Early-Phase Alcoholic Liver Disease: An Update on Animal Models, Pathology, and Pathogenesis

No abstract is available for this paper.

• Publication year

  2004

• Venue

  International journal of toxicology

• Publication date

  2004-07-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1080/10915810490502069PMID 15371166
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Alcoholic liver disease. Histological features and evolution.

  2009cited by this paper
• Hepatic Fibrosis After Long‐Term Administration of Ethanol and Moderate Vitamin A Supplementation in the Rat

  2007cited by this paper
• Effect of daily ethanol ingestion on intestinal permeability to macromolecules

  2005cited by this paper
• Hepatocyte Proliferation is the Possible Mechanism for the Transient Decrease in Liver Injury During Steatosis Stage of Alcoholic Liver Disease

  2004cited by this paper
• Peroxisome proliferator activated receptor-γ in pathogenesis of experimental fatty liver disease

  2004cited by this paper
• Alcohol-induced Liver Disease

  2004cited by this paper
• Peroxisome proliferator activated receptor-gamma in pathogenesis of experimental fatty liver disease.

  2004cited by this paper
• Iron-dependent activation of NF-kappaB in Kupffer cells: a priming mechanism for alcoholic liver disease.

  2003influential reference
• The CYP inhibitor 1-aminobenzotriazole does not prevent oxidative stress associated with alcohol-induced liver injury in rats and mice.

  2003cited by this paper
• Inducible nitric oxide synthase is required in alcohol-induced liver injury: studies with knockout mice.

  2003cited by this paper
• Peroxisome Proliferator-activated Receptor α (PPARα) Agonist Treatment Reverses PPARα Dysfunction and Abnormalities in Hepatic Lipid Metabolism in Ethanol-fed Mice*

  2003cited by this paper
• Who gets alcoholic liver disease: nature or nurture ?

  2003cited by this paper
• L-carnitine alleviates alcohol-induced liver damage in rats: role of tumour necrosis factor-alpha.

  2003cited by this paper
• Oxidants and antioxidants in alcohol-induced liver disease.

  2003cited by this paper
• 228 Osteopontin induction: possible mechanism behind hepatic neutrophil infiltration during alcoholic steatohepatitis

  2003cited by this paper
• Advances in alcoholic liver disease.

  2003cited by this paper
• Peroxisome proliferator-activated receptor alpha (PPARalpha) agonist treatment reverses PPARalpha dysfunction and abnormalities in hepatic lipid metabolism in ethanol-fed mice.

  2003cited by this paper
• Alcohol‐induced liver injury in mice lacking Cu, Zn‐superoxide dismutase

  2003cited by this paper
• Central role of PPARα‐dependent hepatic lipid turnover in dietary steatohepatitis in mice

  2003cited by this paper
• Increased cytochrome P-450 2E1 expression sensitizes hepatocytes to c-Jun-mediated cell death from TNF-alpha.

  2002cited by this paper
• Alcoholic fatty liver

  2002cited by this paper
• Neutrophil-mediated tissue injury in alcoholic hepatitis.

  2002influential reference
• Nitric oxide in liver diseases: friend, foe, or just passerby?

  2002cited by this paper
• Liver disease in alcohol abusers: clinical perspective.

  2002influential reference
• Monocyte activation in alcoholic liver disease.

  2002cited by this paper
• The paradox of nitric oxide in cirrhosis and portal hypertension: Too much, not enough

  2002cited by this paper
• Long-term ethanol feeding enhances susceptibility of the liver to orally administered lipopolysaccharides in rats.

  2002cited by this paper
• Role of Lipopolysaccharide-Binding Protein in Early Alcohol-Induced Liver Injury in Mice1

  2002influential reference
• Neutrophilic infiltration in alcoholic hepatitis.

  2002influential reference
• Ethanol, oxidative stress, and cytokine-induced liver cell injury.

  2002cited by this paper
• The ubiquitin‐proteasome system and its role in ethanol‐induced disorders

  2002cited by this paper
• Pathology of steatohepatitis.

  2002cited by this paper
• Calcium and oxidative stress: from cell signaling to cell death.

  2002cited by this paper
• Nitric Oxide in Liver Diseases

  2002cited by this paper
• Free radicals in the physiological control of cell function.

  2002cited by this paper
• Alcoholic steatosis and steatohepatitis.

  2002cited by this paper
• Alcoholic hepatitis: inflammatory cell-mediated hepatocellular injury.

  2002cited by this paper
• Nonalcoholic steatosis and steatohepatitis. V. Mitochondrial dysfunction in steatohepatitis.

  2002cited by this paper
• Cocoa extract protects against early alcohol-induced liver injury in the rat.

  2002cited by this paper
• Genetic polymorphisms of alcohol metabolizing enzymes.

  2001cited by this paper
• ICAM-1 is involved in the mechanism of alcohol-induced liver injury: studies with knockout mice.

  2001cited by this paper
• Delivery of the Cu/Zn-superoxide dismutase gene with adenovirus reduces early alcohol-induced liver injury in rats.

  2001cited by this paper
• Clinical and biological relevance of hepatocyte apoptosis in alcoholic hepatitis.

  2001cited by this paper
• Diphenyleneiodonium sulfate, an NADPH oxidase inhibitor, prevents early alcohol-induced liver injury in the rat.

  2001cited by this paper
• Distribution of ethanol-induced protein adducts in vivo: relationship to tissue injury.

  2001cited by this paper
• Overexpression of Manganese Superoxide Dismutase Prevents Alcohol-induced Liver Injury in the Rat*

  2001cited by this paper
• The transcriptional and DNA binding activity of peroxisome proliferator-activated receptor alpha is inhibited by ethanol metabolism. A novel mechanism for the development of ethanol-induced fatty liver.

  2001cited by this paper
• Redox signaling in macrophages.

  2001cited by this paper
• Ebselen prevents early alcohol-induced liver injury in rats.

  2001cited by this paper
• Delivery of IkappaB superrepressor gene with adenovirus reduces early alcohol-induced liver injury in rats.

  2001influential reference
• The chemistry and biological effects of malondialdehyde-acetaldehyde adducts.

  2001cited by this paper
• The CYP2E1 knockout delivers another punch: First ASH, now NASH

  2001cited by this paper
• CYP2E1-dependent toxicity and oxidative stress in HepG2 cells.

  2001cited by this paper
• The role of acetaldehyde in the actions of alcohol (update 2000).

  2001cited by this paper
• Delivery of IκB superrepressor gene with adenovirus reduces early alcohol‐induced liver injury in rats

  2001cited by this paper
• The role of acetaldehyde in the actions of alcohol

  2001cited by this paper
• The CYP2E1 knockout delivers another punch: first ASH, now NASH. Alcoholic steatohepatitis. Nonalcoholic steatohepatitis.

  2001cited by this paper
• The Mitochondrial Permeability Transition Augments Fas-induced Apoptosis in Mouse Hepatocytes*

  2000cited by this paper
• Oxygen regulation of gene expression: a study in opposites.

  2000influential reference
• Allopurinol prevents early alcohol-induced liver injury in rats.

  2000cited by this paper
• The effects of alcohol consumption upon the gastrointestinal tract

  2000cited by this paper
• The effect of ethanol-induced cytochrome p4502E1 on the inhibition of proteasome activity by alcohol.

  2000influential reference
• Oxidative stress and gene regulation.

  2000cited by this paper
• Hepatic, Metabolic, and Nutritional Disorders of Alcoholism: From Pathogenesis to Therapy

  2000influential reference
• Interleukin 10 promoter region polymorphisms and susceptibility to advanced alcoholic liver disease

  2000cited by this paper
• Ethanol potentiates tumor necrosis factor‐α cytotoxicity in hepatoma cells and primary rat hepatocytes by promoting induction of the mitochondrial permeability transition

  2000cited by this paper
• ALCOHOL: its metabolism and interaction with nutrients.

  2000influential reference
• The role of hepatic peroxisome proliferator-activated receptors (PPARs) in health and disease.

  2000cited by this paper
• Diet Restriction as a Protective Mechanism in Noncancer Toxicity Outcomes: A Review

  2000cited by this paper
• Nitric oxide prevents tumor necrosis factor α–induced rat hepatocyte apoptosis by the interruption of mitochondrial apoptotic signaling through S‐nitrosylation of caspase‐8

  2000cited by this paper
• Who Gets Alcoholic Liver Disease: Nature or Nurture?

  2000cited by this paper
• Estrogen is involved in early alcohol‐induced liver injury in a rat enteral feeding model

  2000cited by this paper
• Essential role of tumor necrosis factor α in alcohol-induced liver injury in mice

  1999influential reference
• CYP2E1 is not involved in early alcohol-induced liver injury.

  1999cited by this paper
• Modulation of caspase-3 activity and Fas ligand mRNA expression in rat liver cells in vivo by alcohol and lipopolysaccharide.

  1999cited by this paper
• Increased monocyte MCP-1 production in acute alcoholic hepatitis.

  1999cited by this paper
• Development of a new, simple rat model of early alcohol‐induced liver injury based on sensitization of kupffer cells

  1999influential reference
• Essential role of tumor necrosis factor alpha in alcohol-induced liver injury in mice.

  1999cited by this paper
• Serum concentrations and peripheral secretion of the beta chemokines monocyte chemoattractant protein 1 and macrophage inflammatory protein 1α in alcoholic liver disease

  1999cited by this paper
• Redox regulation of cellular signalling.

  1999cited by this paper
• CYP2E1 is not involved in early alcohol-induced liver injury.

  1999cited by this paper
• CYP 2 E 1 is not involved in early alcohol-induced liver injury

  1999cited by this paper
• The Mitochondrial Permeability Transition Is Required for Tumor Necrosis Factor Alpha-Mediated Apoptosis and Cytochrome c Release

  1998cited by this paper
• Hepatic steatosis: Innocent bystander or guilty party?

  1998cited by this paper
• The role of gut-derived bacterial toxins and free radicals in alcohol-induced liver injury.

  1998influential reference
• Selective glutathione depletion of mitochondria by ethanol sensitizes hepatocytes to tumor necrosis factor.

  1998cited by this paper
• Impaired liver regeneration in inducible nitric oxide synthasedeficient mice.

  1998cited by this paper
• Temporal changes in tissue repair permit survival of diet-restricted rats from an acute lethal dose of thioacetamide.

  1998cited by this paper
• The role of gut‐derived bacterial toxins and free radicals in alcohol‐induced liver injury

  1998cited by this paper
• Alcohol causes both tolerance and sensitization of rat Kupffer cells via mechanisms dependent on endotoxin.

  1998cited by this paper
• Role of tissue repair in toxicologic interactions among hepatotoxic organics.

  1998cited by this paper
• Regulation of microsomal triglyceride transfer protein mRNA expression by endotoxin and cytokines.

  1998cited by this paper
• Obesity increases sensitivity to endotoxin liver injury: implications for the pathogenesis of steatohepatitis.

  1997cited by this paper
• Electrogenic Li+/Li+ exchange mediated by the Na+-K+ pump in rabbit cardiac myocytes.

  1997cited by this paper
• Chronic alcohol intoxication induces hepatic injury through enhanced macrophage inflammatory protein‐2 production and intercellular adhesion molecule‐1 expression in the liver

  1997cited by this paper
• Female rats exhibit greater susceptibility to early alcohol-induced liver injury than males.

  1997cited by this paper
• Mechanisms of neutrophil‐induced parenchymal cell injury

  1997cited by this paper
• Association of a tumor necrosis factor promoter polymorphism with susceptibility to alcoholic steatohepatitis

  1997cited by this paper
• Oxidants as stimulators of signal transduction.

  1997cited by this paper
• Gadolinium chloride blocks alcohol-dependent liver toxicity in rats treated chronically with intragastric alcohol despite the induction of CYP2E1.

  1997cited by this paper

• The Preventative Effect of Chitooligosaccharides against Chronic Alcoholic Liver Disease by Regulating Alcohol Metabolism, Fatty Acid Metabolism, and Intestinal Barrier Damage

  2024cites this paper
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  2023cites this paper
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  2023cites this paper
• Protective effect of purple sweet potato leaf (Ipomoea batatas Linn Convolvulaceae) against alcohol-induced liver damage in mice

  2022influential citation
• Saikosaponin D Inhibits the Proliferation and Promotes the Apoptosis of Rat Hepatic Stellate Cells by Inducing Autophagosome Formation

  2021cites this paper
• Genetically encoded probiotic EcN 1917 alleviates alcohol-induced acute liver injury and restore gut microbiota homeostasis

  2021cites this paper
• The triterpenoids-enriched extracts from Antrodia cinnamomea mycelia attenuate alcohol-induced chronic liver injury via suppression lipid accumulation in C57BL/6 mice

  2021cites this paper
• Wheat embryo globulin protects against acute alcohol-induced liver injury in mice.

  2021cites this paper
• Endoplasmic reticulum stress and autophagy dysregulation in alcoholic and non-alcoholic liver diseases

  2020cites this paper
• Liver toxicity of chemical warfare agents

  2020cites this paper
• miR-378b Regulates Insulin Sensitivity by Targeting Insulin Receptor and p110α in Alcohol-Induced Hepatic Steatosis

  2020cites this paper
• Proteoglycan isolated from Corbicula fluminea exerts hepato-protective effects against alcohol-induced liver injury in mice.

  2019cites this paper
• Attenuation of neutrophil-mediated liver injury in mice by drug-free E-Selectin binding polymer.

  2019cites this paper
• Hepatic NPC1L1 overexpression attenuates alcoholic autophagy in mice

  2019cites this paper
• Effect of Repeated Oral Administration of Roundup® and Ammonium Nitrate on Liver of Wistar Rats

  2018cites this paper
• miR-203 Inhibits Alcohol-Induced Hepatic Steatosis by Targeting Lipin1

  2018cites this paper
• Protective Action of Se-Supplement Against Acute Alcoholism Is Regulated by Selenoprotein P (SelP) in the Liver

  2017cites this paper
• Human neutrophil peptide-1 promotes alcohol-induced hepatic fibrosis and hepatocyte apoptosis

  2017cites this paper
• Teratogenic effects and maternal toxicity sprague dawley rats fed Ficusdeltoidea leaves aqueous extract in late gestation

  2016cites this paper
• Alcohol and Obesity: A Dangerous Association for Fatty Liver Disease

  2016cites this paper
• Protective effects of carnosine alone and together with alpha-tocopherol on lipopolysaccharide (LPS) plus ethanol-induced liver injury.

  2016cites this paper
• Ethanolic Extract of Acanthopanax koreanum Nakai Alleviates Alcoholic Liver Damage Combined with a High-Fat Diet in C57BL/6J Mice

  2016cites this paper
• Dynamic metabolic profiling of urine biomarkers in rats with alcohol‑induced liver damage following treatment with Zhi‑Zi‑Da‑Huang decoction.

  2016cites this paper
• EPAC activation inhibits acetaldehyde-induced activation and proliferation of hepatic stellate cell via Rap1.

  2016cites this paper
• Betaine treatment decreased oxidative stress, inflammation, and stellate cell activation in rats with alcoholic liver fibrosis.

  2016cites this paper
• Protective Effects of Korean Red Ginseng against Alcohol-Induced Fatty Liver in Rats

  2015cites this paper
• Chapter 42 – Liver Toxicity of Chemical Warfare Agents

  2015cites this paper
• Changes of the Cytoplasmic Proteome in Response to Alcoholic Hepatotoxicity in Rats

  2015cites this paper
• Chlorella Ethanol Extract Induced Phase II Enzyme Through NFE2L2 (Nuclear Factor [Erythroid-Derived] 2-Like 2, NRF2) Activation and Protected Ethanol-Induced Hepatoxicity

  2015cites this paper
• Identification de nouveaux facteurs de régulation physiopathologique de la NADPH oxydase du neutrophile : Importance de mTOR, de la dégradation de NOX2 via l’élastase et perspectives de traitement des déficits induits au cours de la cirrhose alcoolique

  2015cites this paper
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  2014cites this paper
• Caffeine Inhibits the Activation of Hepatic Stellate Cells Induced by Acetaldehyde via Adenosine A2A Receptor Mediated by the cAMP/PKA/SRC/ERK1/2/P38 MAPK Signal Pathway

  2014cites this paper
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  2014cites this paper
• Biochemical cellular damage indicators and in situ cell death in chronicalcohol consumption: Pseudomonas aeruginosa induced pneumonia ratmodel.

  2014cites this paper
• The effects of daily supplementation of Dendrobium huoshanense polysaccharide on ethanol-induced subacute liver injury in mice by proteomic analysis.

  2014cites this paper
• Hepatoprotective potential of Aloe vera polysaccharides against chronic alcohol-induced hepatotoxicity in mice.

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  2014cites this paper
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  2013cites this paper
• Characterization of 4-HNE Modified L-FABP Reveals Alterations in Structural and Functional Dynamics

  2012cites this paper
• Transcriptome analysis of garlic-induced hepatoprotection against alcoholic fatty liver.

  2012cites this paper
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  2012cites this paper
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  2012cites this paper
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• Rodent models of alcoholic liver disease: of mice and men.

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• Kinetic Analysis of Primate and Ancestral Alcohol Dehydrogenases

  2012cites this paper
• Proteomics of oxidative stress using inducible CYP2E1 expressing HEPG2 cells and 3T3-L1 adipocytes as model systems

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  2011cites this paper
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  2011cites this paper
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  2010cites this paper
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• Evaluation of Possible Carcinogenic Risk to Humans Based on Liver Tumors in Rodent Assays

  2010cites this paper
• A PROTEOMIC STUDY OF OXIDATIVE STRESS IN ALCOHOLIC LIVER DISEASE

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• Translational Biomarkers of Acute Drug‐Induced Liver Injury: The Current State, Gaps, and Future Opportunities

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• Karaciğer ve böbrek üzerine etanolün toksisitesi ve L-NAME. in koruyucu etkisi

  2009cites this paper
• Liver proteome analysis in a rodent model of alcoholic steatosis.

  2009cites this paper
• The role of PKC-epsilon in models of alcohol- and toxin-induced liver disease.

  2009cites this paper
• TGF-beta enhances alcohol dependent hepatocyte damage via down-regulation of alcohol dehydrogenase I.

  2009cites this paper
• Pathophysiological role of osteopontin in hepatic inflammation, toxicity, and cancer.

  2008cites this paper
• Potential relationship between hepatobiliary osteopontin and peroxisome proliferator-activated receptor alpha expression following ethanol-associated hepatic injury in vivo and in vitro.

  2008cites this paper
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  2008cites this paper
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  2007cites this paper
• Hepatic Neutrophil Infiltration in the Pathogenesis of Alcohol-Induced Liver Injury

  2007cites this paper
• Role of osteopontin in regulating hepatic inflammatory responses and toxic liver injury.

  2007cites this paper
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  2007cites this paper
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  2007cites this paper
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  2007cites this paper
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  2007cites this paper
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  2006influential citation
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  2006cites this paper
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  2006influential citation
• Increased toxicity by transforming growth factor-beta 1 in liver cells overexpressing CYP2E1.

  2006cites this paper
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  2006cites this paper
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  2006cites this paper
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  year unknowncites this paper