Identification of cellular proteins that bind to the human immunodeficiency virus type 1 trans-activation-responsive TAR element RNA.

No abstract is available for this paper.

• Publication year

  1989

• Venue

  Proceedings of the National Academy of Sciences of the United States of America

• Publication date

  1989-10-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1073/PNAS.86.20.7828PMID 2510154PMCID PMC298164
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• An inducible transcription factor activates expression of human immunodeficiency virus in T cells

  1990cited by this paper
• Human immunodeficiency viral long terminal repeat is functional and can be trans-activated in Escherichia coli.

  1989cited by this paper
• Activation of double-stranded RNA-dependent kinase (dsl) by the TAR region of HIV-1 mRNA: a novel translational control mechanism.

  1989cited by this paper
• Activation of interferon-regulated, dsRNA-dependent enzymes by human immunodeficiency virus-1 leader RNA.

  1989cited by this paper
• Functional characterization of a complex protein-DNA-binding domain located within the human immunodeficiency virus type 1 long terminal repeat leader region

  1989cited by this paper
• The human immunodeficiency virus: infectivity and mechanisms of pathogenesis.

  1988cited by this paper
• HIV-1 tat trans-activation requires the loop sequence within tar

  1988cited by this paper
• Tat protein from human immunodeficiency virus forms a metal-linked dimer.

  1988cited by this paper
• Transcriptional activation of homologous viral long terminal repeats by the human immunodeficiency virus type 1 or the human T-cell leukemia virus type I tat proteins occurs in the absence of de novo protein synthesis.

  1988cited by this paper
• Synthesis of functional human immunodeficiency virus tat protein in baculovirus as determined by a cell-cell fusion assay

  1988cited by this paper
• A 64 kd nuclear protein binds to RNA segments that include the AAUAAA polyadenylation motif.

  1988cited by this paper
• Purification of the human immunodeficiency virus type 1 enhancer and TAR binding proteins EBP‐1 and UBP‐1.

  1988cited by this paper
• Structure of the mouse nucleolin gene. The complete sequence reveals that each RNA binding domain is encoded by two independent exons.

  1988cited by this paper
• Characterization of cellular factors that interact with the human T-cell leukemia virus type I p40x-responsive 21-base-pair sequence

  1988cited by this paper
• Mutational analysis of the trans-activation-responsive region of the human immunodeficiency virus type I long terminal repeat

  1988cited by this paper
• Structural arrangements of transcription control domains within the 5'-untranslated leader regions of the HIV-1 and HIV-2 promoters.

  1988cited by this paper
• Cytoplasmic protein binds in vitro to a highly conserved sequence in the 5' untranslated region of ferritin heavy- and light-subunit mRNAs.

  1988cited by this paper
• A discrete element 3' of human immunodeficiency virus 1 (HIV-1) and HIV-2 mRNA initiation sites mediates transcriptional activation by an HIV trans activator

  1988cited by this paper
• Multiple tandemly repeated binding sites for cellular nuclear factor 1 that surround the major immediate-early promoters of simian and human cytomegalovirus

  1987cited by this paper
• Purification and properties of Drosophila heat shock activator protein.

  1987cited by this paper
• Anti-termination of transcription within the long terminal repeat of HIV-1 by tat gene product

  1987cited by this paper
• Interactions of cellular proteins involved in the transcriptional regulation of the human immunodeficiency virus.

  1987cited by this paper
• Activation of the HIV-1 LTR by T cell mitogens and the trans-activator protein of HTLV-I.

  1987cited by this paper
• In vitro activation of the HIV‐1 enhancer in extracts from cells treated with a phorbol ester tumor promoter.

  1987cited by this paper
• Human immunodeficiency virus long terminal repeat responds to T-cell activation signals.

  1987cited by this paper
• Trans-activation of human immunodeficiency virus gene expression is mediated by nuclear events.

  1987cited by this paper
• Regulation of mRNA accumulation by a human immunodeficiency virus trans-activator protein.

  1987cited by this paper
• Phorbol ester enhances human immunodeficiency virus-promoted gene expression and acts on a repeated 10-base-pair functional enhancer element

  1987cited by this paper
• Elevated levels of mRNA can account for the trans-activation of human immunodeficiency virus.

  1986cited by this paper
• Post-transcriptional regulation accounts for the trans-activation of the human T-lymphotropic virus type III

  1986cited by this paper
• Expression and characterization of the trans-activator of HTLV-III/LAV virus.

  1986cited by this paper
• Influences of mRNA secondary structure on initiation by eukaryotic ribosomes.

  1986cited by this paper
• Trans-activation of the human immunodeficiency virus long terminal repeat sequence by DNA viruses.

  1986cited by this paper
• Purification and biochemical characterization of the promoter-specific transcription factor, Sp1.

  1986cited by this paper
• Activation of the AIDS retrovirus promoter by the cellular transcription factor, Sp1.

  1986cited by this paper
• Primary rat embryo cells transformed by one or two oncogenes show different metastatic potentials.

  1986cited by this paper
• Trans-activation of human immunodeficiency virus occurs via a bimodal mechanism.

  1986cited by this paper
• HTLV-III expression and production involve complex regulation at the levels of splicing and translation of viral RNA.

  1986cited by this paper
• Multiple nuclear factors interact with the immunoglobulin enhancer sequences.

  1986cited by this paper
• The location of cis-acting regulatory sequences in the human T cell lymphotropic virus type III (HTLV-III/LAV) long terminal repeat.

  1985cited by this paper
• Transcription control by oncogenes.

  1985cited by this paper
• A very strong enhancer is located upstream of an immediate early gene of human cytomegalovirus.

  1985cited by this paper
• A trans-acting factor is responsible for the simian virus 40 enhancer activity in vitro

  1985cited by this paper
• Molecular organization of the AIDS retrovirus.

  1985cited by this paper
• Duplications of a mutated simian virus 40 enhancer restore its activity

  1985cited by this paper
• Efficient in vitro synthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter.

  1984cited by this paper
• Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei.

  1983cited by this paper
• The promoter-specific transcription factor Sp1 binds to upstream sequences in the SV40 early promoter.

  1983cited by this paper

• Unconventional nucleus export and secondary necrosis of human leukemia T lymphocytes (Jurkat cells) transfected with HIV-1 LTR CAT-TAT-72: ultrastructural assessment

  2025cites this paper
• Focus on Translation Initiation of the HIV-1 mRNAs

  2018influential citation
• Binding by TRBP-dsRBD2 Does Not Induce Bending of Double-Stranded RNA.

  2016cites this paper
• Tat RNA silencing suppressor activity contributes to perturbation of lymphocyte miRNA by HIV-1

  2011cites this paper
• The Pennsylvania State University

  2008cites this paper
• Impact of Protein Kinase PKR in Cell Biology: from Antiviral to Antiproliferative Action

  2006cites this paper
• FIV as a Model for HIV: An Overview

  2006cites this paper
• In vivo Models of HIV Disease and Control

  2006cites this paper
• Expression kinetics and subcellular localization of HIV-1 regulatory proteins Nef, Tat and Rev in acutely and chronically infected lymphoid cell lines

  2005cites this paper
• A selective review of RNA-protein interactions in eukaryotes

  2004cites this paper
• The Regulation of HIV-1 Gene Expression: The Emerging Role of Chromatin

  2002cites this paper
• Mining microarray expression data by literature profiling

  2002cites this paper
• Aromatic Polyamidines Inhibiting the Tat-Induced HIV-1 Transcription Recognize Structured TAR-RNA

  2001cites this paper
• Regulatory functions of Cdk9 and of cyclin T1 in HIV Tat transactivation pathway gene expression

  1999cites this paper
• Tackling Tat.

  1999cites this paper
• Molecular analyses of the possible RNA-binding protein gene located in the human leukocyte antigen (HLA)--DR subregion.

  1999cites this paper
• HIV-1 regulatory protein tat induces RNA binding proteins in central nervous system cells that associate with the viral trans-acting-response regulatory motif.

  1999cites this paper
• Regulation of equine infectious anemia virus expression.

  1998cites this paper
• Dissecting the mode of action of various HIV-inhibitor classes in a stable cellular system

  1998cites this paper
• RNA-protein interactions in the Tat-trans-activation response element complex determined by site-specific photo-cross-linking.

  1998cites this paper
• Regulation of Equine Infectious Anemia Virus Expression

  1998cites this paper
• Broad-Spectrum Antiviral Activity and Mechanism of Antiviral Action of the Fluoroquinolone Derivative K-12

  1998cites this paper
• Probing the proximity of the core domain of an HIV-1 Tat fragment in a Tat-TAR complex by affinity cleaving.

  1997cites this paper
• Interaction of prion protein mRNA with CBP35 and other cellular proteins: possible implications for prion replication and age-dependent changes.

  1997cites this paper
• Oncogenic potential of TAR RNA binding protein TRBP and its regulatory interaction with RNA‐dependent protein kinase PKR

  1997cites this paper
• Optimal Tat-mediated activation of the HIV-1 LTR promoter requires a full-length TAR RNA hairpin.

  1997cites this paper
• Sequential steps in Tat trans-activation of HIV-1 mediated through cellular DNA, RNA, and protein binding factors.

  1996cites this paper
• Inhibition of HIV-1 replication in viral mutants with altered TAR RNA stem structures.

  1996cites this paper
• Mechanisms of transcriptional transactivation and restriction of human immunodeficiency virus type I replication in an astrocytic glial cell.

  1996cites this paper
• Protein Orientation in the Tat-TAR Complex Determined by Psoralen Photocross-linking*

  1996cites this paper
• HIV and Cellular Factors

  1996cites this paper
• BIOLOGICAL ACTIVITIES OF HIV-SPECIFIC PEPTIDES

  1996cites this paper
• Function of Exon 2 in Optimal trans-Activation by Tat of HIV Type 2

  1995cites this paper
• Novel mechanism and factor for regulation by HIV‐1 Tat.

  1995cites this paper
• The Retroviridae

  1995cites this paper
• A Tat-induced auto-up-regulatory loop for superactivation of the human immunodeficiency virus type 1 promoter

  1995cites this paper
• Human T-lymphocytes (Jurkat cells) expressing TAT-72: LM and TEM

  1995cites this paper
• Human T-lymphocytes (Jurkat cells) expressing HIV-1 TAT-72: SEM

  1995cites this paper
• Human retroviruses and demyelinating diseases.

  1995cites this paper
• Regulation of Cellular Gene Expression and Function by the Human Immunodeficiency Virus Type 1 Tat Protein.

  1995cites this paper
• Interactions of thyroid hormone receptor with the human immunodeficiency virus type 1 (HIV-1) long terminal repeat and the HIV-1 Tat transactivator

  1995cites this paper
• Intracellular Factors Involved in Gene Expression of Human Retroviruses

  1995cites this paper
• A human chromosome 12-associated 83-kilodalton cellular protein specifically binds to the loop region of human immunodeficiency virus type 1 trans-activation response element RNA

  1995cites this paper
• Expression of TAR RNA-Binding Protein in Baculovirus and Co-Immunoprecipitation with Insect Cell Protein Kinase.

  1995cites this paper
• Effects of the Tat basic domain on human immunodeficiency virus type 1 transactivation, using chemically synthesized Tat protein and Tat peptides

  1994cites this paper
• Activation and inactivation of gene expression using RNA sequences.

  1994cites this paper
• Induction of RNA-binding proteins in mammalian cells by DNA-damaging agents.

  1994cites this paper
• Direct interactions between autoantigen La and human immunodeficiency virus leader RNA

  1994cites this paper
• Gene Therapy for Human Immunodeficiency Virus Infection: Genetic Antiviral Strategies and Targets for Intervention

  1994cites this paper
• Control of RNA initiation and elongation at the HIV-1 promoter.

  1994cites this paper
• The 2-5A system and HIV infection.

  1994cites this paper
• The human immunodeficiency virus type 1 Tat protein transactivates tumor necrosis factor beta gene expression through a TAR-like structure

  1994cites this paper
• Direct interactions between autoantigen La and human immunodeficiency virus leader RNA

  1994cites this paper
• Biological Response Modifiers — Interferons, Double-Stranded RNA and 2′,5′-Oligoadenylates

  1994cites this paper
• Effects of human chromosome 12 on interactions between Tat and TAR of human immunodeficiency virus type 1

  1994cites this paper
• Human Immunodeficiency Virus Type-1 Infection of Human Myeloid Cells

  1994cites this paper
• Similarity of the 5' and 3'-TAR secondary structures in HIV-1.

  1993cites this paper
• A New Approach to Antiviral Chemotherapy: Intervention in Viral Gene Expression by HIV Tat Antagonists

  1993cites this paper
• Structural features of an RNA containing the CUGGGA loop of the human immunodeficiency virus type 1 trans-activation response element.

  1993cites this paper
• Modulation of host cell nuclear proteins that bind to HIV-1 trans-activation-responsive element RNA by phorbol ester.

  1993cites this paper
• A chimeric human immunodeficiency virus type 1 TAR region which mediates high level trans-activation in both rodent and human cells.

  1993cites this paper
• Changes in Cellular Proteins Associated with the Expression of Human Immunodeficiency Virus Type 1 Trans-Activator Protein Tat

  1993cites this paper
• A recombinant retrovirus carrying a non-producer human immunodeficiency virus (HIV) type 1 variant induces resistance to superinfecting HIV.

  1993cites this paper
• Relatedness of an RNA-binding motif in human immunodeficiency virus type 1 TAR RNA-binding protein TRBP to human P1/dsI kinase and Drosophila staufen

  1993cites this paper
• Analysis of 3′ terminals of human immunodeficiency virus type 1 transcripts in persistently infected cells

  1993cites this paper
• In vitro and in vivo binding of human immunodeficiency virus type 1 Tat protein and Sp1 transcription factor

  1993cites this paper
• The type 1 human immunodeficiency virus Tat binding protein is a transcriptional activator belonging to an additional family of evolutionarily conserved genes.

  1993cites this paper
• TAR loop-dependent human immunodeficiency virus trans activation requires factors encoded on human chromosome 12

  1993cites this paper
• Characterization of the inducer of short transcripts, a human immunodeficiency virus type 1 transcriptional element that activates the synthesis of short RNAs

  1993cites this paper
• Regulation of eukaryotic gene expression by transcriptional attenuation.

  1993cites this paper
• Molecular biology of HIV-1: positive and negative regulatory elements important for virus expression.

  1993cites this paper
• RNA targeting by the HIV-1 Tat protein

  1993cites this paper
• High affinity binding of TAR RNA by the human immunodeficiency virus type-1 tat protein requires base-pairs in the RNA stem and amino acid residues flanking the basic region.

  1993cites this paper
• The human immunodeficiency virus type 1 long terminal repeat is activated by monofunctional and bifunctional DNA alkylating agents in human lymphocytes.

  1993cites this paper
• RNA binding assays for Tat-derived peptides: implications for specificity.

  1992cites this paper
• Ribosomal RNA metabolism in macrophages.

  1992cites this paper
• Regulatory genes of human immunodeficiency viruses.

  1992cites this paper
• Cellular transcription factors involved in the regulation of HIV-1 gene expression.

  1992cites this paper
• Unusual structure of the human immunodeficiency virus type 1 trans-activation response element

  1992cites this paper
• Conserved nucleotides in the TAR RNA stem of human immunodeficiency virus type 1 are critical for Tat binding and trans activation: model for TAR RNA tertiary structure

  1992cites this paper
• Cell type-specific anti-human immunodeficiency virus type 1 activity of the transactivation inhibitor Ro5-3335

  1992cites this paper
• RNA packaging signal of human immunodeficiency virus type 1.

  1992cites this paper
• Kinetics of HIV-1 long terminal repeat trans-activation. Use of intragenic ribozyme to assess rate-limiting steps.

  1992cites this paper
• Isolation of a Yeast Gene Encoding a Protein Homologous to the Human Tat-Binding Protein TBP-1

  1992cites this paper
• Human immunodeficiency virus type 1 Tat-mediated trans activation correlates with the phosphorylation state of a cellular TAR RNA stem-binding factor

  1992cites this paper
• Functional analysis of the N-terminal domain of Tat protein of the human immunodeficiency virus type 1.

  1992cites this paper
• Functional roles for the TATA promoter and enhancers in basal and Tat-induced expression of the human immunodeficiency virus type 1 long terminal repeat

  1992cites this paper
• Mechanisms of HIV-1 latency.

  1992cites this paper
• HIV Regulatory Proteins: Potential Targets for Therapeutic Intervention

  1992cites this paper
• Accumulation of transcripts coding for prion protein in human astrocytes during infection with human immunodeficiency virus.

  1992cites this paper
• Overexpression of RRE-derived sequences inhibits HIV-1 replication in CEM cells.

  1992cites this paper
• Two distinct nuclear transcription factors recognize loop and bulge residues of the HIV-1 TAR RNA hairpin.

  1991cites this paper
• The number of positively charged amino acids in the basic domain of Tat is critical for trans-activation and complex formation with TAR RNA.

  1991cites this paper
• The biochemistry of AIDS.

  1991cites this paper
• Critical chemical features in trans-acting-responsive RNA are required for interaction with human immunodeficiency virus type 1 Tat protein

  1991cites this paper
• Transactivation of heterologous promoters by HIV-1 tat.

  1991cites this paper
• Analysis of arginine-rich peptides from the HIV Tat protein reveals unusual features of RNA-protein recognition.

  1991cites this paper
• Mapping of HIV-1 Tat protein sequences required for binding to Tar RNA.

  1991cites this paper
• Molecular biology of the human immunodeficiency virus type 1

  1991cites this paper
• Heterologous basic domain substitutions in the HIV‐1 Tat protein reveal an arginine‐rich motif required for transactivation.

  1991cites this paper