p38 MAPK, microglial signaling, and neuropathic pain

Accumulating evidence over last several years indicates an important role of microglial cells in the pathogenesis of neuropathic pain. Signal transduction in microglia under chronic pain states has begun to be revealed. We will review the evidence that p38 MAPK is activated in spinal microglia after nerve injury and contributes importantly to neuropathic pain development and maintenance. We will discuss the upstream mechanisms causing p38 activation in spinal microglia after nerve injury. We will also discuss the downstream mechanisms by which p38 produces inflammatory mediators. Taken together, current data suggest that p38 plays a critical role in microglial signaling under neuropathic pain conditions and represents a valuable therapeutic target for neuropathic pain management.

• Publication year

  2007

• Venue

  Molecular Pain

• Publication date

  2007-01-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1186/1744-8069-3-33PMID 17974036PMCID 2186318
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Characterization of cell proliferation in rat spinal cord following peripheral nerve injury and the relationship with neuropathic pain

  2008cited by this paper
• Inhibition of spinal microglial cathepsin S for the reversal of neuropathic pain

  2007cited by this paper
• Efficacy of propentofylline, a glial modulating agent, on existing mechanical allodynia following peripheral nerve injury.

  2007cited by this paper
• p38 activation in uninjured primary afferent neurons and in spinal microglia contributes to the development of neuropathic pain induced by selective motor fiber injury.

  2007cited by this paper
• Role of the CX3CR1/p38 MAPK pathway in spinal microglia for the development of neuropathic pain following nerve injury-induced cleavage of fractalkine.

  2007influential reference
• Nerve Conduction Blockade in the Sciatic Nerve Prevents but Does Not Reverse the Activation of p38 Mitogen-activated Protein Kinase in Spinal Microglia in the Rat Spared Nerve Injury Model

  2007influential reference
• Complement Induction in Spinal Cord Microglia Results in Anaphylatoxin C5a-Mediated Pain Hypersensitivity

  2007cited by this paper
• Neuronal mechanism for neuropathic pain

  2007cited by this paper
• Protein kinases as potential targets for the treatment of pathological pain.

  2007cited by this paper
• Spatial and temporal relationship between monocyte chemoattractant protein‐1 expression and spinal glial activation following peripheral nerve injury

  2006cited by this paper
• Systemic and Intrathecal Effects of a Novel Series of Phospholipase A2 Inhibitors on Hyperalgesia and Spinal Prostaglandin E2 Release

  2006cited by this paper
• A Peptide c-Jun N-Terminal Kinase (JNK) Inhibitor Blocks Mechanical Allodynia after Spinal Nerve Ligation: Respective Roles of JNK Activation in Primary Sensory Neurons and Spinal Astrocytes for Neuropathic Pain Development and Maintenance

  2006cited by this paper
• Regulation of Peripheral Inflammation by Spinal p38 MAP Kinase in Rats

  2006cited by this paper
• Activation of Src-Family Kinases in Spinal Microglia Contributes to Mechanical Hypersensitivity after Nerve Injury

  2006cited by this paper
• Persistent postsurgical pain: risk factors and prevention.

  2006cited by this paper
• Activation of p38 mitogen-activated protein kinase in spinal microglia mediates morphine antinociceptive tolerance.

  2006cited by this paper
• Rapid co‐release of interleukin 1β and caspase 1 in spinal cord inflammation

  2006cited by this paper
• Activated Microglia Contribute to the Maintenance of Chronic Pain after Spinal Cord Injury

  2006cited by this paper
• Prostaglandin E2 release evoked by intrathecal dynorphin is dependent on spinal p38 mitogen activated protein kinase.

  2005cited by this paper
• The CNS role of Toll-like receptor 4 in innate neuroimmunity and painful neuropathy.

  2005cited by this paper
• Role of the Immune system in chronic pain

  2005cited by this paper
• Inhibition of p38 mitogen‐activated protein kinase attenuates interleukin‐1β‐induced thermal hyperalgesia and inducible nitric oxide synthase expression in the spinal cord

  2005cited by this paper
• Spinal p38β isoform mediates tissue injury‐induced hyperalgesia and spinal sensitization

  2005cited by this paper
• Spinal blockade of TNF blocks spinal nerve ligation-induced increases in spinal P-p38.

  2005cited by this paper
• BDNF from microglia causes the shift in neuronal anion gradient underlying neuropathic pain

  2005cited by this paper
• ERK is sequentially activated in neurons, microglia, and astrocytes by spinal nerve ligation and contributes to mechanical allodynia in this neuropathic pain model

  2005cited by this paper
• Excitatory monocyte chemoattractant protein-1 signaling is up-regulated in sensory neurons after chronic compression of the dorsal root ganglion.

  2005cited by this paper
• Minocycline attenuates mechanical allodynia and proinflammatory cytokine expression in rat models of pain facilitation

  2005cited by this paper
• Neuropathic pain and spinal microglia: a big problem from molecules in "small" glia.

  2005influential reference
• Activation of p38 mitogen‐activated protein kinase in spinal hyperactive microglia contributes to pain hypersensitivity following peripheral nerve injury

  2004cited by this paper
• Cell Signaling and the Genesis of Neuropathic Pain

  2004cited by this paper
• Fractalkine (CX3CL1) and fractalkine receptor (CX3CR1) distribution in spinal cord and dorsal root ganglia under basal and neuropathic pain conditions

  2004influential reference
• Antinociceptive action of a p38&agr; MAPK inhibitor, SD‐282, in a diabetic neuropathy model

  2004cited by this paper
• Molecular therapeutic targets in inflammation: cyclooxygenase and NF-kappaB.

  2004cited by this paper
• Activation of microglia by human neuromelanin is NF‐κB‐dependent and involves p38 mitogen‐activated protein kinase: implications for Parkinson's disease

  2003cited by this paper
• Similar electrophysiological changes in axotomized and neighboring intact dorsal root ganglion neurons.

  2003cited by this paper
• Inhibition of Spinal Prostaglandin Synthesis Early after L5/L6 Nerve Ligation Prevents the Development of Prostaglandin-dependent and Prostaglandin-independent Allodynia in the Rat

  2003cited by this paper
• P2X4 receptors induced in spinal microglia gate tactile allodynia after nerve injury

  2003cited by this paper
• Trans-synaptic shift in anion gradient in spinal lamina I neurons as a mechanism of neuropathic pain

  2003cited by this paper
• Inhibition of Microglial Activation Attenuates the Development but Not Existing Hypersensitivity in a Rat Model of Neuropathy

  2003cited by this paper
• Induction of tumor necrosis factor-alpha (TNF-alpha) by interleukin-12 p40 monomer and homodimer in microglia and macrophages.

  2003cited by this paper
• Tumor necrosis factor-alpha induces mechanical allodynia after spinal nerve ligation by activation of p38 MAPK in primary sensory neurons.

  2003cited by this paper
• GLIA: A novel drug discovery target for clinical pain

  2003cited by this paper
• Central sensitization and LTP: do pain and memory share similar mechanisms?

  2003cited by this paper
• Activation of p38 mitogen‐activated protein kinase in spinal microglia is a critical link in inflammation‐induced spinal pain processing

  2003cited by this paper
• Spinal Glia and Proinflammatory Cytokines Mediate Mirror-Image Neuropathic Pain in Rats

  2003cited by this paper
• p38 Mitogen-Activated Protein Kinase Is Activated after a Spinal Nerve Ligation in Spinal Cord Microglia and Dorsal Root Ganglion Neurons and Contributes to the Generation of Neuropathic Pain

  2003influential reference
• Impaired neuropathic pain responses in mice lacking the chemokine receptor CCR2

  2003cited by this paper
• Cyclooxygenase-1 in the Spinal Cord Is Altered after Peripheral Nerve Injury

  2003cited by this paper
• p38 MAP kinases: key signalling molecules as therapeutic targets for inflammatory diseases

  2003cited by this paper
• Tumor Necrosis Factor-α Induces Mechanical Allodynia after Spinal Nerve Ligation by Activation of p38 MAPK in Primary Sensory Neurons

  2003cited by this paper
• Induction of tumor necrosis factor‐α (TNF‐α) by interleukin‐12 p40 monomer and homodimer in microglia and macrophages

  2003cited by this paper
• Microglia as a source and target of cytokines

  2002influential reference
• Chronic pain and medullary descending facilitation.

  2002cited by this paper
• p38 MAPK activation by NGF in primary sensory neurons after inflammation increases TRPV1 levels and maintains heat hyperalgesia.

  2002cited by this paper
• Propentofylline, a glial modulating agent, exhibits antiallodynic properties in a rat model of neuropathic pain.

  2001cited by this paper
• Intrathecal interleukin-1 receptor antagonist in combination with soluble tumor necrosis factor receptor exhibits an anti-allodynic action in a rat model of neuropathic pain.

  2001cited by this paper
• Early Onset of Spontaneous Activity in Uninjured C-Fiber Nociceptors after Injury to Neighboring Nerve Fibers

  2001cited by this paper
• Neuronal plasticity and signal transduction in nociceptive neurons: implications for the initiation and maintenance of pathological pain.

  2001influential reference
• Glial activation: a driving force for pathological pain.

  2001cited by this paper
• Nerve injury proximal or distal to the DRG induces similar spinal glial activation and selective cytokine expression but differential behavioral responses to pharmacologic treatment

  2001cited by this paper
• The role of neuroinflammation and neuroimmune activation in persistent pain

  2001cited by this paper
• Neuronal plasticity: increasing the gain in pain.

  2000cited by this paper
• Pathophysiology of damaged nerves in relation to chronic pain

  1999cited by this paper
• Neuropathic pain: aetiology, symptoms, mechanisms, and management.

  1999cited by this paper
• Extracellular Signal-Regulated Kinase and p38 Subgroups of Mitogen-Activated Protein Kinases Regulate Inducible Nitric Oxide Synthase and Tumor Necrosis Factor-α Gene Expression in Endotoxin-Stimulated Primary Glial Cultures

  1998cited by this paper
• Extracellular signal-regulated kinase and p38 subgroups of mitogen-activated protein kinases regulate inducible nitric oxide synthase and tumor necrosis factor-alpha gene expression in endotoxin-stimulated primary glial cultures.

  1998cited by this paper
• Evidence for the involvement of spinal cord glia in subcutaneous formalin induced hyperalgesia in the rat

  1997cited by this paper
• Dissociation of microglial activation and neuropathic pain behaviors following peripheral nerve injury in the rat.

  1997cited by this paper
• The possible role of glia in nociceptive processing and hyperalgesia in the spinal cord of the rat.

  1994cited by this paper
• Staining of glial fibrillary acidic protein (GFAP) in lumbar spinal cord increases following a sciatic nerve constriction injury.

  1991influential reference
• Textbook of pain

  1989cited by this paper
• “Model”

  1981cited by this paper

• From Amputation to Persistent Pain: A Review of Molecular and Cellular Processes in Phantom Limb Pain

  2026cites this paper
• Study on the Analgesic Mechanism of Aloperine in Mice with Neuropathic Pain Based on the p38MAPK/FKN/CX3CR1 Pathway

  2026cites this paper
• Epigallocatechin Gallate Ameliorates Oxaliplatin-Induced Peripheral Neuropathy via Upregulation of IGF-1 Signaling and Suppression of Neuroinflammation.

  2025cites this paper
• Neuronal p38 MAPK Signaling Contributes to Cisplatin-Induced Peripheral Neuropathy

  2025cites this paper
• Antinociceptive and anti-inflammatory effects of dihydroaustrasulfone alcohol in alleviating peripheral neuropathy via Nrf2/HO-1 pathway in rats.

  2025cites this paper
• 4E-BP1–dependent translation in microglia controls mechanical hypersensitivity in male and female mice

  2025cites this paper
• Promising effects of astaxanthin on pain-related behaviors and morphine tolerance in a mouse model of neuropathic pain: Possible involvement of Nrf2 and the NMDA receptor subunit NR2B

  2025cites this paper
• Dual Role of the Spinal Endocannabinoid System in Response to Noxious Stimuli: Antinociceptive Pathways and Neuropathic Pain Mechanisms

  2025cites this paper
• Possible Interaction of Suramin with Thalamic P2X Receptors and NLRP3 Inflammasome Activation Alleviates Reserpine-Induced Fibromyalgia-Like Symptoms

  2025cites this paper
• Chemokine CCL2 Mediates Neuroglial Crosstalk and Drives Chronic Pain Pathogenesis

  2025cites this paper
• Steroid Hormones in Pain: Mechanistic Underpinnings and Therapeutic Perspectives.

  2025cites this paper
• Microglia-derived neuroinflammatory pathways in neuropathic pain

  2025cites this paper
• Hsp90 inhibition in mouse spinal cord enhances Src kinase signaling in microglia to increase opioid antinociception.

  2025cites this paper
• ANA-12 Targets and Inhibits BDNF/TrkB Signaling to Alleviate Pain Behaviors in Rheumatoid Arthritis Mice

  2025cites this paper
• Neuroinflammation: Mechanisms, Dual Roles, and Therapeutic Strategies in Neurological Disorders

  2025cites this paper
• Dosimetric parameters and clinical outcomes of photobiomodulation in diabetic neuropathy: a concise review

  2025cites this paper
• Compounds with dual glutaminase inhibition and Nrf2 activation activities enhance morphine analgesia and reduce pain sensitization in chemotherapy-induced peripheral neuropathy mouse model.

  2025cites this paper
• Autophagy activated by the AMPK/mTOR/ULK1 pathway involves AURKB-mediated microgliosis in neuropathic pain.

  2025cites this paper
• Mechanism analysis and intervention strategies of the inflammatory microenvironment in traumatic spinal cord injury

  2025cites this paper
• Relationship of S100 Proteins with Neuroinflammation

  2025cites this paper
• The Role of Cytokines in Postherpetic Neuralgia.

  2025cites this paper
• Nitroxidative Stress, Cell—Signaling Pathways, and Manganese Porphyrins: Therapeutic Potential in Neuropathic Pain

  2025cites this paper
• Sodium aescinate alleviates neuropathic pain through suppressing OGT-mediated O-GlcNAc modification of TLR3 to inactivate MAPK signaling pathway.

  2024cites this paper
• Ex-vivo patient-derived explant model for neurofibromatosis type 1-related cutaneous neurofibromas.

  2024cites this paper
• TNFR1/p38αMAPK signaling in Nex + supraspinal neurons regulates estrogen-dependent chronic neuropathic pain.

  2024cites this paper
• Exploring neuroinflammation: A key driver in neuropathic pain disorders.

  2024cites this paper
• Gooderoside A from Anoectochilus elatus attenuates acute and chronic pains by inhibiting NO/cGMP and IRAK4/IRAK1/TAK1 signaling pathways.

  2024cites this paper
• MAPK signaling pathway in spinal cord injury: Mechanisms and therapeutic potential.

  2024cites this paper
• Cyclo(L-Pro-L-Trp) from Chilobrachys jingzhao alleviates formalin-induced inflammatory pain by suppressing the inflammatory response and inhibiting TRAF6-mediated MAPK and NF-κB signaling pathways.

  2024cites this paper
• Immune drivers of physiological and pathological pain

  2024cites this paper
• Exploring the potential therapeutic benefits of 7-methoxy coumarin for neuropathy pain: an in vivo, in vitro, and in silico approach

  2024cites this paper
• SPOCK2 modulates neuropathic pain by interacting with MT1-MMP to regulate astrocytic MMP-2 activation in rats with chronic constriction injury

  2024cites this paper
• Astaxanthin has a beneficial influence on pain-related symptoms and opioid-induced hyperalgesia in mice with diabetic neuropathy-evidence from behavioral studies

  2024cites this paper
• The Potential Impact of SGLT2-I in Diabetic Foot Prevention: Promising Pathophysiologic Implications, State of the Art, and Future Perspectives—A Narrative Review

  2024cites this paper
• Sacral Bioneuromodulation: The Role of Bone Marrow Aspirate in Spinal Cord Injuries

  2024cites this paper
• Mechanisms and Therapeutic Prospects of Microglia-Astrocyte Interactions in Neuropathic Pain Following Spinal Cord Injury

  2024cites this paper
• Gabapentin improves neuropathic pain in Minamata disease model rats

  2024cites this paper
• Unlocking the mechanistic potential of Thuja occidentalis for managing diabetic neuropathy and nephropathy

  2024cites this paper
• Advances of the MAPK pathway in the treatment of spinal cord injury

  2024cites this paper
• Relationship between the change of ATP level controlled by ectonucleotidases and endometriosis-associated infertility and pain

  2024cites this paper
• Neuroinflammatory activation in sensory and motor regions of the cortex is related to sensorimotor function in individuals with low back pain maintained by nociplastic mechanisms: A preliminary proof‐of‐concept study

  2024cites this paper
• Molecular mechanisms of Schisandra chinensis in treating depression-neuropathic pain comorbidity by network pharmacology and molecular docking analysis.

  2024cites this paper
• Daphnetin Ameliorates Neuropathic Pain via Regulation of Microglial Responses and Glycerophospholipid Metabolism in the Spinal Cord

  2024cites this paper
• N-methyl-D-aspartate Receptor Subunits 2A and 2B Mediate Connexins and Pannexins in the Trigeminal Ganglion Involved in Orofacial Inflammatory Allodynia during Temporomandibular Joint Inflammation

  2024cites this paper
• CD36 deletion prevents white matter injury by modulating microglia polarization through the Traf5-MAPK signal pathway

  2024cites this paper
• Neuroinflammation in the paraventricular nucleus of the hypothalamus precipitates visceral pain induced by pancreatic cancer in mice

  2023cites this paper
• An aqueous Commiphora myrrha extract ameliorates paclitaxel-induced peripheral neuropathic pain in mice

  2023cites this paper
• Picroside Ⅱ attenuates neuropathic pain by regulating inflammation and spinal excitatory synaptic transmission.

  2023cites this paper
• Advances in Neuropathic Pain Research: Selected Intracellular Factors as Potential Targets for Multidirectional Analgesics

  2023cites this paper
• Microglial P2Y12 Signaling Contributes to Cisplatin-induced Pain Hypersensitivity via IL-18-mediated Central Sensitization in the Spinal Cord.

  2023cites this paper
• Resident immune responses to spinal cord injury: role of astrocytes and microglia

  2023cites this paper
• Targeting Members of the Chemokine Family as a Novel Approach to Treating Neuropathic Pain

  2023cites this paper
• Exercise, Spinal Microglia and Neuropathic Pain: Potential Molecular Mechanisms

  2023influential citation
• Antinociceptive and neuroprotective effect of echinacoside on peripheral neuropathic pain in mice through inhibiting P2X7R/FKN/CX3CR1 pathway.

  2023cites this paper
• Global Trends and Hotspots on Microglia Associated with Pain from 2002 to 2022: A Bibliometric Analysis

  2023cites this paper
• Role of Microglia in Neuropathic Pain

  2023cites this paper
• Electroacupuncture alleviates neuropathic pain caused by SNL by promoting M2 microglia polarization through PD-L1.

  2023cites this paper
• Levo-tetrahydropalmatine ameliorates neuropathic pain by inhibiting the activation of the Clec7a-MAPK/NF-κB-NLRP3 inflammasome axis.

  2023cites this paper
• Microglia and p38 MAPK Inhibitors Suppress Development of Mechanical Allodynia in Both Sexes in a Mouse Model of Antiretroviral-Induced Neuropathic Pain

  2023influential citation
• Activation of G protein‐coupled receptor 39 alleviates neuropathic pain and chronic inflammation

  2023cites this paper
• Glial Glutamate Transporter Modulation Prevents Development of Complete Freund’s Adjuvant-Induced Hyperalgesia and Allodynia in Mice

  2023cites this paper
• Analgesic Effects of Fisetin, Peimine, Astaxanthin, Artemisinin, Bardoxolone Methyl and 740 Y-P and Their Influence on Opioid Analgesia in a Mouse Model of Neuropathic Pain

  2023cites this paper
• Bibliometric and visual analysis of microglia-related neuropathic pain from 2000 to 2021

  2023cites this paper
• The mTOR inhibitor rapamycin suppresses trigeminal neuropathic pain and p-MKK4/p-p38 mitogen-activated protein kinase-mediated microglial activation in the trigeminal nucleus caudalis of mice with infraorbital nerve injury

  2023cites this paper
• Effects of Natural Product-Derived Compounds on Inflammatory Pain via Regulation of Microglial Activation

  2023cites this paper
• Type 2 Diabetes (T2DM) and Parkinson’s Disease (PD): a Mechanistic Approach

  2023cites this paper
• Impact of Plant-Derived Compounds on Amyotrophic Lateral Sclerosis

  2023cites this paper
• Activation of the bile acid receptors TGR5 and FXR in the spinal dorsal horn alleviates neuropathic pain

  2023cites this paper
• The Role of miRNAs in Neuropathic Pain

  2023cites this paper
• Distributed system of nociception as a physiological basis forpain experience in humans

  2023cites this paper
• Microglial Cannabinoid CB2 Receptors in Pain Modulation

  2023cites this paper
• Resolvin D1 attenuates mechanical allodynia after burn injury: Involvement of spinal glia, p38 mitogen-activated protein kinase, and brain-derived neurotrophic factor/tropomyosin-related kinase B signaling

  2023cites this paper
• BDNF as a biomarker for neuropathic pain: Consideration of mechanisms of action and associated measurement challenges

  2023cites this paper
• Sex Differences in the Expression of Neuroimmune Molecules in the Spinal Cord of a Mouse Model of Antiretroviral-Induced Neuropathic Pain

  2023cites this paper
• Mirogabalin Decreases Pain-like Behaviors by Inhibiting the Microglial/Macrophage Activation, p38MAPK Signaling, and Pronociceptive CCL2 and CCL5 Release in a Mouse Model of Neuropathic Pain

  2023cites this paper
• Tuina for peripherally-induced neuropathic pain: A review of analgesic mechanism

  2022influential citation
• Bibliometric analysis of research on gene expression in spinal cord injury

  2022cites this paper
• Therapeutic Potential of Combinative shRNA-Encoded Lentivirus-Mediated Gene Silencing to Accelerate Somatosensory Recovery After Spinal Cord Trauma

  2022influential citation
• Bladder-colon chronic cross-sensitization involves neuro-glial pathways in male mice

  2022cites this paper
• Activation of β2-Adrenergic Receptors in Microglia Alleviates Neuropathic Hypersensitivity in Mice

  2022cites this paper
• Anti-hyperalgesic effects of photobiomodulation therapy (904 nm) on streptozotocin-induced diabetic neuropathy imply MAPK pathway and calcium dynamics modulation

  2022cites this paper
• Study protocol for a phase II, double-blind, randomised controlled trial of cannabidiol (CBD) compared with placebo for reduction of brain neuroinflammation in adults with chronic low back pain

  2022cites this paper
• Fasudil, a ROCK inhibitor, prevents neuropathic pain in Minamata disease model rats.

  2022cites this paper
• Research progress of p38 as a new therapeutic target against morphine tolerance and the current status of therapy of morphine tolerance

  2022cites this paper
• DUSP8/TAK1 signaling mediates neuropathic pain through regulating neuroinflammation and neuron death in a spinal nerve ligation (SNL) rat model.

  2022cites this paper
• Potential Neuroimmune Interaction in Chronic Pain: A Review on Immune Cells in Peripheral and Central Sensitization

  2022cites this paper
• Toward Composite Pain Biomarkers of Neuropathic Pain—Focus on Peripheral Neuropathic Pain

  2022cites this paper
• Systematic analysis of critical genes and pathways identified a signature of neuropathic pain after spinal cord injury

  2022cites this paper
• Strategies for Biomaterial-Based Spinal Cord Injury Repair via the TLR4-NF-κB Signaling Pathway

  2022cites this paper
• Glial cells as target for antidepressants in neuropathic pain

  2022cites this paper
• Hedgehog signaling plays a crucial role in hyperalgesia associated with neuropathic pain in mice

  2022cites this paper
• Glutamate excitotoxicity: Potential therapeutic target for ischemic stroke.

  2022cites this paper
• Microglia-derived TNF-α inhibiting GABAergic neurons in the anterior lateral bed nucleus of the stria terminalis precipitates visceral hypersensitivity induced by colorectal distension in rats

  2022cites this paper
• An exploratory study on the mechanism of Huangqi Guizhi Wuwu Decoction in the treatment of neuropathic pain

  2022cites this paper
• Spinal microglia-derived TNF promotes the astrocytic JNK/CXCL1 pathway activation in a mouse model of burn pain.

  2022cites this paper
• Interleukin 33-mediated inhibition of A-type K+ channels induces sensory neuronal hyperexcitability and nociceptive behaviors in mice

  2022cites this paper
• Cannabinoids in Chronic Pain: Therapeutic Potential Through Microglia Modulation

  2022cites this paper
• Global analyses of mRNA expression in human sensory neurons reveal eIF5A as a conserved target for inflammatory pain

  2022cites this paper
• Empagliflozin mitigates type 2 diabetes-associated peripheral neuropathy: a glucose-independent effect through AMPK signaling

  2022cites this paper
• Activated microglia–induced neuroinflammatory cytokines lead to photoreceptor apoptosis in Aβ-injected mice

  2021cites this paper