Plasmacytoid dendritic cells mediate anti-inflammatory responses to a gut commensal molecule via both innate and adaptive mechanisms.

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Cell Host and Microbe

• Publication date

  2014-04-09

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.chom.2014.03.006PMID 24721570PMCID PMC4020153
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Tolerogenic dendritic cells

  2016influential reference
• Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota

  2013cited by this paper
• The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic Treg Cell Homeostasis

  2013cited by this paper
• Faculty of 1000 evaluation for Deciphering the transcriptional network of the dendritic cell lineage.

  2012cited by this paper
• Outer membrane vesicles of a human commensal mediate immune regulation and disease protection.

  2012cited by this paper
• CD8α+β− and CD8α+β+ plasmacytoid dendritic cells induce Foxp3+ regulatory T cells and prevent the induction of airway hyperreactivity

  2012cited by this paper
• Deciphering the transcriptional network of the DC lineage

  2012cited by this paper
• Oral tolerance to food protein

  2012cited by this paper
• Plasmacytoid dendritic cells transport peripheral antigens to the thymus to promote central tolerance.

  2012cited by this paper
• Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species

  2011cited by this paper
• The Toll-Like Receptor 2 pathway Establishes Colonization by a Commensal of the Human Microbiota

  2011influential reference
• The Toll-Like Receptor 2 Pathway Establishes Colonization by a Commensal of the Human Microbiota

  2011cited by this paper
• Plasmacytoid dendritic cell ablation impacts early interferon responses and antiviral NK and CD8(+) T cell accrual.

  2010influential reference
• Active immunization induces toxicity of diphtheria toxin in diphtheria resistant mice--implications for neuroinflammatory models.

  2010cited by this paper
• How tolerogenic dendritic cells induce regulatory T cells.

  2010cited by this paper
• Plasmacytoid dendritic cells resident in human thymus drive natural Treg cell development.

  2010influential reference
• MHC class II–restricted antigen presentation by plasmacytoid dendritic cells inhibits T cell–mediated autoimmunity

  2010influential reference
• Inducible Foxp3+ regulatory T-cell development by a commensal bacterium of the intestinal microbiota

  2010cited by this paper
• A polysaccharide from the human commensal Bacteroides fragilis protects against CNS demyelinating disease

  2010cited by this paper
• Unraveling the functions of plasmacytoid dendritic cells during viral infections, autoimmunity, and tolerance

  2010influential reference
• Cutting Edge: Plasmacytoid Dendritic Cells Induce IL-10 Production in T Cells via the Delta-Like-4/Notch Axis

  2009influential reference
• Allostimulatory activity of bone marrow-derived plasmacytoid dendritic cells is independent of indoleamine dioxygenase but regulated by inducible costimulator ligand expression.

  2009influential reference
• Lymphoid-tissue-specific homing of bone-marrow-derived dendritic cells.

  2009cited by this paper
• The Indoleamine 2,3-Dioxygenase Pathway Is Essential for Human Plasmacytoid Dendritic Cell-Induced Adaptive T Regulatory Cell Generation1

  2008cited by this paper
• Commensal DNA limits regulatory T cell conversion and is a natural adjuvant of intestinal immune responses.

  2008cited by this paper
• Plasmacytoid dendritic cells mediate oral tolerance.

  2008cited by this paper
• A microbial symbiosis factor prevents intestinal inflammatory disease

  2008cited by this paper
• Differential MHC class II synthesis and ubiquitination confers distinct antigen-presenting properties on conventional and plasmacytoid dendritic cells

  2008cited by this paper
• HIV-activated human plasmacytoid DCs induce Tregs through an indoleamine 2,3-dioxygenase-dependent mechanism.

  2008influential reference
• Plasmacytoid dendritic cells from mouse tumor-draining lymph nodes directly activate mature Tregs via indoleamine 2,3-dioxygenase.

  2007influential reference
• Chemically induced mouse models of intestinal inflammation

  2007cited by this paper
• The Indoleamine 2,3-Dioxygenase Pathway Is Essential for Human Plasmacytoid Dendritic Cell-Induced Adaptive T Regulatory Cell Generation.

  2007cited by this paper
• Plasmacytoid dendritic cells prime IL-10–producing T regulatory cells by inducible costimulator ligand

  2007influential reference
• A bacterial carbohydrate links innate and adaptive responses through Toll-like receptor 2

  2006influential reference
• Antibodies to Complement Receptor 3 Treat Established Inflammation in Murine Models of Colitis and a Novel Model of Psoriasiform Dermatitis

  2006cited by this paper
• Characterization of Siglec-H as a novel endocytic receptor expressed on murine plasmacytoid dendritic cell precursors.

  2006cited by this paper
• Siglec-H is an IPC-specific receptor that modulates type I IFN secretion through DAP12.

  2006cited by this paper
• Oral tolerance originates in the intestinal immune system and relies on antigen carriage by dendritic cells

  2006cited by this paper
• Active induction of experimental allergic encephalomyelitis

  2006influential reference
• Critical appraisal of the current practice in murine TNBS-induced colitis.

  2006cited by this paper
• The B7 family revisited.

  2005cited by this paper
• Modulation of surgical fibrosis by microbial zwitterionic polysaccharides.

  2005cited by this paper
• Effect of B7-2 and CD40 Signals from Activated Antigen-Presenting Cells on the Ability of Zwitterionic Polysaccharides To Induce T-Cell Stimulation

  2005cited by this paper
• An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system.

  2005cited by this paper
• Faculty Opinions recommendation of Murine plasmacytoid dendritic cells initiate the immunosuppressive pathway of tryptophan catabolism in response to CD200 receptor engagement.

  2004influential reference
• Polysaccharide processing and presentation by the MHCII pathway.

  2004influential reference
• Murine Plasmacytoid Dendritic Cells Initiate the Immunosuppressive Pathway of Tryptophan Catabolism in Response to CD200 Receptor Engagement1

  2004cited by this paper
• The immunological and genetic basis of inflammatory bowel disease

  2003cited by this paper
• Tolerogenic dendritic cells.

  2003cited by this paper
• Induction of oral tolerance to cellular immune responses in the absence of Peyer's patches

  2001cited by this paper
• Macrophage-derived IL-18-mediated intestinal inflammation in the murine model of Crohn's disease.

  2001cited by this paper
• Anti‐CD11b/CD18 antibodies reduce inflammation in acute colitis in rats

  1995cited by this paper
• The capsular polysaccharide of Bacteroides fragilis comprises two ionically linked polysaccharides.

  1992cited by this paper

• Mucin-degrading gut bacteria: context-dependent roles in intestinal homeostasis and disease

  2026cites this paper
• The Analysis of Transcriptomes and Microorganisms Reveals Differences Between the Intestinal Segments of New Zealand Rabbits

  2026cites this paper
• Gut colonization by Bacteroides fragilis at juvenile age alters microbiota composition and accelerates type 1 diabetes progression in non-obese diabetic mice

  2025cites this paper
• Microbiome–Immune Interaction and Harnessing for Next-Generation Vaccines Against Highly Pathogenic Avian Influenza in Poultry

  2025cites this paper
• Striking a balance: how the gut microbiome shapes the fate of intestinal CD4+ T cells

  2025cites this paper
• Clinical effects of Bifidobacterium Longum Subsp. Infantis YLGB-1496 on children with respiratory symptoms

  2025cites this paper
• Harnessing the Gut Microbiome in Cancer Immunotherapy: Mechanisms, Challenges, and Routes to Personalized Medicine—A Systematic Review

  2025cites this paper
• TCR-Based Antigen-Specific Therapy for Type 1 Diabetes Mellitus: From Editing Autoreactive Clones to Tolerance Induction

  2025cites this paper
• Self-adaptive biomaterials for tissue repair: from design to application

  2025cites this paper
• Conventional versus emerging techniques in probiotic enumeration: a comprehensive review

  2025cites this paper
• Mechanisms of anastomotic leakage in colorectal cancer surgery: unraveling the roles of inflammation, immunity, and microbiota – a narrative review

  2025cites this paper
• Toll-like receptor 2 deficiency exacerbates corneal angiogenesis in injury by impairing regulatory T cells

  2025cites this paper
• Structure of gut microbial glycolipid modulates host inflammatory response.

  2025cites this paper
• Commensal bacterial glycosylation at the interface of host–bacteria interactions

  2025cites this paper
• Gut microbiota and intestinal immunity interaction in ulcerative colitis and its application in treatment

  2025cites this paper
• Synthesis and Docking Studies of Glycolipids Inspired by Bacteroides fragilis Lipid A

  2025cites this paper
• Nasal–Gut Microbiome Axis in Health and Disease

  2025cites this paper
• Dendritic cells: understanding ontogeny, subsets, functions, and their clinical applications

  2025cites this paper
• Nanotechnology-Microbiota Synergy in Cancer Immunotherapy.

  2025cites this paper
• The hidden piece in inflammatory bowel diseases: The significance of intestinal mucus in mediating the bacteria-cells crosstalk

  2025cites this paper
• The role of the gut and intestinal dysbiosis in the pathogenesis of Spondyloarthritis.

  2025cites this paper
• Human Gut Commensal Bacteroides fragilis Suppresses Mucin Production and Alters Microbiota Composition Resulting in Accelerated Type 1 Diabetes in Mice

  2025cites this paper
• Gut commensal bacteria-derived polysaccharide sub-micron particles induce antigen-specific, tolerogenic responses

  2025cites this paper
• Bacteriophage-driven DNA inversions shape bacterial functionality and long-term co-existence in Bacteroides fragilis

  2025cites this paper
• Gut microbiota in multiple sclerosis and animal models

  2024cites this paper
• Dissecting Innate and Adaptive Immunity in Inflammatory Bowel Disease: Immune Compartmentalization, Microbiota Crosstalk, and Emerging Therapies

  2024cites this paper
• Human milk oligosaccharides in preventing food allergy: A review through gut microbiota and immune regulation.

  2024cites this paper
• The Role of Gut Microbiota in Non-alcoholic Fatty Liver Disease Pathogenesis

  2024cites this paper
• Arctium lappa L. polysaccharides alleviate oxidative stress and inflammation in the liver and kidney of aging mice by regulating intestinal homeostasis.

  2024cites this paper
• The role of plasmacytoid dendritic cells (pDCs) in immunity during viral infections and beyond

  2024cites this paper
• Efficacy and safety of Bacteroides fragilis BF839 for pediatric autism spectrum disorder: a randomized clinical trial

  2024cites this paper
• Neuroactive Steroids, Toll-like Receptors, and Neuroimmune Regulation: Insights into Their Impact on Neuropsychiatric Disorders

  2024cites this paper
• Advances in Bio-Optical Imaging Systems for Spatiotemporal Monitoring of Intestinal Bacteria.

  2024cites this paper
• Impaired immune tolerance mediated by reduced Tfr cells in rheumatoid arthritis linked to gut microbiota dysbiosis and altered metabolites

  2024cites this paper
• Engineered polysaccharides for controlling innate and adaptive immune responses

  2024cites this paper
• Critical role of the gut microbiota in immune responses and cancer immunotherapy

  2024cites this paper
• Microbial transmission in the social microbiome and host health and disease.

  2024cites this paper
• Inflammation and bacteriophages affect DNA inversion states and functionality of the gut microbiota

  2024cites this paper
• Profiling the gut and oral microbiota of hormone receptor-positive, HER2-negative metastatic breast cancer patients receiving pembrolizumab and eribulin

  2024cites this paper
• Gut microbiota-derived GlcNAc-MurNAc is a TLR4 agonist that protects the host gut

  2024cites this paper
• Nontoxigenic Bacteroides fragilis: A double-edged sword.

  2024cites this paper
• The Role of TRP Channels in Sepsis and Colitis

  2024cites this paper
• From gut to brain: understanding the role of microbiota in inflammatory bowel disease

  2024cites this paper
• Association Between Gut and Nasal Microbiota and Allergic Rhinitis: A Systematic Review

  2024cites this paper
• Dissecting the role of the gut microbiome and fecal microbiota transplantation in radio- and immunotherapy treatment of colorectal cancer

  2023cites this paper
• Inflammation and bacteriophages affect DNA inversion states and functionality of the gut microbiota

  2023cites this paper
• The progress of research on immune checkpoint inhibitor resistance and reversal strategies for hepatocellular carcinoma

  2023cites this paper
• When the allergy alarm bells toll: The role of Toll-like receptors in allergic diseases and treatment

  2023influential citation
• Gut microbiota, a hidden protagonist of traditional Chinese medicine for acute ischemic stroke

  2023cites this paper
• Gut microbiota and traumatic central nervous system injuries: Insights into pathophysiology and therapeutic approaches.

  2023cites this paper
• The interaction between intestinal microenvironment and stroke

  2023cites this paper
• The yin and yang of B cells in a constant state of battle: intestinal inflammation and inflammatory bowel disease

  2023cites this paper
• On the features of the correction of intestinal dysbiosis in chronic pancreatitis (literature review)

  2023cites this paper
• The Effect of Bacillus coagulans Induced Interactions among Intestinal Bacteria, Metabolites, and Inflammatory Molecules in Improving Natural Skin Aging

  2023cites this paper
• Tn antigen interactions of macrophage galactose-type lectin (MGL) in immune function and disease.

  2023cites this paper
• The role of fibromodulin in inflammatory responses and diseases associated with inflammation

  2023cites this paper
• Microbiome Alterations and Alzheimer’s Disease: Modeling Strategies with Transgenic Mice

  2023cites this paper
• Checkpoint Inhibitor-Induced Colitis: From Pathogenesis to Management

  2023cites this paper
• Assessing causal relationships between gut microbiota and asthma: evidence from two sample Mendelian randomization analysis

  2023cites this paper
• Regulatory T cells in the face of the intestinal microbiota

  2023cites this paper
• Inflammation and bacteriophages affect DNA inversion states and functionality 1 of the gut microbiota 2

  2023cites this paper
• Microbiome, alveolar bone, and metabolites: Connecting the dots

  2023cites this paper
• An Update on Toll-like Receptor 2, Its Function and Dimerization in Pro- and Anti-Inflammatory Processes

  2023cites this paper
• The role of probiotics in prevention and treatment of food allergy

  2023cites this paper
• Untangling the Role of Pathobionts from Bacteroides Species in Inflammatory Bowel Diseases

  2023cites this paper
• Current perspective on biological properties of plasmacytoid dendritic cells and dysfunction in gut

  2023cites this paper
• Efficacy and regulatory strategies of gut microbiota in immunotherapy: a narrative review

  2023cites this paper
• Cholinergic anti-inflammatory pathway ameliorates murine experimental Th2-type colitis by suppressing the migration of plasmacytoid dendritic cells

  2022cites this paper
• Effects of exercise training with Lactobacillus plantarum intake on ionized calcium‐binding adaptor molecule 1, glial fibrillary acidic protein, interleukin‐6 and interleukin‐1β in cuprizone‐induced demyelination mouse model of multiple sclerosis

  2022cites this paper
• The microbiome and precision oncology: an emerging paradigm in anticancer therapy

  2022cites this paper
• Metagenomic and metabolomic analyses reveal synergistic effects of fecal microbiota transplantation and anti-PD-1 therapy on treating colorectal cancer

  2022cites this paper
• Prebiotics and probiotics

  2022cites this paper
• Immunoregulatory Intestinal Microbiota and COVID-19 in Patients with Type Two Diabetes: A Double-Edged Sword

  2022influential citation
• The immunomodulatory roles of the gut microbiome in autoimmune diseases of the central nervous system: Multiple sclerosis as a model.

  2022cites this paper
• New insights into bacterial mechanisms and potential intestinal epithelial cell therapeutic targets of inflammatory bowel disease

  2022cites this paper
• The Microbiome in Systemic Sclerosis: Pathophysiology and Therapeutic Potential

  2022cites this paper
• Crosstalk between the Intestinal Virome and Other Components of the Microbiota, and Its Effect on Intestinal Mucosal Response and Diseases

  2022cites this paper
• CCR9 axis inhibition enhances hepatic migration of plasmacytoid DCs and protects against liver injury

  2022cites this paper
• Extremely small and incredibly close: Gut microbes as modulators of inflammation and targets for therapeutic intervention

  2022cites this paper
• Local and systemic effects of microbiome‐derived metabolites

  2022cites this paper
• Intestinal Barrier Dysfunction in Fatty Liver Disease: Roles of Microbiota, Mucosal Immune System, and Bile Acids.

  2022cites this paper
• Messengers From the Gut: Gut Microbiota-Derived Metabolites on Host Regulation

  2022cites this paper
• Immunotherapy and Microbiota for Targeting of Liver Tumor-Initiating Stem-like Cells

  2022cites this paper
• The multifaceted roles of common gut microbiota in immune checkpoint inhibitor-mediated colitis: From mechanism to clinical application

  2022cites this paper
• Roles of Plasmacytoid Dendritic Cells in Gastric Cancer

  2022cites this paper
• Intranasal administration of Acinetobacter lwoffii in a murine model of asthma induces IL‐6‐mediated protection associated with cecal microbiota changes

  2022cites this paper
• Interleukin-36β exacerbates DSS-induce acute colitis via inhibiting Foxp3+ regulatory T cell response and increasing Th2 cell response.

  2022cites this paper
• Microbial dysbiosis and childhood asthma development: Integrated role of the airway and gut microbiome, environmental exposures, and host metabolic and immune response

  2022cites this paper
• Exploring the Emerging Role of the Gut Microbiota and Tumor Microenvironment in Cancer Immunotherapy

  2021cites this paper
• Biogeography of the Relationship between the Child Gut Microbiome and Innate Immune System

  2021cites this paper
• Gold digging: Searching for gut microbiota that enhances antitumor immunity

  2021cites this paper
• Gut Microbiota and Acute Central Nervous System Injury: A New Target for Therapeutic Intervention

  2021cites this paper
• Bacteroides ovatus promotes IL-22 production and reduces trinitrobenzene sulfonic acid (TNBS)-driven colonic inflammation.

  2021cites this paper
• Atypical immunometabolism and metabolic reprogramming in liver cancer: Deciphering the role of gut microbiome.

  2021cites this paper
• The Microbiome and Its Implications in Cancer Immunotherapy

  2021cites this paper
• Immune Checkpoint Inhibitor-Associated Colitis: From Mechanism to Management

  2021cites this paper
• Risk factors for immune-related adverse events: what have we learned and what lies ahead?

  2021cites this paper
• Berberine inhibits dendritic cells differentiation in DSS-induced colitis by promoting Bacteroides fragilis.

  2021cites this paper
• How dendritic cells sense and respond to viral infections.

  2021cites this paper
• Type I Interferon Induction and Exhaustion during Viral Infection: Plasmacytoid Dendritic Cells and Emerging COVID-19 Findings

  2021cites this paper