Effect of N-acetylcysteine on plasma cysteine and glutathione following paracetamol administration

No abstract is available for this paper.

• Publication year

  2004

• Venue

  European Journal of Clinical Pharmacology

• Publication date

  Unknown publication date

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1007/BF00609183PMID 2721538
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Pharmacokinetics and bioavailability of reduced and oxidized N-acetylcysteine

  2004cited by this paper
• Pharmacokinetics of N-acetylcysteine in man

  2004cited by this paper
• Therapeutic doses of acetaminophen stimulate the turnover of cysteine and glutathione in man.

  1987cited by this paper
• Methodologies for the analysis of reduced and oxidized N-acetylcysteine in biological systems.

  1987cited by this paper
• Role of glutathione in prevention of acetaminophen-induced hepatotoxicity by N-acetyl-L-cysteine in vivo: studies with N-acetyl-D-cysteine in mice.

  1986cited by this paper
• Mechanism of inhibition of glutathione efflux by methionine from isolated rat hepatocytes.

  1986cited by this paper
• Hepatic Glutathione Homeostasis in the Rat: Efflux Accounts for Glutathione Turnover

  1984cited by this paper
• Determination of non-protein-bound N-acetylcysteine in plasma by high-performance liquid chromatography.

  1984cited by this paper
• Mechanism of action of N-acetylcysteine in the protection against the hepatotoxicity of acetaminophen in rats in vivo.

  1983cited by this paper
• Plasma glutathione and glutathione disulfide in the rat: regulation and response to oxidative stress.

  1983cited by this paper
• N-acetylcysteine: its bioavailability and interaction with ifosfamide metabolites.

  1983cited by this paper
• N-acetylcysteine: its bioavailability and interaction with ifosfamide metabolites.

  1983cited by this paper
• Controlled trial of oral N‐acetylcysteine in cystic fibrosis

  1982cited by this paper
• Analysis of biological thiols: derivatization with monobromobimane and separation by reverse-phase high-performance liquid chromatography.

  1981cited by this paper
• The Role of the Cystathionine Pathway in Glutathione Regulation by Isolated Hepatocytes

  1978cited by this paper
• Treatment of paracetamol (acetaminophen) poisoning with N-acetylcysteine.

  1977cited by this paper
• A controlled trial of intermittent oral acetylcysteine in the long-term treatment of chronic bronchitis

  1976cited by this paper

• Modeling and Simulation of Acetaminophen Pharmacokinetics and Hepatic Biomarkers After Overdoses of Extended‐Release and Immediate‐Release Formulations in Healthy Adults Using the Quantitative Systems Toxicology Software Platform DILIsym

  2025cites this paper
• Human fibroblasts from aged individuals exhibit chromosomal instability through replication stress caused by oxidative stress

  2025cites this paper
• Ten “Cheat Codes” for Measuring Oxidative Stress in Humans

  2024cites this paper
• Glutathione and glutathione disulfide – their biomedical and pharmaceutical applications

  2023cites this paper
• N-acetylcysteine overcomes NF1 loss-driven resistance to PI3Kα inhibition in breast cancer

  2023cites this paper
• N-acetylcysteine (NAC) Inhibits ROS-Induced Ferroptosis in CTNS Knockdown β-Cells in Vitro

  2022cites this paper
• A combination of N-acetyl cysteine and propolis attenuates oxidative-inflammatory parameters during COPD exacerbation.

  2022cites this paper
• The mechanism of action of N-acetylcysteine (NAC): The emerging role of H2S and sulfane sulfur species.

  2021cites this paper
• The use of N-acetylcysteine in the prevention of hangover: a randomized trial

  2021cites this paper
• Crotalus atrox venom‐induced cellular toxicity: Early wound progression involves reactive oxygen species

  2021cites this paper
• The Effect of N-Acetylcysteine on Respiratory Enzymes, ADP/ATP Ratio, Glutathione Metabolism, and Nitrosative Stress in the Salivary Gland Mitochondria of Insulin Resistant Rats

  2020cites this paper
• Attenuating the increased level of creatinine by N ‐acetylcysteine: Raman spectroscopy and density functional theory‐based monitoring of in vitro complexation in aqueous solution

  2020cites this paper
• Pharmacokinetics and Safety of Single and Multiple Doses of Oral N-Acetylcysteine in Healthy Chinese and Caucasian Volunteers: An Open-Label, Phase I Clinical Study

  2020cites this paper
• Conventional and Nanotechnology Based Approaches to Combat Chronic Obstructive Pulmonary Disease: Implications for Chronic Airway Diseases

  2020cites this paper
• Radyasyona Maruz Kalan Ratlarda Oksidan/Antioksidan Durum Üzerine N-Asetilsistein’in Etkisi

  2020cites this paper
• Paracetamol-Induced Glutathione Consumption: Is There a Link With Severe COVID-19 Illness?

  2020cites this paper
• Oxidative Stress in Amyotrophic Lateral Sclerosis: Pathophysiology and Opportunities for Pharmacological Intervention

  2020cites this paper
• Plasma Metabolomic Pro�ling of Individuals Susceptible to High Altitude through Gas Chromatograph-mass Spectrometry

  2020cites this paper
• The Effect of N-Acetylcysteine on Oxidant/Antioxidant Status in Irradiated Rats

  2020influential citation
• Paracetamol use in COVID-19: friend or enemy?

  2020cites this paper
• Cysteine Disulfides (Cys-ss-X) as Sensitive Plasma Biomarkers of Oxidative Stress

  2019cites this paper
• Nutrition and Altitude: Strategies to Enhance Adaptation, Improve Performance and Maintain Health: A Narrative Review

  2019cites this paper
• The Role of Reactive Oxygen Species in Crotalus atrox Venom‐induced Cell Death

  2019cites this paper
• An in vitro analysis of the rat C6 glioma cells to elucidate the linear alkylbenzene sulfonate induced oxidative stress and consequent G2/M phase cell cycle arrest and cellular apoptosis.

  2018cites this paper
• Indicator of Ischemia Syndrome and Reperfusion in Resisted Training

  2018cites this paper
• Cysteine/Glutathione Deficiency: A Significant and Treatable Corollary of Disease

  2018cites this paper
• Attenuating Effect of N-Acetylcysteine onApoptosis Associated with ImidaclopridInduced Testicular Damage inMale Albino Rats

  2018cites this paper
• Effects of blue-light irradiation during dental treatment☆

  2018cites this paper
• Classification and Epidemiologic Aspects of Acute Liver Failure.

  2018cites this paper
• N-acetylcysteine protects against microcystin-LR-induced endoplasmic reticulum stress and germ cell apoptosis in zebrafish testes.

  2018cites this paper
• Beneficial Effects of N-Acetyl-L-cysteine or Taurine Pre- or Post-treatments in the Heart, Spleen, Lung, and Testis of Hexavalent Chromium-Exposed Mice

  2018cites this paper
• Cardioprotective potential of N-acetyl cysteine against hyperglycaemia-induced oxidative damage: a protocol for a systematic review

  2017cites this paper
• Effect of N-Acetylcysteine on Mortality and Liver Transplantation Rate in Non-Acetaminophen-Induced Acute Liver Failure: A Multicenter Study

  2017cites this paper
• Explorer Antioxidant therapeutic advances in COPD

  2017cites this paper
• Homocystein: A new biochemical marker in livestock sector

  2017cites this paper
• Comparative effects of coconut water and N-Acetyl cysteine on the hypothalamo-pituitary-gonadal axis of male rats

  2016cites this paper
• The 100 most influential publications in paracetamol poisoning treatment: a bibliometric analysis of human studies

  2016cites this paper
• FULMINANT HEPA TIC FAILURE Acute hepatic failure

  2016cites this paper
• Novel Thioester Prodrug of N-acetylcysteine for Odor Masking and Bioavailability Enhancement.

  2016cites this paper
• Glutathione redox imbalance in brain disorders

  2015cites this paper
• Perioperative N-acetylcysteine for patients undergoing living donor orthotopic liver transplantation

  2015cites this paper
• Mitochondria: a new therapeutic target in chronic kidney disease

  2015cites this paper
• Dietary l-cysteine inhibits d-galactosamine-induced acute liver injury in rats

  2015cites this paper
• N-acetylcysteine as a potential strategy to attenuate the oxidative stress induced by uremic serum in the vascular system.

  2015cites this paper
• Systematic review regarding metabolic profiling for improved pathophysiological understanding of disease and outcome prediction in respiratory infections

  2015cites this paper
• N-acetylcysteine protects Chinese Hamster ovary cells from oxidative injury and apoptosis induced by microcystin-LR.

  2015influential citation
• Commentary to “Randomized controlled trial of oral glutathione supplementation on body stores of glutathione”

  2015cites this paper
• N-acetylcysteine inhibits the up-regulation of mitochondrial biogenesis genes in livers from rats fed ethanol chronically.

  2014cites this paper
• Intracellular Redox State as Target for Anti-Influenza Therapy: Are Antioxidants Always Effective?

  2014cites this paper
• EVALUATION OF N-ACETYL CYSTEINE PERFORMANCE IN ACETAMINOPHEN POISONING USING CERTAIN LIVER AND RENAL FACTORS IN PLASMA

  2014cites this paper
• Pregestational Diabetes and Congenital Heart Defects: Role of Reactive Oxygen Species

  2014cites this paper
• N-acetylcysteine in COPD may be beneficial, but for whom?

  2014cites this paper
• Effects of randomized supplementation of methionine or alanine on cysteine and glutathione production during the early phase of treatment of children with edematous malnutrition.

  2014cites this paper
• Effect of oral N-acetyl cysteine supplementation in type 2 diabetic patients on intracellular glutathione content and innate immune responses to Burkholderia pseudomallei.

  2014cites this paper
• N-Acetylcysteine prevents congenital heart defects induced by pregestational diabetes

  2014cites this paper
• Dietary L-Cysteine Improves the Antioxidative Potential and Lipid Metabolism in Rats Fed a Normal Diet

  2013cites this paper
• Amino Acids, Gene Expression, and Cell Signaling in the Pig Intestine

  2013cites this paper
• The chemistry and biological activities of N-acetylcysteine.

  2013cites this paper
• for Therapeutic Intervention The Redox State as a Correlate of Senescence and Wasting and as a Target

  2013cites this paper
• Intravenous N-Acetylcysteine for Prevention of Contrast-Induced Nephropathy: A Meta-Analysis of Randomized, Controlled Trials

  2013cites this paper
• N-Acetylcysteine ethyl ester (NACET): a novel lipophilic cell-permeable cysteine derivative with an unusual pharmacokinetic feature and remarkable antioxidant potential.

  2012cites this paper
• Mitochondrial dysfunction and oxidative stress in osteoarthritis

  2012cites this paper
• N-acetyl cysteine improves glycogenesis after segmental liver ischemia and reperfusion injury in pigs

  2012cites this paper
• Dental resin curing blue light induced oxidative stress with reactive oxygen species production.

  2012cites this paper
• Pro-oxidant and antioxidant effects of N-acetylcysteine regulate doxorubicin-induced NF-kappa B activity in leukemic cells.

  2012cites this paper
• Oxidant stress, mitochondria, and cell death mechanisms in drug-induced liver injury: Lessons learned from acetaminophen hepatotoxicity

  2012cites this paper
• Cell Surface Estrogen Receptor Alpha Is Upregulated during Subchronic Metabolic Stress and Inhibits Neuronal Cell Degeneration

  2012cites this paper
• An Analysis of N-Acetylcysteine Treatment for Acetaminophen Overdose Using a Systems Model of Drug-Induced Liver Injury

  2012cites this paper
• The Mitochondrial Genome Is a “Genetic Sanctuary” during the Oncogenic Process

  2011cites this paper
• N-acetilcisteína - ação antioxidante e utilização na clínica de pequenos animais

  2011cites this paper
• Therapeutic paracetamol treatment in older persons induces dietary and metabolic modifications related to sulfur amino acids

  2011cites this paper
• N-acetylcysteine in handgrip exercise: plasma thiols and adverse reactions.

  2011cites this paper
• EFFECT OF ORAL N-ACETYLCYSTEINE TREATMENT ON PLASMA INFLAMMATORY AND OXIDATIVE STRESS MARKERS IN PERITONEAL DIALYSIS PATIENTS: A PLACEBO-CONTROLLED STUDY

  2010influential citation
• Glutathione Synthesis and Turnover in the Human Erythrocyte

  2010cites this paper
• The effect of N-acetylcysteine on blood pressure and markers of cardiovascular risk in non-diabetic patients with chronic kidney disease: a placebo-controlled, randomized, cross-over study.

  2010cites this paper
• Effect of N-acetylcysteine on sympathetic hyperinnervation in post-infarcted rat hearts.

  2010cites this paper
• Oxidative stress in ALS: key role in motor neuron injury and therapeutic target.

  2010influential citation
• N-acetylcysteine does not prevent hepatorenal ischaemia-reperfusion injury in patients undergoing orthotopic liver transplantation.

  2010cites this paper
• Cisplatin combined with zidovudine enhances cytotoxicity and oxidative stress in human head and neck cancer cells via a thiol-dependent mechanism.

  2009cites this paper
• Environmental toxicity, redox signaling and lung inflammation: the role of glutathione.

  2009cites this paper
• GLUTATHIONE SYNTHESIS AGAINST OXIDANT INJURY BY PEROXIDES IN TWO ALVEOLAR EPITHELIAL CELL LINES

  2009cites this paper
• Effects of N-acetylcysteine on substance use in bipolar disorder: a randomised placebo-controlled clinical trial

  2009cites this paper
• The acute effects of NMDA antagonism: from the rodent to the human brain.

  2009cites this paper
• Role of N-acetylcysteine and cystine in glutathione synthesis in human erythrocytes

  2009cites this paper
• Role of N-acetylcysteine in adults with non-acetaminophen-induced acute liver failure in a center without the facility of liver transplantation

  2009cites this paper
• Effects of N-acetylcysteine on substance use in bipolar disorder: A randomised placebo-controlled clinical trial

  2009cites this paper
• N-acetylcysteine suppresses oxidative stress in experimental rats with subarachnoid hemorrhage.

  2009cites this paper
• Phosphoaspirin (MDC-43), a novel benzyl ester of aspirin, inhibits the growth of human cancer cell lines more potently than aspirin: a redox-dependent effect.

  2009cites this paper
• The Effect of N-Acetylcysteine on Proteinuria and Markers of Tubular Injury in Non-Diabetic Patients with Chronic Kidney Disease

  2008cites this paper
• Inflammation and neuroprotective strategies in the immature brain after hypoxic-ischemic brain injury

  2008cites this paper
• Acetyl Cysteine for Depressive Symptoms n Bipolar Disorder — A Double-Blind Randomized lacebo-Controlled Trial

  2008cites this paper
• N-acetylcysteine in the prevention of contrast-induced nephropathy.

  2008cites this paper
• Review: Antioxidant therapeutic advances in COPD

  2008cites this paper
• N-acetylcysteine use to prevent contrast medium-induced nephropathy: premature phase III trials.

  2008cites this paper
• Neuroprotection in emerging psychotic disorders

  2007cites this paper
• Steady State Concentration [ Css ] and Total Clearance Rate of NAC in Adults , Neonates and Children

  2007cites this paper
• N-acetyl cysteine supplementation prevents impairment of spatial working memory functions in rats following exposure to hypobaric hypoxia.

  2007cites this paper
• Senecio latifolius induces in vitro hepatocytotoxicity in a human cell line.

  2007cites this paper
• Glutathione Deficiency : Therapeutic Target in Human Immunodeficiency Virus Infection

  2007cites this paper
• Prevention of ifosfamide nephrotoxicity by N-acetylcysteine: clinical pharmacokinetic considerations.

  2007cites this paper