Washing older blood units before transfusion reduces plasma iron and improves outcomes in experimental canine pneumonia.

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Blood

• Publication date

  2014-02-27

• Fields of study

  Medicine

• Identifiers
  DOI 10.1182/blood-2013-11-539353PMID 24366359PMCID PMC3938151
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2011cited by this paper
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• Transfusion of human volunteers with older, stored red blood cells produces extravascular hemolysis and circulating non-transferrin-bound iron.

  2011cited by this paper
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  2011cited by this paper
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  2010cited by this paper
• Red cell storage.

  2010cited by this paper
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  2010cited by this paper
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  2006cited by this paper
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  2006cited by this paper
• Quality of red blood cells using the Dideco Electa autotransfusion device.

  2005cited by this paper
• Anemia of chronic disease.

  2005cited by this paper
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  2001cited by this paper
• Guide to the Preparation, Use and Quality Assurance of Blood Components.

  1998cited by this paper
• Neutrophil impairment associated with iron therapy in hemodialysis patients with functional iron deficiency.

  1998cited by this paper
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  1977cited by this paper

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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2019cites this paper
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  2018cites this paper
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  2018cites this paper
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