Tissue microarrays for high-throughput molecular profiling of tumor specimens

No abstract is available for this paper.

• Publication year

  1998

• Venue

  Nature Medicine

• Publication date

  1998-06-29

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/NM0798-844PMID 9662379
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Interphase cytogenetics and its role in molecular diagnostics of solid tumors.

  1998cited by this paper
• Quantitation of HER-2/neu and c-myc gene amplification in breast carcinoma using fluorescence in situ hybridization

  1997cited by this paper
• Gene expression profiles in normal and cancer cells.

  1997cited by this paper
• Quantitation of HER-2/neu and c-myc gene amplification in breast carcinoma using fluorescence in situ hybridization.

  1997cited by this paper
• Cyclin‐d1‐gene amplification and expression in breast carcinoma: Relation with clinicopathologic characteristics and with retinoblastoma gene product, p53 and p21waf1 immunohistochemical expression

  1997cited by this paper
• Prognostic significance of estrogen receptors in 405 primary breast cancers: a comparison of immunohistochemical and biochemical methods

  1997cited by this paper
• Increased copy number at 17q22‐q24 by CGH in breast cancer is due to high‐level amplification of two separate regions

  1997cited by this paper
• Mapping of DNA amplifications at 15 chromosomal localizations in 1875 breast tumors: definition of phenotypic groups.

  1997cited by this paper
• Mybl2 (Bmyb) maps to mouse chromosome 2 and human chromosome 20q 13.1.

  1996cited by this paper
• Use of a cDNA microarray to analyse gene expression patterns in human cancer

  1996cited by this paper
• Detection and quantitation of HER-2/neu gene amplification in human breast cancer archival material using fluorescence in situ hybridization.

  1996cited by this paper
• Identification of cryptic sites of DNA sequence amplification in human breast cancer by chromosome microdissection

  1994cited by this paper
• Sensitivity of HER-2/neu antibodies in archival tissue samples: potential source of error in immunohistochemical studies of oncogene expression.

  1994cited by this paper
• Increased copy number at 20q13 in breast cancer: defining the critical region and exclusion of candidate genes.

  1994cited by this paper
• Detection of DNA amplification in 17 primary breast carcinomas with homogeneously staining regions by a modified comparative genomic hybridization technique

  1994cited by this paper
• ERBB2 amplification in breast cancer analyzed by fluorescence in situ hybridization.

  1992cited by this paper
• Association of INT2/HST1 coamplification in primary breast cancer with hormone-dependent phenotype and poor prognosis.

  1991cited by this paper
• The checkerboard tissue block. An improved multitissue control block.

  1990cited by this paper
• Immunocytochemical analysis of estrogen receptors in human breast carcinomas. Evaluation of 130 cases and review of the literature regarding concordance with biochemical assay and clinical relevance.

  1990cited by this paper
• Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer.

  1989cited by this paper
• The multitumor (sausage) tissue block: novel method for immunohistochemical antibody testing.

  1986cited by this paper

• Glucose-transporter 1 (GLUT1) as a prognostic biomarker: evidence from 14,966 human tumors across 134 cancer types

  2026cites this paper
• PTEN Deletions Are Associated With Tumor Progression But Unrelated to Patient Prognosis in Muscle‐Invasive Urothelial Bladder Carcinomas: A Large Multi‐Center Validation Study on 2710 Urothelial Bladder Carcinomas

  2026cites this paper
• Tissue Microarray for Gynecological Pathology Studies: A Mini-Review

  2026cites this paper
• Prevalence of KDM6A deficiency in human cancer: A tissue microarray study on 18,570 cancers from 153 different tumor types.

  2026cites this paper
• Reduced Claudin-3 Expression Is Linked to Unfavorable Tumor Features and Poor Prognosis in Non-Small Cell Lung Cancer

  2026cites this paper
• Noninvasive Tumor Profiling: Quantitative Contrast-Enhanced MRI Markers Predict PD-L1 and CTNNB1 Status in Hepatocellular Carcinoma.

  2025cites this paper
• Differential Androgen Receptor Expression Across Bladder Cancer Stages and Its Link to Poor Outcomes

  2025cites this paper
• Tumor Extracellular Vesicle Digital Scoring Assays for Cancer Detection and Monitoring

  2025cites this paper
• Brachyury expression is highly specific for chordoma: A tissue microarray study involving 14,976 cancers from 135 different tumor types and subtypes.

  2025cites this paper
• Serine-arginine protein kinase 1 (SRPK1) is under-expressed in mucinous colorectal cancer, and may mediate resistance to oxaliplatin

  2025cites this paper
• Differential BACH1 Expression in Basal-like Breast Tumors of Black Women Identified via Immunohistochemistry

  2025cites this paper
• Differential expression of PD-L1, PD-L2 and inflammasome related proteins (NLRP3, ASC, and Caspase-1) in oral squamous cell carcinoma, lymph node metastases, and benign lesions.

  2025cites this paper
• High-level STING expression in tumour and inflammatory cells is linked to microsatellite instability and favourable tumour parameters in a cohort of over 1,900 colorectal cancer patients.

  2025cites this paper
• Expression and prognostic value of MCM2 in type B thymomas

  2025cites this paper
• AnatomyArray: a high-throughput platform for anatomical phenotyping in plants.

  2025cites this paper
• Prognostic value of immune biomarkers in melanoma loco-regional metastases

  2025cites this paper
• L1CAM/CD171 expression in human tumors and its association with tumor phenotype

  2025cites this paper
• Low FODMAP diet improves colonic barrier function and mast cell activation in patients with IBS-D: A mechanistic trial.

  2025cites this paper
• Interobserver concordance of tumor-infiltrating lymphocyte assessment in triple-negative breast carcinoma; tissue microarray versus whole sections

  2025cites this paper
• Investigation of TIGIT, PVRIG, CD112 and CD155 expression in early and late onset preeclampsia

  2025cites this paper
• High GLUT1 protein expression is associated with unfavorable tumor features and poor prognosis in non-small cell lung cancer

  2025cites this paper
• Tissue Microarray-Based Digital Spatial Profiling of Benign Breast Lobules and Breast Cancers: Feasibility, Biological Coherence, and Cross-Platform Benchmarks

  2025cites this paper
• Correlation and Overlap Between Claudin 18.2 and FGFR2b Overexpression: A Tissue Microarray Study With 1,538 Gastric Carcinomas

  2025cites this paper
• GATA3 amplification is associated with high grade disease in non-invasive urothelial bladder cancer but unrelated to patient prognosis

  2025cites this paper
• A cost- and time-efficient method for high-throughput cryoprocessing and tissue analysis using multiplexed tissue molds

  2025cites this paper
• Low CDX2 expression and its clinicopathological associations in colorectal adenocarcinoma: prognostic insights from a retrospective cross-sectional study in Vietnam

  2025cites this paper
• Glucocorticoid Receptor (GR) Expression in Human Tumors: A Tissue Microarray Study on More than 14,000 Tumors

  2025cites this paper
• Nanosecond pulsed electric fields induce cell-size-dependent selective permeabilization of urothelial cancer cells

  2025cites this paper
• An easy and reproducible method for rapid tissue macroarray block construction.

  2025cites this paper
• Virtual tissue microarrays for validating digital biomarker analysis in colorectal carcinoma.

  2025cites this paper
• Loss of chromosome Y is unrelated to the composition of the tumor microenvironment and patient prognosis in muscle-invasive urothelial bladder cancers

  2025cites this paper
• Implications of CYP1B1 in the treatment and prognosis of breast cancer

  2025cites this paper
• Prognostic role of high MTAP expression is reversed by the ERG status in prostate cancer treated by radical prostatectomy

  2025cites this paper
• Deficiency of MTAP Is Frequent and Mostly Homogeneous in Pancreatic Ductal Adenocarcinomas

  2025cites this paper
• Comparison of Manual Versus QuPath Software–based Immunohistochemical Scoring Using Oral Squamous Cell Carcinoma as a Model

  2025cites this paper
• Capecitabine Maintenance Therapy in Patients with Residual Nasopharyngeal Carcinoma: A Single-Arm, Phase II Trial

  2025cites this paper
• How to Write a Pathology Research Paper—Basic Principles and Beyond—A Primer for Residents

  2025cites this paper
• Immune Biomarkers on Tissue Microarray Cores Support the Presence of Adjacent Tertiary Lymphoid Structures in Soft Tissue Sarcoma.

  2025cites this paper
• Unlocking breast cancer in Brazilian public health system: Using tissue microarray for accurate immunohistochemical evaluation with limitations in subtyping

  2025cites this paper
• Reduced occludin expression is related to unfavorable tumor phenotype and poor prognosis in many different tumor types: A tissue microarray study on 16,870 tumors

  2025cites this paper
• Clinicopathological characterization of Switch/Sucrose-non-fermentable (Swi/Snf) complex (ARID1A, SMARCA2, SMARCA4)-deficient endocervical adenocarcinoma

  2025cites this paper
• Disclosing the development and focus of sequencing and omics studies in kidney neoplasm research

  2025cites this paper
• PLAP expression is linked to invasive tumor growth in urothelial carcinoma of the bladder

  2024cites this paper
• Loss of TROP2 and epithelial cell adhesion molecule expression is linked to grade progression in pTa but unrelated to disease outcome in pT2-4 urothelial bladder carcinomas

  2024cites this paper
• Carcinoembryonic Antigen Expression in Human Tumors: A Tissue Microarray Study on 13,725 Tumors

  2024cites this paper
• Loss of MTAP expression is strongly linked to homozygous 9p21 deletion, unfavorable tumor phenotype, and noninflamed microenvironment in urothelial bladder cancer

  2024cites this paper
• The impact of vascular division sequence and epithelial–mesenchymal transition status on postoperative recurrence in lung adenocarcinoma

  2024cites this paper
• PAX6 is a useful marker for pancreatic origin of neuroendocrine neoplasms: A tissue microarray study evaluating more than 19,000 tumors from 150 different tumor types.

  2024cites this paper
• GAD2 Is a Highly Specific Marker for Neuroendocrine Neoplasms of the Pancreas

  2024cites this paper
• Impact of CCND1 amplification on the prognosis of hormone receptor–positive, HER2-negative breast cancer patients—correlation of clinical and pathological markers

  2024cites this paper
• IMMUNOREACT 8: Immune markers of local tumor spread in patients undergoing transanal excision for clinically N0 rectal cancer.

  2024cites this paper
• Application of tissue chip in the production of positive controls

  2024cites this paper
• Loss of vimentin expression in preoperative biopsies independently predicts poor prognosis, lymph node metastasis and recurrence in endometrial cancer

  2024cites this paper
• TTF-1 is a highly sensitive but not fully specific marker for pulmonary and thyroidal cancer: a tissue microarray study evaluating more than 17,000 tumors from 152 different tumor entities

  2024cites this paper
• Expression of Trefoil Factor 1 (TFF1) in Cancer: A Tissue Microarray Study Involving 18,878 Tumors

  2024cites this paper
• PGP9.5 expression in human tumors: A tissue microarray study on 13,920 tumors from 120 different tumor entities.

  2024cites this paper
• Evaluation of SOX-10 immunohistochemical expression in canine melanoma and non-melanocytic tumors by tissue microarray

  2024cites this paper
• Upregulation of Mitochondrial Function is Associated with Advanced Prostate Cancer

  2024cites this paper
• IL-6/STAT3 signaling pathway induces prostate apoptosis response protein-4(PAR-4) to stimulate malignant behaviors of hepatocellular carcinoma cells.

  2024cites this paper
• Reduced p63 expression is linked to unfavourable prognosis in muscle‐invasive urothelial carcinoma of the bladder

  2024cites this paper
• TMA-Grid: An open-source, zero-footprint web application for FAIR Tissue MicroArray De-arraying

  2024cites this paper
• Tissue microarray validation in cervical carcinoma studies. A methodological approach.

  2024cites this paper
• POI-SIMEX for Conditionally Poisson Distributed Biomarkers from Tissue Histology

  2024cites this paper
• Prevalence and Significance of AGR2 Expression in Human Cancer

  2024cites this paper
• Staining pattern of specific and cross‐reacting Melan‐A antibodies: A comparative study on 15,840 samples from 133 human tumor types

  2024cites this paper
• Comprehensive Immunohistochemical Analysis of Epithelial–Mesenchymal Transition Biomarkers in the Invasive Micropapillary Cancer of the Breast

  2024cites this paper
• PD-L1 expression in tumor and inflammatory cells is associated with favorable tumor features and favorable prognosis in muscle-invasive urothelial carcinoma of the bladder not treated by immune checkpoint inhibitors

  2024cites this paper
• CD10 Expression Correlates with Earlier Tumour Stages and Left-Sided Tumour Location in Colorectal Cancer but Has No Prognostic Impact in a European Cohort

  2024cites this paper
• Trophoblast Cell Surface Antigen 2 (Trop2) Is Expressed in Cases of EBV-Positive Diffuse Large B-Cell Lymphoma Emerging from Angioimmunoblastic T-Cell Lymphoma

  2024cites this paper
• Epithelial Cell Adhesion Molecule (EpCAM) Expression in Human Tumors: A Comparison with Pan-Cytokeratin and TROP2 in 14,832 Tumors

  2024cites this paper
• KLK7 expression in human tumors: a tissue microarray study on 13,447 tumors

  2024cites this paper
• The differences between pure and mixed invasive micropapillary breast cancer: the epithelial–mesenchymal transition molecules and prognosis

  2024cites this paper
• CD163+ macrophages in mantle cell lymphoma induce activation of prosurvival pathways and immune suppression

  2024cites this paper
• A study predicting long-term survival capacity in postoperative advanced gastric cancer patients based on MAOA and subcutaneous muscle fat characteristics

  2024cites this paper
• PAX8 expression in cancerous and non-neoplastic tissue: a tissue microarray study on more than 17,000 tumors from 149 different tumor entities

  2024cites this paper
• Prevalence of S-methyl-5′-thioadenosine Phosphorylase (MTAP) Deficiency in Human Cancer

  2024cites this paper
• In Silico Optimization of Tissue Microarray Design for Machine Learning Analysis

  2024cites this paper
• Expression patterns of HDAC6 in correlation to ARID1A status in different subtypes of endometriosis: A retrospective tissue microarray analysis.

  2024cites this paper
• ss of ATRX and DAXX in pancreatic neuroendocrine tumors: association with recurrence risk, cellular phenotype, and heterogeneity.

  2024cites this paper
• Steroidogenic Acute Regulatory Protein Is a Useful Marker for Sex-Cord-Stroma Tumors and Normal and Neoplastic Adrenocortical Tissue.

  2024cites this paper
• CHRNA6 RNA in situ hybridization is a useful tool for the diagnosis of extraskeletal myxoid chondrosarcoma.

  2024cites this paper
• Clinicopathological Implications of Mismatch Repair Status in Endometrioid Endometrial Cancer in Duhok City

  2024cites this paper
• Cadherin-17 (CDH17) expression in human cancer: A tissue microarray study on 18,131 tumors.

  2024cites this paper
• Methylation-Specific Electrophoresis.

  2024cites this paper
• CEA (CEACAM5) expression is common in muscle‐invasive urothelial carcinoma of the bladder but unrelated to the disease course

  2024influential citation
• Stimulator of Interferon Genes Protein (STING) Expression in Cancer Cells: A Tissue Microarray Study Evaluating More than 18,000 Tumors from 139 Different Tumor Entities

  2024influential citation
• 17p13 (TP53) Deletions Are Associated With an Aggressive Phenotype but Unrelated to Patient Prognosis in Urothelial Bladder Carcinomas

  2024cites this paper
• CP-673451, a Selective Platelet-Derived Growth Factor Receptor Tyrosine Kinase Inhibitor, Induces Apoptosis in Opisthorchis viverrini-Associated Cholangiocarcinoma via Nrf2 Suppression and Enhanced ROS

  2023cites this paper
• A dataset of tumour-infiltrating lymphocytes in colorectal cancer patients using limited resources

  2023cites this paper
• Spatial Biology of Breast Cancer.

  2023cites this paper
• Generative and Discriminative Learning for Lung X-Ray Analysis Based on Probabilistic Component Analysis

  2023cites this paper
• Association of KRAS, NRAS, BRAF and PIK3CA gene mutations with clinicopathological features, prognosis and ring finger protein 215 expression in patients with colorectal cancer

  2023influential citation
• Diagnostic Role and Prognostic Impact of PSAP Immunohistochemistry: A Tissue Microarray Study on 31,358 Cancer Tissues

  2023cites this paper
• Altered p53/p16 expression is linked to urothelial carcinoma progression but largely unrelated to prognosis in muscle-invasive tumors

  2023cites this paper
• M2‐like tumor‐associated macrophages promote epithelial–mesenchymal transition through the transforming growth factor β/Smad/zinc finger e‐box binding homeobox pathway with increased metastatic potential and tumor cell proliferation in lung squamous cell carcinoma

  2023cites this paper
• MDM2 amplification is rare in gastric cancer

  2023cites this paper
• Comparison of INSM1 immunostaining with established neuroendocrine markers synaptophysin and chromogranin A in over 14,000 neuroendocrine and non-neuroendocrine tumors.

  2023cites this paper
• Cell Microarray: An Approach to Evaluate Drug-Induced Alterations in Protein Expression

  2023influential citation
• MYC protein is a high-risk factor in mantle cell lymphoma and identifies cases beyond morphology, proliferation and TP53/p53 – a Nordic Lymphoma Group study

  2023cites this paper
• Trop-2 Is Highly Expressed in Early Luminal-Like Breast Cancer

  2023cites this paper