Does prolonged storage of red blood cells cause harm?

No abstract is available for this paper.

• Publication year

  2014

• Venue

  British Journal of Haematology

• Publication date

  2014-04-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1111/bjh.12747PMID 24460532PMCID PMC5515544
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Transfusion of Red Blood Cells.

  2016cited by this paper
• A comprehensive ovine model of blood transfusion

  2014cited by this paper
• Washing older blood units before transfusion reduces plasma iron and improves outcomes in experimental canine pneumonia.

  2014cited by this paper
• Transfusion of older stored blood worsens outcomes in canines depending on the presence and severity of pneumonia

  2014cited by this paper
• Storage time of red blood cells and mortality of transfusion recipients.

  2013influential reference
• Should blood be an essential medicine?

  2013cited by this paper
• Stored blood transfusion induces transient pulmonary arterial hypertension without impairing coagulation in an ovine model of nontraumatic haemorrhage

  2013cited by this paper
• Hemolysis and free hemoglobin revisited: exploring hemoglobin and hemin scavengers as a novel class of therapeutic proteins.

  2013cited by this paper
• Red cell storage: does duration matter?

  2013cited by this paper
• Age of red blood cells and transfusion in critically ill patients

  2013cited by this paper
• Relationship between red cell storage duration and outcomes in adults receiving red cell transfusions: a systematic review

  2013cited by this paper
• Research opportunities in optimizing storage of red blood cell products

  2013cited by this paper
• Glucose‐6‐phosphate dehydrogenase deficiency in transfusion medicine: the unknown risks

  2013cited by this paper
• Red blood cell storage: how long is too long?

  2013cited by this paper
• Effects of red blood cell storage in heavily transfused patients

  2013cited by this paper
• Decreased Erythrocyte Deformability After Transfusion and the Effects of Erythrocyte Storage Duration

  2013cited by this paper
• Erythrocyte Storage Duration Is Not Associated with Increased Mortality in Noncardiac Surgical Patients: A Retrospective Analysis of 6,994 Patients

  2013cited by this paper
• Red blood cells stored for increasing periods produce progressive impairments in nitric oxide–mediated vasodilation

  2013cited by this paper
• Longer storage duration of red blood cells is associated with an increased risk of acute lung injury in patients with sepsis

  2013cited by this paper
• Mortality increases after massive exchange transfusion with older stored blood in canines with experimental pneumonia.

  2013cited by this paper
• Transfusion of older stored blood and risk of death: a meta analysis

  2013cited by this paper
• Transfusion of banked red blood cells and the effects on hemorrheology and microvascular hemodynamics in anemic hematology outpatients

  2013cited by this paper
• Will clinical studies elucidate the connection between the length of storage of transfused red blood cells and clinical outcomes? An analysis based on the simulation of randomized controlled trials

  2013cited by this paper
• Contemporary trends in the diagnosis and management of pulmonary arterial hypertension: an initiative to close the care gap.

  2013cited by this paper
• Effects of red blood cell storage in heavily transfused patients.

  2013cited by this paper
• Fresh red blood cell transfusion and short-term pulmonary, immunologic, and coagulation status: a randomized clinical trial.

  2012cited by this paper
• Hemoglobin-driven pathophysiology is an in vivo consequence of the red blood cell storage lesion that can be attenuated in guinea pigs by haptoglobin therapy.

  2012cited by this paper
• Pulmonary Hypertension in Lambs Transfused with Stored Blood Is Prevented by Breathing Nitric Oxide

  2012cited by this paper
• Transfusion of older stored blood and risk of death: a meta‐analysis

  2012cited by this paper
• Scientific problems in the regulation of red blood cell products

  2012cited by this paper
• Comparative effectiveness research: welcome to the real world

  2012cited by this paper
• The role of comparative effectiveness research in transfusion medicine clinical trials: proceedings of a National Heart, Lung, and Blood Institute workshop

  2012cited by this paper
• The effect of blood storage duration on in‐hospital mortality: a randomized controlled pilot feasibility trial

  2012cited by this paper
• Decreased Erythrocyte NA+,K+-ATPase Activity and Increased Plasma TBARS in Prehypertensive Patients

  2012cited by this paper
• Transfusion of Stored Autologous Blood Does Not Alter Reactive Hyperemia Index in Healthy Volunteers

  2012cited by this paper
• Red blood cell storage in SAGM and AS3: a comparison through the membrane two-dimensional electrophoresis proteome.

  2012influential reference
• A pilot feasibility trial of allocation of freshest available red blood cells versus standard care in critically ill patients

  2012cited by this paper
• Fresh and Stored Red Blood Cell Transfusion Equivalently Induce Subclinical Pulmonary Gas Exchange Deficit in Normal Humans

  2012cited by this paper
• Fresh blood for transfusion: how old is too old for red blood cell units?

  2012cited by this paper
• Effect of fresh red blood cell transfusions on clinical outcomes in premature, very low-birth-weight infants: the ARIPI randomized trial.

  2012influential reference
• Age of blood and recipient factors determine the severity of transfusion-related acute lung injury (TRALI)

  2012cited by this paper
• Time to revisit red blood cell additive solutions and storage conditions: a role for "omics" analyses.

  2012cited by this paper
• Red blood cell storage lesions and related transfusion issues: a Canadian Blood Services research and development symposium.

  2012cited by this paper
• Effects of helicopter transport on red blood cell components.

  2012cited by this paper
• The Age of Blood Evaluation (ABLE) randomized controlled trial: study design.

  2011cited by this paper
• Current problems and future directions of transfusion‐induced alloimmunization: summary of an NHLBI working group

  2011cited by this paper
• The clinical effects of red blood cell transfusions: an overview of the randomized controlled trials evidence base.

  2011cited by this paper
• Transfusion-related acute lung injury in a rat model of trauma-hemorrhage.

  2011cited by this paper
• Nitric Oxide Scavenging by Red Blood Cell Microparticles and Cell-Free Hemoglobin as a Mechanism for the Red Cell Storage Lesion

  2011cited by this paper
• Duration of red blood cell storage and survival of transfused patients

  2011cited by this paper
• A novel in vivo ovine model of transfusion‐related acute lung injury (TRALI)

  2011cited by this paper
• Pitfalls in the current published observational literature on the effects of red blood cell storage

  2011cited by this paper
• Effect of duration of red blood cell storage on early and late mortality after coronary artery bypass grafting.

  2011cited by this paper
• Transfusion of fresh murine red blood cells reverses adverse effects of older stored red blood cells

  2011cited by this paper
• Transfusion of human volunteers with older, stored red blood cells produces extravascular hemolysis and circulating non-transferrin-bound iron.

  2011cited by this paper
• Age of red blood cells and mortality in the critically ill

  2011cited by this paper
• Diagnosis and assessment of pulmonary arterial hypertension

  2010cited by this paper
• Duration of red cell storage influences mortality after trauma.

  2010cited by this paper
• Anaerobic storage of red blood cells.

  2010cited by this paper
• Transfusion of red blood cells after prolonged storage produces harmful effects that are mediated by iron and inflammation.

  2010cited by this paper
• The critical roles of platelet activation and reduced NO bioavailability in fatal pulmonary arterial hypertension in a murine hemolysis model.

  2010cited by this paper
• Comprehensive survey of red blood cell unit life cycle at a large teaching institution in eastern Canada

  2010cited by this paper
• Red blood cell storage duration and mortality in patients undergoing percutaneous coronary intervention.

  2010cited by this paper
• International blood collection and storage: clinical use of blood products.

  2010cited by this paper
• Duration of red cell storage before transfusion and in-hospital mortality.

  2010cited by this paper
• Duration of red blood cell storage and survival of transfused patients (CME)

  2010cited by this paper
• Association between length of storage of transfused red blood cells and multiple organ dysfunction syndrome in pediatric intensive care patients

  2010cited by this paper
• Clinical trial opportunities in Transfusion Medicine: proceedings of a National Heart, Lung, and Blood Institute State-of-the-Science Symposium.

  2010cited by this paper
• Addressing the question of the effect of RBC storage on clinical outcomes: the Red Cell Storage Duration Study (RECESS) (Section 7).

  2010cited by this paper
• BLOOD COMPONENTS: Red blood cell hemolysis during blood bank storage: using national quality management data to answer basic scientific questions

  2009cited by this paper
• A novel mouse model of red blood cell storage and posttransfusion in vivo survival

  2009cited by this paper
• A prospective, double‐blind, randomized clinical feasibility trial of controlling the storage age of red blood cells for transfusion in cardiac surgical patients

  2009cited by this paper
• Anaerobic storage of red blood cells in a novel additive solution improves in vivo recovery

  2009cited by this paper
• Clinical impact of blood storage lesions

  2009cited by this paper
• Impact of age of transfused blood on cerebral oxygenation in male patients with severe traumatic brain injury

  2009cited by this paper
• Diagnosis and assessment of pulmonary arterial hypertension.

  2009cited by this paper
• Erythrocyte storage in hypertonic (SAGM) or isotonic (PAGGSM) conservation medium: influence on cell properties

  2008cited by this paper
• Age of transfused blood: an independent predictor of mortality despite universal leukoreduction.

  2008cited by this paper
• Survival of red blood cells after transfusion: a comparison between red cells concentrates of different storage periods

  2008cited by this paper
• Impact of age of transfused blood on cerebral oxygenation in male patients with severe traumatic brain injury*

  2008cited by this paper
• Evaluation of proposed FDA criteria for the evaluation of radiolabeled red cell recovery trials

  2008cited by this paper
• Inhaled Nitric Oxide Enables Artificial Blood Transfusion Without Hypertension

  2008cited by this paper
• Transfusions in the less severely injured: does age of transfused blood affect outcomes?

  2008cited by this paper
• Red-cell storage and complications of cardiac surgery.

  2008cited by this paper
• Red-cell storage and complications of cardiac surgery.

  2008cited by this paper
• Duration of red-cell storage and complications after cardiac surgery.

  2008cited by this paper
• Fresh blood for everyone? Balancing availability and quality of stored RBCs

  2008cited by this paper
• Age of transfused red cells and early outcomes after cardiac surgery.

  2008cited by this paper
• Why have meta‐analyses of randomized controlled trials of the association between non‐white‐blood‐cell‐reduced allogeneic blood transfusion and postoperative infection produced discordant results?

  2007cited by this paper
• Red blood cell transfusion in clinical practice.

  2007cited by this paper
• I want to say one word to you—just one word—“plastics”

  2006cited by this paper
• An update on solutions for red cell storage

  2006cited by this paper
• Effects of storage time of red blood cell transfusions on the prognosis of coronary artery bypass graft patients

  2006cited by this paper
• Fresh Blood and Aged Stored Blood Are Equally Efficacious in Immediately Reversing Anemia-induced Brain Oxygenation Deficits in Humans

  2006cited by this paper
• Buffering and dilution in red blood cell storage

  2006cited by this paper
• Computation of plasma hemoglobin nitric oxide scavenging in hemolytic anemias.

  2006cited by this paper
• Scleromalacia perforans complicating graft‐versus‐host disease

  2005cited by this paper
• Hemolysis-associated endothelial dysfunction mediated by accelerated NO inactivation by decompartmentalized oxyhemoglobin.

  2005cited by this paper
• A Pilot Trial Evaluating the Clinical Effects of Prolonged Storage of Red Cells

  2005cited by this paper
• The clinical sequelae of intravascular hemolysis and extracellular plasma hemoglobin: a novel mechanism of human disease.

  2005cited by this paper

• Establishing a multinational walking blood bank in Haiti: operational, regulatory, and cultural lessons from the MSSM mission

  2026cites this paper
• Narrative review of strategies for blood product shelf-life extension.

  2026cites this paper
• Reliability of tube-based quality assessment of packed red blood cells: Insights from FTIR and Raman spectroscopic analyses.

  2026cites this paper
• Osmotic Fragility in Leukodepleted Stored Red Blood Cells: Implications for Neurocritical Care Transfusion Strategies

  2025cites this paper
• Biophysical and Biochemical Characterization of High Molecular Weight Co-Polymerized Human Hemoglobin and Albumin as a Potential Hemoglobin-Based Oxygen Carrier.

  2025cites this paper
• A narrative review on the lactic acidosis and hypoglycemia in burkitt lymphoma: navigating metabolic changes

  2025cites this paper
• Impact of Different Red Blood Cell Storage Solutions and Conditions on Cell Function and Viability: A Systematic Review

  2024cites this paper
• Estimated median density identifies donor age and sex differences in red blood cell biological age

  2024cites this paper
• Out of tissue engineering systemic crisis by means of holographic 3D-photopolymerization

  2024cites this paper
• Scalable Production and Biophysical Characterization of High-Molecular-Weight Relaxed and Tense Quaternary State Polymerized Human Hemoglobin as Potential Red Blood Cell Substitutes.

  2024cites this paper
• Exploring the Intersection of Blood Transfusion and Same-Day Computed Tomography Imaging: An Overview of Clinical Risks and Practices

  2024cites this paper
• Microparticles as quality criteria for platelet concentrate

  2024cites this paper
• Red cell concentrates from teen male donors contain poor‐quality biologically older cells

  2024cites this paper
• MicroRNAs as Quality Assessment Tool in Stored Packed Red Blood Cell in Blood Banks

  2023cites this paper
• Effect of red blood cell storage time in pediatric cardiac surgery patients: A subgroup analysis of a randomized controlled trial

  2023cites this paper
• Upregulation of miR-20a-5p as the Potential MicroRNA Marker in Red Blood Cell Storage Lesion

  2023cites this paper
• Transfusion of red blood cells ≥35 days old: A narrative review of clinical outcomes

  2023cites this paper
• The role of anemia on admission in acute coronary syndrome - An umbrella review of systematic reviews and meta-analyses.

  2022cites this paper
• The Effects of Free Heme on Functional and Molecular Changes During Ex Vivo Normothermic Machine Perfusion of Human Kidneys

  2022influential citation
• An intelligent system for blood donation process optimization - smart techniques for minimizing blood wastages

  2022cites this paper
• Assessing the quality of stored red blood cells using handheld Spatially Offset Raman spectroscopy with multisource correlation analysis.

  2022cites this paper
• Effect of Hypoxic Blood Infusion on Pulmonary Physiology

  2022cites this paper
• The influence of leukoreduction on the acute transfusion-related complication rate in 455 dogs receiving 730 packed RBCs: 2014-2017.

  2022cites this paper
• Determination of free heme in stored red blood cells with an apo-horseradish peroxidase-based assay

  2022cites this paper
• Blood Replacement Therapy by Generation of Polymeric Recombinant Hemoglobin Using â•œClick Chemistryâ•š and Circular Tandem Repeat Proteins

  2022cites this paper
• Intraoperative Allogeneic Red Blood Cell Transfusion Negatively Influences Prognosis After Radical Surgery for Pancreatic Cancer

  2021cites this paper
• Association Between Blood Donor Demographics and Post-injury Multiple Organ Failure after Polytrauma

  2021cites this paper
• Current Understanding of the Relationship between Blood Donor Variability and Blood Component Quality

  2021cites this paper
• Optimization of red blood cell inventory: a blood-type compatibility-preference and emergency model

  2021cites this paper
• Non‐invasive monitoring of red blood cells during cold storage using handheld Raman spectroscopy

  2021cites this paper
• Artificial oxygen carriers, from nanometer- to micrometer-sized particles, made of hemoglobin composites substituting for red blood cells

  2021cites this paper
• ATR-FTIR spectroscopy as a quality control system for monitoring the storage of blood products.

  2021cites this paper
• Implementation of a low titer group O whole blood program for a law enforcement tactical team

  2020cites this paper
• Purification of Lumbricus terrestris erythrocruorin (LtEc) with anion exchange chromatography.

  2020cites this paper
• To study the effect of oxygen carrying capacity on expressed changes of erythrocyte membrane protein in different storage times

  2020cites this paper
• Comb-Like Pseudopeptides Enable Very Rapid and Efficient Intracellular Trehalose Delivery for Enhanced Cryopreservation of Erythrocytes.

  2020cites this paper
• In vitro phagocytosis of liquid‐stored red blood cells requires serum and can be inhibited with fucoidan and dextran sulphate

  2020cites this paper
• RBC Storage Lesion Studies in Humans and Experimental Models of Shock

  2020cites this paper
• An outcome-based review of an accredited Specialist in Blood Banking (SBB) program: 25 years and counting

  2020cites this paper
• Extracellular Ubiquitin is the Causal Link between Stored Blood Transfusion Therapy and Tumor Progression in a Melanoma Mouse Model

  2019cites this paper
• Proactive transshipment in the blood supply chain: A stochastic programming approach

  2019cites this paper
• Development of Zinc Chelating Resin Polymer Beads for the Removal of Cell-Free Hemoglobin

  2019cites this paper
• Regulation of complement activation on red blood cells

  2019cites this paper
• Research Risks in Transfusion Medicine and Cellular Therapy

  2019cites this paper
• Intraoperative Transfusion of Red Blood Cell Units Stored >14 Days is Associated with an Increased Risk of Prosthetic Joint Infection

  2019cites this paper
• Comparison of portable blood‐warming devices under simulated pre‐hospital conditions: a randomised in‐vitro blood circuit study

  2019cites this paper
• Proceedings of the Food and Drug Administration public workshop on pathogen reduction technologies for blood safety 2018 (Commentary, p. 3026)

  2019cites this paper
• Biomimetic carbon monoxide delivery based on hemoglobin vesicles ameliorates acute pancreatitis in mice via the regulation of macrophage and neutrophil activity

  2018cites this paper
• Mechanisms of red blood cell transfusion‐related immunomodulation

  2018cites this paper
• Effect of age of red cells for transfusion on patient outcomes: a systematic review and meta-analysis.

  2018cites this paper
• Time-Course Investigation of Small Molecule Metabolites in MAP-Stored Red Blood Cells Using UPLC-QTOF-MS

  2018cites this paper
• Age of transfused blood in critically ill adult trauma patients: a prespecified nested analysis of the Age of Blood Evaluation randomized trial

  2018cites this paper
• Evaluation of serum markers for improved detection of autologous blood transfusions

  2018cites this paper
• Transfusion of packed red blood cells at the end of shelf life is associated with increased risk of mortality – a pooled patient data analysis of 16 observational trials

  2018cites this paper
• Decreased Hemolysis and Improved Platelet Function in Blood Components Washed With Plasma-Lyte A Compared to 0.9% Sodium Chloride

  2018cites this paper
• Raman spectroscopy of stored red blood cell concentrate within sealed transfusion blood bags.

  2018cites this paper
• Hematologic Challenges in the Critically Ill

  2018cites this paper
• Integrated automated particle tracking microfluidic enables high‐throughput cell deformability cytometry for red cell disorders

  2018cites this paper
• Vitamin E Analogue Protects Red Blood Cells against Storage-Induced Oxidative Damage

  2018cites this paper
• Complement Deposition and IgG Binding on Stored Red Blood Cells Are Independent of Storage Time

  2018cites this paper
• Clinical Outcomes and Red Blood Cell Storage

  2018cites this paper
• A Review of the Pathophysiology and Consequences of Red Cell Storage-Fresh Versus Stored Red Cells-Implication for Optimum Use of Scarce Allogenic Blood

  2018cites this paper
• Using Raman spectroscopy to assess hemoglobin oxygenation in red blood cell concentrate: an objective proxy for morphological index to gauge the quality of stored blood?

  2017cites this paper
• Iron accelerates hemoglobin oxidation increasing mortality in vascular diseased guinea pigs following transfusion of stored blood.

  2017cites this paper
• Age of Red Cells for Transfusion and Outcomes in Critically Ill Adults

  2017cites this paper
• The controversy over the age of blood: what do the clinical trials really teach us?

  2017cites this paper
• Microparticles formed during storage of red blood cell units support thrombin generation

  2017cites this paper
• Threshold-Based Allocation Policies for Inventory Management of Red Blood Cells

  2017cites this paper
• Red blood cell hemolysis : protein biomarker discovery for product quality assessment

  2017cites this paper
• Bloody Fast Blood Collection

  2017cites this paper
• Enhancing uniformity and overall quality of red cell concentrate with anaerobic storage.

  2017cites this paper
• The questions surrounding stored blood do not get old

  2017cites this paper
• Comparison of the Pharmacokinetic Properties of Hemoglobin-Based Oxygen Carriers

  2017cites this paper
• Prolonged red cell storage before transfusion increases extravascular hemolysis

  2017cites this paper
• Age of blood and survival after massive transfusion.

  2017cites this paper
• Storage Lesion: Evolving Concepts and Controversies

  2017cites this paper
• Transfusion in critically ill patients : short- and long-term outcomes

  2017cites this paper
• Transfusion‐Associated Complications

  2016cites this paper
• Raman spectroscopy of transfusable red blood cells

  2016cites this paper
• Blood Component Processing and Storage

  2016cites this paper
• Supernatant protein biomarkers of red blood cell storage hemolysis as determined through an absolute quantification proteomics technology

  2016cites this paper
• Preparation of red cell concentrates in low-income countries: Efficacy of whole blood settling method by simple gravity in Burkina Faso

  2016cites this paper
• Raman spectroscopy as a novel tool for monitoring biochemical changes and inter-donor variability in stored red blood cell units.

  2016cites this paper
• Effect of platelet storage time on platelet measurements: a systematic review and meta‐analyses

  2016cites this paper
• Potential explanations for the discrepancy between murine and human studies

  2016cites this paper
• Fresh versus old red cell transfusions: what have the recent clinical trials found?

  2016influential citation
• Reducing the age of transfused red blood cells in hospitals: ordering and allocation policies

  2016cites this paper
• Length of Storage of Red Blood Cells and Patient Survival After Blood Transfusion

  2016cites this paper
• Quality Assessment of Established and Emerging Blood Components for Transfusion

  2016cites this paper
• Long-Term Stored Hemoglobin-Vesicles, a Cellular Type of Hemoglobin-Based Oxygen Carrier, Has Resuscitative Effects Comparable to That for Fresh Red Blood Cells in a Rat Model with Massive Hemorrhage without Post-Transfusion Lung Injury

  2016cites this paper
• Could Microparticles Be the Universal Quality Indicator for Platelet Viability and Function?

  2016cites this paper
• Previous Cryopreservation Alters the Natural History of the Red Blood Cell Storage Lesion

  2016cites this paper
• Transfusion of recently donated (fresh) red blood cells (RBCs) does not improve survival in comparison with current practice, while safety of the oldest stored units is yet to be established: a meta‐analysis

  2016cites this paper
• Effect of storage time and donor sex of transfused red blood cells on 1‐year survival in patients undergoing cardiac surgery: an observational study

  2016cites this paper
• The red blood cell storage lesion: the end of the beginning

  2016cites this paper
• The outsider adverse event in transfusion: Inflammation.

  2016cites this paper
• Introducing the red cell storage lesion

  2016cites this paper
• Impact of the age of stored blood on trauma patient mortality: a systematic review.

  2015cites this paper
• The influence of the storage lesion(s) on pediatric red cell transfusion

  2015cites this paper
• Prolonged storage of packed red blood cells for blood transfusion.

  2015cites this paper