The metabolic role of leucovorin.

No abstract is available for this paper.

• Publication year

  1993

• Venue

  TIBS -Trends in Biochemical Sciences. Regular ed

• Publication date

  1993-03-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/0968-0004(93)90162-GPMID 8480361
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Evidence for the accumulation of a stable intermediate in the nonenzymatic hydrolysis of 5,10-methenyltetrahydropteroylglutamate to 5-formyltetrahydropteroylglutamate.

  1992cited by this paper
• Enzymatic mechanism for the hydrolysis of 5,10-methenyltetrahydropteroylglutamate to 5-formyltetrahydropteroylglutamate by serine hydroxymethyltransferase.

  1992cited by this paper
• 5-Formyltetrahydrofolate polyglutamates are slow tight binding inhibitors of serine hydroxymethyltransferase.

  1991cited by this paper
• Serine hydroxymethyltransferase catalyzes the hydrolysis of 5,10-methenyltetrahydrofolate to 5-formyltetrahydrofolate.

  1990cited by this paper
• Effect of nitrous oxide inactivation of vitamin B12-dependent methionine synthetase on the subcellular distribution of folate coenzymes in rat liver.

  1989cited by this paper
• Folylpolyglutamate synthesis and role in the regulation of one-carbon metabolism.

  1989cited by this paper
• Methenyltetrahydrofolate synthetase prevents the inhibition of phosphoribosyl 5-aminoimidazole 4-carboxamide ribonucleotide formyltransferase by 5-formyltetrahydrofolate polyglutamates.

  1989cited by this paper
• Human liver methenyltetrahydrofolate synthetase: improved purification and increased affinity for folate polyglutamate substrates.

  1987cited by this paper
• Purification and properties of 5,10-methenyltetrahydrofolate synthetase from Lactobacillus casei.

  1984cited by this paper
• 5,10-Methenyltetrahydrofolate synthetase. Purification and properties of the enzyme from rabbit liver.

  1984cited by this paper
• Glutamate formyl- and formimino-transferase activities from pig liver.

  1983cited by this paper
• On the mechanism of action of folate- and biopterin-requiring enzymes.

  1980cited by this paper
• Studies of folic acid compounds in nature. IV. Folic acid compounds in soybeans and cow milk.

  1975cited by this paper
• An external heavy atom effect on biacetyl in the gas phase

  1970cited by this paper
• Further Studies on N5-Formyltetrahydrofolic Acid Cyclodehydrase*

  1965cited by this paper
• A FORMYLATION COFACTOR1

  1954cited by this paper
• THE STIMULATION OF SERINE BIOSYNTHESIS IN PIGEON LIVER EXTRACTS BY TETRAHYDROFOLIC ACID1

  1954cited by this paper
• Studies on the enzymatic formation of citrovorum factor by Streptococcus faecalis.

  1953cited by this paper
• Studies on the enzymatic formation of citrovorum factor by Streptococcus faecalis.

  1953cited by this paper
• Chemistry of Leucovorin

  1952cited by this paper
• Synthetic and Degradative Investigations of the Structure of Folinic Acid-SF

  1951cited by this paper
• Partial purification of a factor essential for growth of Leuconostoc citrovorum.

  1950cited by this paper
• The effect of folic acid upon the urinary excretion of the growth factor required by Leuconostoc citrovorum.

  1949cited by this paper
• The effect of folic acid upon the urinary excretion of the growth factor required by Leuconostoc citrovorum.

  1949cited by this paper
• A factor required for the growth of Leuconostoc citrovorum.

  1948cited by this paper
• A factor required for the growth of Leuconostoc citrovorum.

  1948cited by this paper
• Growth Factors for Bacteria

  1940cited by this paper

• Metabolomic insights into the role of isoleucine in regulating cereulide biosynthesis in emetic Bacillus cereus.

  2026cites this paper
• An Allele of Glutamate Formiminotransferase Triggers 5‐Methyl‐Tetrahydrofolate‐to‐MeFox Conversion and Facilitates Folate Biofortification in Maize

  2025cites this paper
• Power-to-Vitamins: Producing Folate (Vitamin B9) from Renewable Electric Power and CO2 with a Microbial Protein System

  2024cites this paper
• A new mathematical model of folate homeostasis in E. coli highlights the potential importance of the folinic acid futile cycle in cell growth

  2023cites this paper
• Regulatory mechanisms of one-carbon metabolism enzymes

  2023cites this paper
• Insights Into the Known 13C Depletion of Methane—Contribution of the Kinetic Isotope Effects on the Serine Hydroxymethyltransferase Reaction

  2022cites this paper
• Metabolite Damage and Damage Control in a Minimal Genome

  2021cites this paper
• Structural insights of human N-acetyltransferase 10 and identification of its potential novel inhibitors

  2021cites this paper
• The 5-formyl-tetrahydrofolate proteome links folates with C/N metabolism and reveals feedback regulation of folate biosynthesis.

  2021cites this paper
• Modified base-binding EVE and DCD Domains Implicated in the Origins of Programmed Cell Death and the piRNA Pathway

  2020cites this paper
• Treatment strategies targeting persister cell formation in bacterial pathogens

  2020cites this paper
• Modified base-binding EVE and DCD domains: striking diversity of genomic contexts in prokaryotes and predicted involvement in a variety of cellular processes

  2020cites this paper
• Structural Comparison of Enterococcus faecalis and Human Thymidylate Synthase Complexes with the Substrate dUMP and Its Analogue FdUMP Provides Hints about Enzyme Conformational Variabilities

  2019cites this paper
• The 5-formyltetrahydrofolate futile cycle reduces pathway stochasticity in an extended hybrid-stochastic model of folate-mediated one-carbon metabolism

  2019cites this paper
• Evidence of Destabilization of the Human Thymidylate Synthase (hTS) Dimeric Structure Induced by the Interface Mutation Q62R

  2019cites this paper
• Evolution of folate biosynthesis and metabolism across algae and land plant lineages

  2019cites this paper
• Structural and Functional Characterization of the Human Thymidylate Synthase (hTS) Interface Variant R175C, New Perspectives for the Development of hTS Inhibitors

  2019cites this paper
• Development of Chemical Proteomics for the Folateome and Analysis of the Kinetoplastid Folateome

  2018cites this paper
• Emerging therapeutic targets for treatment of leishmaniasis

  2018cites this paper
• Disrupting folate metabolism alters the capacity of bacteria in exponential growth to develop persisters to antibiotics

  2018cites this paper
• Pancreatic cancer: treatment approaches and trends

  2018cites this paper
• Disrupting folate metabolism reduces the capacity of bacteria in exponential growth to develop persisters to antibiotics.

  2018cites this paper
• Toward a better understanding of folate metabolism in health and disease

  2018cites this paper
• Factors that influence E. coli folate synthesis and their impact on C. elegans ageing

  2017cites this paper
• Folate rescues vitamin B12 depletion-induced inhibition of nuclear thymidylate biosynthesis and genome instability

  2017cites this paper
• An LC-MS chemical derivatization method for the measurement of five different one-carbon states of cellular tetrahydrofolate

  2017cites this paper
• Metabolite damage and repair in metabolic engineering design.

  2017cites this paper
• A mathematical model of microbial folate biosynthesis and utilisation: implications for antifolate development.

  2016cites this paper
• The Origin and Nature of Life on Earth: The Emergence of the Fourth Geosphere

  2016cites this paper
• ‘Rod and ring’ formation from IMP dehydrogenase is regulated through the one-carbon metabolic pathway

  2016cites this paper
• 17. Genetic variants of folate metabolic pathways in hematological toxicity of leukemia patients

  2016cites this paper
• Impact of Mutating the Key Residues of a Bifunctional 5,10-Methylenetetrahydrofolate Dehydrogenase-Cyclohydrolase from Escherichia coli on Its Activities.

  2015cites this paper
• The Effect of Using Tae-bo Trainings on Specific Physical Variables, the Concentration of Inter- Leukin-6, Creatine - Phosphokinase Enzyme in Blood and the Effectiveness of Performance Skill in Kata for Karate Young Female Players

  2015cites this paper
• Stability of dietary 5-formyl-tetrahydrofolate and its determination by HPLC: a pilot study on impact of pH, temperature and antioxidants on analytical results

  2013cites this paper
• Occurrence, stability, and determination of formyl folates in foods.

  2013cites this paper
• Modeling cellular compartmentation in one‐carbon metabolism

  2013cites this paper
• Metabolic Evolution of a Deep-Branching Hyperthermophilic Chemoautotrophic Bacterium

  2013cites this paper
• Modeling cellular compartmentation in one-carbon

  2013cites this paper
• Metabolite damage and its repair or pre-emption.

  2013cites this paper
• Frontiers in metabolic reconstruction and modeling of plant genomes.

  2012cites this paper
• Impact of Methotrexate and Leucovorin on Hormonal Regulated Enzymes of Carbohydrate Metabolism in Accessory Reproductive Tissues of Ovariectomized Rats

  2012cites this paper
• The structure of Enterococcus faecalis thymidylate synthase provides clues about folate bacterial metabolism.

  2012cites this paper
• The compositional and evolutionary logic of metabolism

  2012cites this paper
• Investigations of Amino Acids in the ATP Binding Site of 5,10-Methenyltetrahydrofolate Synthetase

  2012cites this paper
• Folate metabolic pathways in Leishmania.

  2011cites this paper
• Potentiation of Available Antibiotics by Targeting Resistance – An Emerging Trend in Tuberculosis Drug Development

  2011cites this paper
• Phenotypic landscape of a bacterial cell.

  2011cites this paper
• The Folylpolyglutamate Synthetase Plastidial Isoform Is Required for Postembryonic Root Development in Arabidopsis1[W][OA]

  2011cites this paper
• A 5-formyltetrahydrofolate cycloligase paralog from all domains of life: comparative genomic and experimental evidence for a cryptic role in thiamin metabolism

  2011cites this paper
• Mthfs is an Essential Gene in Mice and a Component of the Purinosome

  2011influential citation
• Effect of methotrexate and leucovorin on female reproductive tract of albino rats

  2011cites this paper
• Folate production using Lactococcus lactis ssp cremoris with implications for fortification of skim milk and fruit juices

  2011cites this paper
• Bacterial Conversion of Folinic Acid Is Required for Antifolate Resistance*

  2011cites this paper
• Metabolism of Folates in Plants

  2011cites this paper
• Genetic manipulation of folate in rice

  2010cites this paper
• Folate Nutrition In Human Skin: Implications For Cancer Prevention

  2010cites this paper
• Compartmentalization of Mammalian folate-mediated one-carbon metabolism.

  2010cites this paper
• Total folate: diversity within fruit varieties commonly consumed in India

  2010cites this paper
• Moonlighting Glutamate Formiminotransferases Can Functionally Replace 5-Formyltetrahydrofolate Cycloligase*

  2010cites this paper
• Antiestrogenic and antiprogestational activity of methotrexate and its effect on uterine histoarchitecture of ovariectomized albino rats

  2010cites this paper
• Physiological responses to folate overproduction in Lactobacillus plantarum WCFS1

  2010cites this paper
• Folates and Folic Acid: From Fundamental Research Toward Sustainable Health

  2010cites this paper
• Etude de la régulation du métabolisme monocarboné chez Arabidopsis thaliana

  2009cites this paper
• Arabidopsis Photorespiratory Serine Hydroxymethyltransferase Activity Requires the Mitochondrial Accumulation of Ferredoxin-Dependent Glutamate Synthase[W]

  2009cites this paper
• 5,10-Methenyltetrahydrofolate synthetase activity is increased in tumors and modifies the efficacy of antipurine LY309887.

  2009cites this paper
• Thermal degradation of (6R,S)-5,10-methenyltetrahydrofolate in aqueous solution at pH 8

  2009cites this paper
• A Genome-Wide and Metabolic Analysis Determined the Adaptive Response of Arabidopsis Cells to Folate Depletion Induced by Methotrexate1[W]

  2008cites this paper
• Modulation of folate production in lactic acid bacteria

  2008cites this paper
• Folate-mediated one-carbon metabolism.

  2008cites this paper
• Inhibition of 5,10-methenyltetrahydrofolate synthetase.

  2007cites this paper
• Characterization of the Role of para-Aminobenzoic Acid Biosynthesis in Folate Production by Lactococcus lactis

  2007cites this paper
• Meta analysis of advanced cancer survival data using lognormal parametric fitting: a statistical method to identify effective treatment protocols.

  2007cites this paper
• Ferritin and Serine Hydroxymethyltransferase

  2006cites this paper
• Methenyltetrahydrofolate synthetase is a high-affinity catecholamine-binding protein.

  2006cites this paper
• Regulation of de Novo Purine Biosynthesis by Methenyltetrahydrofolate Synthetase in Neuroblastoma*

  2006cites this paper
• Large-scale identification of pathogenicity factors in "Bartonella" by signature-tagged mutagenesis

  2005cites this paper
• A heretofore undisclosed crux of Eosinophilia-Myalgia Syndrome: compromised histamine degradation

  2005cites this paper
• Comparative folate metabolism in humans and malaria parasites (part I): pointers for malaria treatment from cancer chemotherapy.

  2005cites this paper
• Plant gamma-glutamyl hydrolases and folate polyglutamates: characterization, compartmentation, and co-occurrence in vacuoles.

  2005cites this paper
• 5-Formyltetrahydrofolate Is an Inhibitory but Well Tolerated Metabolite in Arabidopsis Leaves*

  2005cites this paper
• Higher Plant Plastids and Cyanobacteria Have Folate Carriers Related to Those of Trypanosomatids*

  2005cites this paper
• Folate Synthesis and Metabolism in Plants and Prospects For Biofortification

  2005cites this paper
• Folate enhancement in staple crops by metabolic engineering

  2005cites this paper
• Large-Scale Identification of Pathogenicity Factors in Bartonella by Signature-Tagged Mutagenesis

  2005cites this paper
• Structural and functional characterization of a 5,10‐methenyltetrahydrofolate synthetase from Mycoplasma pneumoniae (GI: 13508087)

  2004cites this paper
• 21 – Food fermentation by lactic acid bacteria for the prevention of cardiovascular disease

  2004cites this paper
• Deep- Sea Bacteria and their Biotechnological Potentials

  2004cites this paper
• Cloning, expression, and purification of 5,10-methenyltetrahydrofolate synthetase from Mus musculus.

  2004cites this paper
• The Uniqueness of Tetrahydrofolate Synthesis and One-Carbon Metabolism in Plants

  2004cites this paper
• 5,10-methenyltetrahydrofolate cyclohydrolase, rat liver and chemically catalysed formation of 5-formyltetrahydrofolate.

  2003cites this paper
• Metabolic engineering of folate production in lactic acid bacteria

  2003cites this paper
• Untersuchungen zur Bedeutung verschiedener Enzyme des Glycin-Stoffwechsels für die Riboflavin-Bildung in Ashbya gossypii

  2003cites this paper
• Effects of Cultivation Conditions on Folate Production by Lactic Acid Bacteria

  2003cites this paper
• Methenyltetrahydrofolate Synthetase Regulates Folate Turnover and Accumulation*

  2003cites this paper
• Cloning and Characterization of Mitochondrial 5-Formyltetrahydrofolate Cycloligase from Higher Plants*

  2002cites this paper
• Chapter Two A genomics approach to plant one-carbon metabolism

  2002cites this paper
• Cloning and Characterization of Methenyltetrahydrofolate Synthetase from Saccharomyces cerevisiae *

  2002cites this paper
• Lack of catalytic activity of a murine mRNA cytoplasmic serine hydroxymethyltransferase splice variant: evidence against alternative splicing as a regulatory mechanism.

  2001cites this paper
• BIOCHEMICAL ROLE OF FOLATE IN CELLULAR METABOLISM*

  2001cites this paper
• An examination of polymorphic genes and folate metabolism in mothers affected by a spina bifida pregnancy.

  2001cites this paper