Primary tumor hypoxia recruits CD11b+/Ly6Cmed/Ly6G+ immune suppressor cells and compromises NK cell cytotoxicity in the premetastatic niche.

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Cancer Research

• Publication date

  2012-08-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1158/0008-5472.CAN-11-3873PMID 22751463
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Myeloid progenitor cells in the premetastatic lung promote metastases by inducing mesenchymal to epithelial transition.

  2012cited by this paper
• Myeloid cell diversification and complexity: an old concept with new turns in oncology

  2011cited by this paper
• Myeloid-derived suppressor cells are implicated in regulating permissiveness for tumor metastasis during mouse gestation.

  2011cited by this paper
• Hypoxia-inducible factor 1 is a master regulator of breast cancer metastatic niche formation

  2011cited by this paper
• Gr-1+CD11b+ myeloid cells tip the balance of immune protection to tumor promotion in the premetastatic lung.

  2010cited by this paper
• Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics

  2010cited by this paper
• Inaugural Article: Granulocyte-colony stimulating factor promotes lung metastasis through mobilization of Ly6G+Ly6C+ granulocytes

  2010cited by this paper
• Granulocyte-colony stimulating factor promotes lung metastasis through mobilization of Ly6G+Ly6C+ granulocytes

  2010cited by this paper
• DNAM-1/CD155 Interactions Promote Cytokine and NK Cell-Mediated Suppression of Poorly Immunogenic Melanoma Metastases

  2009cited by this paper
• The metastatic niche: adapting the foreign soil

  2009cited by this paper
• Inhibition of Siah ubiquitin ligase function

  2009cited by this paper
• Microenvironmental regulation of metastasis

  2009cited by this paper
• Hypoxia-induced lysyl oxidase is a critical mediator of bone marrow cell recruitment to form the premetastatic niche.

  2009cited by this paper
• Cancer-Expanded Myeloid-Derived Suppressor Cells Induce Anergy of NK Cells through Membrane-Bound TGF-β11

  2009cited by this paper
• Migratory neighbors and distant invaders: tumor-associated niche cells.

  2008cited by this paper
• Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway.

  2008cited by this paper
• Anti-Chemokine Therapy for Inflammatory Diseases

  2007cited by this paper
• Expansion of spleen myeloid suppressor cells represses NK cell cytotoxicity in tumor-bearing host.

  2007cited by this paper
• CD27 Dissects Mature NK Cells into Two Subsets with Distinct Responsiveness and Migratory Capacity1

  2006cited by this paper
• VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche

  2005cited by this paper
• Generation and Analysis of Siah2 Mutant Mice

  2003cited by this paper

• Mechanisms and strategies for reversing NK cell exhaustion in tumor immunotherapy.

  2026cites this paper
• Tumor hypoxia shapes natural killer cell anticancer activities

  2025cites this paper
• Tumor microenvironment and immunotherapy: from bench to bedside

  2025cites this paper
• Defining the Tumor-Bone axis: the role of extracellular vesicles in a crucial exchange route for breast cancer development and progression

  2025cites this paper
• Ischemic stroke of undetermined source as a priming event for brain metastasis: a case report and systematic literature review

  2025cites this paper
• Carbonic anhydrase IX inhibition as a path to treat neuroblastoma

  2025cites this paper
• The Prognostic Value of Tumor‐Associated Neutrophils in Colorectal Cancer: A Systematic Review and Meta‐Analysis

  2025cites this paper
• Cancer-associated fibroblasts secrete CSF3 to promote TNBC progression via enhancing PGM2L1-dependent glycolysis reprogramming

  2025cites this paper
• EYA3 regulation of NF-κB and CCL2 suppresses cytotoxic NK cells in the premetastatic niche to promote TNBC metastasis

  2025cites this paper
• Hypoxia and immunometabolism in the tumor microenvironment: insights into mechanisms and therapeutic potential.

  2025cites this paper
• Hypoxia-induced EGR1 remodels neutrophils to suppress antitumor immunity.

  2025cites this paper
• SIRT5-mediated desuccinylation of PPA2 enhances HIF-1alpha-dependent adaptation to hypoxic stress and colorectal cancer metastasis

  2025cites this paper
• Rearrangement of 3D genome organization in breast cancer epithelial to mesenchymal transition and metastasis organotropism

  2025cites this paper
• The Ly6ghigh Neutrophil Subset Dictates Breast Cancer Lung Metastasis via CD8+ T Cell Death

  2025cites this paper
• Endothelial activation during the diapedesis of cancer cells: between the kiss of death and therapeutic breakthrough

  2025cites this paper
• Lung metastases

  2025cites this paper
• Recent advancements in lung cancer research: a narrative review

  2025cites this paper
• The Recruitment and Immune Suppression Mechanisms of Myeloid‐Derived Suppressor Cells and Their Impact on Bone Metastatic Cancer

  2025cites this paper
• Immune Characteristics of eQTL and Gene Risk Model and the Inhibitory Effect of DCTD and RRAS on Ferroptosis in Glioblastoma.

  2025cites this paper
• Neutrophils in cancer: from immune defense to tumor promotion

  2025cites this paper
• Lung bronchiectasisas a paradigm of the interplay between infection and colonization on plastic modulation of the pre-metastatic niche

  2024cites this paper
• The complexity of immune evasion mechanisms throughout the metastatic cascade

  2024cites this paper
• Myeloid‑derived suppressor cells as targets of emerging therapies and nanotherapies (Review)

  2024cites this paper
• Ly6E on tumor cells impairs anti-tumor T-cell responses: a novel mechanism of tumor-induced immune exclusion

  2024cites this paper
• Neutrophils in glioma microenvironment: from immune function to immunotherapy

  2024cites this paper
• Combined IL6 and CCR2 blockade potentiates antitumor activity of NK cells in HPV-negative head and neck cancer

  2024cites this paper
• Targeted modulation of gut and intra-tumor microbiota to improve the quality of immune checkpoint inhibitor responses.

  2024cites this paper
• Nanoparticles in tumor microenvironment remodeling and cancer immunotherapy

  2024cites this paper
• CCL2‐CCR2 Axis Inhibition in Osteosarcoma Cell Model: The Impact of Oxygen Level on Cell Phenotype

  2024cites this paper
• Rearrangement of 3D genome organization in breast cancer epithelial - mesenchymal transition and metastasis organotropism

  2024cites this paper
• Hypoxic tumor microenvironment: Destroyer of natural killer cell function.

  2024cites this paper
• Exploring the function of myeloid cells in promoting metastasis in head and neck cancer

  2024cites this paper
• Understanding the immunosuppressive microenvironment of glioma: mechanistic insights and clinical perspectives

  2024cites this paper
• A palmitate-rich metastatic niche enables metastasis growth via p65 acetylation resulting in pro-metastatic NF-κB signaling

  2023cites this paper
• Immune determinants of the pre-metastatic niche.

  2023cites this paper
• MDSCs: The Key Players in the Formation of Pre-Metastatic Niche.

  2023cites this paper
• DDQN-based optimal targeted therapy with reversible inhibitors to combat the Warburg effect.

  2023cites this paper
• Communicator Extraordinaire: Extracellular Vesicles in the Tumor Microenvironment Are Essential Local and Long-Distance Mediators of Cancer Metastasis

  2023cites this paper
• The Function of NK Cells in Tumor Metastasis and NK Cell-Based Immunotherapy

  2023cites this paper
• Bacterial Magnetosome‐Hitchhiked Quick‐Frozen Neutrophils for Targeted Destruction of Pre‐Metastatic Niche and Prevention of Tumor Metastasis

  2023cites this paper
• The Role of Cytokines in Neutrophil Development, Tissue Homing, Function and Plasticity in Health and Disease

  2023cites this paper
• MDSCs in breast cancer: an important enabler of tumor progression and an emerging therapeutic target

  2023cites this paper
• Tumor-derived nanoseeds condition the soil for metastatic organotropism.

  2023cites this paper
• Cross-talk between insulin resistance and nitrogen species in hypoxia leads to deterioration of tissue and homeostasis.

  2023cites this paper
• Cellular and molecular characteristics of the premetastatic niches

  2023cites this paper
• Natural killer cells and type 1 innate lymphoid cells in cancer.

  2023cites this paper
• Platycodin D induces neutrophil apoptosis by downregulating PD-L1 expression to inhibit breast cancer pulmonary metastasis.

  2023cites this paper
• Analyzing the Tumor-Immune Microenvironment by Flow Cytometry.

  2023cites this paper
• Disruption of hypoxia inducible factor-2α in neutrophils decreases colitis-associated colon cancer.

  2023cites this paper
• Targeting serine/glycine metabolism improves radiotherapy response in non-small cell lung cancer

  2023cites this paper
• Effector and cytolytic function of natural killer cells in anti-cancer immunity.

  2023cites this paper
• Gas6/AXL pathway: immunological landscape and therapeutic potential

  2023cites this paper
• Locally sourced: site-specific immune barriers to metastasis

  2023cites this paper
• The Effect of Propofol versus Inhalation Anesthetics on Survival after Oncological Surgery

  2022cites this paper
• NK cells and solid tumors: therapeutic potential and persisting obstacles

  2022cites this paper
• Systemic Nos2 Depletion and Cox inhibition limits TNBC disease progression and alters lymphoid cell spatial orientation and density

  2022cites this paper
• Mitochondrial Aldehyde Dehydrogenase 2 Represents a Potential Biomarker of Biochemical Recurrence in Prostate Cancer Patients

  2022cites this paper
• Comparative analysis of tangential flow filtration and ultracentrifugation, both combined with subsequent size exclusion chromatography, for the isolation of small extracellular vesicles

  2022cites this paper
• Ferroptosis: A potential opportunity for intervention of pre-metastatic niche

  2022cites this paper
• The effects of dendritic cell-based vaccines in the tumor microenvironment: Impact on myeloid-derived suppressor cells

  2022cites this paper
• Role of myeloid-derived suppressor cells in the formation of pre-metastatic niche

  2022cites this paper
• The cellular and molecular mediators of metastasis to the lung

  2022cites this paper
• Tumor cell–released LC3‐positive EVs promote lung metastasis of breast cancer through enhancing premetastatic niche formation

  2022cites this paper
• A palmitate-rich metastatic niche enables metastasis growth via p65 acetylation

  2022cites this paper
• NOS2 and COX2 Blockade Limits TNBC Disease Progression and Alters CD8+ T Cell Spatial Orientation and Density

  2022cites this paper
• Physiological function of the dynamic oxygen signaling pathway at the maternal-fetal interface.

  2022cites this paper
• Fusobacterium nucleatum promotes liver metastasis in colorectal cancer by regulating the hepatic immune niche and altering gut microbiota

  2022influential citation
• Feed‐forward loops between metastatic cancer cells and their microenvironment—the stage of escalation

  2022cites this paper
• CXCL10 conditions alveolar macrophages within the premetastatic niche to promote metastasis.

  2022cites this paper
• The role of the natural killer (NK) cell modulation in breast cancer incidence and progress

  2022cites this paper
• The Role of Myeloid-Derived Suppressor Cells in Tumor Growth and Metastasis.

  2022cites this paper
• Exercise in cancer prevention and anticancer therapy: Efficacy, molecular mechanisms and clinical information.

  2022cites this paper
• Influence of Perioperative Anesthesia on Cancer Recurrence: from Basic Science to Clinical Practice

  2022cites this paper
• Role of the Hypoxic-Secretome in Seed and Soil Metastatic Preparation

  2022cites this paper
• Genetically engineered exosomes for targetedly preventing premetastatic niche formation and suppressing postoperative melanoma lung metastasis

  2022cites this paper
• Relationship between Tumor Infiltrating Immune Cells and Tumor Metastasis and Its Prognostic Value in Cancer

  2022cites this paper
• The roles of metabolic profiles and intracellular signaling pathways of tumor microenvironment cells in angiogenesis of solid tumors

  2022cites this paper
• The overall process of metastasis: From initiation to a new tumor.

  2022cites this paper
• Cellular Indoctrination: How the Tumor Microenvironment Reeducates Macrophages Towards Nefarious Ends

  2021cites this paper
• Immunometabolic targeting of NK cells to solid tumors

  2021cites this paper
• Role of Gene Polymorphism in Obesity and Cancer

  2021cites this paper
• Hypoxia Reduction Sensitizes Refractory Cancers to Immunotherapy.

  2021cites this paper
• The Tumour Microenvironment and Circulating Tumour Cells: A Partnership Driving Metastasis and Glycan-Based Opportunities for Cancer Control.

  2021cites this paper
• Kill and Clearance in HCC: An Approach Based on NK Cells and Macrophages

  2021cites this paper
• Neutrophil dynamics in the tumor microenvironment

  2021cites this paper
• Targeting myeloid-derived suppressor cells for cancer therapy

  2021cites this paper
• Cancer biology deciphered by single-cell transcriptomic sequencing

  2021cites this paper
• Role of the CCL2‐CCR2 signalling axis in cancer: Mechanisms and therapeutic targeting

  2021cites this paper
• Engineering Endogenous Tumor‐Associated Macrophage‐Targeted Biomimetic Nano‐RBC to Reprogram Tumor Immunosuppressive Microenvironment for Enhanced Chemo‐Immunotherapy

  2021cites this paper
• Innate Neutrophil Memory Dynamics in Disease Pathogenesis.

  2021cites this paper
• Hypoxia inducible factor signaling in breast tumors controls spontaneous tumor dissemination in a site-specific manner

  2021cites this paper
• Breast Cancer Metastasis.

  2021cites this paper
• Natural Killer Cell Interactions With Myeloid Derived Suppressor Cells in the Tumor Microenvironment and Implications for Cancer Immunotherapy

  2021cites this paper
• Tumor microenvironmental cytokines bound to cancer exosomes determine uptake by cytokine receptor-expressing cells and biodistribution

  2021cites this paper
• Immune Circuits to Shape Natural Killer Cells in Cancer

  2021cites this paper
• Premetastatic Microenvironment

  2021cites this paper
• Pulmonary Delivery of Engineered Exosomes to Suppress Postoperative Melanoma Lung Metastasis through Preventing Premetastatic Niche Formation

  2021cites this paper
• In Vitro Evaluation of CD276-CAR NK-92 Functionality, Migration and Invasion Potential in the Presence of Immune Inhibitory Factors of the Tumor Microenvironment

  2021cites this paper
• How Cells Communicate with Each Other in the Tumor Microenvironment: Suggestions to Design Novel Therapeutic Strategies in Cancer Disease

  2021cites this paper
• Challenges and Recent Advances in NK Cell-Targeted Immunotherapies in Solid Tumors

  2021cites this paper