BRCA1 in cancer, cell cycle and genomic stability.

No abstract is available for this paper.

• Publication year

  2003

• Venue

  Frontiers in Bioscience

• Publication date

  2003-09-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.2741/1131PMID 12957814
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Trends in incidence rates of invasive lobular and ductal breast carcinoma.

  2003cited by this paper
• Regulation of tumor suppressors by nuclear-cytoplasmic shuttling.

  2003cited by this paper
• BRCA1/2 mutation status influences somatic genetic progression in inherited and sporadic epithelial ovarian cancer cases.

  2003cited by this paper
• MDC1 is a mediator of the mammalian DNA damage checkpoint

  2003cited by this paper
• Cell Cycle Differences in DNA Damage-induced BRCA1 Phosphorylation Affect Its Subcellular Localization*

  2003cited by this paper
• Incidence of invasive breast cancer by hormone receptor status from 1992 to 1998.

  2003cited by this paper
• Structural Consequences of a Cancer-causing BRCA1-BRCT Missense Mutation*

  2003cited by this paper
• Differences in breast cancer stage, treatment, and survival by race and ethnicity.

  2003cited by this paper
• Enhancement of BRCA1 E3 Ubiquitin Ligase Activity through Direct Interaction with the BARD1 Protein*

  2003cited by this paper
• BRCA1 transcriptionally regulates genes involved in breast tumorigenesis

  2002cited by this paper
• Regulation of BRCA1 phosphorylation by interaction with protein phosphatase 1alpha.

  2002cited by this paper
• Autoubiquitination of the BRCA1·BARD1 RING Ubiquitin Ligase*

  2002cited by this paper
• The cancer connection: BRCA1 and BRCA2 tumor suppression in mice and humans

  2002cited by this paper
• BRCA1 Directs a Selective p53-Dependent Transcriptional Response towards Growth Arrest and DNA Repair Targets

  2002cited by this paper
• Promoter hypermethylation and post-transcriptional mechanisms for reduced BRCA1 immunoreactivity in sporadic human breast cancers.

  2002cited by this paper
• Increased CpG methylation of the estrogen receptor gene in BRCA1-linked estrogen receptor-negative breast cancers

  2002cited by this paper
• Re: Gene expression profiles of BRCA1-linked, BRCA2-linked, and sporadic ovarian cancers.

  2002cited by this paper
• BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage

  2002cited by this paper
• DNA repair/pro-apoptotic dual-role proteins in five major DNA repair pathways: fail-safe protection against carcinogenesis.

  2002cited by this paper
• Cancer susceptibility and the functions of BRCA1 and BRCA2.

  2002cited by this paper
• The BRCA1 suppressor hypothesis: an explanation for the tissue-specific tumor development in BRCA1 patients.

  2002cited by this paper
• Recombinational DNA repair and human disease.

  2002cited by this paper
• The frequency of founder mutations in the BRCA1, BRCA2, and APC genes in australian Ashkenazi Jews

  2001cited by this paper
• Mutant BRCA1 genes antagonize phenotype of wild-type BRCA1

  2001cited by this paper
• Functional analysis of CpG methylation in the BRCA1 promoter region

  2001cited by this paper
• Gene-expression profiles in hereditary breast cancer.

  2001cited by this paper
• BACH1, a novel helicase-like protein, interacts directly with BRCA1 and contributes to its DNA repair function.

  2001cited by this paper
• BRCA1 and BRCA2 and the genetics of breast and ovarian cancer.

  2001cited by this paper
• Cytoplasmic occurrence of the Chk1/Cdc25 pathway and regulation of Chk1 in Xenopus oocytes.

  2001cited by this paper
• Direct DNA binding by Brca1

  2001cited by this paper
• Cancer-predisposing mutations within the RING domain of BRCA1: Loss of ubiquitin protein ligase activity and protection from radiation hypersensitivity

  2001cited by this paper
• DNA double-strand breaks: signaling, repair and the cancer connection

  2001cited by this paper
• Functions of BRCA1 and BRCA2 in the biological response to DNA damage.

  2001cited by this paper
• In-frame deletions of BRCA1 may define critical functional domains

  2000cited by this paper
• Tumor Suppressor p53 Is Required To Modulate BRCA1 Expression

  2000cited by this paper
• Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress.

  2000cited by this paper
• Collaboration of signal transducer and activator of transcription 1 (STAT1) and BRCA1 in differential regulation of IFN-gamma target genes.

  2000cited by this paper
• Promoter hypermethylation and BRCA1 inactivation in sporadic breast and ovarian tumors.

  2000cited by this paper
• Repression of BRCA1 through a Feedback Loop Involving p53*

  2000cited by this paper
• Roles of BRCA1 and its interacting proteins

  2000cited by this paper
• BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures.

  2000cited by this paper
• In search of the tumour-suppressor functions of BRCA1 and BRCA2

  2000cited by this paper
• Methylation of the BRCA1 promoter region in sporadic breast and ovarian cancer: correlation with disease characteristics

  1999cited by this paper
• Positive Regulation of the BRCA1 Promoter*

  1999cited by this paper
• Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks.

  1999cited by this paper
• BRCA1-associated growth arrest is RB-dependent.

  1999cited by this paper
• Identification of a C/G polymorphism in the promoter region of the BRCA1 gene and its use as a marker for rapid detection of promoter deletions

  1999cited by this paper
• DNA Methylation de Novo

  1999cited by this paper
• BRCA1 Is Phosphorylated at Serine 1497 In Vivo at a Cyclin-Dependent Kinase 2 Phosphorylation Site

  1999cited by this paper
• Association of BRCA1 with the hRad50-hMre11-p95 complex and the DNA damage response.

  1999cited by this paper
• RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination.

  1999cited by this paper
• BRCA1 interacts with components of the histone deacetylase complex.

  1999cited by this paper
• Breast Cancer Genes and DNA Repair

  1999cited by this paper
• Defining biochemical functions for the BRCA1 tumor suppressor protein: analysis of the BRCA1 binding protein BAP1.

  1999cited by this paper
• Decreased BRCA1 expression levels may arrest the cell cycle through activation of p53 checkpoint in human sporadic breast tumors.

  1998cited by this paper
• BAP1: a novel ubiquitin hydrolase which binds to the BRCA1 RING finger and enhances BRCA1-mediated cell growth suppression

  1998cited by this paper
• BRCA1 required for transcription-coupled repair of oxidative DNA damage.

  1998cited by this paper
• BRCA1 binds c-Myc and inhibits its transcriptional and transforming activity in cells

  1998cited by this paper
• Down-regulation of BRCA1 in human sporadic breast cancer; analysis of DNA methylation patterns of the putative promoter region

  1998cited by this paper
• Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells.

  1998cited by this paper
• CpG methylation within the 5′ regulatory region of the BRCA1 gene is tumor specific and includes a putative CREB binding site

  1998cited by this paper
• Characterization of paired tumor and non‐tumor cell lines established from patients with breast cancer

  1998cited by this paper
• Complex Regulation of the BRCA1 Gene*

  1997cited by this paper
• Homonucleotide tracts, short repeats and CpG/CpNpG motifs are frequent sites for heterogeneous mutations in the neurofibromatosis type 1 (NF1) tumour-suppressor gene.

  1997cited by this paper
• Association of BRCA1 with Rad51 in mitotic and meiotic cells.

  1997cited by this paper
• Frequently occurring germ-line mutations of the BRCA1 gene in ovarian cancer families from Russia.

  1997cited by this paper
• Cancer-susceptibility genes. Gatekeepers and caretakers.

  1997cited by this paper
• Dynamic changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damage.

  1997cited by this paper
• Isolation and characterisation of the NBR2 gene which lies head to head with the human BRCA1 gene.

  1997cited by this paper
• From BRCA1 to RAP1: a widespread BRCT module closely associated with DNA repair

  1997cited by this paper
• Tumour biological features of BRCA1-induced breast and ovarian cancer.

  1997cited by this paper
• Germline BRCA1 185delAG mutations in Jewish women with breast cancer.

  1996cited by this paper
• Identification of a RING protein that can interact in vivo with the BRCA1 gene product

  1996cited by this paper
• The 5' end of the BRCA1 gene lies within a duplicated region of human chromosome 17q21.

  1996cited by this paper
• BRCA1 protein products ... Functional motifs...

  1996cited by this paper
• Haplotype and phenotype analysis of six recurrent BRCA1 mutations in 61 families: results of an international study.

  1996cited by this paper
• A possible role in chemical carcinogenesis for epigenetic, heritable changes in gene expression

  1996cited by this paper
• Distinct transcription start sites generate two forms of BRCA1 mRNA.

  1995cited by this paper
• Germline BRCA1 mutations and loss of the wild-type allele in tumors from families with early onset breast and ovarian cancer.

  1995cited by this paper
• Inherited breast and ovarian cancer.

  1995cited by this paper
• Demethylation of the estrogen receptor gene in estrogen receptor-negative breast cancer cells can reactivate estrogen receptor gene expression.

  1995cited by this paper
• The carrier frequency of the BRCA1 185delAG mutation is approximately 1 percent in Ashkenazi Jewish individuals

  1995cited by this paper
• Decreased expression of BRCA1 accelerates growth and is often present during sporadic breast cancer progression

  1995cited by this paper
• BRCA1 mutations in primary breast and ovarian carcinomas.

  1994cited by this paper
• A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1.

  1994cited by this paper
• An estrogen-responsive element derived from the 5' flanking region of the Xenopus vitellogenin A2 gene functions in transfected human cells.

  1986cited by this paper

• MiR-409-3p/Rab10/BRCA1 axis inhibits malignant transformation of endometrial carcinoma

  2025cites this paper
• Technologies in Biomarker Discovery for Animal Diseases: Mechanisms, Classification, and Diagnostic Applications

  2025cites this paper
• Exploring the Therapeutic Potential of BRCA1 and BRCA2 as Targets in Canine Oncology: A Comprehensive Review of Their Role in Cancer Development and Treatment

  2025cites this paper
• The role of cell cycle-related genes in the tumorigenesis of adrenal and thyroid neuroendocrine tumors

  2024cites this paper
• The crucial role of HFM1 in regulating FUS ubiquitination and localization for oocyte meiosis prophase I progression in mice

  2024cites this paper
• Nutritional Genomics and Cancer Prevention.

  2024cites this paper
• Expression of DNAJB9 and some other genes is more sensitive to SWCNTs in normal human astrocytes than glioblastoma cells

  2023cites this paper
• A systematic review on the association between ovarian and prostate cancer with BRCA1 and BRCA2 gene

  2023cites this paper
• Integrated ACMG-approved genes and ICD codes for the translational research and precision medicine

  2023cites this paper
• Emerging Roles of RNF168 in Tumor Progression

  2023cites this paper
• Exposure to nanographene oxide induces gene expression dysregulation in normal human astrocytes

  2022cites this paper
• Identification and Validation of SNP-Containing Genes With Prognostic Value in Gastric Cancer via Integrated Bioinformatics Analysis

  2021cites this paper
• miR-522 regulates cell proliferation, migration, invasion capacities and acts as a potential biomarker to predict prognosis in triple-negative breast cancer

  2021cites this paper
• Application of weighted gene co-expression network analysis to identify the hub genes in H1N1.

  2021cites this paper
• Nutrigenomics and Breast Cancer: State-of-Art, Future Perspectives and Insights for Prevention

  2020cites this paper
• Role of tumor suppressor molecules in genomic perturbations and damaged DNA repair involved in the pathogenesis of cancer and neurodegeneration (Review)

  2020cites this paper
• Low expression of LINC00982 and PRDM16 is associated with altered gene expression, damaged pathways and poor survival in lung adenocarcinoma.

  2018cites this paper
• Mismatch tolerance during homologous recombination in mammalian cells.

  2018cites this paper
• Cell Cycle Regulation via the p 53 , PTEN , and BRCA 1 Tumor Suppressors

  2017cites this paper
• Sensitive impedimetric DNA biosensor based on (Nb,V) codoped TiO2 for breast cancer susceptible gene detection.

  2017cites this paper
• Protein kinase CK2 in DNA damage and repair

  2016cites this paper
• Intrachromosomal recombination between highly diverged DNA sequences is enabled in human cells deficient in Bloom helicase.

  2016cites this paper
• Regulation of DNA repair by non-coding miRNAs

  2016cites this paper
• JAK 2 V 617 F Mutation Affects Downstream LIN 28 A and HMGA 2 Methylation in Myeloproliferative Neoplasms

  2016cites this paper
• Cell Cycle Regulation via the p53, PTEN, and BRCA1 Tumor Suppressors

  2016cites this paper
• Epigenetic Control of Genes Involved in Cancer Initiation and Progression

  2016cites this paper
• BRCA1 and p53 Tumor Suppressor Molecules in Alzheimer’s Disease

  2015cites this paper
• BRCA‐mutated Invasive Breast Carcinomas: Immunohistochemical Analysis of Insulin‐like Growth Factor II mRNA‐binding Protein (IMP3), Cytokeratin 8/18, and Cytokeratin 14

  2015cites this paper
• Depletion of eIF2.GTP.Met-tRNAi translation initiation complex up-regulates BRCA1 expression in vitro and in vivo

  2015cites this paper
• Nuclear morphometry, apoptotic and mitotic indices, and tubular differentiation in Libyan breast cancer

  2014cites this paper
• Molecular Detection of Hereditary Breast Cancer Susceptibility Genes (BRCA1 / BRCA2) in Palestine

  2014cites this paper
• Connection between Tumor Suppressor BRCA1 and PTEN in Damaged DNA Repair

  2014cites this paper
• Ultrasensitive dual amplification sandwich immunosensor for breast cancer susceptibility gene based on sheet materials.

  2014cites this paper
• DNA damage checkpoints in nasopharyngeal carcinoma.

  2014cites this paper
• Targeting the microRNA-regulating DNA damage/repair pathways in cancer

  2014cites this paper
• STEROID RECEPTOR EXPRESSION IN DIAGNOSIS AND PROGNOSIS OF LIBYAN BREAST CANCER by

  2012cites this paper
• Crosstalk between the DNA damage response pathway and microRNAs

  2012cites this paper
• BRCA1 regulates microRNA biogenesis via the DROSHA microprocessor complex

  2012cites this paper
• Epigenetic modulation of BRCA1 and BRCA2 gene expression by equol in breast cancer cell lines

  2012cites this paper
• Application of morphometry, static DNA ploidy analysis, and steroid receptor expression in diagnosis and prognosis of Libyan breast cancer

  2012cites this paper
• Epidemiology of Genetic Alterations in Progression of Breast Cancer

  2012cites this paper
• Ultrasensitive electrochemical immunoassay for BRCA1 using BMIM·BF₄-coated SBA-15 as labels and functionalized graphene as enhancer.

  2011cites this paper
• Epidemiology of Genetic Alterations in Progression of Breast Cancer

  2011cites this paper
• CK8/18 expression, the basal phenotype, and family history in identifying BRCA1‐associated breast cancer in the Ontario site of the Breast Cancer Family Registry

  2011cites this paper
• On the role of autophagy in human diseases: a gender perspective

  2011cites this paper
• Breast cancer and genetics.

  2011cites this paper
• NUTRIGENOMICS: A NON - CONVENTIONAL THERAPY

  2011cites this paper
• Novel Roles for 185delAG Mutant BRCA1 in Ovarian Cancer Pathology

  2010influential citation
• DNA damage and polyploidization.

  2010cites this paper
• Polyploidization and cancer

  2010cites this paper
• Wild-Type BRCA1, but not Mutated BRCA1, Regulates the Expression of the Nuclear Form of β-Catenin

  2010cites this paper
• BRCA1 16 years later: risk‐associated BRCA1 mutations and their functional implications

  2010cites this paper
• Mechanism and consequence of the hypermethylator phenotype in human breast cancer

  2008cites this paper
• Oncogenic pathways in hereditary and sporadic breast cancer.

  2008cites this paper
• Tumorigenesis and neurodegeneration: two sides of the same coin?

  2008cites this paper
• Nutrigenomics: Looking to DNA for nutrition advice

  2008cites this paper
• Molecular Signaling Pathways in Pancreatic Cancer

  2008cites this paper
• Reprint of Oncogenic pathways in hereditary and sporadic breast cancer

  2008cites this paper
• Accurate Homologous Recombination Is a Prominent Double-Strand Break Repair Pathway in Mammalian Chromosomes and Is Modulated by Mismatch Repair Protein Msh2

  2007cites this paper
• The DNA Damage Response, DNA Repair, and AML

  2007cites this paper
• Stalled replication induces p53 accumulation through distinct mechanisms from DNA damage checkpoint pathways.

  2006cites this paper
• Breast cancer gene therapy

  2006cites this paper
• The BRCA1 COOH-terminal Region Acts as an RNA Polymerase II Carboxyl-terminal Domain Kinase Inhibitor That Modulates p21WAF1/CIP1 Expression*

  2006cites this paper
• Regulation of the p14ARF-Mdm2-p53 pathway: an overview in breast cancer.

  2006cites this paper
• Plasma epigenetic markers for cancer detection and prenatal diagnosis.

  2006influential citation
• The Epstein-Barr Virus Replication Protein BBLF2/3 Provides an Origin-Tethering Function through Interaction with the Zinc Finger DNA Binding Protein ZBRK1 and the KAP-1 Corepressor

  2005cites this paper
• Genotoxic stress: novel biomarkers and detection methods : Uncovering RNAs role in epigenetics of carcinogenesis

  2005cites this paper
• DNA methylation and cancer-associated genetic instability.

  2005cites this paper
• Genetic models of human cancer as a multistep process. Paradigm models of colorectal cancer, breast cancer, and chronic myelogenous and acute lymphoblastic leukaemia.

  2005cites this paper
• Prediction of protein-protein interactions by combining structure and sequence conservation in protein interfaces

  2005cites this paper
• The evolution of meiosis: Recruitment and modification of somatic DNA‐repair proteins

  2005cites this paper
• A Role for DNA Mismatch Repair Protein Msh2 in Error-Prone Double-Strand-Break Repair in Mammalian Chromosomes

  2005cites this paper
• Gene expression profiling of breast cancer in relation to estrogen receptor status and estrogen-metabolizing enzymes: clinical implications.

  2005cites this paper
• Oncogenic pathways in hereditary and sporadic breast cancer.

  2004cites this paper
• Candidate nsSNPs that can affect the functions and interactions of cell cycle proteins

  2004cites this paper
• The centrosome in higher organisms: structure, composition, and duplication.

  2004cites this paper
• Patrón de metilación génico en el cáncer de mama

  2004cites this paper
• [Promoter methylation profile in breast cancer].

  2004cites this paper
• Analysis of Microsatellite Instability and hMLH1, hMSH2 and Bax Expression in Sporadic Endometrioid Endometrial Adenocarcinoma

  2004cites this paper
• Frontiers in nutrigenomics, proteomics, metabolomics and cancer prevention.

  2004cites this paper
• Epigenetics and Cancer

  2004cites this paper
• Jcb: Report

  year unknowncites this paper