Activated protein C: a potential cardioprotective factor against ischemic injury during ischemia/reperfusion.

No abstract is available for this paper.

• Publication year

  2009

• Venue

  American journal of translational research

• Publication date

  2009-07-15

• Fields of study

  Medicine

• Identifiers
  PMID 19956450PMCID PMC2780036
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Macrophage migration inhibitory factor stimulates AMP-activated protein kinase in the ischaemic heart

  2008cited by this paper
• Endothelial protein C receptor polymorphisms and risk of myocardial infarction

  2008cited by this paper
• Ischemia-reperfusion injury and cardioprotection: investigating PTEN, the phosphatase that negatively regulates PI3K, using a congenital model of PTEN haploinsufficiency

  2008cited by this paper
• Protein kinase B/Akt activity is involved in renal TGF-β1-driven epithelial-mesenchymal transition in vitro and in vivo

  2008cited by this paper
• Signalosomes: delivering cardioprotective signals from GPCRs to mitochondria.

  2008cited by this paper
• TNFalpha in myocardial ischemia/reperfusion: damage vs. protection.

  2008cited by this paper
• AMP-activated protein kinase in skeletal muscle: From structure and localization to its role as a master regulator of cellular metabolism

  2008cited by this paper
• Interaction of Cardiovascular Risk Factors with Myocardial Ischemia/Reperfusion Injury, Preconditioning, and Postconditioning

  2007influential reference
• Proteinase-activated receptor agonists stimulate the increase in intracellular Ca2+ in cardiomyocytes and proliferation of cardiac fibroblasts from chick embryos

  2007cited by this paper
• Activated Protein C Decreases Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand by an EPCR- Independent Mechanism Involving Egr-1/Erk-1/2 Activation

  2007cited by this paper
• Non‐hematopoietic EPCR regulates the coagulation and inflammatory responses during endotoxemia

  2007cited by this paper
• Recombinant human-activated protein C inhibits cardiomyocyte apoptosis in a rat model of myocardial ischemia–reperfusion

  2007cited by this paper
• Protective signaling pathways of activated protein C in endothelial cells.

  2007cited by this paper
• The ligand occupancy of endothelial protein C receptor switches the protease-activated receptor 1-dependent signaling specificity of thrombin from a permeability-enhancing to a barrier-protective response in endothelial cells.

  2007cited by this paper
• Leukocyte filter enhances neutrophil activation during combined aortic valve and coronary artery bypass surgery.

  2006cited by this paper
• Activated Protein C in the Cardioplegic Solution on a Porcine Model of Coronary Ischemia-Reperfusion has Deleterious Hemodynamic Effects

  2006cited by this paper
• Vasculoprotective effect of insulin in the ischemic/reperfused canine heart: role of Akt-stimulated NO production.

  2006cited by this paper
• Activation of AMPK alpha- and gamma-isoform complexes in the intact ischemic rat heart.

  2006cited by this paper
• Mammalian TAK1 Activates Snf1 Protein Kinase in Yeast and Phosphorylates AMP-activated Protein Kinase in Vitro*

  2006cited by this paper
• Predominant α2/β2/γ3 AMPK activation during exercise in human skeletal muscle

  2006cited by this paper
• Deficiency of LKB1 in heart prevents ischemia-mediated activation of AMPKalpha2 but not AMPKalpha1.

  2006cited by this paper
• Modulation of Monocyte Function by Activated Protein C, a Natural Anticoagulant1

  2006cited by this paper
• Mitochondrial permeability transition pore and postconditioning.

  2006cited by this paper
• Ca2+/calmodulin-dependent protein kinase kinase-beta acts upstream of AMP-activated protein kinase in mammalian cells.

  2005cited by this paper
• The Ca2+/Calmodulin-dependent Protein Kinase Kinases Are AMP-activated Protein Kinase Kinases*

  2005cited by this paper
• Deficiency of LKB1 in skeletal muscle prevents AMPK activation and glucose uptake during contraction

  2005cited by this paper
• A cardioprotective role for the endothelial protein C receptor in lipopolysaccharide-induced endotoxemia in the mouse.

  2005cited by this paper
• AMP-Activated Protein Kinase Activates p38 Mitogen-Activated Protein Kinase by Increasing Recruitment of p38 MAPK to TAB1 in the Ischemic Heart

  2005cited by this paper
• PAR1 Cleavage and Signaling in Response to Activated Protein C and Thrombin*

  2005cited by this paper
• Structural basis for glycogen recognition by AMP-activated protein kinase.

  2005cited by this paper
• Sex differences in the myocardial inflammatory response to ischemia-reperfusion injury.

  2005cited by this paper
• AMP-activated protein kinase: a key stress signaling pathway in the heart.

  2005cited by this paper
• Role of the nitric oxide pathway in AMPK-mediated glucose uptake and GLUT4 translocation in heart muscle.

  2004influential reference
• Activated protein C and ischemic stroke

  2004influential reference
• Regulation of cardiomyocyte apoptosis in ischemic reperfused mouse heart by glutathione peroxidase

  2004cited by this paper
• AMP-activated protein kinase mediates ischemic glucose uptake and prevents postischemic cardiac dysfunction, apoptosis, and injury.

  2004influential reference
• Modifying the first minute of reperfusion: potential for myocardial salvage.

  2004cited by this paper
• Tissue plasminogen activator neurovascular toxicity is controlled by activated protein C

  2004cited by this paper
• Role of calcium and AMP kinase in the regulation of mitochondrial biogenesis and GLUT4 levels in muscle

  2004cited by this paper
• G Protein–Coupled Receptor Internalization Signaling Is Required for Cardioprotection in Ischemic Preconditioning

  2004cited by this paper
• Differential contribution of necrosis and apoptosis in myocardial ischemia-reperfusion injury.

  2004cited by this paper
• The alpha2-5'AMP-activated protein kinase is a site 2 glycogen synthase kinase in skeletal muscle and is responsive to glucose loading.

  2004cited by this paper
• Activation of 5′-AMP-activated Kinase Is Mediated through c-Src and Phosphoinositide 3-Kinase Activity during Hypoxia-Reoxygenation of Bovine Aortic Endothelial Cells

  2003cited by this paper
• Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective

  2003influential reference
• A1 adenosine receptor overexpression attenuates ischemia-reperfusion-induced apoptosis and caspase 3 activity.

  2003cited by this paper
• ERK inhibitor PD98059 enhances docetaxel‐induced apoptosis of androgen‐independent human prostate cancer cells

  2003influential reference
• Expression of Macrophage Migration Inhibitory Factor in Acute Ischemic Myocardial Injury

  2003cited by this paper
• Exosite-dependent regulation of the protein C anticoagulant pathway.

  2003cited by this paper
• Expression and function of the endothelial protein C receptor in human neutrophils.

  2003cited by this paper
• Physiological role of AMP-activated protein kinase in the heart: graded activation during exercise.

  2003cited by this paper
• Activated protein C alters cytosolic calcium flux in human brain endothelium via binding to endothelial protein C receptor and activation of protease activated receptor-1.

  2003cited by this paper
• Complexes between the LKB1 tumor suppressor, STRADα/β and MO25α/β are upstream kinases in the AMP-activated protein kinase cascade

  2003cited by this paper
• Cardiac ischemia causes inhibition of the Na/K ATPase by a labile cytosolic compound whose production is linked to oxidant stress.

  2003cited by this paper
• Phosphorylation of Glycogen Synthase Kinase-3β During Preconditioning Through a Phosphatidylinositol-3-Kinase–Dependent Pathway Is Cardioprotective

  2002cited by this paper
• Recombinant human activated protein C attenuates the inflammatory response in endothelium and monocytes by modulating nuclear factor-&kgr;B

  2002cited by this paper
• Activation of Endothelial Cell Protease Activated Receptor 1 by the Protein C Pathway

  2002influential reference
• The Crystal Structure of the Endothelial Protein C Receptor and a Bound Phospholipid*

  2002cited by this paper
• Prolonged exposure of chromaffin cells to nitric oxide down-regulates the activity of soluble guanylyl cyclase and corresponding mRNA and protein levels

  2002cited by this paper
• Phosphorylation of Glycogen Synthase Kinase-3&bgr; During Preconditioning Through a Phosphatidylinositol-3-Kinase–Dependent Pathway Is Cardioprotective

  2002cited by this paper
• The phosphoinositide 3-kinase pathway.

  2002cited by this paper
• ERK and p38 MAP kinase activation are components of opioid-induced delayed cardioprotection

  2001cited by this paper
• Characterization of protein C receptor expression in monocytes

  2001cited by this paper
• Anti-Inflammatory, Antithrombotic, and Neuroprotective Effects of Activated Protein C in a Murine Model of Focal Ischemic Stroke

  2001cited by this paper
• MAPK/ERK Overrides the Apoptotic Signaling from Fas, TNF, and TRAIL Receptors*

  2001cited by this paper
• Activation of extracellular-regulated kinases by normal and mutant EGF receptors.

  2001cited by this paper
• Activated protein C reduces ischemia/reperfusion-induced renal injury in rats by inhibiting leukocyte activation.

  2000cited by this paper
• Phosphorylation and activation of heart PFK-2 by AMPK has a role in the stimulation of glycolysis during ischaemia.

  2000cited by this paper
• Activation of Akt during simulated ischemia/reperfusion in cardiac myocytes.

  2000cited by this paper
• Activated protein C inhibits tumor necrosis factor and macrophage migration inhibitory factor production in monocytes.

  2000influential reference
• The anticoagulant and anti-inflammatory roles of the protein C anticoagulant pathway.

  2000influential reference
• Mitochondrial Ca(2+)homeostasis in the regulation of apoptotic and necrotic cell deaths.

  2000cited by this paper
• The endothelial cell protein C receptor aids in host defense against Escherichia coli sepsis.

  2000cited by this paper
• Activated Protein C Reduces the Ischemia/Reperfusion-Induced Spinal Cord Injury in Rats by Inhibiting Neutrophil Activation

  2000cited by this paper
• Cardiac ischemia oxidizes regulatory thiols on ryanodine receptors: captopril acts as a reducing agent to improve Ca2+ uptake by ischemic sarcoplasmic reticulum.

  2000cited by this paper
• Inhibition of extracellular signal-regulated kinase enhances Ischemia/Reoxygenation-induced apoptosis in cultured cardiac myocytes and exaggerates reperfusion injury in isolated perfused heart.

  2000cited by this paper
• Store-operated Calcium Entry in Vascular Endothelial Cells Is Inhibited by cGMP via a Protein Kinase G-dependent Mechanism*

  2000cited by this paper
• MEK/ERK signaling pathway regulates the expression of Bcl‐2, Bcl‐XL, and Mcl‐1 and promotes survival of human pancreatic cancer cells

  2000cited by this paper
• The endothelial cell protein C receptor (EPCR) functions as a primary receptor for protein C activation on endothelial cells in arteries, veins, and capillaries.

  1999cited by this paper
• Phosphorylation control of cardiac acetyl-CoA carboxylase by cAMP-dependent protein kinase and 5'-AMP activated protein kinase.

  1999cited by this paper
• Translocation of myocardial GLUT-4 and increased glucose uptake through activation of AMPK by AICAR.

  1999cited by this paper
• Insulin-like Growth Factor (IGF)-I Regulates IGF-binding Protein-5 Gene Expression through the Phosphatidylinositol 3-Kinase, Protein Kinase B/Akt, and p70 S6 Kinase Signaling Pathway*

  1999cited by this paper
• The effect of membrane composition on the hemostatic balance.

  1999cited by this paper
• AMP‐activated protein kinase phosphorylation of endothelial NO synthase

  1999cited by this paper
• PKC-dependent activation of p44/p42 MAPKs during myocardial ischemia-reperfusion in conscious rabbits.

  1999cited by this paper
• Activation Mechanism of Anticoagulant Protein C in Large Blood Vessels Involving the Endothelial Cell Protein C Receptor

  1998cited by this paper
• Activated protein C resistance and myocardial infarction

  1998cited by this paper
• Role of cytokines in myocardial ischemia and reperfusion

  1997cited by this paper
• Thrombomodulin gene mutations associated with myocardial infarction.

  1997cited by this paper
• Human protein C receptor is present primarily on endothelium of large blood vessels: implications for the control of the protein C pathway.

  1997cited by this paper
• A rapid ischemia-induced apoptosis in isolated rat hearts and its attenuation by the sodium-hydrogen exchange inhibitor HOE 642 (cariporide).

  1997cited by this paper
• A Common Thrombomodulin Amino Acid Dimorphism Is Associated with Myocardial Infarction

  1997cited by this paper
• The effect of Arg306 → Ala and Arg506 → Gln substitutions in the inactivation of recombinant human factor Va by activated protein C and protein S

  1997cited by this paper
• The AMP-activated protein kinase--fuel gauge of the mammalian cell?

  1997cited by this paper
• Characterization of 5'AMP-activated protein kinase activity in the heart and its role in inhibiting acetyl-CoA carboxylase during reperfusion following ischemia.

  1996cited by this paper
• Acute inflammatory reaction after myocardial ischemic injury and reperfusion. Development and use of a neutrophil-specific antibody.

  1996cited by this paper
• The 2.8 A crystal structure of Gla‐domainless activated protein C.

  1996cited by this paper
• Apoptosis in ischemic and reperfused rat myocardium.

  1996cited by this paper
• Cardiac release of cytokines and inflammatory responses in acute myocardial infarction.

  1995cited by this paper
• Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis

  1995cited by this paper
• Resistance to activated protein C and risk of premature myocardial infarction.

  1994cited by this paper

• Analysis of the urinary metabolic profiles in irradiated rats treated with Activated Protein C (APC), a potential mitigator of radiation toxicity

  2023cites this paper
• Xinshuaining preparation protects H9c2 cells from H2O2-induced oxidative damage through the PI3K/Akt/Nrf-2 signaling pathway

  2022cites this paper
• Vitamin K Contribution to DNA Damage—Advantage or Disadvantage? A Human Health Response

  2022cites this paper
• Low-Dose Activated Protein C Suppresses the Development of Cerebral Infarction and Neurological Deficits in Mice

  2020cites this paper
• Resveratrol alleviates ischemia/reperfusion injury of diabetic myocardium via inducing autophagy.

  2019cites this paper
• Genistein Protects H9c2 Cardiomyocytes against Chemical Hypoxia-Induced Injury via Inhibition of Apoptosis

  2019cites this paper
• Activated protein C protects against pressure overload-induced hypertrophy through AMPK signaling.

  2018cites this paper
• Effects of Postconditioning with Fructose on Arrhythmias and the Size of Infarct Caused by Global Ischemia and Reperfusion in Isolated Rat Heart

  2018cites this paper
• Lower plasma protein C activity is associated with early myocardial necrosis and no-reflow phenomenon in patients with ST elevation myocardial infarction

  2018cites this paper
• Hypothermic Machine Perfusion's Protection on Porcine Kidney Graft Uncovers Greater Akt-Erk Phosphorylation.

  2017cites this paper
• Activation of autophagy improved the neurologic outcome after cardiopulmonary resuscitation in rats.

  2016cites this paper
• Mechanisms involved in attenuated cardio-protective role of ischemic preconditioning in metabolic disorders

  2015cites this paper
• Alpha1 catalytic subunit of AMPK modulates contractile function of cardiomyocytes through phosphorylation of troponin I.

  2014cites this paper
• Trans-system mechanisms against ischemic myocardial injury.

  2014cites this paper
• Effect of limb ischemic preconditioning on myocardial apoptosis-related proteins in ischemia-reperfusion injury

  2013cites this paper
• Natural Antioxidant-Isoliquiritigenin Ameliorates Contractile Dysfunction of Hypoxic Cardiomyocytes via AMPK Signaling Pathway

  2013cites this paper
• AMPK in myocardial infarction and diabetes: the yin/yang effect.

  2012cites this paper
• Activated protein C attenuates cardiopulmonary bypass-induced acute lung injury through the regulation of neutrophil activation.

  2011cites this paper
• Effects of bpV(pic) and bpV(phen) on H9c2 cardiomyoblasts during both hypoxia/reoxygenation and H2O2-induced injuries.

  2011cites this paper
• Macrophage migration inhibitory factor deficiency augments cardiac dysfunction in Type 1 diabetic murine cardiomyocytes

  2010cites this paper