Myelin volume fraction imaging with MRI☆

Abstract MRI is a valuable tool to assess myelin during development and demyelinating disease processes. While multiexponential T2 and quantitative magnetization transfer measures correlate with myelin content, neither provides the total myelin volume fraction. In many cases correlative measures are adequate; but to assess microstructure of myelin, (e.g. calculate the g‐ratio using MRI), an accurate measure of myelin volume fraction is imperative. Using a volumetric model of white matter, we relate MRI measures of myelin to absolute measures of myelin volume fraction and compare them to quantitative histology. We assess our approach in control mice along with two models of hypomyelination and one model of hypermyelination and find strong agreement between MRI and histology amongst models. This work investigates the sensitivities of MRI myelin measures to changes in axon geometry and displays promise for estimating g‐ratio from MRI. Graphical abstract Figure. No caption available.

• Publication year

  2016

• Venue

  NeuroImage

• Publication date

  2016-12-23

• Fields of study

  Medicine, Computer Science, Engineering

• Identifiers
  DOI 10.1016/j.neuroimage.2016.12.067PMID 28025129PMCID PMC5481512
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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