Uncoupling coreceptor usage of human immunodeficiency virus type 1 (HIV-1) from macrophage tropism reveals biological properties of CCR5-restricted HIV-1 isolates from patients with acquired immunodeficiency syndrome.

The mechanisms underlying the pathogenicity of CCR5-restricted (R5) human immunodeficiency virus type-1 (HIV-1) strains are incompletely understood. Acquisition or enhancement of macrophage (M)-tropism by R5 viruses contributes to R5 HIV-1 pathogenesis. In this study, we show that M-tropic R5 viruses isolated from individuals with acquired immunodeficiency syndrome (late R5 viruses) require lower levels of CD4/CCR5 expression for entry, have decreased sensitivity to inhibition by the entry inhibitors TAK-779 and T-20, and have increased sensitivity to neutralization by the Env MAb IgG1b12 compared with non-M-tropic R5 viruses isolated from asymptomatic, immunocompetent individuals (early R5 viruses). Augmenting CCR5 expression levels on monocyte-derived macrophages via retroviral transduction led to a complete or marginal restoration of M-tropism by early R5 viruses, depending on the viral strain. Thus, reduced CD4/CCR5 dependence is a phenotype of R5 HIV-1 associated with M-tropism and late stage infection, which may affect the efficacy of HIV-1 entry inhibitors.

• Publication year

  2005

• Venue

  Virology

• Publication date

  2005-07-05

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/J.VIROL.2005.04.034PMID 15916792
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2004influential reference
• Apoptosis of Bystander T Cells Induced by Human Immunodeficiency Virus Type 1 with Increased Envelope/Receptor Affinity and Coreceptor Binding Site Exposure

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• Impact of Mutations in the Coreceptor Binding Site on Human Immunodeficiency Virus Type 1 Fusion, Infection, and Entry Inhibitor Sensitivity

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• Coevolution of RANTES Sensitivity and Mode of CCR5 Receptor Use by Human Immunodeficiency Virus Type 1 of the R5 Phenotype

  2004influential reference
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  2003influential reference
• The influence of cytokines, chemokines and their receptors on HIV‐1 replication in monocytes and macrophages

  2003cited by this paper
• The emergence and characterization of macrophage‐tropic SIV/HIV chimeric viruses (SHIVs) present in CD4+ T cell‐depleted rhesus monkeys

  2003cited by this paper
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  2002cited by this paper
• Regulation of CC chemokine receptor 5 and CD4 expression and human immunodeficiency virus type 1 replication in human macrophages and microglia by T helper type 2 cytokines.

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• Increased CCR5 Affinity and Reduced CCR5/CD4 Dependence of a Neurovirulent Primary Human Immunodeficiency Virus Type 1 Isolate

  2002cited by this paper
• Persistence of dual-tropic HIV-1 in an individual homozygous for the CCR5 Delta 32 allele.

  2002cited by this paper
• Increased Replication of Non-Syncytium-Inducing HIV Type 1 Isolates in Monocyte-Derived Macrophages Is Linked to Advanced Disease in Infected Children

  2002cited by this paper
• HIV-1 escape from a small molecule, CCR5-specific entry inhibitor does not involve CXCR4 use

  2002cited by this paper
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  2002cited by this paper
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  2002cited by this paper
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  2001cited by this paper
• Increased Neutralization Sensitivity of CD4-Independent Human Immunodeficiency Virus Variants

  2001cited by this paper
• Postentry Restriction to Human Immunodeficiency Virus-Based Vector Transduction in Human Monocytes

  2001influential reference
• Analysis of cellular factors influencing the replication of human immunodeficiency virus type I in human macrophages derived from blood of different healthy donors.

  2001influential reference
• Differential CD4/CCR5 Utilization, gp120 Conformation, and Neutralization Sensitivity between Envelopes from a Microglia-Adapted Human Immunodeficiency Virus Type 1 and Its Parental Isolate

  2001influential reference
• Ability of the V3 Loop of Simian Immunodeficiency Virus To Serve as a Target for Antibody-Mediated Neutralization: Correlation of Neutralization Sensitivity, Growth in Macrophages, and Decreased Dependence on CD4

  2001cited by this paper
• Cytopathicity of Human Immunodeficiency Virus Type 1 Primary Isolates Depends on Coreceptor Usage and Not Patient Disease Status

  2001cited by this paper
• Concordant Utilization of Macrophage Entry Coreceptors by Related Variants within an HIV Type 1 Primary Isolate Viral Swarm

  2001cited by this paper
• Macrophage are the principal reservoir and sustain high virus loads in rhesus macaques after the depletion of CD4+ T cells by a highly pathogenic simian immunodeficiency virus/HIV type 1 chimera (SHIV): Implications for HIV-1 infections of humans.

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• Macrophage Tropism of Human Immunodeficiency Virus Type 1 Isolates from Brain and Lymphoid Tissues Predicts Neurotropism Independent of Coreceptor Specificity

  2001cited by this paper
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  2001cited by this paper
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  2001cited by this paper
• Cooperation of Multiple CCR5 Coreceptors Is Required for Infections by Human Immunodeficiency Virus Type 1

  2000influential reference
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  2000cited by this paper
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  2000cited by this paper
• Pathogenesis of Primary R5 Human Immunodeficiency Virus Type 1 Clones in SCID-hu Mice

  2000cited by this paper
• Determinants of Syncytium Formation in Microglia by Human Immunodeficiency Virus Type 1: Role of the V1/V2 Domains

  2000influential reference
• Mechanisms for Adaptation of Simian Immunodeficiency Virus to Replication in Alveolar Macrophages

  2000influential reference
• Beyond receptor expression: the influence of receptor conformation, density, and affinity in HIV-1 infection.

  2000influential reference
• The level of HIV infection of macrophages is determined by interaction of viral and host cell genotypes

  2000cited by this paper
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  2000cited by this paper
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  1999cited by this paper
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  1999cited by this paper
• Relationship between productive HIV-1 infection of macrophages and CCR5 utilization.

  1999cited by this paper
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  1999cited by this paper
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  1999cited by this paper
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  1999influential reference
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  1999cited by this paper
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  1999cited by this paper
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  1999cited by this paper
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  1999cited by this paper
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  1999cited by this paper
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  1999influential reference
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  1999cited by this paper
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  1998cited by this paper
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  1998cited by this paper
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  1998influential reference
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  1998influential reference
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  1998cited by this paper
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  1998cited by this paper
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  1998cited by this paper
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  1997cited by this paper
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  1997cited by this paper
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  1997cited by this paper
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  1997cited by this paper
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  1996cited by this paper
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  1996cited by this paper
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  1996cited by this paper
• Surface CD4 Is Critical to in Vitro HIV Infection of Human Alveolar Macrophages

  1996cited by this paper
• HIV-1 neutralization: the consequences of viral adaptation to growth on transformed T cells.

  1995cited by this paper
• Cross-clade neutralization of primary isolates of human immunodeficiency virus type 1 by human monoclonal antibodies and tetrameric CD4-IgG

  1995influential reference
• Infection of human tonsil histocultures: A model for HIV pathogenesis

  1995cited by this paper
• Distinct effects in primary macrophages and lymphocytes of the human immunodeficiency virus type 1 accessory genes vpr, vpu, and nef: mutational analysis of a primary HIV-1 isolate.

  1994cited by this paper
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  1994cited by this paper
• Efficient neutralization of primary isolates of HIV-1 by a recombinant human monoclonal antibody.

  1994cited by this paper
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  1994cited by this paper
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  1994cited by this paper
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  1993cited by this paper
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  1992cited by this paper
• An infectious molecular clone of an unusual macrophage-tropic and highly cytopathic strain of human immunodeficiency virus type 1

  1992cited by this paper
• A large array of human monoclonal antibodies to type 1 human immunodeficiency virus from combinatorial libraries of asymptomatic seropositive individuals.

  1991cited by this paper
• Evidence for a role of virulent human immunodeficiency virus (HIV) variants in the pathogenesis of acquired immunodeficiency syndrome: studies on sequential HIV isolates

  1989cited by this paper
• Infection of monocyte-derived macrophages with human immunodeficiency virus type 1 (HIV-1). Monocyte-tropic and lymphocyte-tropic strains of HIV-1 show distinctive patterns of replication in a panel of cell types

  1989cited by this paper
• Efficient isolation and propagation of human immunodeficiency virus on recombinant colony-stimulating factor 1-treated monocytes

  1988cited by this paper
• Production of acquired immunodeficiency syndrome-associated retrovirus in human and nonhuman cells transfected with an infectious molecular clone

  1986influential reference
• Human monoclonal antibody

  1986cited by this paper
• Structures of O-linked oligosaccharides isolated from normal granulocytes, chronic myelogenous leukemia cells, and acute myelogenous leukemia cells.

  1986cited by this paper
• Structural variations of O-linked oligosaccharides present in leukosialin isolated from erythroid, myeloid, and T-lymphoid cell lines.

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  year unknowninfluential reference

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  2018influential citation
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  2017cites this paper
• Evolution of Host Target Cell Specificity During HIV-1 Infection.

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  2015cites this paper
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  2010cites this paper
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