Trichostatin A, a Histone Deacetylase Inhibitor, Suppresses Collagen Synthesis and Prevents TGF-β1-Induced Fibrogenesis in Skin Fibroblasts

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Experimental Cell Research

• Publication date

  2002-08-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1006/EXCR.2002.5577
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

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• The human histone deacetylase family.

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• Potent histone deacetylase inhibitors built from trichostatin A and cyclic tetrapeptide antibiotics including trapoxin.

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• Transcriptional control by the TGF‐β/Smad signaling system

  2000cited by this paper
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  2000cited by this paper
• Histone deacetylase inhibitor selectively induces p21WAF1 expression and gene-associated histone acetylation.

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  2000cited by this paper
• Regulation of Smad activity.

  2000cited by this paper
• Histone deacetylase inhibitors: inducers of differentiation or apoptosis of transformed cells.

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• Up-regulation of costimulatory/adhesion molecules by histone deacetylase inhibitors in acute myeloid leukemia cells.

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  2000cited by this paper
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• SnoN and Ski protooncoproteins are rapidly degraded in response to transforming growth factor beta signaling.

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• Biology of Hepatic Stellate Cells and Their Possible Relevance in the Pathogenesis of Portal Hypertension in Cirrhosis

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• Multiple Modes of Repression by the Smad Transcriptional Corepressor TGIF*

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• All-trans and 9-cis retinoic acid alter rat hepatic stellate cell phenotype differentially

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• The Ski oncoprotein interacts with the Smad proteins to repress TGFbeta signaling.

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• Interaction of the Ski Oncoprotein with Smad3 Regulates TGF-β Signaling

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• Regulation of connective tissue growth factor expression by prostaglandin E2.

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• Cytokines and Fibrogenesis

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• Purification of rat hepatic stellate cells by side scatter–activated cell sorting

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• Essential and redundant functions of histone acetylation revealed by mutation of target lysines and loss of the Gcn5p acetyltransferase

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• Physical and Functional Interaction of SMADs and p300/CBP*

  1998cited by this paper
• A class of hybrid polar inducers of transformed cell differentiation inhibits histone deacetylases.

  1998cited by this paper
• Histone acetylation and transcriptional regulatory mechanisms.

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• Ultraviolet A irradiation upregulates type VII collagen expression in human dermal fibroblasts.

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• Interrelationships of the pathways of mRNA decay and translation in eukaryotic cells.

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• Cell-type-specific expression of neural cell adhesion molecule (N-CAM) in Ito cells of rat liver. Up-regulation during in vitro activation and in hepatic tissue repair.

  1996cited by this paper
• Regulation of type I collagen production by insulin and transforming growth factor-beta in human lung fibroblasts.

  1996cited by this paper
• The expression of a small fraction of cellular genes is changed in response to histone hyperacetylation.

  1996cited by this paper
• Turnover of glutathione S-transferase alpha mRNAs is accelerated by 12-O-tetradecanoyl phorbol-13-acetate in human hepatoma and colon carcinoma cell lines.

  1995cited by this paper
• Modulation of fibroblastic cytoskeletal features during pathological situations: the role of extracellular matrix and cytokines.

  1994cited by this paper
• Mitogen-stimulated phosphorylation of histone H3 is targeted to a small hyperacetylation-sensitive fraction.

  1994cited by this paper
• Collagen network of the myocardium: function, structural remodeling and regulatory mechanisms.

  1994cited by this paper
• Identification of connective tissue gene transcripts in freshly isolated parenchymal, endothelial, Kupffer and fat-storing cells by northern hybridization analysis.

  1993cited by this paper
• Transforming growth factor-beta in disease: the dark side of tissue repair.

  1992cited by this paper
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  1991cited by this paper
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  1990cited by this paper
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  1989cited by this paper
• Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction.

  1987cited by this paper
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  1987cited by this paper
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  1986cited by this paper
• Construction of DNA sequences complementary to rat alpha 1 and alpha 2 collagen mRNA and their use in studying the regulation of type I collagen synthesis by 1,25-dihydroxyvitamin D.

  1984cited by this paper
• Different accessibilities in chromatin to histone acetylase.

  1979cited by this paper

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  2006cites this paper
• DFT-based ranking of zinc-binding groups in histone deacetylase inhibitors.

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  2005cites this paper