Cyclooxygenase Isozymes: The Biology of Prostaglandin Synthesis and Inhibition

No abstract is available for this paper.

• Publication year

  2004

• Venue

  Pharmacological Reviews

• Publication date

  2004-09-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1124/pr.56.3.3PMID 15317910
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Efficacy and Tolerability of Nimesulide in Asthmatic Patients Intolerant to Aspirin

  2012cited by this paper
• Nimesulide Binding to Components within Blood

  2012cited by this paper
• A comparison of the effects of prostacyclin and the 15 (S), 15-methyl analogs of PGE2 and PGF2α on gastric parietal and nonparietal secretion

  2005cited by this paper
• On the Evolutionary Origin of Cyclooxygenase (COX) Isozymes

  2004cited by this paper
• Meta-analysis of three double-blind comparative trials with sustained-release etodolac in the treatment of osteoarthritis of the knee

  2004cited by this paper
• Tristetraprolin Binds to the 3′-Untranslated Region of Cyclooxygenase-2 mRNA

  2003cited by this paper
• Regulation of COX-2 expression in human cancers.

  2003cited by this paper
• Effects of acetaminophen on constitutive and inducible prostanoid biosynthesis in human blood cells

  2003cited by this paper
• Non-steroidal anti-inflammatory drugs and molecular carcinogenesis of colorectal carcinomas

  2003cited by this paper
• Leptomycin B, an Inhibitor of the Nuclear Export Receptor CRM1, Inhibits COX-2 Expression*

  2003cited by this paper
• A randomized trial of aspirin to prevent colorectal adenomas.

  2003cited by this paper
• Genetic variation in cyclooxygenase 1: Effects on response to aspirin

  2003influential reference
• COX-1/COX-2

  2003cited by this paper
• Specific roles of cyclooxygenase‐1 and cyclooxygenase‐2 in lipopolysaccharide‐induced fever and fos expression in rat brain

  2003cited by this paper
• Amino acid determinants in cyclooxygenase-2 oxygenation of the endocannabinoid anandamide.

  2003cited by this paper
• A randomized, double-blind, placebo-controlled trial of the effects of rofecoxib, a selective cyclooxygenase-2 inhibitor, on rectal polyps in familial adenomatous polyposis patients.

  2003cited by this paper
• Cyclooxygenase-1-coupled prostaglandin biosynthesis constitutes an essential prerequisite for skin repair.

  2003cited by this paper
• A randomized trial of aspirin to prevent colorectal adenomas in patients with previous colorectal cancer.

  2003cited by this paper
• Epidemiology of non-steroidal anti-inflammatory drugs and cancer.

  2003cited by this paper
• Paracetamol effectively reduces prostaglandin E2 synthesis in brain macrophages by inhibiting enzymatic activity of cyclooxygenase but not phospholipase and prostaglandin E synthase

  2003cited by this paper
• Variants of cyclooxygenase-1 and their roles in medicine.

  2003cited by this paper
• Methanandamide increases COX‐2 expression and tumor growth in murine lung cancer

  2003cited by this paper
• Ceramide is involved in r(+)-methanandamide-induced cyclooxygenase-2 expression in human neuroglioma cells.

  2003cited by this paper
• Meloxicam and selective COX-2 inhibitors in the management of pain in the palliative care population

  2003cited by this paper
• Association of a promoter variant in the inducible cyclooxygenase-2 gene (PTGS2) with type 2 diabetes mellitus in Pima Indians

  2003influential reference
• Daily soluble aspirin and prevention of colorectal adenoma recurrence: one-year results of the APACC trial.

  2003cited by this paper
• Expression of cyclooxygenase-2 in rat testis.

  2003influential reference
• COX-3: in the wrong frame in mind.

  2003cited by this paper
• Cooperation of cyclooxygenase 1 and cyclooxygenase 2 in intestinal polyposis.

  2003cited by this paper
• The RNA-binding Protein HuR Regulates the Expression of Cyclooxygenase-2*

  2003cited by this paper
• Identification and characterization of a cyclooxygenase-like enzyme from Entamoeba histolytica

  2003cited by this paper
• Inhibition of Prostaglandin H2 Synthases by Salicylate Is Dependent on the Oxidative State of the Enzymes

  2003cited by this paper
• Expression of Cyclooxygenase-1 and -2 in Human Breast Cancer

  2003cited by this paper
• The gastrointestinal safety of the COX-2 selective inhibitor etoricoxib assessed by both endoscopy and analysis of upper gastrointestinal events

  2003cited by this paper
• The structures of prostaglandin endoperoxide H synthases-1 and -2.

  2002cited by this paper
• Mouse skin as a model for cancer chemoprevention by nonsteroidal anti-inflammatory drugs.

  2002cited by this paper
• Degradation or Maintenance: Actions of the Ubiquitin System on Eukaryotic Chromatin

  2002cited by this paper
• Susceptibility of cyclooxygenase-2-deficient mice to pulmonary fibrogenesis.

  2002cited by this paper
• Renal pathology resulting from PGHS-2 gene ablation in DBA/B6 mice.

  2002cited by this paper
• A randomised, double blind, placebo controlled study of celecoxib, a selective cyclooxygenase 2 inhibitor, on duodenal polyposis in familial adenomatous polyposis

  2002cited by this paper
• Simultaneous detection of CpG methylation and single nucleotide polymorphism by denaturing high performance liquid chromatography.

  2002cited by this paper
• Cyclooxygenase-2 polymorphism: putting a brake on the inflammatory response to vascular injury?

  2002cited by this paper
• 15-deoxy-delta 12,14-prostaglandin J2. A prostaglandin D2 metabolite generated during inflammatory processes.

  2002cited by this paper
• Metabolism of the Endocannabinoids, 2-Arachidonylglycerol and Anandamide, into Prostaglandin, Thromboxane, and Prostacyclin Glycerol Esters and Ethanolamides*

  2002cited by this paper
• Prostaglandin H synthase 2 variant (Val511Ala) in African Americans may reduce the risk for colorectal neoplasia.

  2002influential reference
• A collection of 33 novel human mtDNA homoplasmic variants

  2002cited by this paper
• Lack of CD34 positive stromal cells within angiomyomas (vascular leiomyomas).

  2002cited by this paper
• Differential binding mode of diverse cyclooxygenase inhibitors.

  2002cited by this paper
• Functional coupling between phospholipase A2S and cyclooxygenases in immediate and delayed prostanoid biosynthetic pathways.

  2002cited by this paper
• COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: Cloning, structure, and expression

  2002influential reference
• Determinants of the cellular specificity of acetaminophen as an inhibitor of prostaglandin H2 synthases

  2002cited by this paper
• Common Promoter Variant in Cyclooxygenase-2 Represses Gene Expression: Evidence of Role in Acute-Phase Inflammatory Response

  2002cited by this paper
• Prostaglandin E(2) protects intestinal tumors from nonsteroidal anti-inflammatory drug-induced regression in Apc(Min/+) mice.

  2002cited by this paper
• Nonsteroidal anti-inflammatory drugs as anticancer agents: mechanistic, pharmacologic, and clinical issues.

  2002influential reference
• Control of Prostaglandin Stereochemistry at the 15-Carbon by Cyclooxygenases-1 and -2

  2002influential reference
• Cyclooxygenase 1 (COX1) polymorphisms in African‐American and caucasian populations

  2002cited by this paper
• Prostaglandin E2 Protects Intestinal Tumors from Nonsteroidal Anti-inflammatory Drug-induced Regression in ApcMin/+ Mice

  2002cited by this paper
• Lumiracoxib (Novartis).

  2002cited by this paper
• Diverse functional coupling of cyclooxygenase 1 and 2 with final prostanoid synthases in liver macrophages.

  2002influential reference
• Prostaglandin E synthase.

  2002cited by this paper
• Hepatotoxicity associated with nimesulide: data from the Spanish Pharmacovigilance System.

  2002cited by this paper
• A multicenter, randomized, controlled trial to evaluate the safety profile, tolerability, and efficacy of rofecoxib in advanced elderly patients with osteoarthritis

  2001cited by this paper
• Cancer research. Anti-inflammatories inhibit cancer growth--but how?

  2001cited by this paper
• Cyclooxygenase-2 upregulation as a perigenetic change in carcinogenesis.

  2001cited by this paper
• Discovery and design of selective cyclooxygenase-2 inhibitors as non-ulcerogenic, anti-inflammatory drugs with potential utility as anti-cancer agents.

  2001cited by this paper
• Efficacy and tolerability of celecoxib versus hydrocodone/acetaminophen in the treatment of pain after ambulatory orthopedic surgery in adults.

  2001cited by this paper
• Non-steroidal anti-inflammatory drugs protect against chondrocyte apoptotic death.

  2001cited by this paper
• The coxibs, selective inhibitors of cyclooxygenase-2.

  2001cited by this paper
• Prostaglandin E2 Increases Growth and Motility of Colorectal Carcinoma Cells*

  2001cited by this paper
• Induction of endothelial cell cytoplasmic lipid bodies during hypoxia.

  2001cited by this paper
• Arachidonyl trifluoromethyl ketone induces lipid body formation in leukocytes.

  2001cited by this paper
• The selective cyclooxygenase‐2 inhibitor rofecoxib reduces kainate‐induced cell death in the rat hippocampus

  2001cited by this paper
• Functional characterization of cyclooxygenase-2 polymorphisms.

  2001cited by this paper
• Cyclooxygenase and Alzheimer's disease: implications for preventive initiatives to slow the progression of clinical dementia.

  2001cited by this paper
• Cyclooxygenase-2: a novel target for cancer chemotherapy?

  2001cited by this paper
• Coupling between Cyclooxygenase, Terminal Prostanoid Synthase, and Phospholipase A2 *

  2001cited by this paper
• Inflammatory response: Pathway across the blood–brain barrier

  2001influential reference
• Genetic disruption of PPARdelta decreases the tumorigenicity of human colon cancer cells.

  2001cited by this paper
• The Cycloxygenase-2 inhibitor SC58236 is neuroprotective in an in vivo model of focal ischemia in the rat.

  2001cited by this paper
• Colocalization and Interaction of Cyclooxygenase-2 with Caveolin-1 in Human Fibroblasts*

  2001influential reference
• Failure of ductus arteriosus closure and remodeling in neonatal mice deficient in cyclooxygenase-1 and cyclooxygenase-2.

  2001influential reference
• Efficacy of single-dose and multidose rofecoxib in the treatment of post-orthopedic surgery pain.

  2001cited by this paper
• Abnormal differentiation of epidermis in transgenic mice constitutively expressing cyclooxygenase-2 in skin

  2001cited by this paper
• Rat colorectal tumours treated with a range of non-steroidal anti-inflammatory drugs show altered cyclooxygenase-2 and cyclooxygenase-1 splice variant mRNA expression levels.

  2001cited by this paper
• Overexpression of Cyclooxygenase-2 Is Sufficient to Induce Tumorigenesis in Transgenic Mice*

  2001influential reference
• Extranuclear Lipid Bodies, Elicited by CCR3-mediated Signaling Pathways, Are the Sites of Chemokine-enhanced Leukotriene C4 Production in Eosinophils and Basophils*

  2001cited by this paper
• Structural analysis of NSAID binding by prostaglandin H2 synthase: time-dependent and time-independent inhibitors elicit identical enzyme conformations.

  2001cited by this paper
• Mechanism of acetaminophen inhibition of cyclooxygenase isoforms.

  2001cited by this paper
• Neuronal cyclooxygenase 2 expression in the hippocampal formation as a function of the clinical progression of Alzheimer disease.

  2001cited by this paper
• Cyclooxygenase inhibitors--current status and future prospects.

  2001cited by this paper
• The origin of 15R-prostaglandins in the Caribbean coral Plexaura homomalla: Molecular cloning and expression of a novel cyclooxygenase

  2001cited by this paper
• Etoricoxib (MK-0663): preclinical profile and comparison with other agents that selectively inhibit cyclooxygenase-2.

  2001influential reference
• Risk of cardiovascular events associated with selective COX-2 inhibitors.

  2001cited by this paper
• Characterization of the glycosylation sites in cyclooxygenase-2 using mass spectrometry.

  2001cited by this paper
• Interleukin-1β-mediated induction of Cox-2 in the CNS contributes to inflammatory pain hypersensitivity

  2001cited by this paper
• Prostaglandin Endoperoxide H Synthase-1

  2001influential reference
• Increased expression of the pro‐inflammatory enzyme cyclooxygenase‐2 in amyotrophic lateral sclerosis

  2001cited by this paper
• Reduced susceptibility to ischemic brain injury and N-methyl-D-aspartate-mediated neurotoxicity in cyclooxygenase-2-deficient mice.

  2001cited by this paper
• The prostaglandin E2 EP1 receptor mediates pain perception and regulates blood pressure.

  2001cited by this paper
• Asexual reproduction: 'Midwives' assist dividing amoebae

  2001cited by this paper

• TGF-β1 and Estradiol Modulate Prostaglandin Concentrations and Related Gene Expression in Equine Endometrium during the Follicular Phase.

  2026cites this paper
• Enabling Anti-inflammatory Activity through Hyaluronan-coated PLGA Nanoparticles Loaded with Carvacrol.

  2026cites this paper
• Signaling lipids: Molecular targets for targeted therapies.

  2026cites this paper
• Lipidomics in Melanoma: Insights into Disease Progression and Therapeutical Targets

  2026cites this paper
• COX-2 downregulation via G-quadruplex structure induction in the PTGS2-promoter region by mononuclear octahedral cobalt(III) Schiff base complex [CoL3] in colorectal cancer cells.

  2026cites this paper
• COX‑2 rs20417 polymorphism and susceptibility to type 2 diabetes mellitus

  2026cites this paper
• The Role of Prostaglandins as Major Inflammatory Mediators in Colorectal Cancer

  2025cites this paper
• Substituted aryl piperazine ligands as new dual 5-hLOX/COX-2 inhibitors. Synthesis, biological and computational studies.

  2025cites this paper
• Hepatotoxicity of Phytolacca acinosa Roxb mediated by phytolaccagenin via ferroptosis/PPAR/P53/arachidonic acid metabolism.

  2025cites this paper
• Intramammary lipopolysaccharide infusion alters the fatty acid composition of blood lipid fractions but not milk in dairy cows

  2025cites this paper
• Effects of increasing the dietary contents of metabolizable energy and protein during the peripartum period on mammary gland development in Sistani goats

  2025cites this paper
• Lipopolysaccharide-Induced Inflammatory Response and Its Prominent Suppression by Paspalum thunbergii Extract

  2025influential citation
• Yeokwisan: Standardised Herbal Formula Enhancing Gastric Mucosal Protection Against Gastric Ulcers in Mice, a Preclinical Study

  2025cites this paper
• Ameliorative effects of piroxicam on anthracene-induced lung toxicity in female Rattus norvegicus

  2025cites this paper
• Alkylglycerol monooxygenase represses prostanoid biosynthesis in a sex-dependent manner

  2025cites this paper
• The role of inflammation in colorectal Cancer and the preventive potential of natural compounds

  2025cites this paper
• Effects of Sodium Diclofenac on Daphnia magna: Growth, Locomotion, Heartbeat and Risk Assessment

  2025cites this paper
• A comprehensive review of peptic ulcer disease: epidemiology, experimental models, and mechanistic insights

  2025cites this paper
• Moringa oleifera as a multifunctional feed additive: synergistic nutritional and immunomodulatory mechanisms in livestock production

  2025cites this paper
• Chemoproteomics identifies protein ligands for monoacylglycerol lipids

  2025influential citation
• The Phenotypical and Functional Effect of PGE2 on Human Macrophages

  2025cites this paper
• Evaluation of Polmacoxib 2 mg for the Management of Hip and Knee Osteoarthritis: A Prospective, Single-Arm, Multicenter, Open-Label Study

  2025cites this paper
• Synthesis and investigation of substituted 1,5-diaryl-1H-1,2,4-triazoles for the discovery of 18F-labeled probes for imaging brain cyclooxygenase-1.

  2025cites this paper
• Rosmarinus officinalis L. as Fascinating Source of Potential Anticancer Agents Targeting Aromatase and COX-2: An Overview

  2025cites this paper
• Distinct roles of PGE2 signaling via EP2 and EP4 in circulating pDCs: implications for immune modulation in the tumor microenvironment.

  2025cites this paper
• Reversible posterior encephalopathy syndrome and metamizole: a new pharmacological precipitant?

  2025cites this paper
• Regulatory effect of inflammatory mediators in spinal cord injury

  2025cites this paper
• Marine Phytoplankton Bioactive Lipids and Their Perspectives in Clinical Inflammation

  2025cites this paper
• Design, synthesis, and evaluation of carboxylic acid-substituted celecoxib isosteres as potential anti-inflammatory agents.

  2025cites this paper
• Hormonal regulation of labor: a review of physiological mechanisms and diagnostic capabilities

  2025cites this paper
• Single-Dose Pharmacokinetics of Grapiprant in Rhesus Macaques (Macaca mulatta)

  2025cites this paper
• Prostaglandin E2 alleviates inflammatory response and lung injury through EP4/cAMP/IKK/NF-κB pathway.

  2025cites this paper
• Acquired resistance to jadomycin B in human triple-negative breast cancer cells is associated with increased cyclooxygenase-2 expression

  2025cites this paper
• The tumor suppressor role and epigenetic regulation of 15-hydroxyprostaglandin dehydrogenase (15-PGDH) in cancer and tumor microenvironment (TME).

  2025cites this paper
• From chronic obstructive pulmonary disease (COPD) to lung cancer: a Mendelian randomization study revealing mediation pathways through plasma metabolomics, proteomics, and immunophenotyping

  2025cites this paper
• Elevated NGF provokes decidual lipid peroxidation and promotes preterm birth in mice

  2025cites this paper
• Updates in clinical trial-explored chemopreventive agents for cutaneous melanoma: mechanisms affecting melanocytes

  2025cites this paper
• Discovery of small molecules with anthelmintic potential in the Medicines for Malaria Venture’s COVID and Global Health Priority Boxes using an infrared-based assay for Caenorhabditis elegans motility

  2025cites this paper
• Platelet activation, aspirin, and cancer: From basic science to clinical trials.

  2025cites this paper
• Neuroinflammation: Mechanisms, Dual Roles, and Therapeutic Strategies in Neurological Disorders

  2025cites this paper
• SPB-201 Alleviates Indomethacin-Induced Gastric Damage in Rats through Its Antioxidant, Anti-inflammatory, and Pro-angiogenic Properties

  2025cites this paper
• Reprogramming Inflammation: Mechanisms and Therapeutic Targeting of Eicosanoids and Pro-Resolving Mediators.

  2025cites this paper
• Anti-Inflammatory Activity of 1,2-Benzothiazine 1,1-Dioxide Derivatives

  2025cites this paper
• Pharmacokinetics of carprofen in Siamese crocodiles (Crocodylus siamensis).

  2025cites this paper
• Trifluoromethyl–pyrazole–carboxamides as COX inhibitors: synthesis, microed structural analysis, computational profiling, and biological evaluation

  2025cites this paper
• Synthesis and in silico studies of novel thiophene-celecoxib hybrid with excellent cardiotoxicity and nephrotoxicity safety profiles.

  2025cites this paper
• Acute alkalinity stress induces functional damage and alters immune metabolic pathways in the gill tissue of spotted scat (Scatophagus argus)

  2025cites this paper
• Ibuprofen, Flurbiprofen or Naproxen Sodium Minimally Influences Musculoskeletal Adaptations to Treadmill Exercise in Rats

  2025cites this paper
• Design and synthesis of new 1,4-naphthoquinones appended sulfenylated thiazoles as cyclooxygenase II inhibitors: Exploring the utility in the development of anticancer agents.

  2025cites this paper
• A rationale approach in developing proline based small peptide as U-shaped analogues of arachidonic acid: Dual inhibitors of cyclooxygenase-2 and 5-lipoxygenase for developing anti-inflammatory agents.

  2025cites this paper
• INTERACTION OF PARACETAMOL, PROPYPHENAZONE AND THEIR COMPLEXES WITH CYCLOOXYGENASE ISOFORMS: A MOLECULAR DOCKING APPROACH

  2025cites this paper
• Astaxanthin enhances antioxidant capacity to alleviate thermal stress-induced liver inflammation in largemouth bass (Micropterus salmoides): a multi-omics insight into glutathione metabolism remodeling

  2025cites this paper
• Molecular docking of flavonoids from Phaleria macrocarpa on the NF-kB p65, VEGFR2, Ki67, COX-2, and CXCR4 pathways in endometriosis

  2025cites this paper
• Acetylsalicylic acid aggravates anaphylaxis in a PGE2-dependent manner

  2025cites this paper
• Protein Kinase A regulates Cyclooxygenase-2 expression through the RNA-binding proteins HuR and TTP.

  2025cites this paper
• Anticancer, anti-inflammatory and antioxidant potential of Schiff base-functionalized 1,2-benzothiazine derivatives

  2025cites this paper
• Clinical and radiological insights into fibrodysplasia ossificans progressiva: A report on two cases.

  2024cites this paper
• Prostaglandin pathways in equine myometrium regulations: endometrosis progression

  2024cites this paper
• Polmacoxib 2mg in patients with mild to moderate idiopathic osteoarthritis of hip/knee-a randomized, double-anonymous study.

  2024cites this paper
• Prostaglandin E2 regulates senescence and post-senescence neoplastic escape in primary human keratinocytes

  2024cites this paper
• Modular Assembly of Heterotrifunctional Molecules Enabled by Iodosulfonylation of Allenes and Subsequent Amination.

  2024cites this paper
• Drug-Induced Liver Toxicity

  2024cites this paper
• Emerging COX-2 inhibitors-based nanotherapeutics for cancer diagnosis and treatment.

  2024cites this paper
• The Benzoxazole Heterocycle: A Comprehensive Review of the Most Recent Medicinal Chemistry Developments of Antiproliferative, Brain-Penetrant, and Anti-inflammatory Agents

  2024cites this paper
• Development of a selective COX-2 inhibitor: from synthesis to enhanced efficacy via nano-formulation

  2024cites this paper
• Renal injury in NSAIDs: a real-world analysis based on the FAERS database

  2024cites this paper
• Dispelling Stasis and Detoxification Method based on COX-2/PGE2 Pathway

  2024cites this paper
• Combination of Metabolomics, Lipidomics, and Molecular Biology for the Investigation of the Metabolic Disturbance of Short-Term Administration of Emodin.

  2024cites this paper
• In-silico based Designing of benzo[d]thiazol-2-amine Derivatives as Anal-gesic and Anti-inflammatory Agents.

  2024cites this paper
• Identification of a Novel Ibuprofen Biotransformation Pathway in Streptomyces sp. D218 and Detoxification as Indicated by the Green Algae Scenedesmus obliquus.

  2024cites this paper
• The role of Pim-1 kinases in inflammatory signaling pathways

  2024cites this paper
• NSAIDs between past and present; a long journey towards an ideal COX-2 inhibitor lead

  2024cites this paper
• Cyclooxygenase-2 (COX-2)-dependent mechanisms mediate sleep responses to microbial and thermal stimuli.

  2024cites this paper
• The role of the cyclooxygenase-2 pathway in tissue ischemia and revascularization following skeletal muscle injury induced by bothropic snake venom.

  2024cites this paper
• A drug repurposing screen reveals dopamine signaling as a critical pathway underlying potential therapeutics for the rare disease DPAGT1-CDG

  2024cites this paper
• Comparison of serum levels of IL-10 and IL-11 and mRNA expression of IL-10, IL-11, COX-2, BCL6, and ZEB Family in peripheral blood mononuclear cells (PBMC) of women with polycystic ovary syndrome and healthy individuals.

  2024cites this paper
• Causal relationship between anti-inflammatory drugs and cancer: a pan-cancer study with Mendelian randomization

  2024cites this paper
• Astrocyte atrophy induced by L-PGDS/PGD2/Src signaling dysfunction in the central amygdala mediates postpartum depression.

  2024cites this paper
• Fused Thienopyrimidines as Versatile Pharmacophores for the Development of Cyclooxygenase‐2 Inhibitors

  2024cites this paper
• Development of Cytotoxic GW7604-Zeise’s Salt Conjugates as Multitarget Compounds with Selectivity for Estrogen Receptor- Positive Tumor Cells

  2024cites this paper
• Epoxidase inhibitor-aspirin resistance and the relationship with genetic polymorphisms: a review

  2024cites this paper
• Inside the genome: understanding genetic influences on oxidative stress

  2024cites this paper
• Imidazo[1,2‐α] azine's esters increase selectivity and anti‐inflammatory activity in microglial cells

  2024cites this paper
• Lysophosphatidylserine: A Signaling Lipid with Implications in Human Diseases.

  2024cites this paper
• NSAIDs do not prevent exercise-induced performance deficits or alleviate muscle soreness: A placebo-controlled randomized, double-blinded, cross-over study.

  2024cites this paper
• Anti-Inflammatory Effects of Hydroethanolic Extract from Ehretia asperula on Lipopolysaccharide-Stimulated RAW264.7 Macrophages

  2024cites this paper
• Anti-rheumatic property and physiological safety of KMU-11342 in in vitro and in vivo models

  2024cites this paper
• Treponema pallidum protein Tp47 induced prostaglandin E2 to inhibit the phagocytosis in human macrophages

  2024cites this paper
• The dose-response effects of flurbiprofen, indomethacin, ibuprofen, and naproxen on primary skeletal muscle cells

  2024cites this paper
• EP2 and EP4 blockade prevents tumor-induced suppressive features in human monocytic myeloid-derived suppressor cells

  2024cites this paper
• The importance of cyclooxigenase in dentistry

  2024cites this paper
• Development of safe and antioxidant COX-2 inhibitors; Synthesis, molecular docking analysis and biological evaluation of novel pyrrolizine 5-carboxamides.

  2024cites this paper
• Ibuprofen-induced multiorgan malformation during embryogenesis in Xenopus laevis (FETAX).

  2024cites this paper
• Seagrass as a potential nutraceutical to decrease pro-inflammatory markers

  2024cites this paper
• Black soldier fly larvae meal as a potential modulator of immune, inflammatory, and antioxidant status in gilthead seabream juveniles.

  2024cites this paper
• Effect of arachidonic acid on pre- and post-hatching in vitro bovine embryo development.

  2023cites this paper
• Embryo-derive TNF promotes decidualization via fibroblast activation

  2023cites this paper
• Pain Management in Children Admitted to the Emergency Room: A Narrative Review

  2023cites this paper
• Cyclooxygenases and platelet functions.

  2023cites this paper
• Development of an electrochemical cyclooxygenase biosensor to evaluate target–drug viability and interactions

  2023cites this paper