TLR4 promotes fibrosis but attenuates tubular damage in progressive renal injury.

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Journal of the American Society of Nephrology

• Publication date

  2010-08-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1681/ASN.2009070722PMID 20595685PMCID PMC2938595
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The Role of Toll-Like Receptor 2 in Inflammation and Fibrosis during Progressive Renal Injury

  2009cited by this paper
• LPS-induced IL-6, IL-8, VCAM-1, and ICAM-1 Expression in Human Lymphatic Endothelium

  2008cited by this paper
• Antifibroblast antibodies in systemic sclerosis induce fibroblasts to produce profibrotic chemokines, with partial exploitation of toll-like receptor 4.

  2008cited by this paper
• Cellular and molecular mechanisms of fibrosis

  2008cited by this paper
• Overexpression of toll-like receptors 3 and 4 in synovial tissue from patients with early rheumatoid arthritis: toll-like receptor expression in early and longstanding arthritis.

  2008cited by this paper
• Toll-Like Receptor-4 Coordinates the Innate Immune Response of the Kidney to Renal Ischemia/Reperfusion Injury

  2008cited by this paper
• MMP-2 inhibition reduces renal macrophage infiltration with increased fibrosis in UUO.

  2007cited by this paper
• Recognition of Hyaluronan Released in Sterile Injury Involves a Unique Receptor Complex Dependent on Toll-like Receptor 4, CD44, and MD-2*

  2007cited by this paper
• TLR4 enhances TGF-beta signaling and hepatic fibrosis.

  2007cited by this paper
• The Role of Tubular Epithelial-Mesenchymal Transition in Progressive Kidney Disease

  2007cited by this paper
• TLR4 activation mediates kidney ischemia/reperfusion injury.

  2007cited by this paper
• Common and unique mechanisms regulate fibrosis in various fibroproliferative diseases.

  2007cited by this paper
• Human heat shock protein 60 stimulates vascular smooth muscle cell proliferation through Toll-like receptors 2 and 4.

  2006cited by this paper
• The renal cortical fibroblast in renal tubulointerstitial fibrosis.

  2006cited by this paper
• Renal fibroblasts and myofibroblasts in chronic kidney disease.

  2006cited by this paper
• Renal Toll-like receptors: recent advances and implications for disease

  2006cited by this paper
• [Cellular and molecular mechanisms of fibrosis].

  2006cited by this paper
• Cox-2 is regulated by Toll-like receptor-4 (TLR4) signaling: Role in proliferation and apoptosis in the intestine.

  2006cited by this paper
• The matrix component biglycan is proinflammatory and signals through Toll-like receptors 4 and 2 in macrophages.

  2005cited by this paper
• Renal-associated TLR2 mediates ischemia/reperfusion injury in the kidney.

  2005cited by this paper
• Lipopolysaccharide-induced expression of intercellular adhesion molecule-1 and chemokines in cultured human corneal fibroblasts.

  2005cited by this paper
• Obstructive nephropathy: insights from genetically engineered animals.

  2005cited by this paper
• Regulation of lung injury and repair by Toll-like receptors and hyaluronan

  2005cited by this paper
• Signaling danger: toll-like receptors and their potential roles in kidney disease.

  2004cited by this paper
• TGF‐β signaling and the fibrotic response

  2004cited by this paper
• CD44 deficiency increases tubular damage but reduces renal fibrosis in obstructive nephropathy.

  2004cited by this paper
• Involvement of Toll-like Receptors 2 and 4 in Cellular Activation by High Mobility Group Box 1 Protein*

  2004cited by this paper
• Endotoxin Inhibits Intestinal Epithelial Restitution through Activation of Rho-GTPase and Increased Focal Adhesions*

  2004cited by this paper
• Roles of Toll-like receptors in C-C chemokine production by renal tubular epithelial cells

  2004cited by this paper
• Obstructive nephropathy and renal fibrosis: The role of bone morphogenic protein-7 and hepatocyte growth factor.

  2003cited by this paper
• Intestinal myofibroblasts in innate immune responses of the intestine.

  2003cited by this paper
• Activation of mammalian Toll-like receptors by endogenous agonists.

  2003cited by this paper
• The Endoplasmic Reticulum-resident Heat Shock Protein Gp96 Activates Dendritic Cells via the Toll-like Receptor 2/4 Pathway*

  2002cited by this paper
• Obstructive nephropathy and renal fibrosis.

  2002cited by this paper
• Receptor-Mediated Monitoring of Tissue Well-Being Via Detection of Soluble Heparan Sulfate by Toll-Like Receptor 41

  2002cited by this paper
• In Vivo Expression of Toll-Like Receptor 2 and 4 by Renal Epithelial Cells: IFN-γ and TNF-α Mediated Up-Regulation During Inflammation1

  2002cited by this paper
• HSP70 as Endogenous Stimulus of the Toll/Interleukin-1 Receptor Signal Pathway*

  2002cited by this paper
• Roles of Toll-Like Receptors in C-C Chemokine Production by Renal Tubular Epithelial Cells1

  2002cited by this paper
• TIMP-1 deficiency does not attenuate interstitial fibrosis in obstructive nephropathy.

  2001cited by this paper
• The role of tubulointerstitial injury in chronic renal failure.

  2000cited by this paper
• Molecular basis of renal fibrosis

  2000cited by this paper
• Silencing of TGF-beta signalling by the pseudoreceptor BAMBI.

  1999cited by this paper
• Immunological aspects of acute ureteral obstruction: immune cell infiltrate in the kidney.

  1988cited by this paper
• Gene Product Lps the Lipopolysaccharide: Evidence for TLR4 as to (TLR4)-Deficient Mice Are Hyporesponsive Cutting Edge: Toll-Like Receptor 4

  year unknowncited by this paper
• J Am Soc Nephrol 12: 2358–2369, 2001 Expression of the Type IV Collagenase System during Mouse Kidney Development and Tubule Segmentation

  year unknowncited by this paper

• Inhibition of GRK2 mitigates renal fibrosis via Oxidative Stress Pathway.

  2025cites this paper
• Modulation of TGF-β/Smad and Nrf2 Signaling Pathways by Thymoquinone in the Attenuation of Renal Fibrosis: A Systematic Review and Meta-Analysis of Pre-clinical Models

  2025cites this paper
• Therapeutic Peptides Mitigates TLR4 Pathway Activation by Ang II in Renal and Vascular Smooth Muscle Cells

  2025cites this paper
• Actin cytoskeleton stabilization inhibits NLRP3 inflammasome activation and mitigates renal inflammation and fibrosis in obstructive nephropathy.

  2025cites this paper
• DAMPs Drive Fibroinflammatory Changes in the Glaucomatous ONH

  2024cites this paper
• Protective effect of modified Huangqi Chifeng decoction on immunoglobulin A nephropathy through toll-like receptor 4/myeloid differentiation factor 88/nuclear factor-kappa B signaling pathway.

  2024cites this paper
• Sulforaphane (Sul) reduces renal interstitial fibrosis (RIF) by controlling the inflammation and TGF-β/Smad signaling pathway

  2024cites this paper
• Lipid Nanoparticles Elicit Reactogenicity and Sickness Behavior in Mice Via Toll-Like Receptor 4 and Myeloid Differentiation Protein 88 Axis.

  2024cites this paper
• The Fibro-Inflammatory Response in the Glaucomatous Optic Nerve Head

  2023cites this paper
• Lipopolysaccharide (LPS) extracted from Bacteroides vulgatus effectively prevents LPS extracted from Escherichia coli from inducing epithelial‑mesenchymal transition

  2023cites this paper
• The long noncoding RNA Meg3 mediates TLR4-induced inflammation in experimental obstructive nephropathy

  2023cites this paper
• Immune Response in COVID-19-associated Acute Kidney Injury and Maladaptive Kidney Repair

  2023cites this paper
• NQO1 alleviates renal fibrosis by inhibiting the TLR4/NF-κB and TGF-β/Smad signaling pathways in diabetic nephropathy.

  2023cites this paper
• Ketogenic Diet Alleviates Renal Interstitial Fibrosis in UUO Mice by Regulating Macrophage Proliferation.

  2023cites this paper
• S100-A8/A9 activated TLR4 in renal tubular cells to promote ischemia-reperfusion injury and fibrosis.

  2023cites this paper
• Disease-modifying interactions between chronic kidney disease and osteoarthritis: a new comorbid mouse model

  2023cites this paper
• NLRX1 Prevents M2 Macrophage Polarization and Excessive Renal Fibrosis in Chronic Obstructive Nephropathy

  2023cites this paper
• Berberis integerrima hydro-alcoholic root extract ant its constituent berberine protect against cisplatin-induced nephro- and hepato-toxicity.

  2022cites this paper
• Three-Dimensional Visualization With Tissue Clearing Uncovers Dynamic Alterations of Renal Resident Mononuclear Phagocytes After Acute Kidney Injury

  2022cites this paper
• Candida Administration in 5/6 Nephrectomized Mice Enhanced Fibrosis in Internal Organs: An Impact of Lipopolysaccharide and (1→3)-β-D-Glucan from Leaky Gut

  2022cites this paper
• TLR4 signaling modulates extracellular matrix production in the lamina cribrosa

  2022cites this paper
• Repression of inflammatory pathways with Boswellia for alleviation of liver injury after renal ischemia reperfusion.

  2022cites this paper
• Toll-Like Receptor 4 Signaling in the Trabecular Meshwork

  2022cites this paper
• Inflammation in kidney repair: Mechanism and therapeutic potential.

  2022cites this paper
• Immunometabolic rewiring of tubular epithelial cells in kidney disease

  2022cites this paper
• Relaxin Inhibits the Cardiac Myofibroblast NLRP3 Inflammasome as Part of Its Anti-Fibrotic Actions via the Angiotensin Type 2 and ATP (P2X7) Receptors

  2022cites this paper
• Fibronectin extra domain A (FN-EDA) causes glaucomatous trabecular meshwork, retina, and optic nerve damage in mice

  2021cites this paper
• Toll-like receptor 4 mutation protects the kidney from Ang-II-induced hypertensive injury.

  2021cites this paper
• Dissect the immunity using cytokine profiling and NF-kB target gene analysis in systemic inflammatory minipig model

  2021cites this paper
• Effects of Curcumin on High Glucose-Induced Epithelial-to-Mesenchymal Transition in Renal Tubular Epithelial Cells Through the TLR4-NF-κB Signaling Pathway

  2021influential citation
• DMSO_A_296990 929..940

  2021influential citation
• Colchicine Attenuates Renal Ischemia-Reperfusion-Induced Liver Damage: Implication of TLR4/NF-κB, TGF-β, BAX and Bcl-2 gene expression.

  2021cites this paper
• Chlorogenic acid supplementation ameliorates hyperuricemia, relieves renal inflammation, and modulates intestinal homeostasis.

  2021cites this paper
• TLR4/NF-KB SIGNALING PATHWAY IS A KEY PATHOGENIC EVENT LEADING TO KIDNEY DAMAGE IN UUO INDUCED RENAL FIBROSIS

  2020cites this paper
• Naringin attenuates renal interstitial fibrosis by regulating the TGF-β/Smad signaling pathway and inflammation

  2020cites this paper
• Curcumin attenuates renal interstitial fibrosis by regulating autophagy and retaining mitochondrial function in unilateral ureteral obstruction rats

  2020cites this paper
• The proteomic landscape of small urinary extracellular vesicles during kidney transplantation

  2020cites this paper
• The Emerging Role of Renal Tubular Epithelial Cells in the Immunological Pathophysiology of Lupus Nephritis

  2020cites this paper
• Curcumin attenuates renal interstitial fibrosis of obstructive nephropathy by suppressing epithelial-mesenchymal transition through inhibition of the TLR4/NF-кB and PI3K/AKT signalling pathways

  2020cites this paper
• Nuclear factor-kappa beta signaling is required for transforming growth factor Beta-2 induced ocular hypertension.

  2020cites this paper
• Telbivudine antagonizes TLR4 to inhibit the epithelial-to-mesenchymal transition in human proximal tubular epithelial cells in vitro.

  2019cites this paper
• Ellagic acid attenuates streptozocin induced diabetic nephropathy via the regulation of oxidative stress and inflammatory signaling.

  2019cites this paper
• Endothelial or vascular smooth muscle cell-specific expression of human NOX5 exacerbates renal inflammation, fibrosis and albuminuria in the Akita mouse

  2019cites this paper
• Toll-like receptors as potential therapeutic targets in kidney diseases.

  2019cites this paper
• The histone demethylase LSD1 promotes renal inflammation by mediating TLR4 signaling in hepatitis B virus-associated glomerulonephritis

  2019cites this paper
• Protective effect of DMDD, isolated from the root of Averrhoa carambola L., on high glucose induced EMT in HK-2 cells by inhibiting the TLR4-BAMBI-Smad2/3 signaling pathway.

  2019cites this paper
• A comparative analysis of the molecular basis of fibrosis between tissues

  2019cites this paper
• The proteome of small urinary extracellular vesicles after kidney transplantation as an indicator of renal cellular biology and a source for markers predicting outcome

  2019cites this paper
• Inhibitive effect of TAK-242 on Tenon's capsule fibroblasts proliferation in rat eyes.

  2019cites this paper
• Inflammation in Renal Diseases: New and Old Players

  2019cites this paper
• Complement C3 exacerbates renal interstitial fibrosis by facilitating the M1 macrophage phenotype in a mouse model of unilateral ureteral obstruction.

  2019cites this paper
• How Tubular Epithelial Cell Injury Contributes to Renal Fibrosis.

  2019cites this paper
• Inflammatory Mediators and Renal Fibrosis.

  2019cites this paper
• The immunopathogenesis of fibrosis

  2019cites this paper
• The protective effect of Nigella Sativa oil on Penconazole induced -renal toxicity in adult albino rats: Histological, Immunohistochemical and Biochemical study

  2019cites this paper
• Blocking interleukin-6 trans-signaling protects against renal fibrosis by suppressing STAT3 activation

  2019cites this paper
• Renal tubule injury: a driving force toward chronic kidney disease.

  2018cites this paper
• S100A8/A9 promotes parenchymal damage and renal fibrosis in obstructive nephropathy

  2018cites this paper
• No difference in renal injury and fibrosis between wild-type and NOD1/NOD2 double knockout mice with chronic kidney disease induced by ureteral obstruction

  2018cites this paper
• Role of DAMPs in Tissue Regeneration and Repair

  2018cites this paper
• Renal involvement in autoinflammatory diseases and inflammasome-mediated chronic kidney damage.

  2018cites this paper
• TLR4-dependent fibroblast activation drives persistent organ fibrosis in skin and lung.

  2018cites this paper
• Cardiac and renal fibrosis and oxidative stress balance in lipopolysaccharide-induced inflammation in male rats

  2018cites this paper
• Targeting receptor-interacting serine/threonine-protein kinase (RIPK)3 in renal tubulointerstitial fibrosis

  2018influential citation
• Regulation of TLR4 expression mediates the attenuating effect of erythropoietin on inflammation and myocardial fibrosis in rat heart

  2018influential citation
• Toll-like Receptor 4 Signaling Pathway in the Protective Effect of Pioglitazone on Experimental Immunoglobulin A Nephropathy

  2017cites this paper
• The Increased Expression of Toll-Like Receptor 4 in Renal and Skin Lesions in Lupus Erythematosus

  2017cites this paper
• TREM‐1 and its potential ligands in non‐infectious diseases: from biology to clinical perspectives

  2017cites this paper
• Pericyte MyD88 and IRAK4 control inflammatory and fibrotic responses to tissue injury

  2017cites this paper
• NLRX1 dampens oxidative stress and apoptosis in tissue injury via control of mitochondrial activity

  2017cites this paper
• Relaxin abrogates renal interstitial fibrosis by regulating macrophage polarization via inhibition of Toll-like receptor 4 signaling

  2017cites this paper
• SOCS2 overexpression alleviates diabetic nephropathy in rats by inhibiting the TLR4/NF-κB pathway

  2017cites this paper
• Soluble Uric Acid Activates the NLRP3 Inflammasome

  2017cites this paper
• Thymoquinone protects the rat kidneys against renal fibrosis

  2017cites this paper
• Slit2 ameliorates renal inflammation and fibrosis after hypoxia‐and lipopolysaccharide‐induced epithelial cells injury in vitro

  2017cites this paper
• Crosstalk Between Transforming Growth Factor Beta-2 and Toll-Like Receptor 4 in the Trabecular Meshwork

  2017cites this paper
• Toll-like Receptor 4 Deficiency Reduces Oxidative Stress and Macrophage Mediated Inflammation in Hypertensive Kidney

  2017cites this paper
• The pattern recognition receptor, Mincle, is essential for maintaining the M1 macrophage phenotype in acute renal inflammation.

  2017cites this paper
• Toll-like receptors in the pathogenesis of pulmonary fibrosis.

  2017cites this paper
• Astragaloside IV from Astragalus membranaceus ameliorates renal interstitial fibrosis by inhibiting inflammation via TLR4/NF‐&kgr;B in vivo and in vitro

  2017cites this paper
• IL-36 Signaling Facilitates Activation of the NLRP3 Inflammasome and IL-23/IL-17 Axis in Renal Inflammation and Fibrosis.

  2017cites this paper
• Knockdown of Angiopoietin-Like Protein 2 Ameliorates Diabetic Nephropathy by Inhibiting TLR4

  2017cites this paper
• Effects of celecoxib on expression of TLR 4 , Hepcidin , and NF-κB in rats bearing uremia with peritoneal dialysis treatment

  2017cites this paper
• Adipose‐derived stem cells ameliorate renal interstitial fibrosis through inhibition of EMT and inflammatory response via TGF‐&bgr;1 signaling pathway

  2017cites this paper
• Piceatannol Attenuates Renal Fibrosis Induced by Unilateral Ureteral Obstruction via Downregulation of Histone Deacetylase 4/5 or p38-MAPK Signaling

  2016cites this paper
• LPS/TLR4 Signaling Enhances TGF-β Response Through Downregulating BAMBI During Prostatic Hyperplasia

  2016cites this paper
• The Journal of Clinical Investigation

  2016cites this paper
• Inhibition of Toll-Like Receptor 4 Signaling Mitigates Microvascular Loss but Not Fibrosis in a Model of Ischemic Acute Kidney Injury

  2016cites this paper
• Genipin ameliorates hypertension-induced renal damage via the angiotensin II-TLR/MyD88/MAPK pathway.

  2016cites this paper
• An update on the role of the inflammasomes in the pathogenesis of kidney diseases

  2016cites this paper
• The role of Toll-like receptor 4 in high-glucose-induced inflammatory and fibrosis markers in human peritoneal mesothelial cells

  2016cites this paper
• Age-dependent shifts in renal response to injury relate to altered BMP6/CTGF expression and signaling.

  2016cites this paper
• Bletilla striata polysaccharide inhibits angiotensin II-induced ROS and inflammation via NOX4 and TLR2 pathways.

  2016cites this paper
• TLR4 mutant mice are protected from renal fibrosis and chronic kidney disease progression

  2015influential citation
• The calcium-binding protein complex S100A8/A9 has a crucial role in controlling macrophage-mediated renal repair following ischemia/reperfusion.

  2015cites this paper
• Identificación de nuevos mecanismos patogénicos de la inflamación renal por inhibidores de calcineurina

  2015cites this paper
• Protective Effects of the Total Coumarin Fraction of Urtica dentata on Experimental Diabetic Nephropathy In Vitro and In Vivo

  2015cites this paper
• Possible involvement of Toll-like receptor 7 in the development of type 1 autoimmune pancreatitis

  2015cites this paper
• How the Innate Immune System Senses Trouble and Causes Trouble.

  2015cites this paper
• Toll-like receptor 4 promotes fibrosis in bleomycin-induced lung injury in mice.

  2015cites this paper