E‐cadherin dysfunction in gastric cancer ‐ Cellular consequences, clinical applications and open questions

E‐cadherin plays a major role in cell–cell adhesion and inactivating germline mutations in its encoding gene predispose to hereditary diffuse gastric cancer. Evidence indicates that aside from its recognized role in early tumourigenesis, E‐cadherin is also pivotal for tumour progression, including invasion and metastization. Herein, we discuss E‐cadherin alterations found in a cancer context, associated cellular effects and signalling pathways, and we raise new key questions that will impact in the management of GC patients and families.

• Publication year

  2012

• Venue

  FEBS Letters

• Publication date

  2012-08-31

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.febslet.2012.07.045PMID 22841718
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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