Human Hepatocyte Growth Factor Receptor Is a Cellular Coreceptor for Adeno-Associated Virus Serotype 3

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Human Gene Therapy

• Publication date

  2010-11-24

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1089/hum.2010.075PMID 20545554PMCID PMC2999576
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Novel properties of tyrosine-mutant AAV2 vectors in the mouse retina.

  2011cited by this paper
• Optimized Adeno-Associated Virus (AAV)–Protein Phosphatase-5 Helper Viruses for Efficient Liver Transduction by Single-Stranded AAV Vectors: Therapeutic Expression of Factor IX at Reduced Vector Doses

  2010cited by this paper
• An animal model of PDH deficiency using AAV8-siRNA vector-mediated knockdown of pyruvate dehydrogenase E1α.

  2010cited by this paper
• Epidermal growth factor receptor is a co-receptor for adeno-associated virus serotype 6

  2010cited by this paper
• Enhanced Long-Term Transduction and Multilineage Engraftment of Human Hematopoietic Stem Cells Transduced with Tyrosine-Modified Recombinant Adeno-Associated Virus Serotype 2

  2010cited by this paper
• High-Efficiency Transduction of Fibroblasts and Mesenchymal Stem Cells by Tyrosine-Mutant AAV2 Vectors for Their Potential Use in Cellular Therapy

  2010cited by this paper
• High-efficiency transduction and correction of murine hemophilia B using AAV2 vectors devoid of multiple surface-exposed tyrosines.

  2010cited by this paper
• Adeno-Associated Virus Serotype 6 Capsid Tyrosine-to-Phenylalanine Mutations Improve Gene Transfer to Skeletal Muscle

  2010cited by this paper
• High-efficiency transduction of the mouse retina by tyrosine-mutant AAV serotype vectors.

  2009cited by this paper
• Establishment and characterization of a cancer cell line derived from an aggressive childhood liver tumor

  2009cited by this paper
• AAV3-mediated transfer and expression of the pyruvate dehydrogenase E1 alpha subunit gene causes metabolic remodeling and apoptosis of human liver cancer cells.

  2009cited by this paper
• Next generation of adeno-associated virus 2 vectors: Point mutations in tyrosines lead to high-efficiency transduction at lower doses

  2008cited by this paper
• Analysis of AAV serotypes 1-9 mediated gene expression and tropism in mice after systemic injection.

  2008cited by this paper
• Gene Therapy Using Adeno-Associated Virus Vectors

  2008cited by this paper
• CD9 promotes adeno-associated virus type 2 infection of mammary carcinoma cells with low cell surface expression of heparan sulphate proteoglycans.

  2007cited by this paper
• Self-Complementary Recombinant Adeno-Associated Viral Vectors: Packaging Capacity And The Role of Rep Proteins in Vector Purity

  2007cited by this paper
• α2,3 and α2,6 N-Linked Sialic Acids Facilitate Efficient Binding and Transduction by Adeno-Associated Virus Types 1 and 6

  2006cited by this paper
• Attachment of adeno-associated virus type 3H to fibroblast growth factor receptor 1

  2006influential reference
• Adeno-associated virus type 2 contains an integrin alpha5beta1 binding domain essential for viral cell entry.

  2006cited by this paper
• The 37/67-Kilodalton Laminin Receptor Is a Receptor for Adeno-Associated Virus Serotypes 8, 2, 3, and 9

  2006cited by this paper
• Adeno-Associated Virus Type 2 Contains an Integrin α5β1 Binding Domain Essential for Viral Cell Entry

  2006cited by this paper
• Alpha2,3 and alpha2,6 N-linked sialic acids facilitate efficient binding and transduction by adeno-associated virus types 1 and 6.

  2006cited by this paper
• Hepatocyte Growth Factor Receptor Is a Coreceptor for Adeno-Associated Virus Type 2 Infection

  2005influential reference
• Rapid Uncoating of Vector Genomes Is the Key toEfficient Liver Transduction with Pseudotyped Adeno-Associated VirusVectors

  2004cited by this paper
• Crystal structure of the HGF β‐chain in complex with the Sema domain of the Met receptor

  2004cited by this paper
• Clades of Adeno-Associated Viruses Are Widely Disseminated in Human Tissues

  2004cited by this paper
• Cross-Dressing the Virion: the Transcapsidation of Adeno-Associated Virus Serotypes Functionally Defines Subgroups

  2004influential reference
• Identification of PDGFR as a receptor for AAV-5 transduction

  2003cited by this paper
• Novel adeno-associated viruses from rhesus monkeys as vectors for human gene therapy

  2002cited by this paper
• Binding of Adeno-associated Virus Type 5 to 2,3-Linked Sialic Acid Is Required for Gene Transfer*

  2001cited by this paper
• Isolation of Highly Infectious and Pure Adeno-Associated Virus Type 2 Vectors with a Single-Step Gravity-Flow Column

  2001cited by this paper
• Adeno-Associated Virus Serotype 4 (AAV4) and AAV5 Both Require Sialic Acid Binding for Hemagglutination and Efficient Transduction but Differ in Sialic Acid Linkage Specificity

  2001cited by this paper
• αVβ5 integrin: a co-receptor for adeno-associated virus type 2 infection

  1999cited by this paper
• Expression of hepatocyte growth factor (HGF) and HGF receptor (c-met) proteins in liver diseases: an immunohistochemical study.

  1999cited by this paper
• AlphaVbeta5 integrin: a co-receptor for adeno-associated virus type 2 infection.

  1999cited by this paper
• Adeno-associated virus 2 co-receptors?-first reply

  1999cited by this paper
• Human fibroblast growth factor receptor 1 is a co-receptor for infection by adeno-associated virus 2

  1999cited by this paper
• Cloning and Characterization of Adeno-Associated Virus Type 5

  1999cited by this paper
• Membrane-Associated Heparan Sulfate Proteoglycan Is a Receptor for Adeno-Associated Virus Type 2 Virions

  1998cited by this paper
• Infectious Clones and Vectors Derived from Adeno-Associated Virus (AAV) Serotypes Other Than AAV Type 2

  1998cited by this paper
• Quantitative DNA slot blot analysis: inhibition of DNA binding to membranes by magnesium ions.

  1997cited by this paper
• Cloning of adeno-associated virus type 4 (AAV4) and generation of recombinant AAV4 particles

  1997cited by this paper
• Differential expression in human cells from the p6 promoter of human parvovirus B19 following plasmid transfection and recombinant adeno-associated virus 2 (AAV) infection: human megakaryocytic leukaemia cells are non-permissive for AAV infection.

  1996cited by this paper
• Nucleotide sequencing and generation of an infectious clone of adeno-associated virus 3.

  1996cited by this paper
• Overexpression of c‐met protooncogene product and raised Ki67 index in hepatocellular carcinomas with respect to benign liver conditions

  1995cited by this paper
• Tumorigenicity of the met proto-oncogene and the gene for hepatocyte growth factor

  1992cited by this paper
• Growth of human hepatoma cells lines with differentiated functions in chemically defined medium.

  1982cited by this paper

• mGem: AAV, from almost a virus to an awesome vector—or is it?

  2026cites this paper
• Adeno-Associated Virus Vectors: Principles, Practices, and Prospects in Gene Therapy

  2025cites this paper
• Molecular Engineering of Virus Tropism

  2024cites this paper
• Biodistribution and safety of a single rAAV3B-AAT vector for silencing and replacement of alpha-1 antitrypsin in Cynomolgus macaques

  2024cites this paper
• Comparing liver RNA-seq analysis of human, rhesus monkey, mouse and rat

  2024cites this paper
• Natural Adeno-Associated Virus Serotypes and Engineered Adeno-Associated Virus Capsid Variants: Tropism Differences and Mechanistic Insights

  2024cites this paper
• Enhanced transgene expression from single-stranded AAV vectors in human cells in vitro and in murine hepatocytes in vivo

  2024cites this paper
• AAV vectors for long-term gene therapy of hemophilia B: Are we there yet?

  2024cites this paper
• Recombinant Adeno-Associated Virus Vectors for Gene Therapy of the Central Nervous System: Delivery Routes and Clinical Aspects

  2024cites this paper
• Adeno-associated virus gene therapy prevents progression of kidney disease in genetic models of nephrotic syndrome

  2023cites this paper
• Rationale and strategies for the development of safe and effective optimized AAV vectors for human gene therapy

  2023cites this paper
• Characterization of a Bioengineered AAV3B Capsid Variant with Enhanced Hepatocyte Tropism and Immune Evasion

  2023cites this paper
• ADENO-ASSOCIATED VIRUSES IN GENE THERAPY FOR SPINAL MUSCULAR ATROPHIES: TREND OR TRIUMPH?

  2023cites this paper
• Predicted deleterious variants in the human genome relevant to gene therapy with adeno-associated virus vectors

  2023cites this paper
• Rational design and experimental evaluation of peptide ligands for the purification of adeno‐associated viruses via affinity chromatography

  2023cites this paper
• AAV vectors: The Rubik’s cube of human gene therapy

  2022cites this paper
• Organoids and microphysiological systems: Promising models for accelerating AAV gene therapy studies

  2022cites this paper
• Hepatocellular Carcinoma Is a Natural Target for Adeno-Associated Virus (AAV) 2 Vectors

  2022cites this paper
• Survival Advantage of Both Human Hepatocyte Xenografts and Survival Advantage of Both Human Hepatocyte Xenografts and Genome-Edited Hepatocytes for Treatment of alpha-1 Antitrypsin Genome-Edited Hepatocytes for Treatment of alpha-1 Antitrypsin Deficiency Deficiency

  2022cites this paper
• Adeno-Associated Virus (AAV)-Mediated Gene Therapy for Duchenne Muscular Dystrophy: The Issue of Transgene Persistence

  2022cites this paper
• Coagulation factor IX gene transfer to non-human primates using engineered AAV3 capsid and hepatic optimized expression cassette

  2021cites this paper
• Engineered adeno-associated virus 3 vector with reduced reactivity to serum antibodies

  2021cites this paper
• Receptor Switching in Newly Evolved Adeno-associated Viruses

  2021cites this paper
• Development of a Clinical Candidate AAV3 Vector for Gene Therapy of Hemophilia B

  2020cites this paper
• Site-Directed Mutagenesis Improves the Transduction Efficiency of Capsid Library-Derived Recombinant AAV Vectors

  2020cites this paper
• AAV Vectors: Are They Safe?

  2020cites this paper
• Breaking the sound barrier: Towards next-generation AAV vectors for gene therapy of hearing disorders.

  2020cites this paper
• Journey to the Center of the Cell: Tracing the Path of AAV Transduction.

  2020cites this paper
• Massively parallel in vivo characterization of novel adeno-associated viral (AAV) capsids using DNA/RNA barcoding and next generation sequencing

  2020cites this paper
• Chinese Medicine Protein and Peptide in Gene and Cell Therapy.

  2019cites this paper
• A Genome-Wide Knock-Out Screen Identifies Novel Host Cell Entry Factor Requirements for Divergent Adeno-Associated Virus Serotypes

  2019cites this paper
• GPR108 Is a Highly Conserved AAV Entry Factor.

  2019cites this paper
• Clinical Considerations for Capsid Choice in the Development of Liver-Targeted AAV-Based Gene Transfer

  2019cites this paper
• Next Generation of Adeno-Associated Virus Vectors for Gene Therapy for Human Liver Diseases.

  2019cites this paper
• Recombinant Adeno-Associated Virus Gene Therapy in Light of Luxturna (and Zolgensma and Glybera): Where Are We, and How Did We Get Here?

  2019cites this paper
• Gene manipulation in liver ductal organoids by optimized recombinant adeno-associated virus vectors

  2019cites this paper
• Next Generation of AAV Vectors for Gene Therapy of Human Liver Diseases

  2019cites this paper
• Capsid Modifications for Targeting and Improving the Efficacy of AAV Vectors

  2019cites this paper
• Gene therapy for neurological disorders: progress and prospects

  2018cites this paper
• AAV-8 and AAV-9 Vectors Cooperate with Serum Proteins Differently Than AAV-1 and AAV-6

  2018cites this paper
• Adeno-associated Virus Vectors in Gene Therapy

  2018cites this paper
• DETERMINANTS OF AAV TRANSPORT ACROSS THE BLOOD-BRAIN BARRIER

  2018cites this paper
• High-Throughput Dissection of AAV-Host Interactions: The Fast and the Curious.

  2018cites this paper
• An Alternate Route for Adeno-associated Virus (AAV) Entry Independent of AAV Receptor

  2018cites this paper
• Recent progress and considerations for AAV gene therapies targeting the central nervous system

  2018cites this paper
• Survival Advantage of Both Human Hepatocyte Xenografts and Genome-Edited Hepatocytes for Treatment of α-1 Antitrypsin Deficiency

  2017cites this paper
• Seek and destroy: targeted adeno-associated viruses for gene delivery to hepatocellular carcinoma

  2017cites this paper
• Antiviral activity of a synthesized shikonin ester against influenza A (H1N1) virus and insights into its mechanism.

  2017cites this paper
• Host determinants of adeno-associated viral vector entry.

  2017cites this paper
• And Then There Was Light: Perspectives of Optogenetics for Deep Brain Stimulation and Neuromodulation

  2017cites this paper
• In vivo tissue-tropism of adeno-associated viral vectors.

  2016cites this paper
• Engineering AAV receptor footprints for gene therapy.

  2016cites this paper
• Strategies to generate high-titer, high-potency recombinant AAV3 serotype vectors

  2016cites this paper
• Improvement of the cytotoxic T lymphocyte response against hepatocellular carcinoma by transduction of cancer cells with an adeno-associated virus carrying the interferon-γ gene.

  2016cites this paper
• Viral infection: A key host receptor for AAV

  2016cites this paper
• Superior In vivo Transduction of Human Hepatocytes Using Engineered AAV3 Capsid.

  2016cites this paper
• Systemic delivery of adeno-associated viral vectors.

  2016cites this paper
• Developing an Adeno-Associated Viral Vector (AAV) Toolbox for CNS Gene Therapy: A Dissertation

  2016cites this paper
• Chemical modulation of AAV trafficking

  2016influential citation
• Prevalence of neutralizing antibodies against liver-tropic adeno-associated virus serotype vectors in 100 healthy Chinese and its potential relation to body constitutions.

  2015cites this paper
• Identification of an adeno-associated virus binding epitope for AVB sepharose affinity resin

  2015cites this paper
• Efficient and Targeted Transduction of Nonhuman Primate Liver With Systemically Delivered Optimized AAV3B Vectors.

  2015cites this paper
• Gene and splicing therapies for neuromuscular diseases.

  2015cites this paper
• Effective Gene Delivery to Valvular Interstitial Cells Using Adeno-Associated Virus Serotypes 2 and 3

  2015cites this paper
• The SUMOylation Pathway Restricts Gene Transduction by Adeno-Associated Viruses

  2015cites this paper
• Current status of gene therapy for hepatocellular carcinoma, with a focus on gene delivery approaches.

  2015cites this paper
• Site-Directed Mutagenesis of Surface-Exposed Lysine Residues Leads to Improved Transduction by AAV2, But Not AAV8, Vectors in Murine Hepatocytes In Vivo

  2015cites this paper
• Adeno-associated Virus as a Mammalian DNA Vector

  2015cites this paper
• The Use of Viral Vectors to Enhance Cognition

  2015cites this paper
• Caractérisation du profil d'expression et des potentielles cibles off-targets d'un U7snRNA optimisé pour le traitement par saut d'exon de la Dystrophie Musculaire de Duchenne

  2015cites this paper
• Gene Delivery and Gene Therapy for Alzheimer’s Disease

  2015cites this paper
• Perspective on Adeno-Associated Virus Capsid Modification for Duchenne Muscular Dystrophy Gene Therapy

  2015cites this paper
• Adeno-associated Virus as a Mammalian DNA Vector

  2015cites this paper
• The roles of traditional Chinese medicine in gene therapy.

  2014cites this paper
• recombinant AAV vectors in human cell lines in vitro and in murine hepatocytes in

  2014cites this paper
• Adeno-Associated Virus Vectors for Gene Therapy

  2014cites this paper
• Pristimerin enhances recombinant adeno-associated virus vector-mediated transgene expression in human cell lines in vitro and murine hepatocytes in vivo.

  2014cites this paper
• Cytotoxic genes from traditional Chinese medicine inhibit tumor growth both in vitro and in vivo.

  2014cites this paper
• Enhanced Transgene Expression from Recombinant Single-Stranded D-Sequence-Substituted Adeno-Associated Virus Vectors in Human Cell Lines In Vitro and in Murine Hepatocytes In Vivo

  2014cites this paper
• Methods for gene transfer to the central nervous system.

  2014cites this paper
• Functional Analysis of the Putative Integrin Recognition Motif on Adeno-associated Virus 9*

  2014cites this paper
• Selective In Vivo Targeting of Human Liver Tumors by Optimized AAV3 Vectors in a Murine Xenograft Model

  2014influential citation
• The use of matrix attachment regions to enhance the in-vivo potency of rAAV vectors

  2014cites this paper
• Synthetic Heparins and Other Glycans Serotype-Specific Interaction Patterns with Differential Adeno-Associated Virus

  2014cites this paper
• C-Reactive Protein (CRP) Is Essential for Efficient Systemic Transduction of Recombinant Adeno-Associated Virus Vector 1 (rAAV-1) and rAAV-6 in Mice

  2013cites this paper
• Characterization of interactions between heparin/glycosaminoglycan and adeno-associated virus.

  2013cites this paper
• Optimal delivery of therapeutic genes to pancreatic islets.

  2013cites this paper
• Differential Adeno-Associated Virus Serotype-Specific Interaction Patterns with Synthetic Heparins and Other Glycans

  2013cites this paper
• Pseudotyped adeno-associated viral vectors for gene transfer in dermal fibroblasts: implications for wound-healing applications.

  2013cites this paper
• Selection and evaluation of clinically relevant AAV variants in a xenograft liver model

  2013cites this paper
• Intracellular transport of recombinant adeno-associated virus vectors

  2012cites this paper
• Modules Identification in Gene Positive Networks of Hepatocellular Carcinoma Using Pearson Agglomerative Method and Pearson Cohesion Coupling Modularity

  2012cites this paper
• Limitations of Encapsidation of Recombinant Self-Complementary Adeno-Associated Viral Genomes in Different Serotype Capsids and Their Quantitation

  2012cites this paper
• The AAV Vector Toolkit: Poised at the Clinical Crossroads.

  2012cites this paper
• Adeno-Associated Viral Vectors Based on Serotype 3b Use Components of the Fibroblast Growth Factor Receptor Signaling Complex for Efficient Transduction

  2012cites this paper
• The AAV vector toolkit: poised at the clinical crossroads.

  2012cites this paper
• Parvoviruses: structure and infection

  2012cites this paper
• Structure of AAV-DJ, a retargeted gene therapy vector: cryo-electron microscopy at 4.5 Å resolution.

  2012cites this paper
• Novel Approaches to Deliver Molecular Therapeutics in Cardiac Disease Using Adeno-Associated Virus Vectors

  2012cites this paper
• Femoral artery regeneration in ischemic hind limb by AAV9 expressing conditionally silenced VEGF

  2012cites this paper