A meta-analysis on association of CYP2E1 rs2031920 and rs3813867 polymorphisms with breast cancer risk

Breast cancer remains a challenging disease globally due to its heterogeneity and complexity, with an annual increase rate of 3.1%. Cytochrome P450 2E1 (CYP2E1) rs2031920 and rs3813867 polymorphisms that reside in the 5’-flanking promoter region of the gene are in a complete linkage disequilibrium and have been associated with breast cancer risk, but the findings are inconsistent and inconclusive. Therefore, we investigated the association of the CYP2E1 rs2031920 and rs3813867 polymorphisms with the risk of breast cancer through a meta-analysis. After literature search, eight eligible studies were included in this meta-analysis with a total of 3650 breast cancer cases and 3607 controls. Our meta-analysis revealed no significant association of the CYP2E1 rs2031920 and rs3813867 polymorphisms with breast cancer risk in all comparison models including the allelic (OR = 0.968, 95% CI = 0.855-1.097; p = 0.612), heterozygous (OR = 1.003, 95% CI = 0.869-1.159; p = 0.963), homozygous (OR = 0.792, 95% CI = 0.519-1.207; p = 0.278), dominant (OR = 0.987, 95% CI = 0.858-1.134; p = 0.851), and recessive (OR = 1.265, 95% CI = 0.831-1.924; p = 0.273). In conclusion, this meta-analysis suggests that the CYP2E1 rs2031920 and rs3813867 polymorphisms are not associated with the risk of breast cancer.

• Publication year

  2018

• Venue

  Asia-Pacific Journal of Molecular Biology and Biotechnology

• Publication date

  2018-11-15

• Fields of study

  Medicine

• Identifiers
  DOI 10.35118/APJMBB.2018.026.2.02
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Exposure to multiple sources of polycyclic aromatic hydrocarbons and breast cancer incidence.

  2016cited by this paper
• Lifetime grain consumption and breast cancer risk

  2016cited by this paper
• Association of CYP2E1, STK15 and XRCC1 Polymorphisms with Risk of Breast Cancer in Malaysian Women.

  2016cited by this paper
• Red meat, poultry, and fish intake and breast cancer risk among Hispanic and Non-Hispanic white women: The Breast Cancer Health Disparities Study

  2016cited by this paper
• Abstract 1276: Red meat, poultry, and fish intake, genetic risk variants, and breast cancer risk among Hispanic and non-Hispanic white women: Results from the Breast Cancer Health Disparities Study

  2014cited by this paper
• Genetic polymorphisms of CYP2E1, GST, and NAT2 enzymes are not associated with risk of breast cancer in a sample of Lebanese women.

  2013cited by this paper
• Cytochrome P450 2E1 (CYP2E1) regulates the response to oxidative stress and migration of breast cancer cells

  2013cited by this paper
• Alcohol, genetics and risk of breast cancer in the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial

  2012cited by this paper
• Passive cigarette smoke exposure during various periods of life, genetic variants, and breast cancer risk among never smokers.

  2012cited by this paper
• Breast and cervical cancer in 187 countries between 1980 and 2010: a systematic analysis.

  2011cited by this paper
• VARIOUS TYPES AND MANAGEMENT OF BREAST CANCER: AN OVERVIEW

  2010cited by this paper
• Genetic polymorphisms in folate and alcohol metabolism and breast cancer risk: a case–control study in Thai women

  2010cited by this paper
• Practice of Epidemiology Hardy-Weinberg Equilibrium Testing of Biological Ascertainment for Mendelian Randomization Studies

  2009cited by this paper
• Genetic Polymorphism of Metabolic Enzymes P450 (CYP) as a Susceptibility Factor for Drug Response, Toxicity, and Cancer Risk

  2009cited by this paper
• Implication of Xenobiotic Metabolizing Enzyme gene (CYP2E1, CYP2C19, CYP2D6, mEH and NAT2) Polymorphisms in Breast Carcinoma

  2008cited by this paper
• Interaction of genetic polymorphisms in cytochrome P450 2E1 and glutathione S-transferase M1 to breast cancer in Taiwanese woman without smoking and drinking habits

  2006cited by this paper
• Association of CYP2E1 gene polymorphism with predisposition to cancer development.

  2005cited by this paper
• Role of alcohol and genetic polymorphisms of CYP2E1 and ALDH2 in breast cancer development.

  2003cited by this paper
• Environmental and heritable factors in the causation of cancer--analyses of cohorts of twins from Sweden, Denmark, and Finland.

  2000cited by this paper
• Can alcohol promote aromatization of androgens to estrogens? A review.

  2000cited by this paper
• Alcohol-induced breast cancer: a proposed mechanism.

  1999cited by this paper
• Bias in meta-analysis detected by a simple, graphical test

  1997cited by this paper
• Operating characteristics of a rank correlation test for publication bias.

  1994cited by this paper
• Different regulation and expression of the human CYP2E1 gene due to the RsaI polymorphism in the 5'-flanking region.

  1994cited by this paper
• Genetic polymorphisms in the 5'-flanking region change transcriptional regulation of the human cytochrome P450IIE1 gene.

  1991cited by this paper
• PstI and RsaI RFLPs in complete linkage disequilibrium at the CYP2E gene.

  1990cited by this paper
• Meta-analysis in clinical trials.

  1986cited by this paper
• Statistical aspects of the analysis of data from retrospective studies of disease.

  1959cited by this paper

• No citing papers are available for this paper.