Inhibition of the Na+/Ca2+ exchanger suppresses torsades de pointes in an intact heart model of long QT syndrome-2 and long QT syndrome-3.

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Heart Rhythm

• Publication date

  2008-10-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1016/j.hrthm.2008.06.017PMID 18929333
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Verapamil prevents torsade de pointes by reduction of transmural dispersion of repolarization and suppression of early afterdepolarizations in an intact heart model of LQT3

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• Excitation–Contraction Coupling in Na+–Ca2+ Exchanger Knockout Mice: Reduced Transsarcolemmal Ca2+ Flux

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• Transmural Heterogeneity of Na+–Ca2+ Exchange: Evidence for Differential Expression in Normal and Failing Hearts

  2005cited by this paper
• Effects of SEA0400, a Na+/Ca2+ exchange inhibitor, on ventricular arrhythmias in the in vivo dogs.

  2005cited by this paper
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  2005cited by this paper
• Effects of SEA0400, a Na[+]/Ca[2+] exchange inhibitor, on ventricular arrhythmias in the in vivo dogs

  2005cited by this paper
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  2005cited by this paper
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  2004cited by this paper
• A mathematical treatment of integrated Ca dynamics within the ventricular myocyte.

  2004cited by this paper
• Selective inhibition of sodium–calcium exchanger by SEA‐0400 decreases early and delayed afterdepolarization in canine heart

  2004cited by this paper
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  2004cited by this paper
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  2004cited by this paper
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  2003cited by this paper
• Effects of Na+/Ca2+ exchange induced by SR Ca2+ release on action potentials and afterdepolarizations in guinea pig ventricular myocytes.

  2003cited by this paper
• Molecular mechanisms underlying the long QT syndrome.

  2002cited by this paper
• Effect of SEA0400, a novel inhibitor of sodium‐calcium exchanger, on myocardial ionic currents

  2002cited by this paper
• Electrophysiologic characterization of the antipsychotic drug sertindole in a rabbit heart model of torsade de pointes: low torsadogenic potential despite QT prolongation.

  2002cited by this paper
• Cellular mechanisms underlying the long QT syndrome.

  2002cited by this paper
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  2002cited by this paper
• Molecular diversity of structure and function of the voltage-gated Na+ channels.

  2002cited by this paper
• Instability and Triangulation of the Action Potential Predict Serious Proarrhythmia, but Action Potential Duration Prolongation Is Antiarrhythmic

  2001cited by this paper
• Long QT Syndrome:

  2000cited by this paper
• Progress in the understanding of cardiac early afterdepolarizations and torsades de pointes: time to revise current concepts.

  2000cited by this paper
• The Long QT Syndrome and Torsade De Pointes

  1999cited by this paper
• Influence of the genotype on the clinical course of the long-QT syndrome. International Long-QT Syndrome Registry Research Group.

  1998cited by this paper
• Experimental models of torsade de pointes.

  1998cited by this paper
• Electrophysiologic Features of Torsades de Pointes:

  1997cited by this paper
• Clinical Management of Patients with the Long QT Syndrome: Drugs, Devices, and Gene‐Specific Therapy

  1997cited by this paper
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  1997cited by this paper
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  1995cited by this paper
• Mexiletine antagonizes effects of sotalol on QT interval duration and its proarrhythmic effects in a canine model of torsade de pointes.

  1995cited by this paper
• Clinical relevance of cardiac arrhythmias generated by afterdepolarizations. Role of M cells in the generation of U waves, triggered activity and torsade de pointes.

  1994cited by this paper
• The relationship between charge movements associated with ICa and INa-Ca in cardiac myocytes.

  1990cited by this paper
• Two components of cardiac delayed rectifier K+ current. Differential sensitivity to block by class III antiarrhythmic agents

  1990cited by this paper
• Drug-induced torsades de pointes: role of early afterdepolarizations and dispersion of repolarization.

  1990cited by this paper

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  2026cites this paper
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• Inhibiting NCX delays the early onset of Ca2+ alternans in myocytes from spontaneously hypertensive rats (SHR).

  2025cites this paper
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  2025cites this paper
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  2025cites this paper
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  2024cites this paper
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  2024cites this paper
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  2021cites this paper
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  2021cites this paper
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  2021cites this paper
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