Ultra-low dose naloxone restores the antinociceptive effect of morphine in pertussis toxin-treated rats and prevents glutamate transporter downregulation by suppressing the p38 mitogen-activated protein kinase signaling pathway.

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Neuroscience

• Publication date

  2009-04-10

• Fields of study

  Medicine

• Identifiers
  DOI 10.1016/j.neuroscience.2009.01.058PMID 19409222
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Inflammation, Glutamate, and Glia in Depression: A Literature Review

  2008cited by this paper
• Ultra-Low-Dose Naloxone Restores the Antinociceptive Effect of Morphine and Suppresses Spinal Neuroinflammation in PTX-Treated Rats

  2008cited by this paper
• Neurotransmitter receptors on microglia.

  2007cited by this paper
• p38 MAPK, microglial signaling, and neuropathic pain

  2007cited by this paper
• Kynurenine pathway in major depression: evidence of impaired neuroprotection.

  2007cited by this paper
• Memantine protects against LPS-induced neuroinflammation, restores behaviorally-induced gene expression and spatial learning in the rat.

  2006cited by this paper
• Amitriptyline suppresses neuroinflammation and up‐regulates glutamate transporters in morphine‐tolerant rats

  2006cited by this paper
• Morphine, gabapentin, or their combination for neuropathic pain.

  2005cited by this paper
• Inhibition of p38 mitogen‐activated protein kinase attenuates interleukin‐1β‐induced thermal hyperalgesia and inducible nitric oxide synthase expression in the spinal cord

  2005cited by this paper
• Ultra-low-dose naloxone suppresses opioid tolerance, dependence and associated changes in mu opioid receptor-G protein coupling and Gbetagamma signaling.

  2005cited by this paper
• Effects of naltrexone on lipopolysaccharide-induced sepsis in rats.

  2005cited by this paper
• Ultra-low-dose naloxone suppresses opioid tolerance, dependence and associated changes in mu opioid receptor–G protein coupling and Gβγ signaling

  2005cited by this paper
• Role of Mitogen-Activated Protein Kinase Activation in Injured and Intact Primary Afferent Neurons for Mechanical and Heat Hypersensitivity after Spinal Nerve Ligation

  2004cited by this paper
• The opioid antagonist naltrexone blocks acute endotoxic shock by inhibiting tumor necrosis factor-alpha production.

  2004cited by this paper
• Activation of p38 mitogen‐activated protein kinase in spinal hyperactive microglia contributes to pain hypersensitivity following peripheral nerve injury

  2004cited by this paper
• The opioid antagonist naltrexone blocks acute endotoxic shock by inhibiting tumor necrosis factor-α production☆

  2004cited by this paper
• A Role for Proinflammatory Cytokines and Fractalkine in Analgesia, Tolerance, and Subsequent Pain Facilitation Induced by Chronic Intrathecal Morphine

  2004cited by this paper
• p38 Mitogen-Activated Protein Kinase Is Activated after a Spinal Nerve Ligation in Spinal Cord Microglia and Dorsal Root Ganglion Neurons and Contributes to the Generation of Neuropathic Pain

  2003cited by this paper
• Intrathecal pertussis toxin induces thermal hyperalgesia: involvement of excitatory and inhibitory amino acids.

  2003cited by this paper
• Spinal p38 MAP kinase is necessary for NMDA-induced spinal PGE2 release and thermal hyperalgesia

  2003cited by this paper
• Neuroprotection of naloxone against ischemic injury in rats: role of mu receptor antagonism.

  2003cited by this paper
• Inhibition of Microglial Activation Attenuates the Development but Not Existing Hypersensitivity in a Rat Model of Neuropathy

  2003cited by this paper
• Role of Microglia in Inflammation-Mediated Neurodegenerative Diseases: Mechanisms and Strategies for Therapeutic Intervention

  2003cited by this paper
• Activation of p38 MAP kinase in the rat dorsal root ganglia and spinal cord following peripheral inflammation and nerve injury

  2002cited by this paper
• The Role of Spinal Neuroimmune Activation in Morphine Tolerance/Hyperalgesia in Neuropathic and Sham-Operated Rats

  2002cited by this paper
• Phosphorylation of Extracellular Signal-Regulated Kinase in Primary Afferent Neurons by Noxious Stimuli and Its Involvement in Peripheral Sensitization

  2002cited by this paper
• In the Cellular Garden of Forking Paths: How p38 MAPKs Signal for Downstream Assistance

  2002cited by this paper
• IL-10-Deficient B10.Q Mice Develop More Severe Collagen-Induced Arthritis, but Are Protected from Arthritis Induced with Anti-Type II Collagen Antibodies

  2002cited by this paper
• Paradoxical effects of the opioid antagonist naltrexone on morphine analgesia, tolerance, and reward in rats.

  2002cited by this paper
• Mitogen-Activated Protein Kinase Pathways Mediated by ERK, JNK, and p38 Protein Kinases

  2002cited by this paper
• Loss of intrathecal morphine analgesia in terminal cancer patients is associated with high levels of excitatory amino acids in the CSF

  2002cited by this paper
• Inhibition by Naloxone Stereoisomers of β-Amyloid Peptide (1–42)-induced Superoxide Production in Microglia and Degeneration of Cortical and Mesencephalic Neurons

  2002cited by this paper
• Partial sciatic nerve ligation induces increase in the phosphorylation of extracellular signal‐regulated kinase (ERK) and c‐Jun N‐terminal kinase (JNK) in astrocytes in the lumbar spinal dorsal horn and the gracile nucleus

  2002cited by this paper
• Glutamate uptake.

  2001cited by this paper
• IL-10-Deficient B10.Q Mice Develop More Severe Collagen-Induced Arthritis, but Are Protected from Arthritis Induced with Anti-Type II Collagen Antibodies1

  2001cited by this paper
• p38 Mitogen-Activated Protein Kinase Inhibition Increases Cytokine Release by Macrophages In Vitro and During Infection In Vivo

  2001cited by this paper
• Stimulation of multiple MAPK pathways by mechanical overload in the perfused amphibian heart.

  2001cited by this paper
• Systemic infusion of naloxone reduces degeneration of rat substantia nigral dopaminergic neurons induced by intranigral injection of lipopolysaccharide.

  2000cited by this paper
• Nociceptive-specific activation of ERK in spinal neurons contributes to pain hypersensitivity

  1999cited by this paper
• Mitogen-activated protein kinase: conservation of a three-kinase module from yeast to human.

  1999cited by this paper
• Extracellular signal-regulated kinase and p38 subgroups of mitogen-activated protein kinases regulate inducible nitric oxide synthase and tumor necrosis factor-alpha gene expression in endotoxin-stimulated primary glial cultures.

  1998cited by this paper
• Intrathecal Administration of Excitatory Amino Acid Receptor Antagonists or Nitric Oxide Synthase Inhibitor Reduced Autotomy Behavior in Rats

  1998cited by this paper
• Extracellular Signal-Regulated Kinase and p38 Subgroups of Mitogen-Activated Protein Kinases Regulate Inducible Nitric Oxide Synthase and Tumor Necrosis Factor-α Gene Expression in Endotoxin-Stimulated Primary Glial Cultures

  1998cited by this paper
• Some new insights into the effects of opioids in phasic and tonic nociceptive tests

  1998cited by this paper
• Intrathecal pertussis toxin produces hyperalgesia and allodynia in mice

  1997cited by this paper
• Mitogen-activated protein (MAP) kinase regulates production of tumor necrosis factor-alpha and release of arachidonic acid in mast cells. Indications of communication between p38 and p42 MAP kinases.

  1997cited by this paper
• Effect of IL-10 on collagen-induced arthritis in mice

  1996cited by this paper
• Ultra-low concentrations of naloxone selectively antagonize excitatory effects of morphine on sensory neurons, thereby increasing its antinociceptive potency and attenuating tolerance/dependence during chronic cotreatment.

  1995cited by this paper
• Interleukin-10 expression and chemokine regulation during the evolution of murine type II collagen-induced arthritis.

  1995cited by this paper
• Cytokine‐mediated inflammatory hyperalgesia limited by interleukin‐10

  1995cited by this paper
• Cytokine‐mediated inflammatory hyperalgesia limited by interleukin‐4

  1995cited by this paper
• Spinal and supraspinal effects of pertussis toxin on opioid analgesia.

  1994cited by this paper
• Differential effects of N-methyl-D-aspartate (NMDA) and non-NMDA receptor antagonists on spinal release of amino acids after development of acute arthritis in rats.

  1994cited by this paper
• An evaluation of the role of extracellular amino acids in the delayed neurodegeneration induced by quinolinic acid in the rat striatum.

  1993cited by this paper
• An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat

  1992cited by this paper
• IL-10 inhibits cytokine production by activated macrophages.

  1991cited by this paper
• A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man

  1988cited by this paper
• The effects of intrathecal morphine and naltrexone on autotomy in sciatic nerve sectioned rats

  1984cited by this paper

• Gestational and Developmental Contributors of Pediatric MASLD

  2024cites this paper
• µ-Opioid receptor antagonism facilitates the anxiolytic-like effect of oxytocin in mice

  2024cites this paper
• Neuronal Correlates of Hyperalgesia and Somatic Signs of Heroin Withdrawal in Male and Female Mice

  2022cites this paper
• Non-Peptide Opioids Differ in Effects on Mu-Opioid (MOP) and Serotonin 1A (5-HT1A) Receptors Heterodimerization and Cellular Effectors (Ca2+, ERK1/2 and p38) Activation

  2022cites this paper
• Formulation of a recombinant HIV‐1 polytope candidate vaccine with naloxone/alum mixture: induction of multi‐cytokine responses with a higher regulatory mechanism

  2021cites this paper
• Analgesic Effect of Morphine Added to Bupivacaine in Serratus Anterior Plane Block Following Modified Radical Mastectomy. Only a Local Effect? Randomized Clinical Trial

  2020cites this paper
• Evidence for a Dynorphin-Mediated Inner Ear Immune/Inflammatory Response and Glutamate-Induced Neural Excitotoxicity: An Updated Analysis.

  2019influential citation
• Interactions between the opioid and serotonin systems in chronic pain : quantitative live cell study by Fluorescence Cross-Correlation Spectroscopy (FCCS)

  2019cites this paper
• Mitogen‐activated protein kinase signaling mediates opioid‐induced presynaptic NMDA receptor activation and analgesic tolerance

  2018cites this paper
• Opioid-induced hyperalgesia: Cellular and molecular mechanisms.

  2016cites this paper
• (+)-Naloxone inhibits morphine-induced chemotaxis via prevention of heat shock protein 90 cleavage in microglia.

  2015cites this paper
• Naloxone added to bupivacaine or bupivacaine–fentanyl prolongs motor and sensory block during supraclavicular brachial plexus blockade: a randomized clinical trial

  2015cites this paper
• Baicalin ameliorates neuropathic pain by suppressing HDAC1 expression in the spinal cord of spinal nerve ligation rats.

  2014cites this paper
• Increasing Maternal Body Mass Index Is Associated with Systemic Inflammation in the Mother and the Activation of Distinct Placental Inflammatory Pathways1

  2014cites this paper
• Adiponectin inhibits insulin function in primary trophoblasts by PPARα-mediated ceramide synthesis.

  2014cites this paper
• Studying the Effects of Naloxone-Alum Adjuvant Mixture on Cytokines in Model of Multi- Epitope Vaccine in HIV-1

  2014cites this paper
• Opioid antagonists for pain

  2013cites this paper
• Ultra-low dose (+)-naloxone restores the thermal threshold of morphine tolerant rats.

  2013cites this paper
• Oxycodone combined with opioid receptor antagonists: efficacy and safety

  2013cites this paper
• Naloxone infusion and post‐hysterectomy morphine consumption: a double‐blind, placebo‐controlled study

  2012cites this paper
• Resveratrol Regulates N-Methyl-D-Aspartate Receptor Expression and Suppresses Neuroinflammation in Morphine-Tolerant Rats

  2012cites this paper
• Ultra-low dose naloxone restores the antinocicepitve effect of morphine in PTX-treated rats: association of IL-10 upregulation in the spinal cord.

  2012cites this paper
• Ultra-low-dose naloxone enhances the antinociceptive effect of morphine in PTX-treated rats: regulation on global histone methylation.

  2012cites this paper
• Analgesic and anti-hyperalgesic effects of epidural morphine in an equine LPS-induced acute synovitis model.

  2012cites this paper
• Evidence from basic research for opioid combinations

  2012cites this paper
• Naloxone Inhibition of Lipopolysaccharide-Induced Activation of Retinal Microglia is Partly Mediated via the p38 Mitogen Activated Protein Kinase Signalling Pathway

  2012cites this paper
• Naloxone and Ouabain in Ultralow Concentrations Restore Na+/K+-ATPase and Cytoskeleton in Lipopolysaccharide-treated Astrocytes*

  2011cites this paper
• Current world literature.

  2010cites this paper
• Ultra-low dose naltrexone attenuates chronic morphine-induced gliosis in rats

  2010cites this paper
• Researchdose naltrexone attenuates chronic morphine-induced gliosis in rats

  2010cites this paper
• Ultra-low dose naloxone restores the antinociceptive effect of morphine in pertussis toxin-treated rats by reversing the coupling of mu-opioid receptors from Gs-protein to coupling to Gi-protein.

  2009cites this paper