Four New Members Expand the Interleukin-1 Superfamily*

We report here the cloning and characterization of four new members of the interleukin-1 (IL-1) family (FIL1δ, FIL1ε, FIL1ζ, and FIL1η, with FIL1 standing for “Family of IL-1”). The novel genes demonstrate significant sequence similarity to IL-1α, IL-1β, IL-1ra, and IL-18, and in addition maintain a conserved exon-intron arrangement that is shared with the previously known members of the family. Protein structure modeling also suggests that the FIL1 genes are related to IL-1β and IL-1ra. The novel genes form a cluster with the IL-1s on the long arm of human chromosome 2.

• Publication year

  2000

• Venue

  Journal of Biological Chemistry

• Publication date

  2000-01-14

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1074/jbc.275.2.1169PMID 10625660
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Molecular cloning and biological characterization of NK cell activation‐inducing ligand, a counterstructure for CD48

  1999cited by this paper
• Interleukin-18 binding protein: a novel modulator of the Th1 cytokine response.

  1999cited by this paper
• Overview of interleukin‐18: more than an interferon‐γ inducing factor

  1998cited by this paper
• Cloning of a Novel Receptor Subunit, AcPL, Required for Interleukin-18 Signaling*

  1998cited by this paper
• Fold prediction by a hierarchy of sequence, threading, and modeling methods

  1998cited by this paper
• Interleukin-1, interleukin-1 receptors and interleukin-1 receptor antagonist.

  1998cited by this paper
• Signal transduction pathways activated by the IL‐1 receptor family: ancient signaling machinery in mammals, insects, and plants

  1998cited by this paper
• Binding of Interleukin-18 to the Interleukin-1 Receptor Homologous Receptor IL-1Rrp1 Leads to Activation of Signaling Pathways Similar to Those Used by Interleukin-1

  1998cited by this paper
• IL-1 receptor accessory protein is an essential component of the IL-1 receptor.

  1998cited by this paper
• Purification and Characterization of the Human Interleukin-18 Receptor*

  1997cited by this paper
• Activation of interferon-gamma inducing factor mediated by interleukin-1beta converting enzyme.

  1997cited by this paper
• Caspase-1 processes IFN-gamma-inducing factor and regulates LPS-induced IFN-gamma production.

  1997cited by this paper
• Biologic basis for interleukin-1 in disease.

  1996cited by this paper
• A newly defined interleukin-1?

  1996cited by this paper
• A radiation hybrid map of the human genome.

  1996cited by this paper
• Cloning of the cDNA for human IFN-gamma-inducing factor, expression in Escherichia coli, and studies on the biologic activities of the protein.

  1996cited by this paper
• IL-1Rrp Is a Novel Receptor-like Molecule Similar to the Type I Interleukin-1 Receptor and Its Homologues T1/ST2 and IL-1R AcP (*)

  1996cited by this paper
• AQUA and PROCHECK-NMR: Programs for checking the quality of protein structures solved by NMR

  1996cited by this paper
• Ligands for the receptor tyrosine kinases hek and elk: isolation of cDNAs encoding a family of proteins.

  1995cited by this paper
• Molecular Cloning and Characterization of a Second Subunit of the Interleukin 1 Receptor Complex (*)

  1995cited by this paper
• Evaluation of comparative protein modeling by MODELLER

  1995cited by this paper
• Cloning of a new cytokine that induces IFN-gamma production by T cells.

  1995cited by this paper
• Genomic organization of the type I and type II IL-1 receptors.

  1995cited by this paper
• Utilization of the beta and gamma chains of the IL‐2 receptor by the novel cytokine IL‐15.

  1994cited by this paper
• The type II 'decoy' receptor: a novel regulatory pathway for interleukin 1.

  1994cited by this paper
• Differential regulation of interleukin-12 (IL-12), tumor necrosis factor alpha, and IL-1 beta production in human myeloid leukemia cell lines and peripheral blood mononuclear cells.

  1994cited by this paper
• Interleukin 12 synergizes with B7/CD28 interaction in inducing efficient proliferation and cytokine production of human T cells

  1994cited by this paper
• Interleukin 1 signaling occurs exclusively via the type I receptor.

  1993cited by this paper
• Interleukin-1 type II receptor: a decoy target for IL-1 that is regulated by IL-4.

  1993cited by this paper
• Molecular cloning of the interleukin-1 beta converting enzyme.

  1992cited by this paper
• A novel heterodimeric cysteine protease is required for interleukin-1βprocessing in monocytes

  1992cited by this paper
• A novel IL‐1 receptor, cloned from B cells by mammalian expression, is expressed in many cell types.

  1991cited by this paper
• Interleukin-1 receptor antagonist activity of a human interleukin-1 inhibitor

  1990cited by this paper
• Primary structure and functional expression from complementary DNA of a human interleukin-1 receptor antagonist

  1990cited by this paper
• Cloning the interleukin 1 receptor from human T cells.

  1989cited by this paper
• cDNA expression cloning of the IL-1 receptor, a member of the immunoglobulin superfamily.

  1988cited by this paper
• Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs

  1985cited by this paper
• Cloning, sequence and expression of human interleukin-2 receptor

  1984cited by this paper

• The IL-36 cytokine family: From barrier immunity to therapeutic target in inflammatory diseases.

  2026cites this paper
• Physiological role of the IL-1 family cytokines and receptors in the human brain

  2026cites this paper
• The stress and the alarmin-like cytokine interleukin-37 mediated extracellular and intracellular signal pathways.

  2025cites this paper
• Structural basis of pro-inflammatory signaling via the Interleukin-36 receptor (IL-36R) mediated by IL-36γ and IL-37

  2025cites this paper
• Interleukin 18 and the brain: neuronal functions, neuronal survival and psycho-neuro-immunology during stress

  2025cites this paper
• IL-36R deletion mitigates cigarette smoke-induced airway inflammation and skeletal muscle dysfunction.

  2025cites this paper
• The role of the interleukin family in liver fibrosis

  2025cites this paper
• The complex roles of IL-36 and IL-38 in cancer: friends or foes?

  2025cites this paper
• Interleukin-37 in respiratory diseases: molecular mechanisms and immune modulation

  2025cites this paper
• The landscape of new therapeutic opportunities for IBD.

  2024cites this paper
• AMPK activation modulates IL‐36‐induced inflammatory responses by regulating IκBζ expression in the skin

  2024cites this paper
• The role of IL-36 and 37 in hepatocellular carcinoma

  2024cites this paper
• Molecular aspects of Interleukin-36 cytokine activation and regulation.

  2024cites this paper
• The role of interleukin‐36 in health and disease states

  2024cites this paper
• Emerging Role of the IL-36/IL-36R Axis in Multiple Inflammatory Skin Diseases.

  2024cites this paper
• Serum Interleukin-36 α as a Candidate Biomarker to Distinguish Behçet’s Syndrome and Psoriatic Arthritis

  2023cites this paper
• Novel insights into IL-37: an anti-inflammatory cytokine with emerging roles in anti-cancer process

  2023cites this paper
• Immune regulation based on sex differences in ischemic stroke pathology

  2023cites this paper
• The Pro-Tumor Biological Function of IL-36α Plays an Important Role in the Tumor Microenvironment of HCC

  2023cites this paper
• New insights on IL‑36 in intestinal inflammation and colorectal cancer (Review)

  2023cites this paper
• The nuclear cytokine IL-37a controls lethal cytokine storms primarily via IL-1R8-independent transcriptional upregulation of PPARγ

  2023cites this paper
• A review of IL-36: an emerging therapeutic target for inflammatory dermatoses

  2022cites this paper
• Recent Advances in Progresses and Prospects of IL-37 in Central Nervous System Diseases

  2022cites this paper
• The Role of IL-37 and IL-38 in Colorectal Cancer

  2022cites this paper
• Interleukins and Ischemic Stroke

  2022influential citation
• The role of IL-36 subfamily in intestinal disease.

  2022cites this paper
• The role of IL-35 and IL-37 in breast cancer – potential therapeutic targets for precision medicine

  2022cites this paper
• Modulation of interleukin‐36 based inflammatory feedback loop through the hepatocyte‐derived IL‐36R‐P2X7R axis improves steatosis in alcoholic steatohepatitis

  2022cites this paper
• CCN1 upregulates IL‐36 via AKT/NF‐κB and ERK/CEBP β‐mediated signaling pathways in psoriasis‐like models

  2022cites this paper
• Treponema denticola Induces Interleukin-36γ Expression in Human Oral Gingival Keratinocytes via the Parallel Activation of NF-κB and Mitogen-Activated Protein Kinase Pathways

  2022cites this paper
• Pro- and anti-inflammatory roles of interleukin (IL)-33, IL-36, and IL-38 in inflammatory bowel disease

  2022cites this paper
• The role of cytokines and vitamin D in vitiligo pathogenesis

  2022cites this paper
• IL-1 Family Antagonists in Mouse and Human Skin Inflammation

  2021influential citation
• IL-37 Was Involved in Progress of Acute Myeloid Leukemia Through Regulating IL-6 Expression

  2021cites this paper
• Interleukin-36 Cytokines in Infectious and Non-Infectious Lung Diseases

  2021cites this paper
• CMAR_A_303017 3393..3402

  2021cites this paper
• Walking down the “IL”: The Newfound Marriage between IL-36 and Chronic Obstructive Pulmonary Disease

  2021cites this paper
• Roles of IL‐1 and IL‐10 family cytokines in the progression of systemic lupus erythematosus: Friends or foes?

  2021cites this paper
• IL-36 in chronic inflammation and fibrosis - bridging the gap?

  2021influential citation
• Downregulation of interleukin 36γ and its cleaver cathepsin G following treatment with narrow-band ultraviolet B phototherapy in psoriasis vulgaris

  2021cites this paper
• Targeting immunometabolism of neoplasms by interleukins: A promising immunotherapeutic strategy for cancer treatment.

  2021cites this paper
• The Role of the Interleukin 1 Family in Lung Disease

  2021cites this paper
• Role of IL-36γ/IL-36R Signaling in Corneal Innate Defense Against Candida albicans Keratitis

  2021cites this paper
• IL‐36 cytokines and gut immunity

  2021cites this paper
• Role for IL-1 Family Cytokines in Fungal Infections

  2021cites this paper
• Interleukin-36α inhibits colorectal cancer metastasis by enhancing the infiltration and activity of CD8+ T lymphocytes.

  2021cites this paper
• The Role of IL-37 and IL-38 in Obstetrics Abnormalities

  2021cites this paper
• IL-36α and Lipopolysaccharide Cooperatively Induce Autophagy by Triggering Pro-Autophagic Biased Signaling

  2021cites this paper
• Parsing the IL-37-Mediated Suppression of Inflammasome Function

  2020cites this paper
• IL-37 as a potential biotherapeutics of inflammatory diseases.

  2020cites this paper
• Correlation between serum IL 37 levels with keloid severity.

  2020cites this paper
• Association of genetic variants of interleukin-1β gene -511T/C (rs16944) and +3954C/T (rs1143634) and serum levels of pentaxin (PTX3) and interleukin -1β (IL-1β) with disease activity of systemic lupus erythematosus patients

  2020cites this paper
• Epigenetic differences in the innate response after immune stimulation during zebrafish sex differentiation.

  2020cites this paper
• Walking Down the "IL": The Newfound Marriage Between IL-36 and COPD.

  2020cites this paper
• Protective effect of interleukin-36 receptor antagonist on liver injury induced by concanavalin A in mice

  2020cites this paper
• A new target for the treatment of inflammatory bowel disease: Interleukin-37.

  2020cites this paper
• Enhanced IL-36R signaling promotes barrier impairment and inflammation in skin and intestine

  2020cites this paper
• The effect of IL-1R1 and IL-1RN polymorphisms on osteoporosis predisposition in a Chinese Han population.

  2020cites this paper
• IL-37/ STAT3/ HIF-1α negative feedback signaling drives gemcitabine resistance in pancreatic cancer

  2020cites this paper
• Profile of IL-36 cytokines (IL-36α, IL-36β, IL-36γ and IL-36Ra) in patients with primary immune thrombocytopenia.

  2020cites this paper
• IL-36 Signaling in the Tumor Microenvironment.

  2020cites this paper
• Interleukin-36: Structure, Signaling and Function.

  2020cites this paper
• The role of IL-37 in skin and connective tissue diseases.

  2019cites this paper
• Keratin 5-Cre-driven deletion of Ncstn in an acne inversa-like mouse model leads to a markedly increased IL-36a and Sprr2 expression

  2019cites this paper
• Structural Basis of IL-1 Family Cytokine Signaling

  2019cites this paper
• Falta de associação entre mutação no IL36RN e psoríase pustulosa palmoplantar em pacientes chineses

  2019cites this paper
• Function and Regulation of IL-36 Signaling in Inflammatory Diseases and Cancer Development

  2019cites this paper
• Immune genes, IL1β and Casp9, show sexual dimorphic methylation patterns in the zebrafish gonads

  2019cites this paper
• Immune genes, IL1β and Casp9, show sexual dimorphic methylation patterns in zebrafish gonads.

  2019cites this paper
• Divergent Roles for the IL-1 Family in Gastrointestinal Homeostasis and Inflammation

  2019cites this paper
• Designed DNA-Encoded IL-36 Gamma Acts as a Potent Molecular Adjuvant Enhancing Zika Synthetic DNA Vaccine-Induced Immunity and Protection in a Lethal Challenge Model

  2019cites this paper
• Interleukin‐37 is highly expressed in regulatory T cells of melanoma patients and enhanced by melanoma cell secretome

  2019influential citation
• Association between chronic obstructive pulmonary disease and interleukins gene variants: A systematic review and meta-analysis.

  2019cites this paper
• Regulation of Endogenous Interleukin-36 Activity

  2019cites this paper
• 1H, 13C, and 15N resonance assignments of the cytokine interleukin-36β isoform-2

  2019cites this paper
• Insight into interleukin-37: The potential therapeutic target in allergic diseases.

  2019cites this paper
• IL-36 Cytokines: Regulators of Inflammatory Responses and Their Emerging Role in Immunology of Reproduction

  2019influential citation
• The zebrafish: A research model to understand the evolution of vertebrate immunity.

  2019cites this paper
• Interleukin-36 in Infectious and Inflammatory Skin Diseases

  2019cites this paper
• Lack of association between mutation in IL36RN and palmoplantar pustular psoriasis in Chinese patients

  2019cites this paper
• Interleukin-36beta provides protection against HSV-1 infection, but does not modulate initiation of adaptive immune responses

  2019cites this paper
• Laboratory options for risk assessment of pregnancy pathologies.

  2019cites this paper
• Expression level of serum Interleukin-37 in Rheumatoid Arthritis patients and its correlation with Disease Activity Score

  2018cites this paper
• Lack of association between interleukin-1 receptor antagonist gene 86-bp VNTR polymorphism and ischemic stroke

  2018cites this paper
• Induction of Tolerogenic Dendritic Cells by Endogenous Biomolecules: An Update

  2018cites this paper
• Interleukin-37: A crucial cytokine with multiple roles in disease and potentially clinical therapy.

  2018cites this paper
• IL-1RN and IL-1β Polymorphism and ARV-Associated Hepatotoxicity

  2018influential citation
• Biology of IL‐38 and its role in disease

  2018cites this paper
• The emergence of the IL‐36 cytokine family as novel targets for inflammatory diseases

  2018cites this paper
• Protective Role of Rabbit Nucleotide-Binding Oligomerization Domain-2 (NOD2)-Mediated Signaling Pathway in Resistance to Enterohemorrhagic Escherichia coli Infection

  2018cites this paper
• IL-37 isoform D downregulates pro-inflammatory cytokines expression in a Smad3-dependent manner

  2018cites this paper
• Anti-Inflammatory Effect of IL-37-Producing T-Cell Population in DSS-Induced Chronic Inflammatory Bowel Disease in Mice

  2018cites this paper
• Interleukin-36 beta provides protection against HSV-1 infection , but does not modulate initiation of adaptive immune responses

  2018cites this paper
• The family of the interleukin‐1 receptors

  2018cites this paper
• AN INTRODUCTION TO SELECTED INNATE IMMUNE-RELEVANT GENES IN FISH

  2018cites this paper
• Interleukin 30 to Interleukin 40

  2018cites this paper
• Cytokines: the yin and yang of vitiligo pathogenesis

  2018cites this paper
• Increased serum IL‐36&agr; and IL‐36&ggr; levels in patients with systemic lupus erythematosus: Association with disease activity and arthritis

  2018cites this paper
• Association of interleukin 1 receptor antagonist intron 2 variable number of tandem repeats polymorphism with vitiligo susceptibility in Gujarat population

  2018cites this paper
• Neurobiology of Sleep and Circadian Rhythms

  2018cites this paper