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Current Therapies and New Pharmacologic Targets for Metastatic Melanoma

Claudriana Locatelli,F. Filippin-Monteiro,T. Creczynski‐Pasa

Published 2013 in Unknown venue

ABSTRACT

Malignant melanoma is a tumor that originates from the melanocytes and manifests mainly on the skin. Melanomas are usually strongly pigmented, however amelanotic forms have been observed. Relative to the tumor mass, melanomas have an early tendency to metastasize; the prognosis is therefore poor. Malignant melanoma is responsible for about 90% of skin cancer related mortality [1]. Several risk factors for the development of melanoma have been identi‐ fied. Ethnic origin is particularly important with a disease that mostly affects people of European origin. Epidemiological studies have shown that exposure to the sun, especially in childhood, is a major environmental cause of melanoma, and that up to 65% of the cases of melanoma are frequently related to sunburn [2,3].

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