Trillions of microbes inhabit the human gut, not only providing nutrients and energy to the host from the ingested food, but also producing metabolic bioactive signaling molecules to maintain health and elicit disease, such as cardiovascular disease (CVD). CVD is the leading cause of mortality worldwide. In this review, we presented gut microbiota derived metabolites involved in cardiovascular health and disease, including trimethylamine-N-oxide (TMAO), uremic toxins, short chain fatty acids (SCFAs), phytoestrogens, anthocyanins, bile acids and lipopolysaccharide. These gut microbiota derived metabolites play critical roles in maintaining a healthy cardiovascular function, and if dysregulated, potentially causally linked to CVD. A better understanding of the function and dynamics of gut microbiota derived metabolites holds great promise toward mechanistic predicative CVD biomarker discoveries and precise interventions.
Gut microbiota derived metabolites in cardiovascular health and disease
Published 2018 in Protein & Cell
ABSTRACT
PUBLICATION RECORD
- Publication year
2018
- Venue
Protein & Cell
- Publication date
2018-05-01
- Fields of study
Biology, Medicine, Environmental Science
- Identifiers
- External record
- Source metadata
Semantic Scholar, PubMed
CITATION MAP
EXTRACTION MAP
CLAIMS
CONCEPTS
- anthocyanins
Plant pigment compounds considered among the gut microbiota-associated metabolites discussed for cardiovascular relevance.
- bile acids
Steroid-derived molecules whose microbial modification is discussed in connection with cardiovascular health and disease.
- cardiovascular disease
Disease affecting the heart and blood vessels that is used here as the main clinical outcome context for the reviewed metabolites.
Aliases: CVD
- gut microbiota derived metabolites
Metabolic products made by gut microbes and discussed as mediators between intestinal microbiota and host cardiovascular biology.
Aliases: gut microbiota-derived metabolites
- lipopolysaccharide
A bacterial cell-envelope molecule included among the gut microbiota-derived factors discussed in the review.
Aliases: LPS
- phytoestrogens
Plant-derived estrogen-like compounds that are transformed or influenced by gut microbes and discussed in the review.
- short chain fatty acids
Small fatty acid metabolites produced by gut microbes and discussed in relation to cardiovascular health.
Aliases: SCFAs
- trimethylamine-n-oxide
A gut microbiota-associated metabolite included in the review's set of cardiovascular-relevant microbial products.
Aliases: TMAO
- uremic toxins
Microbial or host-derived toxic metabolites discussed as part of the gut microbiota metabolite set relevant to cardiovascular disease.