Epigenetic Mechanisms in Liver and Pancreas Generation and Regeneration

Abstract The liver and pancreas are fundamental organs of multicellular organisms. The severity and occurrence of diseases due to hepatic and pancreatic malfunction necessitates an understanding of mechanisms of gene regulation and dysregulation. This review describes how transcription factors and dynamics in the epigenetic landscape affect liver and pancreatic cell identity and physiological function during homeostasis and regenerative responses to disease and environmental insults. Understanding the intricate connection of genetics, epigenetics, and environmental cues, in both homeostatic and altered conditions, will provide a roadmap to develop targeted therapeutic strategies to combat liver and pancreas dysfunction.

• Publication year

  2019

• Venue

  Epigenetics and Regeneration

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/B978-0-12-814879-2.00010-8
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

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