Full-Breadth Analysis of CD8+ T-Cell Responses in Acute Hepatitis C Virus Infection and Early Therapy

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Journal of Virology

• Publication date

  2005-10-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/JVI.79.20.12979-12988.2005PMID 16189000PMCID PMC1235828
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Short‐term interferon‐alfa therapy for acute hepatitis C: A randomized controlled trial

  2004cited by this paper
• Long‐term follow‐up after successful interferon therapy of acute hepatitis C

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  2003influential reference
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• HCV Persistence and Immune Evasion in the Absence of Memory T Cell Help

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  2001cited by this paper
• Determinants of Viral Clearance and Persistence during Acute Hepatitis C Virus Infection

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• Association of hepatitis C virus-specific CD8+ T cells with viral clearance in acute hepatitis C.

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  1999cited by this paper
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• Liver-derived CTL in hepatitis C virus infection: breadth and specificity of responses in a cohort of persons with chronic infection.

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  1997influential reference
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  1996cited by this paper
• Phenotypic Analysis of Antigen-Specific T Lymphocytes

  1996cited by this paper
• Phototyping: comprehensive DNA typing for HLA-A, B, C, DRB1, DRB3, DRB4, DRB5 & DQB1 by PCR with 144 primer mixes utilizing sequence-specific primers (PCR-SSP).

  1995cited by this paper
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  2016cites this paper
• Cross‐genotype‐specific T‐cell responses in acute hepatitis E virus (HEV) infection

  2016cites this paper
• Current knowledge and future perspectives on acute hepatitis C infection.

  2015cites this paper
• Impact of hepatitis C virus coinfection on T-cell dynamics in long-term HIV-suppressors under combined antiretroviral therapy

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• Acute HCV in HIV positive men; viral evolution and cellular immune responses

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• I linfociti T regolatori nella patologia epatica da HCV: dall'epatite cronica al trapianto

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• Comparison of Immune Restoration in Early versus Late Alpha Interferon Therapy against Hepatitis C Virus

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• Acute hepatitis C in HIV-infected patients: rare spontaneous clearance correlates with weak memory CD4 T-cell responses to hepatitis C virus

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• Cellular immune responses during high-dose interferon-alpha induction therapy for hepatitis C virus infection.

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  2009cites this paper
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  2009cites this paper
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  2009cites this paper
• Caracterização imunoistoquímica da população linfocitária septal e perisseptal na cirrose secundária à hepatopatia alcoólica

  2009cites this paper
• Hepatitis C virus : epidemiology and immunology

  2009cites this paper
• Development of novel treatments for hepatitis C.

  2009cites this paper
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  2009cites this paper
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  2009cites this paper
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  2009cites this paper
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  2009cites this paper
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  2008cites this paper
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  2008cites this paper
• Towards optimal treatment for chronic hepatitis C infection

  2008influential citation
• Immune responses against the hepatitis C virus and the outcome of therapy

  2008cites this paper
• Acute hepatitis C: clinical aspects, diagnosis, and outcome of acute HCV infection.

  2008cites this paper
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  2008cites this paper
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  2008cites this paper
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  2008cites this paper
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  2008cites this paper
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  2008cites this paper
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  2008cites this paper
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  2008cites this paper
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  2008cites this paper
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  2008cites this paper
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  2008cites this paper
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  2007cites this paper
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  2007cites this paper
• [Adaptive cell immune response against the hepatitis C virus infection].

  2007cites this paper
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  2007cites this paper
• Respuesta inmunitaria celular adaptativa frente a la infección por el virus de la hepatitis C

  2007cites this paper
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  2007cites this paper
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  2007cites this paper
• Neutralizing antibodies in patients with chronic hepatitis C infection treated with (Peg)-interferon/ribavirin.

  2007cites this paper
• Induction of neutralizing antibody responses to hepatitis C virus with synthetic peptide constructs incorporating both antibody and T‐helper epitopes

  2007cites this paper
• HCV–HIV Coinfection: Simple Messages from a Complex Disease

  2007cites this paper