Mitochondrial DNA, base excision repair and neurodegeneration.

No abstract is available for this paper.

• Publication year

  2008

• Venue

  DNA Repair

• Publication date

  2008-07-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.dnarep.2008.03.011PMID 18485834PMCID PMC4625841
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• [Parkinson's disease].

  2022cited by this paper
• Dementia with Lewy bodies.

  2007cited by this paper
• Defective DNA base excision repair in brain from individuals with Alzheimer's disease and amnestic mild cognitive impairment

  2007cited by this paper
• Neurodegeneration: nicked to death.

  2007cited by this paper
• Progressive parkinsonism in mice with respiratory-chain-deficient dopamine neurons

  2007cited by this paper
• Identification and characterization of OGG1 mutations in patients with Alzheimer's disease

  2007cited by this paper
• Mitochondrial disease--its impact, etiology, and pathology.

  2007cited by this paper
• Diagnostic challenges of mitochondrial DNA disorders.

  2007cited by this paper
• Parkinson's disease.

  2007cited by this paper
• 8-oxo-guanine bypass by human DNA polymerases in the presence of auxiliary proteins

  2007cited by this paper
• Mitochondrial oxidative stress: implications for cell death.

  2007cited by this paper
• Transgenic Mice with Human Mutant Genes Causing Parkinson's Disease and Amyotrophic Lateral Sclerosis Provide Common Insight into Mechanisms of Motor Neuron Selective Vulnerability to Degeneration

  2007cited by this paper
• Cockayne syndrome B protein stimulates apurinic endonuclease 1 activity and protects against agents that introduce base excision repair intermediates

  2007cited by this paper
• Intracellular trafficking and regulation of mammalian AP-endonuclease 1 (APE1), an essential DNA repair protein.

  2007cited by this paper
• Theories of ageing

  2007cited by this paper
• Mitochondrial dysfunction in Parkinson's disease

  2007cited by this paper
• Mitochondrial point mutations do not limit the natural lifespan of mice

  2007cited by this paper
• The metabolic syndrome resulting from a knockout of the NEIL1 DNA glycosylase.

  2006cited by this paper
• Parkinson's Disease α-Synuclein Transgenic Mice Develop Neuronal Mitochondrial Degeneration and Cell Death

  2006cited by this paper
• Mitochondrial and nuclear DNA-repair capacity of various brain regions in mouse is altered in an age-dependent manner.

  2006cited by this paper
• Mitochondrial DNA deletions are abundant and cause functional impairment in aged human substantia nigra neurons

  2006cited by this paper
• DNA polymerase gamma in mitochondrial DNA replication and repair.

  2006cited by this paper
• Mitochondrial disease criteria

  2006cited by this paper
• mtDNA clock runs out for dopaminergic neurons

  2006cited by this paper
• RNA polymerase II bypass of oxidative DNA damage is regulated by transcription elongation factors

  2006cited by this paper
• Identification and characterization of mitochondrial abasic (AP)-endonuclease in mammalian cells

  2006cited by this paper
• The influence of the DNA polymerase gamma accessory subunit on base excision repair by the catalytic subunit.

  2006cited by this paper
• Parkinson's disease alpha-synuclein transgenic mice develop neuronal mitochondrial degeneration and cell death.

  2006cited by this paper
• Increased oxidative damage in nuclear and mitochondrial DNA in mild cognitive impairment

  2006cited by this paper
• High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease

  2006cited by this paper
• No evidence of mitochondrial respiratory dysfunction in OGG1-null mice deficient in removal of 8-oxodeoxyguanine from mitochondrial DNA.

  2005cited by this paper
• Somatic mitochondrial DNA mutations in single neurons and glia.

  2005cited by this paper
• Increased oxidative damage in nuclear and mitochondrial DNA in Alzheimer's disease

  2005cited by this paper
• Effect of aging on intracellular distribution of abasic (AP) endonuclease 1 in the mouse liver.

  2005cited by this paper
• Analysis of nuclear transport signals in the human apurinic/apyrimidinic endonuclease (APE1/Ref1)

  2005cited by this paper
• Somatic mtDNA mutations cause aging phenotypes without affecting reactive oxygen species production.

  2005cited by this paper
• Capillary electrophoresis‐laser induced fluorescence analysis of endogenous damage in mitochondrial and genomic DNA

  2005cited by this paper
• Mitochondrial DNA Mutations, Oxidative Stress, and Apoptosis in Mammalian Aging

  2005cited by this paper
• mtDNA mutations and common neurodegenerative disorders.

  2005cited by this paper
• Repair of Formamidopyrimidines in DNA Involves Different Glycosylases

  2005cited by this paper
• Oxidative stress and mitochondrial DNA repair: implications for NRTIs induced DNA damage.

  2004cited by this paper
• Alzheimer's brains harbor somatic mtDNA control-region mutations that suppress mitochondrial transcription and replication.

  2004cited by this paper
• The Energetics of Huntington's Disease

  2004cited by this paper
• High frequency of mitochondrial complex I mutations in Parkinson's disease and aging.

  2004cited by this paper
• Premature ageing in mice expressing defective mitochondrial DNA polymerase

  2004cited by this paper
• The C-terminal alphaO helix of human Ogg1 is essential for 8-oxoguanine DNA glycosylase activity: the mitochondrial beta-Ogg1 lacks this domain and does not have glycosylase activity.

  2004cited by this paper
• Mouse NEIL1 protein is specific for excision of 2,6-diamino-4-hydroxy-5-formamidopyrimidine and 4,6-diamino-5-formamidopyrimidine from oxidatively damaged DNA.

  2004cited by this paper
• Mitochondrial DNA polymorphisms as risk factors for Parkinson’s disease and Parkinson’s disease dementia

  2004cited by this paper
• Base excision repair activities required for yeast to attain a full chronological life span

  2003cited by this paper
• Compromised Incision of Oxidized Pyrimidines in Liver Mitochondria of Mice Deficient in NTH1 and OGG1 Glycosylases*

  2003cited by this paper
• The novel DNA glycosylase, NEIL1, protects mammalian cells from radiation-mediated cell death.

  2003cited by this paper
• DNA Polymerase Gamma in Mitochondrial DNA Replication and Repair

  2003cited by this paper
• Decline of nuclear and mitochondrial oxidative base excision repair activity in late passage human diploid fibroblasts.

  2003cited by this paper
• Mammalian 8-Oxoguanine DNA Glycosylase 1 Incises 8-Oxoadenine Opposite Cytosine in Nuclei and Mitochondria, while a Different Glycosylase Incises 8-Oxoadenine Opposite Guanine in Nuclei*

  2003cited by this paper
• Differential intracellular localization of the human and mouse endonuclease III homologs and analysis of the sorting signals.

  2002cited by this paper
• Determinants in nuclease specificity of Ape1 and Ape2, human homologues of Escherichia coli exonuclease III.

  2002cited by this paper
• A novel human DNA glycosylase that removes oxidative DNA damage and is homologous to Escherichia coli endonuclease VIII.

  2002cited by this paper
• Age‐dependent decline of DNA repair activity for oxidative lesions in rat brain mitochondria

  2002cited by this paper
• Mitochondrial DNA A4336G Mutation in Alzheimer’s and Parkinson’s Diseases

  2002cited by this paper
• Global genome repair of 8-oxoG in hamster cells requires a functional CSB gene product

  2002cited by this paper
• Fapy.dG instructs Klenow exo(-) to misincorporate deoxyadenosine.

  2002cited by this paper
• Mitochondrial repair of 8-oxoguanine is deficient in Cockayne syndrome group B

  2002cited by this paper
• Expression of 8-oxoguanine DNA glycosylase is reduced and associated with neurofibrillary tangles in Alzheimer's disease brain

  2002cited by this paper
• Identification and characterization of a human DNA glycosylase for repair of modified bases in oxidatively damaged DNA

  2002cited by this paper
• Toxin-induced mitochondrial dysfunction.

  2002cited by this paper
• H(2)O(2) induces translocation of APE/Ref-1 to mitochondria in the Raji B-cell line.

  2002cited by this paper
• Fapy.dA induces nucleotide misincorporation translesionally by a DNA polymerase.

  2002cited by this paper
• H2O2 induces translocation of APE/Ref‐1 to mitochondria in the Raji B‐cell line

  2002cited by this paper
• A reliable assessment of 8-oxo-2-deoxyguanosine levels in nuclear and mitochondrial DNA using the sodium iodide method to isolate DNA.

  2001cited by this paper
• DNA repair and aging in mouse liver: 8-oxodG glycosylase activity increase in mitochondrial but not in nuclear extracts.

  2001cited by this paper
• DNA repair and aging in mouse liver: 8-oxodG glycosylase activity increase in mitochondrial but not in nuclear extracts

  2001cited by this paper
• Genome maintenance mechanisms for preventing cancer

  2001cited by this paper
• Mitochondrial localization of APE/Ref-1 in thyroid cells.

  2001cited by this paper
• Complex I and Parkinson's Disease

  2001cited by this paper
• Human APE2 protein is mostly localized in the nuclei and to some extent in the mitochondria, while nuclear APE2 is partly associated with proliferating cell nuclear antigen.

  2001cited by this paper
• Repair of 8-oxodeoxyguanosine lesions in mitochondrial dna depends on the oxoguanine dna glycosylase (OGG1) gene and 8-oxoguanine accumulates in the mitochondrial dna of OGG1-defective mice.

  2001cited by this paper
• Mitochondrial DNA ligase III function is independent of Xrcc1.

  2000cited by this paper
• XRCC1 keeps DNA from getting stranded.

  2000cited by this paper
• Human mitochondrial DNA polymerase holoenzyme: reconstitution and characterization.

  2000cited by this paper
• The frequency of point mutations in mitochondrial DNA is elevated in the Alzheimer's brain.

  2000cited by this paper
• A method for detecting abasic sites in living cells: age-dependent changes in base excision repair.

  2000cited by this paper
• Decreased base excision repair and increased helicase activity in Alzheimer's disease brain.

  2000cited by this paper
• Substrate Specificity and Reaction Mechanism of Murine 8-Oxoguanine-DNA Glycosylase*

  2000cited by this paper
• Oxidative damage to mitochondrial DNA is inversely related to maximum life span in the heart and brain of mammals

  2000cited by this paper
• Mitochondrial free radical generation, oxidative stress, and aging.

  2000cited by this paper
• Cell-cycle regulation, intracellular sorting and induced overexpression of the human NTH1 DNA glycosylase involved in removal of formamidopyrimidine residues from DNA.

  2000cited by this paper
• Identification of human MutY homolog (hMYH) as a repair enzyme for 2-hydroxyadenine in DNA and detection of multiple forms of hMYH located in nuclei and mitochondria.

  2000cited by this paper
• [Dementia with Lewy bodies].

  2000cited by this paper
• Excision of oxidatively damaged DNA bases by the human α-hOgg1 protein and the polymorphic α-hOgg1(Ser326Cys) protein which is frequently found in human populations

  1999cited by this paper
• Alzheimer's disease and its management in the year 2010.

  1999cited by this paper
• Expression and differential intracellular localization of two major forms of human 8-oxoguanine DNA glycosylase encoded by alternatively spliced OGG1 mRNAs.

  1999cited by this paper
• Oxidative Stress in Huntington's Disease

  1999cited by this paper
• Parkinson's disease is associated with oxidative damage to cytoplasmic DNA and RNA in substantia nigra neurons.

  1999cited by this paper
• Repair of 8-oxoguanine in DNA is deficient in Cockayne syndrome group B cells.

  1999cited by this paper
• The Human DNA Ligase III Gene Encodes Nuclear and Mitochondrial Proteins

  1999cited by this paper
• Implication of Poly(ADP‐Ribose) Polymerase (PARP) in Neurodegeneration and Brain Energy Metabolism: Decreases in Mouse Brain NAD+ and ATP Caused by MPTP Are Prevented by the PARP Inhibitor Benzamide

  1999cited by this paper
• Differential subcellular localization of human MutY homolog (hMYH) and the functional activity of adenine:8-oxoguanine DNA glycosylase.

  1999cited by this paper
• Age-associated increase in 8-oxo-deoxyguanosine glycosylase/AP lyase activity in rat mitochondria.

  1999cited by this paper
• The Mitochondrial p55 Accessory Subunit of Human DNA Polymerase γ Enhances DNA Binding, Promotes Processive DNA Synthesis, and Confers N-Ethylmaleimide Resistance*

  1999cited by this paper
• Mitochondrial DNA 4977 bp deletion and OH8dG levels correlate in the brain of aged subjects but not Alzheimer's disease patients

  1999cited by this paper

• Maternal exercise before and during pregnancy protects against genotoxicity and promotes offspring hippocampal health in mice prenatally exposed to high fructose.

  2025cites this paper
• Mitochondrial function maintenance and mitochondrial training in ageing and related diseases

  2025cites this paper
• Decoding the Role of NEIL1 Gene in DNA Repair and Lifespan: A Literature Review with Bioinformatics Analysis

  2024cites this paper
• Biallelic variants in the NDUFAF6 cause mitochondrial respiratory complex assembly defects associated with Leigh syndrome in probands

  2024cites this paper
• The Mitochondrial Connection: The Nek Kinases’ New Functional Axis in Mitochondrial Homeostasis

  2024cites this paper
• Metabolic and proteostatic differences in quiescent and active neural stem cells

  2023cites this paper
• Altered DNA repair related proteins in Parkinson’s disease model VMAT2 Lo mice

  2023cites this paper
• Simultaneous Short- and Long-Patch Base Excision Repair (BER) Assay in Live Mammalian Cells.

  2023cites this paper
• G-quadruplexes and associated proteins in aging and Alzheimer’s disease

  2023cites this paper
• Expression of DNA repair genes is modulated during differentiation of olfactory sensory neurons

  2023cites this paper
• Poly (ADP-ribose) polymerase 1 and neurodegenerative diseases: past, present, and future.

  2023cites this paper
• Chemotherapy-induced neuronal DNA damage: an intriguing toolbox to elucidate DNA repair mechanisms in the brain

  2023cites this paper
• Activated or Impaired: An Overview of DNA Repair in Neurodegenerative Diseases

  2022cites this paper
• Trapped topoisomerase-DNA covalent complexes in the mitochondria and their role in human diseases.

  2021cites this paper
• Current and emerging roles of Cockayne syndrome group B (CSB) protein.

  2021cites this paper
• NEK5 interacts with LonP1 and its kinase activity is essential for the regulation of mitochondrial functions and mtDNA maintenance

  2021cites this paper
• Mitochondrial genome stability in human: understanding the role of DNA repair pathways.

  2021cites this paper
• The role of exercise in brain DNA damage

  2020cites this paper
• The Similarities between Human Mitochondria and Bacteria in the Context of Structure, Genome, and Base Excision Repair System

  2020cites this paper
• Melatonin supplementation over different time periods until ageing modulates genotoxic parameters in mice.

  2020cites this paper
• Mitochondrial and Nuclear DNA Oxidative Damage in Physiological and Pathological Aging

  2020cites this paper
• Telomere length and oxidative stress variations in a murine model of Alzheimer’s disease progression

  2019cites this paper
• SCAN1-TDP1 trapping on mitochondrial DNA promotes mitochondrial dysfunction and mitophagy

  2019cites this paper
• Loss of Mitochondrial DNA by Gemcitabine Triggers Mitophagy and Cell Death.

  2019cites this paper
• DNA damage response and repair pathway modulation by non-histone protein methylation: implications in neurodegeneration

  2019cites this paper
• Mitochondrial DNA Integrity: Role in Health and Disease

  2019cites this paper
• S-Adenosylmethionine Metabolism and Aging

  2018cites this paper
• Rôle des dommages à l’ADN dans la dégénérescence des cellules de la cochlée et criblage des molécules thérapeutiques

  2018cites this paper
• Chloroplasts and Mitochondria: Similarities and Differences

  2018cites this paper
• Aerobic and strength training induce changes in oxidative stress parameters and elicit modifications of various cellular components in skeletal muscle of aged rats

  2018cites this paper
• Biothiols and oxidative stress markers and polymorphisms of TOMM40 and APOC1 genes in Alzheimer’s disease patients

  2018cites this paper
• Mitochondrial Aging and Metabolism: The Importance of a Good Relationship in the Central Nervous System

  2018cites this paper
• International Society for Neurochemistry Committee for Aid and Education in Neurochemistry (ISN-CAEN)

  2017cites this paper
• Shared molecular and cellular mechanisms of premature ageing and ageing-associated diseases

  2017cites this paper
• Naked mole-rats maintain healthy skeletal muscle and Complex IV mitochondrial enzyme function into old age

  2016cites this paper
• Oxidative DNA damage stalls the human mitochondrial replisome

  2016cites this paper
• Mechanisms of DNA repair in mitochondria

  2016cites this paper
• The role of DNA damage and repair in toxicity to postmitotic cells caused by cancer therapies

  2016cites this paper
• DNA Damage, DNA Repair, Aging, and Neurodegeneration.

  2015cites this paper
• Targeting Mitochondria and Reactive Oxygen Species-Driven Pathogenesis in Diabetic Nephropathy.

  2015cites this paper
• Effects of chronic exposure to microcystin-LR on hepatocyte mitochondrial DNA replication in mice.

  2015cites this paper
• Human Apurinic/Apyrimidinic Endonuclease 1

  2014cites this paper
• Metabolic Regulation of Redox Status in Stem Cells

  2014cites this paper
• Exercise-Induced Neuroprotection of Hippocampus in APP/PS1 Transgenic Mice via Upregulation of Mitochondrial 8-Oxoguanine DNA Glycosylase

  2014cites this paper
• Overexpression of DNA ligase III in mitochondria protects cells against oxidative stress and improves mitochondrial DNA base excision repair.

  2014cites this paper
• RECQL4 and p53 potentiate the activity of polymerase γ and maintain the integrity of the human mitochondrial genome.

  2014cites this paper
• Role of the ASPP Family in the Regulation of p53-Mediated Apoptotic Death of Retinal Ganglion Cells after Optic Nerve Injury

  2014cites this paper
• Oxidative DNA damage in disease—Insights gained from base excision repair glycosylase‐deficient mouse models

  2014cites this paper
• Generation and transmission of mtDNA mutations and their effect on aging

  2013cites this paper
• Mitochondrial abnormalities in temporal lobe of autistic brain.

  2013cites this paper
• The role of DNA repair in brain related disease pathology.

  2013cites this paper
• Mitochondria as a Source of Reactive Oxygen and Nitrogen Species: From Molecular Mechanisms to Human Health

  2013cites this paper
• Novel XPG (ERCC5) Mutations Affect DNA Repair and Cell Survival after Ultraviolet but not Oxidative Stress

  2013cites this paper
• Maintaining genome stability in the nervous system

  2013cites this paper
• DNA Base Excision Repair Pathways

  2013cites this paper
• The C8ORF38 homologue Sicily is a cytosolic chaperone for a mitochondrial complex I subunit

  2013cites this paper
• The Polymorphic AluYb8 Insertion in the MUTYH Gene is Associated with Reduced Type 1 Protein Expression and Reduced Mitochondrial DNA Content

  2013cites this paper
• The molecular basis of retinal ganglion cell death in glaucoma.

  2012cites this paper
• Misconceptions regarding nuclear mitochondrial pseudogenes (Numts) may obscure detection of mitochondrial evolutionary novelties

  2012cites this paper
• Diseases associated with defective responses to DNA damage.

  2012cites this paper
• Use of the in situ proximity ligation assay (PLA) for studies of CKS2 interactions in HeLa cells

  2012cites this paper
• Indo-US workshop on base excision DNA repair, brain function and aging.

  2012cites this paper
• Mitochondria and reactive oxygen species. Which role in physiology and pathology?

  2012cites this paper
• Mitochondrial DNA damage and its consequences for mitochondrial gene expression.

  2012cites this paper
• Friedreich ataxia : investigating the relationships between mismatch repair gene expression, FXN gene expression and GAA repeat instability in human and mouse cells and tissues

  2012cites this paper
• The role of mtDNA damage in mitochondrial dysfunction

  2011cites this paper
• Role of Human DNA Glycosylase Nei-like 2 (NEIL2) and Single Strand Break Repair Protein Polynucleotide Kinase 3′-Phosphatase in Maintenance of Mitochondrial Genome*

  2011cites this paper
• 6‐Thioguanine damages mitochondrial DNA and causes mitochondrial dysfunction in human cells

  2011cites this paper
• Role of polynucleotide kinase/phosphatase in mitochondrial DNA repair

  2011influential citation
• 3rd International Genome Dynamics in Neuroscience Conference: "DNA repair and neurological disease".

  2011cites this paper
• Recombinant human mitochondrial transcription factor A stimulates mitochondrial biogenesis and ATP synthesis, improves motor function after MPTP, reduces oxidative stress and increases survival after endotoxin.

  2011cites this paper
• Telomere shortening reduces Alzheimer's disease amyloid pathology in mice.

  2011cites this paper
• Delayed response of the CYS326 variant of the DNA repair protein OGG1 to cellular oxidative stress

  2011cites this paper
• The Functions of Human Dna2 in Mitochondrial and Nuclear DNA Maintenance

  2011cites this paper
• Polyphenol compounds as antioxidants for disease prevention: Reactive oxygen species scavenging, enzyme regulation, and metal chelation mechanisms in E. coli and human cells

  2011cites this paper
• Excision repair deficiencies in man and mice; lessons from CSA and Fen1 mutants

  2011cites this paper
• Mitochondrial base excision repair assays.

  2010cites this paper
• HypothesisDNA, chloroplast DNA and the origins of development in eukaryotic organisms

  2010cites this paper
• Análise da natureza genotípica de pacientes Xeroderma pigmentosum brasileiros.

  2010cites this paper
• S-Adenosylmethionine: Simple Agent of Methylation and Secret to Aging and Metabolism?

  2010cites this paper
• Somatic mitochondrial DNA mutations in mammalian aging.

  2010cites this paper
• Cockayne syndrome group B protein promotes mitochondrial DNA stability by supporting the DNA repair association with the mitochondrial membrane

  2010cites this paper
• Role of Mitochondrial DNA Damage in the Development of Diabetic Retinopathy, and the Metabolic Memory Phenomenon Associated with Its Progression

  2010cites this paper
• Role of tyrosyl-DNA phosphodiesterase (TDP1) in mitochondria

  2010cites this paper
• Mitochondrial DNA Toxicity in Forebrain Neurons Causes Apoptosis, Neurodegeneration, and Impaired Behavior

  2010cites this paper
• Accumulation of oxidative DNA damage in brain mitochondria in mouse model of hereditary ferritinopathy.

  2010cites this paper
• Genomic and proteomic responses to environmentally relevant exposures to dieldrin: indicators of neurodegeneration?

  2010cites this paper
• DNA repair in mammalian mitochondria: Much more than we thought?

  2010cites this paper
• Mitochondrial DNA repair and association with aging--an update.

  2010cites this paper
• Mitochondrial DNA, chloroplast DNA and the origins of development in eukaryotic organisms

  2010cites this paper
• DNA damage and repair in age-related macular degeneration.

  2009cites this paper
• DNA damage, aging, and cancer.

  2009cites this paper
• Membrane association of mitochondrial DNA facilitates base excision repair in mammalian mitochondria

  2009cites this paper
• DNA repair deficiency and neurological disease

  2009cites this paper
• Mitochondrial DNA Damage Initiates a Cell Cycle Arrest by a Chk2-associated Mechanism in Mammalian Cells

  2009cites this paper
• Mitochondrial generation of free radicals and hypoxic signaling.

  2009cites this paper
• Parkin protects mitochondrial genome integrity and supports mitochondrial DNA repair.

  2009cites this paper
• Reactive Oxygen Species in the Induction of Toxicity

  2009cites this paper
• Un rôle pour les protéines de la famille Whirly dans le maintien de la stabilité du génome des organelles chez Arabidopsis thaliana

  2009cites this paper
• Human Dna2 Is a Nuclear and Mitochondrial DNA Maintenance Protein

  2009cites this paper