Protein kinase CK2 in DNA damage and repair

No abstract is available for this paper.

• Publication year

  2016

• Venue

  Translational cancer research

• Publication date

  2016-01-29

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.21037/6469
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Casein kinases as potential therapeutic targets

  2016cited by this paper
• Modulation of LSD1 phosphorylation by CK2/WIP1 regulates RNF168-dependent 53BP1 recruitment in response to DNA damage

  2015influential reference
• Casein kinase 2 (CK2) phosphorylates the deubiquitylase OTUB1 at Ser16 to trigger its nuclear localization

  2015influential reference
• DNA damage and the balance between survival and death in cancer biology

  2015influential reference
• Protein kinase CK2 in breast cancer: the CK2β regulatory subunit takes center stage in epithelial plasticity

  2015cited by this paper
• Tissue-Specific Functions and Regulation of Protein Kinase CK2

  2015cited by this paper
• Multi-layered molecular mechanisms of polypeptide holding, unfolding and disaggregation by HSP70/HSP110 chaperones

  2015cited by this paper
• New insights into the mechanism of DNA mismatch repair

  2015cited by this paper
• Envisioning the dynamics and flexibility of Mre11-Rad50-Nbs1 complex to decipher its roles in DNA replication and repair.

  2015cited by this paper
• The structural basis of XRCC1-mediated DNA repair.

  2015cited by this paper
• CK2 phosphorylation of human centrins 1 and 2 regulates their binding to the DNA repair protein XPC, the centrosomal protein Sfi1 and the phototransduction protein transducin β

  2014cited by this paper
• Thioguanine : A DrugWith Unrealized Potential for Cancer Therapy

  2014cited by this paper
• Interaction between Rad9-Hus1-Rad1 and TopBP1 activates ATR-ATRIP and promotes TopBP1 recruitment to sites of UV-damage.

  2014cited by this paper
• TopBP1: A BRCT-scaffold protein functioning in multiple cellular pathways.

  2014cited by this paper
• JWA reverses cisplatin resistance via the CK2—XRCC1 pathway in human gastric cancer cells

  2014cited by this paper
• Elevated expression of nuclear protein kinase CK2α as a poor prognosis indicator in lymph node cancerous metastases of human thyroid cancers.

  2014cited by this paper
• Tyrosine phosphorylation of histone H2A by CK2 regulates transcriptional elongation

  2014cited by this paper
• HspA1A facilitates DNA repair in human bronchial epithelial cells exposed to Benzo[a]pyrene and interacts with casein kinase 2

  2014cited by this paper
• Protein kinase CK2 and angiogenesis.

  2014cited by this paper
• Protein kinase CK2 is required for the recruitment of 53BP1 to sites of DNA double-strand break induced by radiomimetic drugs.

  2014cited by this paper
• Inhibition of CK2 enhances UV-triggered apoptotic cell death in lung cancer cell lines.

  2013cited by this paper
• DNA damage-induced cell death: from specific DNA lesions to the DNA damage response and apoptosis.

  2013influential reference
• Chromatin PTEN is involved in DNA damage response partly through regulating Rad52 sumoylation

  2013influential reference
• [Casein kinase 2, the versatile regulator of cell survival].

  2012cited by this paper
• Plk1 and CK2 Act in Concert to Regulate Rad51 during DNA Double Strand Break Repair

  2012cited by this paper
• Protein kinase CK2 localizes to sites of DNA double-strand break regulating the cellular response to DNA damage

  2012cited by this paper
• Casein kinase 2 inhibition modulates the DNA damage response but fails to radiosensitize malignant glioma cells.

  2012cited by this paper
• CK2 Inhibitor CX-4945 Suppresses DNA Repair Response Triggered by DNA-Targeted Anticancer Drugs and Augments Efficacy: Mechanistic Rationale for Drug Combination Therapy

  2012cited by this paper
• CK2 phosphorylation of XRCC1 facilitates dissociation from DNA and single-strand break formation during base excision repair.

  2011cited by this paper
• Lack of the catalytic subunit of DNA-dependent protein kinase (DNA-PKcs) is accompanied by increased CK2α′ levels

  2011influential reference
• A specific inhibitor of protein kinase CK2 delays gamma-H2Ax foci removal and reduces clonogenic survival of irradiated mammalian cells

  2011cited by this paper
• Rad52 SUMOylation affects the efficiency of the DNA repair

  2010cited by this paper
• Structure and function of the Rad9-binding region of the DNA-damage checkpoint adaptor TopBP1

  2010cited by this paper
• XRCC1 phosphorylation by CK2 is required for its stability and efficient DNA repair.

  2010cited by this paper
• Non-canonical inhibition of DNA damage-dependent ubiquitination by OTUB1

  2010cited by this paper
• Dual Modes of Interaction between XRCC4 and Polynucleotide Kinase/Phosphatase

  2010influential reference
• The DNA-dependent protein kinase (DNA-PK): More than just a case of making ends meet?

  2010cited by this paper
• Photoaffinity labeling reveals nuclear proteins that uniquely recognize cisplatin-DNA interstrand cross-links.

  2009cited by this paper
• 14-3-3 proteins, FHA domains and BRCT domains in the DNA damage response.

  2009cited by this paper
• Localization of X-ray cross complementing gene 1 protein in the nuclear matrix is controlled by casein kinase II-dependent phosphorylation in response to oxidative damage.

  2009cited by this paper
• Repair of ionizing radiation-induced DNA double-strand breaks by non-homologous end-joining.

  2009cited by this paper
• CK2 phosphorylation-dependent interaction between aprataxin and MDC1 in the DNA damage response

  2009influential reference
• Protein Kinase CK2 in Health and Disease

  2009cited by this paper
• Structural and Functional Interaction between the Human DNA Repair Proteins DNA Ligase IV and XRCC4

  2009cited by this paper
• Breaking the chains: structure and function of the deubiquitinases

  2009cited by this paper
• JWA regulates XRCC1 and functions as a novel base excision repair protein in oxidative-stress-induced DNA single-strand breaks

  2009cited by this paper
• Available online at www.sciencedirect.com Biochimica et Biophysica Acta xx (2008) xxx–xxx

  2008cited by this paper
• HP1-β mobilization promotes chromatin changes that initiate the DNA damage response

  2008cited by this paper
• Constitutive phosphorylation of MDC1 physically links the MRE11–RAD50–NBS1 complex to damaged chromatin

  2008cited by this paper
• Phosphorylation of SDT repeats in the MDC1 N terminus triggers retention of NBS1 at the DNA damage–modified chromatin

  2008cited by this paper
• Protein kinase CK2 catalyzes tyrosine phosphorylation in mammalian cells.

  2008cited by this paper
• A novel human AP endonuclease with conserved zinc‐finger‐like motifs involved in DNA strand break responses

  2007cited by this paper
• Identification of JWA as a novel functional gene responsive to environmental oxidative stress induced by benzo[a]pyrene and hydrogen peroxide.

  2007cited by this paper
• 53BP1 and p53 synergize to suppress genomic instability and lymphomagenesis.

  2006cited by this paper
• Mechanism of Stimulation of Human DNA Ligase I by the Rad9-Rad1-Hus1 Checkpoint Complex*

  2006cited by this paper
• Heat shock protein 70 enhanced deoxyribonucleic acid base excision repair in human leukemic cells after ionizing radiation

  2006cited by this paper
• Protein Kinase CK2 Is Inhibited by Human Nucleolar Phosphoprotein p140 in an Inositol Hexakisphosphate-dependent Manner*

  2006cited by this paper
• Casein Kinase 2 Regulates Both Apoptosis and the Cell Cycle Following DNA Damage Induced by 6-Thioguanine

  2005influential reference
• Regulation of NuA4 Histone Acetyltransferase Activity in Transcription and DNA Repair by Phosphorylation of Histone H4

  2005cited by this paper
• The protein kinase CK2 facilitates repair of chromosomal DNA single-strand breaks.

  2004cited by this paper
• The XRCC genes: expanding roles in DNA double-strand break repair.

  2004cited by this paper
• Regulation of Casein Kinase-2 (CK2) Activity by Inositol Phosphates*

  2004cited by this paper
• CK2α - protein phosphatase 2A molecular complex: Possible interaction with the MAP kinase pathway

  2004cited by this paper
• Breaking in a new function for casein kinase 2.

  2004cited by this paper
• Increased Sensitivity to UV Radiation in Mice with a p53 Point Mutation at Ser389

  2004cited by this paper
• Phosphorylation of XPB helicase regulates TFIIH nucleotide excision repair activity

  2004cited by this paper
• Role for the BRCA1 C-terminal Repeats (BRCT) Protein 53BP1 in Maintaining Genomic Stability*

  2003cited by this paper
• CK2 Is a C-Terminal IkappaB Kinase Responsible for NF-kappaB Activation during the UV Response.

  2003cited by this paper
• Loading of the human 9-1-1 checkpoint complex onto DNA by the checkpoint clamp loader hRad17-replication factor C complex in vitro

  2003cited by this paper
• BRCA1 in cancer, cell cycle and genomic stability.

  2003cited by this paper
• One‐thousand‐and‐one substrates of protein kinase CK2?

  2003cited by this paper
• Protein Kinase CK2 Phosphorylates the High Mobility Group Domain Protein SSRP1, Inducing the Recognition of UV-damaged DNA*

  2003cited by this paper
• From DNA damage to G2 arrest: the many roles of topoisomerase II.

  2003cited by this paper
• A Bicyclic Monoterpene Diol and UVB Stimulate BRCA1 Phosphorylation in Human Keratinocytes ¶

  2003influential reference
• CK2 Is a C-Terminal IκB Kinase Responsible for NF-κB Activation during the UV Response

  2003cited by this paper
• Defective Human MutY Phosphorylation Exists in Colorectal Cancer Cell Lines with Wild-type MutY Alleles*

  2003cited by this paper
• The cyclin H/cdk7/Mat1 kinase activity is regulated by CK2 phosphorylation of cyclin H

  2002cited by this paper
• p53 Serine 392 Phosphorylation Increases after UV through Induction of the Assembly of the CK2·hSPT16·SSRP1 Complex*

  2002cited by this paper
• Phosphorylation of mismatch repair proteins MSH2 and MSH6 affecting MutSalpha mismatch-binding activity.

  2002cited by this paper
• The Protein Kinase Complement of the Human Genome

  2002cited by this paper
• Wild‐type p53 inhibits protein kinase CK2 activity

  2001cited by this paper
• Heat Shock Protein 70 Binds to Human Apurinic/Apyrimidinic Endonuclease and Stimulates Endonuclease Activity at Abasic Sites*

  2001cited by this paper
• Centrosome Protein Centrin 2/Caltractin 1 Is Part of the Xeroderma Pigmentosum Group C Complex That Initiates Global Genome Nucleotide Excision Repair*

  2001cited by this paper
• A DNA damage-induced p53 serine 392 kinase complex contains CK2, hSpt16, and SSRP1.

  2001cited by this paper
• Subcellular localization of protein kinase CK2

  2000cited by this paper
• Subcellular localization of protein kinase CK2. A key to its function?

  2000cited by this paper
• Phosphorylation of the DNA repair protein APE/REF-1 by CKII affects redox regulation of AP-1

  1999influential reference
• Regulation of p53 mediated transactivation by the β‐subunit of protein kinase CK2

  1999cited by this paper
• Casein kinase 2 binds to and phosphorylates BRCA1.

  1999cited by this paper
• The chromatin-specific transcription elongation factor FACT comprises human SPT16 and SSRP1 proteins

  1999cited by this paper
• The replication factory targeting sequence/PCNA‐binding site is required in G1 to control the phosphorylation status of DNA ligase I

  1999cited by this paper
• Solution structure of the single-strand break repair protein XRCC1 N-terminal domain

  1999cited by this paper
• Detection of an appropriate kinase activity in branchial arches I and II that coincides with peak expression of the Treacher Collins syndrome gene product, treacle.

  1999cited by this paper
• Protein kinase CK2 and its role in cellular proliferation, development and pathology

  1999cited by this paper
• The DNA repair activity of human redox/repair protein APE/Ref-1 is inactivated by phosphorylation.

  1997cited by this paper
• Casein kinase II is a selective target of HIV-1 transcriptional inhibitors.

  1997cited by this paper
• DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2.

  1997cited by this paper
• Identification of redox/repair protein Ref-1 as a potent activator of p53.

  1997cited by this paper
• Casein Kinase II Catalyzes Tyrosine Phosphorylation of the Yeast Nucleolar Immunophilin Fpr3*

  1997cited by this paper
• Casein kinase 2 inhibits the renaturation of complementary DNA strands mediated by p53 protein.

  1996cited by this paper

• CK2: the master regulator in tumor immune-microenvironment - a crucial target in oncotherapy.

  2025cites this paper
• Phosphorylation inhibits intramolecular interactions, DNA-binding and protein interactions of Claspin through disordered/ structured conformation transition

  2024cites this paper
• Protective effect of CK2 against endoplasmic reticulum stress in pancreatic β cells

  2024cites this paper
• The Janus face of HIF-1α in ischemic stroke and the possible associated pathways.

  2024cites this paper
• MiR-93 alleviates DEHP plasticizer-induced neurotoxicity by negatively regulating TNFAIP1 and inhibiting ubiquitin-mediated degradation of CK2β.

  2023cites this paper
• Protein Kinase CK2α’, More than a Backup of CK2α

  2023cites this paper
• Minor Kinases with Major Roles in Cytokinesis Regulation

  2022cites this paper
• An overview of cdc2‐like kinase 1 (Clk1) inhibitors and their therapeutic indications

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• Protein Kinase CK2 Contributes to Glucose Homeostasis by Targeting Fructose-1,6-Bisphosphatase 1

  2022cites this paper
• CK2 and the Hallmarks of Cancer

  2022cites this paper
• Structural and Enzymological Evidence for an Altered Substrate Specificity in Okur-Chung Neurodevelopmental Syndrome Mutant CK2αLys198Arg

  2022cites this paper
• Regulation of RAD51 at the Transcriptional and Functional Levels: What Prospects for Cancer Therapy?

  2021cites this paper
• Spatial proteomics reveals subcellular reorganization in human keratinocytes exposed to UVA light

  2021cites this paper
• CX-4945 and siRNA-Mediated Knockdown of CK2 Improves Cisplatin Response in HPV(+) and HPV(−) HNSCC Cell Lines

  2021cites this paper
• SGC-CK2-1 Is an Efficient Inducer of Insulin Production and Secretion in Pancreatic β-Cells

  2021cites this paper
• Development of a potent and selective chemical probe for the pleiotropic kinase CK2.

  2020cites this paper
• The stability of CREB3/Luman is regulated by protein kinase CK2 phosphorylation.

  2020cites this paper
• Impact of Increased FUT8 Expression on the Extracellular Vesicle Proteome in Prostate Cancer Cells.

  2020cites this paper
• Protein Kinase CK2 Controls CaV2.1-Dependent Calcium Currents and Insulin Release in Pancreatic β-cells

  2020cites this paper
• Kinetin/N6-furfuryladenine: A New Neurodegenerative Disease Lead from an Old Plant Cytokine

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• Casein Kinase2 and Its Dynamism in Abiotic Stress Management

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• Cancer immunology of cutaneous melanoma: a systems biology approach

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• DNA Damage Repair in Huntington’s Disease and Other Neurodegenerative Diseases

  2019cites this paper
• Casein Kinase 2 Inhibitor, CX-4945, as a Potential Targeted Anticancer Agent in Gastric Cancer

  2018cites this paper
• Phosphorylation meets DNA mismatch repair.

  2018cites this paper
• DNA mismatch repair activity of MutLα is regulated by CK2‐dependent phosphorylation of MLH1 (S477)

  2018cites this paper
• N6-Furfuryladenine is protective in Huntington’s disease models by signaling huntingtin phosphorylation

  2018cites this paper
• Protein kinase CK2 in development and differentiation.

  2017cites this paper
• The mammalian STE20-like kinase 1 (MST1) is a substrate for the apoptosis inhibiting protein kinase CK2.

  2017cites this paper
• CK2-dependent phosphorylation positively regulates stress-induced activation of Msn2 in Saccharomyces cerevisiae.

  2017cites this paper
• The Thesis Committee for Antony Martin Harvey Certifies that this is the approved version of the following thesis: Evaluation of MRN Complex and ATM Protein-Protein Interactions using Cleavable DSSO Crosslinking and Mass Spectrometry APPROVED BY SUPERVISING COMMITTEE:

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