Analysis of White Matter Damage in Patients with Multiple Sclerosis via a Novel In Vivo MR Method for Measuring Myelin, Axons, and G-Ratio

BACKGROUND AND PURPOSE: Myelin and axon volume fractions can now be estimated via MR imaging in vivo, as can the g-ratio, which equals the ratio of the inner to the outer diameter of a nerve fiber. The purpose of this study was to evaluate WM damage in patients with MS via this novel MR imaging technique. MATERIALS AND METHODS: Twenty patients with relapsing-remitting MS with a combined total of 149 chronic plaques were analyzed. Myelin volume fraction was calculated based on simultaneous tissue relaxometry. Intracellular and CSF compartment volume fractions were quantified via neurite orientation dispersion and density imaging. Axon volume fraction and g-ratio were calculated by combining these measurements. Myelin and axon volume fractions and g-ratio were measured in plaques, periplaque WM, and normal-appearing WM. RESULTS: All metrics differed significantly across the 3 groups (P < .001, except P = .027 for g-ratio between periplaque WM and normal-appearing WM). Those in plaques differed most from those in normal-appearing WM. The percentage changes in plaque and periplaque WM metrics relative to normal-appearing WM were significantly larger in absolute value for myelin volume fraction than for axon volume fraction and g-ratio (P < .001, except P = .033 in periplaque WM relative to normal-appearing WM for comparison between myelin and axon volume fraction). CONCLUSIONS: In this in vivo MR imaging study, the myelin of WM was more damaged than axons in plaques and periplaque WM of patients with MS. Myelin and axon volume fractions and g-ratio may potentially be useful for evaluating WM damage in patients with MS.

• Publication year

  2017

• Venue

  American Journal of Neuroradiology

• Publication date

  2017-10-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.3174/ajnr.A5312PMID 28775058PMCID PMC7963610
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Synthetic MRI in the Detection of Multiple Sclerosis Plaques

  2017cited by this paper
• SyMRI of the Brain

  2017cited by this paper
• Characterizing axonal myelination within the healthy population: a tract-by-tract mapping of effects of age and gender on the fiber g-ratio

  2017cited by this paper
• Promise and pitfalls of g‐ratio estimation with MRI

  2017cited by this paper
• Utility of a Multiparametric Quantitative MRI Model That Assesses Myelin and Edema for Evaluating Plaques, Periplaque White Matter, and Normal-Appearing White Matter in Patients with Multiple Sclerosis: A Feasibility Study

  2017cited by this paper
• Myelin Detection Using Rapid Quantitative MR Imaging Correlated to Macroscopically Registered Luxol Fast Blue–Stained Brain Specimens

  2017cited by this paper
• Rapid multicomponent relaxometry in steady state with correction of magnetization transfer effects

  2016cited by this paper
• Mapping an index of the myelin g-ratio in infants using magnetic resonance imaging

  2016cited by this paper
• Myelin volume fraction imaging with MRI☆

  2016cited by this paper
• Modeling the Presence of Myelin and Edema in the Brain Based on Multi-Parametric Quantitative MRI

  2016influential reference
• Clinical Feasibility of Synthetic MRI in Multiple Sclerosis: A Diagnostic and Volumetric Validation Study

  2016influential reference
• Longitudinal development in the preterm thalamus and posterior white matter: MRI correlations between diffusion weighted imaging and T2 relaxometry

  2016cited by this paper
• Contrast-enhanced synthetic MRI for the detection of brain metastases

  2016cited by this paper
• The Advantage of Synthetic MRI for the Visualization of Early White Matter Change in an Infant with Sturge-Weber Syndrome

  2016cited by this paper
• Whole-Brain In-vivo Measurements of the Axonal G-Ratio in a Group of 37 Healthy Volunteers

  2015cited by this paper
• In vivo histology of the myelin g-ratio with magnetic resonance imaging

  2015influential reference
• Inefficient clearance of myelin debris by microglia impairs remyelinating processes

  2015cited by this paper
• Accelerated Microstructure Imaging via Convex Optimization (AMICO) from diffusion MRI data

  2015cited by this paper
• Dural Enhancement in a Patient with Sturge-Weber Syndrome Revealed by Double Inversion Recovery Contrast Using Synthetic MRI

  2015cited by this paper
• Removal of cerebrospinal fluid partial volume effects in quantitative magnetization transfer imaging using a three‐pool model with nonexchanging water component

  2015cited by this paper
• A unified cell biological perspective on axon–myelin injury

  2014cited by this paper
• Multiple sclerosis: Benefits of q-space imaging in evaluation of normal-appearing and periplaque white matter.

  2014cited by this paper
• Adaptive smoothing of multi-shell diffusion weighted magnetic resonance data by msPOAS

  2014cited by this paper
• Position-orientation adaptive smoothing of diffusion weighted magnetic resonance data (POAS)

  2012cited by this paper
• NODDI: Practical in vivo neurite orientation dispersion and density imaging of the human brain

  2012cited by this paper
• Diffusional kurtosis imaging of normal-appearing white matter in multiple sclerosis: preliminary clinical experience

  2012cited by this paper
• Magnetic resonance techniques in multiple sclerosis: the present and the future.

  2011cited by this paper
• Axonal damage in multiple sclerosis.

  2011cited by this paper
• Diagnostic criteria for multiple sclerosis: 2010 Revisions to the McDonald criteria

  2011influential reference
• Correcting eddy current and motion effects by affine whole‐brain registrations: Evaluation of three‐dimensional distortions and comparison with slicewise correction

  2010cited by this paper
• Wallerian Degeneration: A Major Component of Early Axonal Pathology in Multiple Sclerosis

  2010cited by this paper
• Characterizing healthy and diseased white matter using quantitative magnetization transfer and multicomponent T2 relaxometry: A unified view via a four‐pool model

  2009cited by this paper
• Rapid magnetic resonance quantification on the brain: Optimization for clinical usage

  2008cited by this paper
• Extensive Cortical Remyelination in Patients with Chronic Multiple Sclerosis

  2007cited by this paper
• Diagnostic criteria for multiple sclerosis: 2005 revisions to the “McDonald Criteria”

  2005cited by this paper
• [Axonal damage in multiple sclerosis].

  2002cited by this paper
• Multiple sclerosis: diffusion tensor MR imaging for evaluation of normal-appearing white matter.

  2002cited by this paper
• Recommended diagnostic criteria for multiple sclerosis: Guidelines from the international panel on the diagnosis of multiple sclerosis

  2001cited by this paper
• Neurological disability correlates with spinal cord axonal loss and reduced N‐acetyl aspartate in chronic multiple sclerosis patients

  2000cited by this paper
• Distinct Patterns of Multiple Sclerosis Pathology Indicates Heterogeneity in Pathogenesis

  1996cited by this paper
• Diameter of axons and thickness of myelin sheaths of the pyramidal tract fibres in the adult human medullary pyramid.

  1984cited by this paper
• A New Scale for Evaluating Disability in Multiple Sclerosis

  1955cited by this paper
• A theory of the effects of fibre size in medullated nerve

  1951cited by this paper

• Technical aspects and clinical applications of synthetic MRI: a scoping review

  2025cites this paper
• White Matter Injury in Central Nervous System Disorders

  2025cites this paper
• Synthetic MR: Clinical applications in neuroradiology

  2025cites this paper
• Decoding Brain Development and Aging

  2024cites this paper
• A Mitochondrial Nanoguard Modulates Redox Homeostasis and Bioenergy Metabolism in Diabetic Peripheral Neuropathy.

  2023cites this paper
• Oligodendrocyte Progenitor Cell Transplantation Ameliorates Preterm Infant Cerebral White Matter Injury in Rats Model

  2023cites this paper
• [MR findings of the inflammatory demyelinating diseases of the central nervous system].

  2023cites this paper
• The Value of Various Post-Processing Modalities of Diffusion Weighted Imaging in the Detection of Multiple Sclerosis

  2023cites this paper
• Multiparametric MRI

  2023cites this paper
• Axonal and myelin changes and their inter-relationship in the optic radiations in people with multiple sclerosis

  2023influential citation
• MR myelin imaging in multiple sclerosis: A scoping review.

  2023influential citation
• Comparing myelin-sensitive magnetic resonance imaging measures and resulting g-ratios in healthy and multiple sclerosis brains

  2022cites this paper
• Preparation and assessment of an optimized multichannel acellular nerve allograft for peripheral nerve regeneration

  2022cites this paper
• Rationale and design of the brain magnetic resonance imaging protocol for FutureMS: a longitudinal multi-centre study of newly diagnosed patients with relapsing-remitting multiple sclerosis in Scotland [version 1; peer review: awaiting peer review]

  2022cites this paper
• Advanced Diffusion MR Imaging for Multiple Sclerosis in the Brain and Spinal Cord

  2022cites this paper
• Quantitative myelin imaging with MRI and PET: an overview of techniques and their validation status

  2022cites this paper
• Future Directions for Diffusion Imaging of the Brain and Spinal Cord

  2021cites this paper
• Multiple sclerosis plaques may undergo continuous myelin degradation: a cross-sectional study with myelin and axon-related quantitative magnetic resonance imaging metrics

  2021influential citation
• Exploratory Radiomic Analysis of Conventional vs. Quantitative Brain MRI: Toward Automatic Diagnosis of Early Multiple Sclerosis

  2021cites this paper
• Rationale and design of the brain magnetic resonance imaging protocol for FutureMS: a longitudinal multi-centre study of newly diagnosed patients with relapsing-remitting multiple sclerosis in Scotland

  2021cites this paper
• Exogenous Oligodendrocyte Progenitor Cell Transplantation Results in Structural and Functional Recovery in a Preterm Infant Cerebral White Matter Injury Rat Model

  2021cites this paper
• MRI-derived g-ratio and lesion severity in newly diagnosed multiple sclerosis

  2021cites this paper
• Experimental Imaging Study of Encephalomalacia Fluid-Attenuated Inversion Recovery (FLAIR) Hyperintense Lesions in Posttraumatic Epilepsy

  2021cites this paper
• Myelin and Axonal Damage in Normal-Appearing White Matter in Patients with Moyamoya Disease

  2020cites this paper
• Myelin Measurement Using Quantitative Magnetic Resonance Imaging: A Correlation Study Comparing Various Imaging Techniques in Patients with Multiple Sclerosis

  2020cites this paper
• Variability and Standardization of Quantitative Imaging

  2020cites this paper
• Myelin Imaging Can Be Affected by a Number of Factors

  2020cites this paper
• Machine Learning and Multiparametric Brain MRI to Differentiate Hereditary Diffuse Leukodystrophy with Spheroids from Multiple Sclerosis

  2020cites this paper
• Towards in vivo g-ratio mapping using MRI: Unifying myelin and diffusion imaging

  2020cites this paper
• Synthetic MRI: Technologies and Applications in Neuroradiology

  2020cites this paper
• Scan–rescan and inter-vendor reproducibility of neurite orientation dispersion and density imaging metrics

  2019cites this paper
• Magnetic resonance imaging diagnosis of demyelinating diseases: An update

  2019cites this paper
• Review of synthetic MRI in pediatric brains: Basic principle of MR quantification, its features, clinical applications, and limitations.

  2019cites this paper
• Imaging G-Ratio in Multiple Sclerosis Using High-Gradient Diffusion MRI and Macromolecular Tissue Volume

  2019influential citation
• MR g-ratio-weighted connectome analysis in patients with multiple sclerosis

  2019cites this paper
• White Matter Abnormalities in Multiple Sclerosis Evaluated by Quantitative Synthetic MRI, Diffusion Tensor Imaging, and Neurite Orientation Dispersion and Density Imaging

  2019cites this paper
• Aberrant myelination in patients with Sturge-Weber syndrome analyzed using synthetic quantitative magnetic resonance imaging

  2019cites this paper
• Improving the Quality of Synthetic FLAIR Images with Deep Learning Using a Conditional Generative Adversarial Network for Pixel-by-Pixel Image Translation

  2019cites this paper
• Gray Matter Alterations in Early and Late Relapsing-Remitting Multiple Sclerosis Evaluated with Synthetic Quantitative Magnetic Resonance Imaging

  2019cites this paper
• The Utility of a Convolutional Neural Network for Generating a Myelin Volume Index Map from Rapid Simultaneous Relaxometry Imaging

  2019cites this paper
• The Use of Synthetic MRI in Pediatric Brain

  2018cites this paper
• Application of Quantitative Microstructural MR Imaging with Atlas-based Analysis for the Spinal Cord in Cervical Spondylotic Myelopathy

  2018cites this paper
• Analysis of White Matter Damage in Patients with Multiple Sclerosis via a Novel In Vivo MR Method for Measuring Myelin, Axons, and G-Ratio [Proceedings of the 2017 Young Investigator Award]

  2018cites this paper
• Myelin Measurement: Comparison Between Simultaneous Tissue Relaxometry, Magnetization Transfer Saturation Index, and T1w/T2w Ratio Methods

  2018cites this paper
• MRI in multiple sclerosis: what is changing?

  2018cites this paper
• Effect of Gadolinium on the Estimation of Myelin and Brain Tissue Volumes Based on Quantitative Synthetic MRI

  2018cites this paper
• A Comparison of Techniques for Correcting Eddy-current and Motion-induced Distortions in Diffusion-weighted Echo-planar Images

  2018cites this paper
• Emerging Magnetic Resonance Imaging Techniques and Analysis Methods in Amyotrophic Lateral Sclerosis

  2018cites this paper
• Limitation of neurite orientation dispersion and density imaging for the detection of focal cortical dysplasia with a "transmantle sign".

  2018cites this paper
• 脳MRI最近の進歩：synthetic MRIと拡散MRIを中心に

  2017cites this paper
• Promise and pitfalls of g‐ratio estimation with MRI

  2017cites this paper