Periderm prevents pathological epithelial adhesions during embryogenesis.

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Journal of Clinical Investigation

• Publication date

  2014-09-02

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1172/JCI71946PMID 25133425PMCID PMC4151209
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Recapitulation of morphogenetic cell shape changes enables wound re-epithelialisation

  2014cited by this paper
• Dominant mutations in GRHL3 cause Van der Woude Syndrome and disrupt oral periderm development.

  2014cited by this paper
• Interferon Regulatory Factor 6 promotes differentiation of the periderm by activating expression of Grainyhead-like 3

  2012cited by this paper
• Cell–cell connectivity: desmosomes and disease

  2012cited by this paper
• Exome sequence identifies RIPK4 as the Bartsocas-Papas syndrome locus.

  2012cited by this paper
• Mutations in RIPK4 cause the autosomal-recessive form of popliteal pterygium syndrome.

  2012cited by this paper
• Developmental factor IRF6 exhibits tumor suppressor activity in squamous cell carcinomas

  2011cited by this paper
• Mutant CHUK and severe fetal encasement malformation.

  2010cited by this paper
• Structural insights into interferon regulatory factor activation.

  2010cited by this paper
• Developmental changes in cellular and extracellular structural macromolecules in the secondary palate and in the nasal cavity of the mouse.

  2010cited by this paper
• Integration of IRF6 and Jagged2 signalling is essential for controlling palatal adhesion and fusion competence

  2009cited by this paper
• Temporal and spatial expression patterns for the tumor suppressor Maspin and its binding partner interferon regulatory factor 6 during breast development

  2009cited by this paper
• Interferon Regulatory Factor 6 Promotes Cell Cycle Arrest and Is Regulated by the Proteasome in a Cell Cycle-Dependent Manner

  2008cited by this paper
• Missense mutations that cause Van der Woude syndrome and popliteal pterygium syndrome affect the DNA-binding and transcriptional activation functions of IRF6

  2008cited by this paper
• Scratching the surface of skin development

  2007cited by this paper
• IKKα Shields 14-3-3σ, a G2/M Cell Cycle Checkpoint Gene, from Hypermethylation, Preventing Its Silencing

  2007cited by this paper
• Lineage tracing using matrilin-1 gene expression reveals that articular chondrocytes exist as the joint interzone forms.

  2007cited by this paper
• IKKalpha shields 14-3-3sigma, a G(2)/M cell cycle checkpoint gene, from hypermethylation, preventing its silencing.

  2007cited by this paper
• Developmental expression analysis of the mouse and chick orthologues of IRF6: The gene mutated in Van der Woude syndrome

  2006cited by this paper
• Abnormal skin, limb and craniofacial morphogenesis in mice deficient for interferon regulatory factor 6 (Irf6)

  2006cited by this paper
• A keratin cytoskeletal protein regulates protein synthesis and epithelial cell growth

  2006cited by this paper
• Tight junctions and cell polarity.

  2006cited by this paper
• Irf6 is a key determinant of the keratinocyte proliferation-differentiation switch

  2006cited by this paper
• Exploiting the Keratin 17 Gene Promoter To Visualize Live Cells in Epithelial Appendages of Mice

  2005cited by this paper
• Identification of 14-3-3sigma mutation causing cutaneous abnormality in repeated-epilation mutant mouse.

  2005cited by this paper
• Asymmetric cell divisions promote stratification and differentiation of mammalian skin

  2005cited by this paper
• In vivo genetic ablation by Cre‐mediated expression of diphtheria toxin fragment A

  2005cited by this paper
• A mutation in stratifin is responsible for the repeated epilation (Er) phenotype in mice

  2005cited by this paper
• Characterization of stage-specific embryonic antigen-1 expression during early stages of human embryogenesis.

  2004cited by this paper
• Getting under the skin of epidermal morphogenesis

  2002cited by this paper
• Epithelial fusions in the embryo.

  2002cited by this paper
• RIP4 is an ankyrin repeat-containing kinase essential for keratinocyte differentiation.

  2002cited by this paper
• Mutations in IRF6 cause Van der Woude and popliteal pterygium syndromes

  2002cited by this paper
• A reporter transgene based on a human keratin 6 gene promoter is specifically expressed in the periderm of mouse embryos.

  2001cited by this paper
• IKKα controls formation of the epidermis independently of NF-κB

  2001cited by this paper
• Gene expression pattern A reporter transgene based on a human keratin 6 gene promoter is specifically expressed in the periderm of mouse embryos

  2001cited by this paper
• Stem cell fate and patterning in mammalian epidermis.

  2001cited by this paper
• IKKalpha controls formation of the epidermis independently of NF-kappaB.

  2001cited by this paper
• Fate of the mammalian cranial neural crest during tooth and mandibular morphogenesis.

  2000cited by this paper
• Abnormal morphogenesis but intact IKK activation in mice lacking the IKKalpha subunit of IkappaB kinase.

  1999cited by this paper
• IKK1-deficient mice exhibit abnormal development of skin and skeleton.

  1999cited by this paper
• Barrier formation in the human fetus is patterned.

  1999cited by this paper
• Signal transduction pathways controlling the switch between keratinocyte growth and differentiation.

  1999cited by this paper
• Limb and skin abnormalities in mice lacking IKKalpha.

  1999cited by this paper
• Periderm cells form cornified cell envelope in their regression process during human epidermal development.

  1999cited by this paper
• Abnormal Morphogenesis But Intact IKK Activation in Mice Lacking the IKKα Subunit of IκB Kinase

  1999cited by this paper
• Onset of Keratin 17 Expression Coincides with the Definition of Major Epithelial Lineages during Skin Development

  1998cited by this paper
• Programming gene expression in developing epidermis.

  1994cited by this paper
• Development and morphology of the periderm of mouse embryos (days 9-12 of gestation).

  1988cited by this paper
• Ventral duplication of the autopod: chemical induction by methoxyacetic acid in rat embryos.

  1987cited by this paper
• Use of a recombinant retrovirus to study post‐implantation cell lineage in mouse embryos.

  1986cited by this paper
• The permeability of the epithelium of the skin of fetal rats demonstrated with a lanthanum-containing solution.

  1983cited by this paper
• The permeability of the epithelium of the skin of fetal rats demonstrated with a lanthanum-containing solution.

  1983cited by this paper
• Repeated epilation: a genetic epidermal syndrome in mice.

  1979cited by this paper
• The fine structure of developing human epidermis: light, scanning, and transmission electron microscopy of the periderm.

  1975cited by this paper

• Zfp750 prevents oral adhesions and promotes temporary epithelial fusions

  2026cites this paper
• Notch signaling in the embryonic ectoderm promotes periderm cell fate and represses mineralization of vibrissa hair follicles

  2026cites this paper
• Therapeutic p63 Isoform Switching Rescues Epidermal Defects in AEC Syndrome.

  2025cites this paper
• The Epithelial Egg Tooth of the Chicken Shares Protein Markers with the Embryonic Subperiderm and Feathers

  2025cites this paper
• A Bioengineered Skin Organoid Platform for Modeling Human Skin Physiology and Cytotoxicity

  2025cites this paper
• Orofacial cleft repair: A clinical model for studying genetic contribution to scar severity.

  2025cites this paper
• Decoding the Spatial and Epigenetic Logic of Early Skin Development

  2025influential citation
• Epidermal stem cells control periderm injury repair via matrix-driven specialization of intercellular junctions

  2025cites this paper
• Z-Plasty technique in congenital midline cervical cleft; a rare case report & literature review

  2025cites this paper
• The roles of different forms of cell death in the fate decision and morphogenesis of craniofacial organs

  2025cites this paper
• Rare variants in PRKCI cause Van der Woude syndrome and other features of peridermopathy.

  2025cites this paper
• Functional Validation of Noncoding Variants Associated With Nonsyndromic Orofacial Cleft

  2025cites this paper
• The developmental bases of cleft lip and cleft palate: cellular and molecular mechanisms

  2025influential citation
• Epidermal Stem Cells Control Periderm Injury Repair via Matrix-Driven Specialization of Intercellular Junctions

  2025cites this paper
• Deciphering gene regulatory programs in mouse embryonic skin through single-cell multiomics analysis

  2025cites this paper
• Ankyloblepharon–Ectodermal Defects–Cleft Lip/Palate Syndrome-Linked p63 Mutations Disrupt Keratinocyte Proliferation and Survival Through Oxidative Stress and Impaired Slc7a11 Expression

  2025cites this paper
• The Functional Impact of the Noncoding SNP rs3741442 on Orofacial Clefting

  2025cites this paper
• Neural crest and periderm-specific requirements of Irf6 during neural tube and craniofacial development.

  2025cites this paper
• The ectodermal loss of ARHGAP29 alters epithelial morphology and organization and disrupts murine palatal development

  2025cites this paper
• A Single-cell Atlas of Developing Mouse Palates Reveals Cellular and Molecular Transitions in Periderm Cell Fate

  2025cites this paper
• 5’tiRNA-35-GlyTCC-3 and 5’tiRNA-33-CysGCA-11 target BMP6, CUL1 and SPR of non-syndromic cleft palate

  2025cites this paper
• Regulation of chromatin modifications through coordination of nucleus size and epithelial cell morphology heterogeneity

  2025cites this paper
• Molecular Regulation of Palatogenesis and Clefting: An Integrative Analysis of Genetic, Epigenetic Networks, and Environmental Interactions

  2025cites this paper
• Rare variants in PRKCI cause Van der Woude syndrome and other features of peridermopathy

  2025cites this paper
• Epithelium Stratifies via Nucleation and Growth Induced by Foam-Geometric Instability

  2025cites this paper
• A spatiotemporal and machine-learning platform facilitates the manufacturing of hPSC-derived esophageal mucosa.

  2025cites this paper
• Embryologic layers in dermatology: Developmental checkpoint disorders, diagnostic insight, and regenerative futures

  2025cites this paper
• High incidence and geographic distribution of cleft palate cases in Finland are associated with a regulatory variant in IRF6

  2024cites this paper
• Epidermal loss of PRMT5 leads to the emergence of an atypical basal keratinocyte-like cell population and defective skin stratification

  2024cites this paper
• High incidence and geographic distribution of cleft palate in Finland are associated with the IRF6 gene

  2024cites this paper
• Single‐cell transcriptome and chromatin accessibility mapping of upper lip and primary palate fusion

  2024cites this paper
• Molecular and Cellular Function of p63 in Skin Development and Genetic Diseases.

  2024cites this paper
• Skin Development and Disease: A Molecular Perspective

  2024cites this paper
• Cell differentiation in the embryonic periderm and in scaffolding epithelia of skin appendages.

  2024cites this paper
• Neural crest and periderm-specific requirements of Irf6 during neural tube and craniofacial development

  2024cites this paper
• A novel noncanonical function for IRF6 in the recycling of E-cadherin

  2024cites this paper
• Development-Associated Genes of the Epidermal Differentiation Complex (EDC)

  2024cites this paper
• The roles of JAK2/STAT3 signaling in fusion of the secondary palate

  2023cites this paper
• Craniofacial developmental biology in the single-cell era.

  2023cites this paper
• Functions of the RIP kinase family members in the skin

  2023cites this paper
• Molecular and spatial landmarks of early mouse skin development.

  2023cites this paper
• A human embryonic limb cell atlas resolved in space and time

  2023cites this paper
• Gene Regulatory Networks and Signaling Pathways in Palatogenesis and Cleft Palate: A Comprehensive Review

  2023cites this paper
• SPECC1L: a cytoskeletal protein that regulates embryonic tissue dynamics.

  2023cites this paper
• Insights into the formation and diversification of a novel chiropteran wing membrane from embryonic development

  2023cites this paper
• Polarity in skin development and cancer.

  2023cites this paper
• Analysis of candidate genes for cleft lip ± cleft palate using murine single-cell expression data

  2023cites this paper
• Periderm Fate during Palatogenesis: TGF-β and Periderm Dedifferentiation

  2023cites this paper
• Epidermal Barrier Development via Corneoptosis: A Unique Form of Cell Death in Stratum Granulosum Cells

  2023cites this paper
• A Spatiotemporal and Machine-Learning Platform Accelerates the Manufacturing of hPSC-derived Esophageal Mucosa

  2023cites this paper
• Two rare variants reveal the significance of Grainyhead-like 3 Arginine 391 underlying non-syndromic cleft palate only.

  2022cites this paper
• Building vs. Rebuilding Epidermis: Comparison Embryonic Development and Adult Wound Repair

  2022cites this paper
• Orofacial Cleft and Mandibular Prognathism—Human Genetics and Animal Models

  2022cites this paper
• Understanding the development of oral epithelial organs through single cell transcriptomic analysis

  2022cites this paper
• A human embryonic limb cell atlas resolved in 1 space and time 2

  2022cites this paper
• Molecular and spatial design of early skin development

  2022influential citation
• Disruption of fos causes craniofacial anomalies in developing zebrafish

  2022cites this paper
• Consistent downregulation of the cleft lip/palate-associated genes IRF6 and GRHL3 in carcinomas

  2022cites this paper
• Single-cell multi-omics decodes regulatory programs during development of mouse secondary palate

  2022cites this paper
• Dual nature of mouse periderm structure, function and fate

  2022cites this paper
• Time-series expression profiles of mRNAs and lncRNAs during mammalian palatogenesis.

  2022cites this paper
• Skin cells undergo asynthetic fission to expand body surfaces in zebrafish

  2022cites this paper
• Mouse models in palate development and orofacial cleft research: Understanding the crucial role and regulation of epithelial integrity in facial and palate morphogenesis.

  2022cites this paper
• Revisiting the embryogenesis of lip and palate development

  2022cites this paper
• RIPK4 regulates cell-cell adhesion in epidermal development and homeostasis.

  2022cites this paper
• To Stick or Not to Stick: Adhesions in Orofacial Clefts

  2022influential citation
• A unique form of collective epithelial migration is crucial for tissue fusion in the secondary palate and can overcome loss of epithelial apoptosis

  2021influential citation
• Ultrastructural studies of developing egg tooth in grass snake Natrix natrix (Squamata, Serpentes) embryos, supported by X-ray microtomography analysis.

  2021cites this paper
• Notch signaling mediates olfactory multiciliated cell specification.

  2021cites this paper
• Integrative approaches generate insights into the architecture of non-syndromic cleft lip with or without cleft palate

  2021cites this paper
• Interferon regulatory factor 6 regulates the delivery of E-cadherin to the plasma membrane.

  2021cites this paper
• Lack of IRF6 Disrupts Human Epithelial Homeostasis by Altering Colony Morphology, Migration Pattern, and Differentiation Potential of Keratinocytes

  2021cites this paper
• Programmed Cell Death Not as Sledgehammer but as Chisel: Apoptosis in Normal and Abnormal Craniofacial Patterning and Development

  2021cites this paper
• The conundrum of pharyngeal teeth origin: the role of germ layers, pouches, and gill slits

  2021cites this paper
• High incidence and regional distribution of cleft palate in Finns are associated with a functional variant in an IRF6 enhancer

  2021cites this paper
• A mechanistic basis for the malignant progression of salivary gland tumors.

  2021cites this paper
• Analysis of zebrafish periderm enhancers facilitates identification of a regulatory variant near human KRT8/18

  2020cites this paper
• SPECC1L regulates palate development downstream of IRF6.

  2020cites this paper
• The Nuclear Factor Kappa B (NF-kB) signaling in cancer development and immune diseases

  2020cites this paper
• Epithelial dynamics shed light on the mechanisms underlying ear canal defects

  2020cites this paper
• A Novel Van der Woude Syndrome-Causing IRF6 Variant Is Subject to Incomplete Non-sense-Mediated mRNA Decay Affecting the Phenotype of Keratinocytes

  2020cites this paper
• Cellular and developmental basis of orofacial clefts

  2020cites this paper
• Sox2 Controls Periderm and Rugae Development to Inhibit Oral Adhesions

  2020influential citation
• RT-qPCR Gene Expression Analysis on the Irf6 Intron Polymorphism in Oral Epithelium of Non-Syndromic Oral Cleft Risk of Deutero-Malay Sub-Race Indonesian

  2020cites this paper
• Machine learning in prediction of genetic risk of nonsyndromic oral clefts in the Brazilian population

  2020cites this paper
• Multiple epithelia are required to develop teeth deep inside the pharynx

  2020cites this paper
• The Role of Grainyhead-like 2 (Grhl2) Transcription Factor in Embryonic Development

  2020cites this paper
• Poised cell circuits in human skin are activated in disease

  2020cites this paper
• Foxg1 Organizes Cephalic Ectoderm to Repress Mandibular Fate, Regulate Apoptosis, Generate Choanae, Elaborate the Auxiliary Eye and Pattern the Upper Jaw

  2020cites this paper
• Foxg1 organizes cephalic ectoderm to repress mandibular fate, regulate apoptosis, and pattern the upper jaw

  2020cites this paper
• Epithelial Migration and Non-adhesive Periderm Are Required for Digit Separation during Mammalian Development.

  2020cites this paper
• Epidermal structure and differentiation.

  2020cites this paper
• Anterior cleft palate due to Cbfb deficiency and its rescue by folic acid

  2019cites this paper
• Embryogenesis of the Skin

  2019cites this paper
• Organized cell movement is a major mechanism underlying facial morphogenesis

  2019cites this paper
• Deregulated Adhesion Program in Palatal Keratinocytes of Orofacial Cleft Patients

  2019cites this paper
• POLIMORFISMOS GENÉTICOS EN PACIENTES CON FISURAS LABIO Y/O PALATINAS NO SINDRÓMICOS

  2019cites this paper
• Tissue-Specific Transcriptomes Reveal Gene Expression Trajectories in Two Maturing Skin Epithelial Layers in Zebrafish Embryos

  2019cites this paper
• Candidate tumor suppressor gene IRF6 is involved in human breast cancer pathogenesis via modulating PI3K-regulatory subunit PIK3R2 expression

  2019cites this paper
• The molecular anatomy of mammalian upper lip and primary palate fusion at single cell resolution

  2019cites this paper