Early Development of Posterior Cardiac Tube Segment

  2022cites this paper
• Tbx5 drives Aldh1a2 expression to regulate a RA-Hedgehog-Wnt gene regulatory network coordinating cardiopulmonary development

  2021cites this paper
• Highlighting the gaps in hazard and risk assessment of unregulated Endocrine Active Substances in surface waters: retinoids as a European case study

  2021cites this paper
• Wheat germin-like protein: Studies on chitin/chitosan matrix for tissue engineering applications.

  2021cites this paper
• Patterning of vertebrate cardiac progenitor fields by retinoic acid signaling

  2021cites this paper
• Reorganization of Metabolism during Cardiomyogenesis Implies Time-Specific Signaling Pathway Regulation

  2021influential citation
• Non-Coding RNAs in Retinoic Acid as Differentiation and Disease Drivers

  2021cites this paper
• Retinoic acid signaling in heart development: Application in the differentiation of cardiovascular lineages from human pluripotent stem cells

  2021influential citation
• Atrial and Sinoatrial Node Development in the Zebrafish Heart

  2021cites this paper
• Identification and characterization of hPSC-derived FOXA2+ progenitor cells with ventricular cardiac differentiation potential

  2021cites this paper
• Atrial-specific hiPSC-derived cardiomyocytes in drug discovery and disease modeling.

  2021cites this paper
• Expression dynamics of HAND1/2 in in vitro human cardiomyocyte differentiation

  2021cites this paper
• Outflow Tract Formation—Embryonic Origins of Conotruncal Congenital Heart Disease

  2021cites this paper
• Understanding Mechanisms of Chamber-Specific Differentiation Through Combination of Lineage Tracing and Single Cell Transcriptomics

  2021cites this paper
• Characterization of Ventricular and Atrial Cardiomyocyte Subtypes from Human-Induced Pluripotent Stem Cells.

  2021cites this paper
• Gene network transitions in embryos depend upon interactions between a pioneer transcription factor and core histones

  2020cites this paper
• Regulating Retinoic Acid Availability during Development and Regeneration: The Role of the CYP26 Enzymes

  2020cites this paper
• Role of carotenoids and retinoids during heart development.

  2020cites this paper
• Hox-dependent coordination of mouse cardiac progenitor cell patterning and differentiation

  2020cites this paper
• Retinoid Signaling in Skeletal Development: Scoping the System for Predictive Toxicology.

  2020cites this paper
• Mouse gastrulation: Coordination of tissue patterning, specification and diversification of cell fate.

  2020cites this paper
• Ventricular, atrial, and outflow tract heart progenitors arise from spatially and molecularly distinct regions of the primitive streak

  2020cites this paper
• The Biochemistry of Retinoid Signaling III: Vitamin A and Retinoic Acid in Embryonic Development

  2020cites this paper
• Drug screening platform using human induced pluripotent stem cell‐derived atrial cardiomyocytes and optical mapping

  2020cites this paper
• Mesoderm patterning by a dynamic gradient of retinoic acid signalling

  2020cites this paper
• Notch Signaling Commits Mesoderm to the Cardiac Lineage

  2020cites this paper
• Hox-dependent coordination of cardiac progenitor cell patterning and differentiation

  2020cites this paper
• Drug Screening Platform Using Human Induced Pluripotent Stem Cell-Derived Atrial Cardiomyocytes and Optical Mapping

  2020cites this paper
• Retinoic Acid Signaling and Heart Development.

  2020cites this paper
• Vitamin A as a Transcriptional Regulator of Cardiovascular Disease

  2020cites this paper
• Reiterative Mechanisms of Retinoic Acid Signaling during Vertebrate Heart Development

  2019cites this paper
• Production of hiPSC-derived atrial cardiomyocytes to study the contribution of the KCNN3 variants to lone atrial fibrillation

  2019cites this paper
• Cardiac competence of the paraxial head mesoderm fades concomitant with a shift towards the head skeletal muscle programme

  2019cites this paper
• Human Pluripotent Stem Cell-Derived Cardiovascular Cells: From Developmental Biology to Therapeutic Applications.

  2019cites this paper
• Retinoic acid signaling in heart development

  2019influential citation
• Cardiopharyngeal Progenitor Specification: Multiple Roads to the Heart and Head Muscles.

  2019influential citation
• Recent insights on the role and regulation of retinoic acid signaling during epicardial development

  2019cites this paper
• Retinoic acid signaling pathways

  2019cites this paper
• Desenvolvimento de ensaios para a determinação da atividade enzimática das aldeído desidrogenases de cordados invertebrados.

  2018cites this paper
• Left-right asymmetry in heart development and disease: forming the right loop

  2018cites this paper
• T‐box genes and retinoic acid signaling regulate the segregation of arterial and venous pole progenitor cells in the murine second heart field

  2018cites this paper
• An epiblast stem cell-derived multipotent progenitor population for axial extension

  2018cites this paper
• Establishing a Single-cell and High-throughput Phenotypical Platform to Identify Novel Arrhythmia-Causing Genes

  2018cites this paper
• Embryological Origins: How Does the Right Ventricle Form

  2018cites this paper
• Retinoic acid signaling promotes the cytoskeletal rearrangement of embryonic epicardial cells

  2018cites this paper
• Location, Location, Location: Signals in Muscle Specification

  2018cites this paper
• Electrophysiologic Characterization of Calcium Handling in Human Induced Pluripotent Stem Cell-Derived Atrial Cardiomyocytes

  2018cites this paper
• Retinoic acid in developmental toxicology: Teratogen, morphogen and biomarker.

  2017cites this paper
• Growth and Morphogenesis during Early Heart Development in Amniotes

  2017cites this paper
• New insights and changing paradigms in the regulation of vitamin A metabolism in development

  2017cites this paper
• PREPARING CARDOMYOCYTES FROM STEM CELLS AND USES THEREOF

  2017cites this paper
• Human Pluripotent Stem Cell-Derived Atrial and Ventricular Cardiomyocytes Develop from Distinct Mesoderm Populations.

  2017cites this paper
• Retinoic Acid Plays Critical Roles in the Late Development of the Heart

  2017cites this paper
• Sept7b is required for the subcellular organization of cardiomyocytes and cardiac function in zebrafish.

  2017cites this paper
• Foxa2 identifies a cardiac progenitor population with ventricular differentiation potential

  2017cites this paper
• Efficient Differentiation of TBX18+/WT1+ Epicardial-Like Cells from Human Pluripotent Stem Cells Using Small Molecular Compounds

  2017cites this paper
• Mechanisms of retinoic acid signaling during cardiogenesis.

  2017cites this paper
• Morphological analysis of the hagfish heart. II. The venous pole and the pericardium

  2016cites this paper
• A strategy to discover new organizers identifies a putative heart organizer

  2016cites this paper
• Retinoic Acid Signaling Is Essential for Valvulogenesis by Affecting Endocardial Cushions Formation in Zebrafish Embryos

  2016cites this paper
• Atrial-like cardiomyocytes from human pluripotent stem cells are a robust preclinical model for assessing atrial-selective pharmacology

  2015influential citation
• Input overload: Contributions of retinoic acid signaling feedback mechanisms to heart development and teratogenesis

  2015cites this paper
• Signaling through retinoic acid receptors in cardiac development: Doing the right things at the right times.

  2015influential citation
• An in vitro gastrulation model recapitulates the morphogenetic impact of pharmacological inhibitors of developmental signaling pathways

  2015cites this paper
• Modeling Atrial Fibrillation using Human Embryonic Stem Cells

  2015cites this paper
• Role of Embryonic and Differentiated Cells in Cardiac Development

  2015cites this paper
• Retinoic Acid Signaling and Heart Development

  2015cites this paper
• Novel Video Imaging to Examine Cardiac Function in Xenopus Embryos

  2015cites this paper
• Additional Sex Combs-like Family Genes Regulate Embryonic Development

  2014cites this paper
• O papel dos receptores nucleares na especificação atrial.

  2014cites this paper
• Cyp26 enzymes are required to balance the cardiac and vascular lineages within the anterior lateral plate mesoderm

  2014cites this paper
• Molecular Basis of Cardiac Development

  2014cites this paper
• Retinoids and Cardiac Development

  2014influential citation
• Anterior Hox Genes in Cardiac Development and Great Artery Patterning

  2014cites this paper