Rac, PAK and p38 regulate cell contact‐dependent nuclear translocation of myocardin‐related transcription factor

No abstract is available for this paper.

• Publication year

  2008

• Venue

  FEBS Letters

• Publication date

  2008-01-23

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.febslet.2007.12.021PMID 18154735PMCID PMC5047756
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2007influential reference
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  2007cited by this paper
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